Aliases for SP9 Gene

Aliases for SP9 Gene

  • Sp9 Transcription Factor 2 3 5
  • Transcription Factor Sp9 3 4
  • Zinc Finger Protein 990 2 3
  • Sp9 Transcription Factor Homolog (Mouse) 2
  • Sp9 Transcription Factor Homolog 3
  • ZNF990 3

External Ids for SP9 Gene

Previous GeneCards Identifiers for SP9 Gene

  • GC02P174908
  • GC02P175199
  • GC02P167080

Summaries for SP9 Gene

GeneCards Summary for SP9 Gene

SP9 (Sp9 Transcription Factor) is a Protein Coding gene. An important paralog of this gene is SP8.

UniProtKB/Swiss-Prot Summary for SP9 Gene

  • Transcription factor which plays a key role in limb development. Positively regulates FGF8 expression in the apical ectodermal ridge (AER) and contributes to limb outgrowth in embryos (By similarity).

Additional gene information for SP9 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SP9 Gene

Genomics for SP9 Gene

GeneHancer (GH) Regulatory Elements for SP9 Gene

Promoters and enhancers for SP9 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J174333 Promoter 0.7 Ensembl 500.7 -1.5 -1453 0.6 CBX2 RARA RNF2 SUZ12 EZH2 RXRA FOXA2 FOXA1 LOC102724194 SP9 CIR1 lnc-CIR1-1 LINC01305
GH02J173401 Enhancer 1 ENCODE CraniofacialAtlas 11.9 -932.7 -932746 1.9 CTCF TRIM28 REST ZBTB25 RAD21 SKI TRIM22 TEAD1 ZBTB26 ZEB1 SP9 ENSG00000236391 CDCA7 piR-42799-010 ENSG00000213148 LOC100130171 lnc-SP3-14
GH02J174263 Enhancer 0.9 Ensembl ENCODE 11.7 -70.7 -70691 1.7 JUND EP300 TRIM24 CEBPG FOS SAP130 FOSL2 CEBPB JUN FOSL1 ENSG00000201088 SP9 RF00017-3367
GH02J174153 Enhancer 0.8 Ensembl ENCODE 11.7 -180.6 -180553 1.6 FOS MYC OSR2 ZNF316 TRIM28 MAX RBM22 NFE2 FOSL1 ZFHX2 OLA1 SP9 ENSG00000270799 RF00994-536
GH02J174246 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 4.7 -86.8 -86833 2.6 HNRNPK ZBTB40 ZNF217 SIN3A NRF1 TCF12 MYC USF1 POLR2G SP1 OLA1 lnc-SP9-11 SP9 RF00017-3366 RN7SL65P
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SP9 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SP9

Top Transcription factor binding sites by QIAGEN in the SP9 gene promoter:
  • Arnt
  • C/EBPalpha
  • CHOP-10
  • Egr-4
  • Nkx6-1
  • Pax-5
  • POU2F1
  • PPAR-alpha
  • USF-1
  • USF1

Genomic Locations for SP9 Gene

Genomic Locations for SP9 Gene
chr2:174,334,954-174,346,005
(GRCh38/hg38)
Size:
11,052 bases
Orientation:
Plus strand
chr2:175,199,674-175,203,220
(GRCh37/hg19)
Size:
3,547 bases
Orientation:
Plus strand

Genomic View for SP9 Gene

Genes around SP9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SP9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SP9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SP9 Gene

Proteins for SP9 Gene

  • Protein details for SP9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0CG40-SP9_HUMAN
    Recommended name:
    Transcription factor Sp9
    Protein Accession:
    P0CG40

    Protein attributes for SP9 Gene

    Size:
    484 amino acids
    Molecular mass:
    48915 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SP9 Gene

Post-translational modifications for SP9 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SP9 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SP9 Gene

Domains & Families for SP9 Gene

Gene Families for SP9 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for SP9 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SP9 Gene

GenScript: Design optimal peptide antigens:
  • Transcription factor Sp9 (SP9_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P0CG40

UniProtKB/Swiss-Prot:

SP9_HUMAN :
  • The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors. In SP9, the motif is inactive.
  • Belongs to the Sp1 C2H2-type zinc-finger protein family.
Domain:
  • The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors. In SP9, the motif is inactive.
Family:
  • Belongs to the Sp1 C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with SP9: view

Function for SP9 Gene

Molecular function for SP9 Gene

UniProtKB/Swiss-Prot Function:
Transcription factor which plays a key role in limb development. Positively regulates FGF8 expression in the apical ectodermal ridge (AER) and contributes to limb outgrowth in embryos (By similarity).

