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Aliases for SP5 Gene

Aliases for SP5 Gene

  • Sp5 Transcription Factor 2 3 5
  • Transcription Factor Sp5 3

External Ids for SP5 Gene

Previous GeneCards Identifiers for SP5 Gene

  • GC02P171774
  • GC02P171398
  • GC02P171280
  • GC02P171571
  • GC02P163460

Summaries for SP5 Gene

GeneCards Summary for SP5 Gene

SP5 (Sp5 Transcription Factor) is a Protein Coding gene. Among its related pathways are Regulation of Wnt-mediated beta catenin signaling and target gene transcription. Gene Ontology (GO) annotations related to this gene include sequence-specific DNA binding. An important paralog of this gene is SP9.

UniProtKB/Swiss-Prot for SP5 Gene

  • Binds to GC boxes promoters elements. Probable transcriptional activator that has a role in the coordination of changes in transcription required to generate pattern in the developing embryo (By similarity).

Additional gene information for SP5 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SP5 Gene

Genomics for SP5 Gene

GeneHancer (GH) Regulatory Elements for SP5 Gene

Promoters and enhancers for SP5 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J170713 Promoter/Enhancer 2.3 UCNEbase EPDnew Ensembl ENCODE dbSUPER 650.7 +0.7 703 4.7 HDGF PKNOX1 SMAD1 FOXA2 ARID4B DMAP1 ZNF766 CBX5 ZNF143 PAF1 LINC01124 SP5 LOC101926913 DAP3P2 GAD1 EIF2S2P4
GH02J170737 Enhancer 0.7 Ensembl ENCODE 11.6 +24.2 24232 2.3 SP1 JUND HLF FOSL2 MNT SPI1 TEAD3 LOC101926913 GAD1 SP5 LINC01124 EIF2S2P4
GH02J170501 Enhancer 1.2 UCNEbase Ensembl ENCODE 5.2 -210.4 -210400 4.8 USF1 FOXA2 NANOG SOX6 MAX GABPA ETS1 CTBP1 POU5F1 ZFP36 LOC101929753 SP5 MYO3B GC02P170510 GC02P170458
GH02J170743 Enhancer 1.2 Ensembl ENCODE 0.3 +29.6 29552 1.9 HDGF FOXA2 MLX ARNT ARID4B DMAP1 YY1 SP5 ZHX2 MXD4 LOC101926913 GAD1 EIF2S2P4 SP5
GH02J170747 Enhancer 0.9 Ensembl ENCODE 0.3 +33.3 33313 1.3 HDAC1 PKNOX1 ATF1 JUN BACH1 CHAMP1 FOSL1 ZNF316 POLR2A ZFP91 GAD1 LOC101926913 EIF2S2P4 SP5
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SP5 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SP5 gene promoter:
  • Pax-5
  • Arnt
  • MZF-1
  • GATA-1
  • CRE-BP1
  • ATF-2
  • SEF-1 (1)
  • STAT1alpha
  • STAT1beta
  • AML1a

Genomic Locations for SP5 Gene

Genomic Locations for SP5 Gene
chr2:170,714,738-170,718,078
(GRCh38/hg38)
Size:
3,341 bases
Orientation:
Plus strand
chr2:171,571,857-171,574,588
(GRCh37/hg19)
Size:
2,732 bases
Orientation:
Plus strand

Genomic View for SP5 Gene

Genes around SP5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SP5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SP5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SP5 Gene

Proteins for SP5 Gene

  • Protein details for SP5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6BEB4-SP5_HUMAN
    Recommended name:
    Transcription factor Sp5
    Protein Accession:
    Q6BEB4

    Protein attributes for SP5 Gene

    Size:
    398 amino acids
    Molecular mass:
    41964 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SP5 Gene

Post-translational modifications for SP5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SP5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SP5 Gene

Domains & Families for SP5 Gene

Gene Families for SP5 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for SP5 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SP5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6BEB4

UniProtKB/Swiss-Prot:

SP5_HUMAN :
  • Belongs to the Sp1 C2H2-type zinc-finger protein family.
Family:
  • Belongs to the Sp1 C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with SP5: view

Function for SP5 Gene

Molecular function for SP5 Gene

UniProtKB/Swiss-Prot Function:
Binds to GC boxes promoters elements. Probable transcriptional activator that has a role in the coordination of changes in transcription required to generate pattern in the developing embryo (By similarity).

Phenotypes From GWAS Catalog for SP5 Gene

Gene Ontology (GO) - Molecular Function for SP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IEA --
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA,NAS 19274049
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with SP5: view
genes like me logo Genes that share phenotypes with SP5: view

Animal Models for SP5 Gene

MGI Knock Outs for SP5:
  • Sp5 Sp5<tm1b(KOMP)Wtsi>

Animal Model Products

CRISPR Products

miRNA for SP5 Gene

miRTarBase miRNAs that target SP5

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SP5

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SP5 Gene

Localization for SP5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SP5 Gene

Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SP5 gene
Compartment Confidence
nucleus 5

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
genes like me logo Genes that share ontologies with SP5: view

Pathways & Interactions for SP5 Gene

genes like me logo Genes that share pathways with SP5: view

Pathways by source for SP5 Gene

Gene Ontology (GO) - Biological Process for SP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IBA --
GO:0036342 post-anal tail morphogenesis IEA --
genes like me logo Genes that share ontologies with SP5: view

No data available for SIGNOR curated interactions for SP5 Gene

Drugs & Compounds for SP5 Gene

No Compound Related Data Available

Transcripts for SP5 Gene

mRNA/cDNA for SP5 Gene

(3) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(27) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SP5 Gene

Sp5 transcription factor:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SP5

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SP5 Gene

No ASD Table

Relevant External Links for SP5 Gene

GeneLoc Exon Structure for
SP5
ECgene alternative splicing isoforms for
SP5

Expression for SP5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SP5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SP5 Gene

This gene is overexpressed in Cervix - Endocervix (x6.9) and Cervix - Ectocervix (x6.3).

Protein differential expression in normal tissues from HIPED for SP5 Gene

This gene is overexpressed in Retina (64.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SP5 Gene



Protein tissue co-expression partners for SP5 Gene

NURSA nuclear receptor signaling pathways regulating expression of SP5 Gene:

SP5

SOURCE GeneReport for Unigene cluster for SP5 Gene:

Hs.368802
genes like me logo Genes that share expression patterns with SP5: view

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SP5 Gene

Orthologs for SP5 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SP5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SP5 34 33
  • 99.16 (n)
OneToOne
dog
(Canis familiaris)
Mammalia SP5 34 33
  • 92.7 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Sp5 16 34 33
  • 91.12 (n)
oppossum
(Monodelphis domestica)
Mammalia SP5 34
  • 91 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sp5 33
  • 90.62 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia SP5 34
  • 89 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SP5 34 33
  • 87.91 (n)
OneToOne
chicken
(Gallus gallus)
Aves SP5 34 33
  • 86.49 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SP5 34
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sp5 33
  • 65.37 (n)
MGC76071 33
African clawed frog
(Xenopus laevis)
Amphibia spr1-A 33
zebrafish
(Danio rerio)
Actinopterygii sp5a 34 33
  • 66.76 (n)
OneToMany
SP5 (1 of 3) 34
  • 54 (a)
OneToMany
sp5l 34
  • 51 (a)
OneToMany
sp5 33
fruit fly
(Drosophila melanogaster)
Insecta Sp1 34
  • 18 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CRZ1 36
Species where no ortholog for SP5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SP5 Gene

ENSEMBL:
Gene Tree for SP5 (if available)
TreeFam:
Gene Tree for SP5 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SP5: view image

Paralogs for SP5 Gene

Paralogs for SP5 Gene

(12) SIMAP similar genes for SP5 Gene using alignment to 1 proteins:

  • SP5_HUMAN
genes like me logo Genes that share paralogs with SP5: view

Variants for SP5 Gene

Sequence variations from dbSNP and Humsavar for SP5 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000468558 -- 170,714,323(+) C/A upstream_transcript_variant
rs1001606976 -- 170,714,959(+) G/C 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant
rs1001912616 -- 170,713,738(+) T/C upstream_transcript_variant
rs1002156800 -- 170,715,198(+) T/G 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant
rs1002567696 -- 170,717,031(+) G/A/T coding_sequence_variant, missense_variant

Structural Variations from Database of Genomic Variants (DGV) for SP5 Gene

Variant ID Type Subtype PubMed ID
dgv7158n54 CNV loss 21841781
esv26289 CNV loss 19812545
nsv821786 CNV gain 20364138

Variation tolerance for SP5 Gene

Residual Variation Intolerance Score: 38.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.75; 94.69% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SP5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SP5

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SP5 Gene

Disorders for SP5 Gene

No disorders were found for SP5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SP5 Gene

Publications for SP5 Gene

  1. The WNT target SP5 negatively regulates WNT transcriptional programs in human pluripotent stem cells. (PMID: 29044119) Huggins IJ … Willert K (Nature communications 2017) 3 58
  2. A census of human transcription factors: function, expression and evolution. (PMID: 19274049) Vaquerizas JM … Luscombe NM (Nature reviews. Genetics 2009) 3 58
  3. Nkx3.1 binds and negatively regulates the transcriptional activity of Sp-family members in prostate-derived cells. (PMID: 16201967) Simmons SO … Horowitz JM (The Biochemical journal 2006) 3 58
  4. Elevated expression and potential roles of human Sp5, a member of Sp transcription factor family, in human cancers. (PMID: 16380080) Chen Y … Aburatani H (Biochemical and biophysical research communications 2006) 3 58
  5. Mammalian SP/KLF transcription factors: bring in the family. (PMID: 15820306) Suske G … Philipsen S (Genomics 2005) 3 58

Products for SP5 Gene

Sources for SP5 Gene

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