Phenotypes From GWAS Catalog for SP9 Gene

Gene Ontology (GO) - Molecular Function for SP9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific NAS 19274049
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with SP9: view
genes like me logo Genes that share phenotypes with SP9: view

Animal Models for SP9 Gene

MGI Knock Outs for SP9:
  • Sp9 Sp9<tm1.1Zyan>

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SP9 Gene

Localization for SP9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SP9 Gene

Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SP9 gene
Compartment Confidence
nucleus 4
extracellular 2
plasma membrane 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
cytosol 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for SP9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin ISA --
GO:0005634 nucleus IBA 21873635
genes like me logo Genes that share ontologies with SP9: view

Pathways & Interactions for SP9 Gene

PathCards logo

SuperPathways for SP9 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SP9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006357 regulation of transcription by RNA polymerase II IBA 21873635
GO:0030326 embryonic limb morphogenesis IEA --
genes like me logo Genes that share ontologies with SP9: view

No data available for Pathways by source and SIGNOR curated interactions for SP9 Gene

Drugs & Compounds for SP9 Gene

No Compound Related Data Available

Transcripts for SP9 Gene

mRNA/cDNA for SP9 Gene

1 REFSEQ mRNAs :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SP9 Gene

No ASD Table

Relevant External Links for SP9 Gene

GeneLoc Exon Structure for
SP9

Expression for SP9 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SP9 Gene

mRNA differential expression in normal tissues according to GTEx for SP9 Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (x8.8), Brain - Putamen (basal ganglia) (x7.4), Brain - Caudate (basal ganglia) (x7.3), and Brain - Anterior cingulate cortex (BA24) (x5.9).

Protein differential expression in normal tissues from HIPED for SP9 Gene

This gene is overexpressed in Bone (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SP9 Gene



Protein tissue co-expression partners for SP9 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SP9

SOURCE GeneReport for Unigene cluster for SP9 Gene:

Hs.516603
genes like me logo Genes that share expression patterns with SP9: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SP9 Gene

Orthologs for SP9 Gene

This gene was present in the common ancestor of animals.

Orthologs for SP9 Gene

Organism Taxonomy Gene Similarity Type Details
oppossum
(Monodelphis domestica)
Mammalia SP9 31
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SP9 31
  • 95 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SP9 31 30
  • 94.87 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Sp9 17 31 30
  • 93.46 (n)
rat
(Rattus norvegicus)
Mammalia Sp9 30
  • 93.04 (n)
chicken
(Gallus gallus)
Aves SP9 30
  • 86.43 (n)
lizard
(Anolis carolinensis)
Reptilia SP9 31
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sp9 30
  • 77.15 (n)
zebrafish
(Danio rerio)
Actinopterygii sp9 31 30
  • 74.56 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Sp1 31
  • 33 (a)
OneToMany
Species where no ortholog for SP9 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SP9 Gene

ENSEMBL:
Gene Tree for SP9 (if available)
TreeFam:
Gene Tree for SP9 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SP9: view image

Paralogs for SP9 Gene

genes like me logo Genes that share paralogs with SP9: view

Variants for SP9 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SP9 Gene

SNP ID Clinical significance and condition Chr 02 pos Variation AA Info Type
770876 Likely Benign: not provided 174,337,471(+) A/G SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for SP9 Gene

Structural Variations from Database of Genomic Variants (DGV) for SP9 Gene

Variant ID Type Subtype PubMed ID
nsv583666 CNV loss 21841781

Variation tolerance for SP9 Gene

Gene Damage Index Score: 0.86; 18.01% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SP9 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SP9

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SP9 Gene

Disorders for SP9 Gene

No disorders were found for SP9 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SP9 Gene

Publications for SP9 Gene

  1. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 3 4 54
  2. The evolution of the 9aaTAD domain in Sp2 proteins: inactivation with valines and intron reservoirs. (PMID: 31375868) Piskacek M … Keegan LP (Cellular and molecular life sciences : CMLS 2019) 4 54
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3 54
  4. A census of human transcription factors: function, expression and evolution. (PMID: 19274049) Vaquerizas JM … Luscombe NM (Nature reviews. Genetics 2009) 3 54

Products for SP9 Gene

Sources for SP9 Gene