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This gene encodes a member of the Sp subfamily of Sp/XKLF transcription factors. Sp family proteins are sequence-specific DNA-binding proteins characterized by an amino-terminal trans-activation domain and three carboxy-terminal zinc finger motifs. This protein contains the least conserved DNA-binding domain within the Sp subfamily of proteins, and its DNA sequence specificity differs from the other Sp proteins. It localizes primarily within subnuclear foci associated with the nuclear matrix, and can activate or in some cases repress expression from different promoters. [provided by RefSeq, Jul 2008]
SP2 (Sp2 Transcription Factor) is a Protein Coding gene. Diseases associated with SP2 include Ciliary Dyskinesia, Primary, 10 and Ciliary Dyskinesia, Primary, 9. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity, RNA polymerase II-specific and histone deacetylase binding. An important paralog of this gene is SP4.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000976 | transcription regulatory region sequence-specific DNA binding | IBA | 21873635 |
GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding | IDA | 10744779 |
GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific | ISA | -- |
GO:0001227 | DNA-binding transcription repressor activity, RNA polymerase II-specific | IDA | 10744779 |
GO:0003676 | nucleic acid binding | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000790 | nuclear chromatin | ISA | -- |
GO:0005634 | nucleus | IBA | 21873635 |
GO:0005654 | nucleoplasm | IDA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000122 | negative regulation of transcription by RNA polymerase II | IDA | 10744779 |
GO:0006357 | regulation of transcription by RNA polymerase II | TAS | 1341900 |
GO:0006955 | immune response | TAS | 1341900 |
GO:0035264 | multicellular organism growth | IEA | -- |
GO:0045944 | positive regulation of transcription by RNA polymerase II | IBA | 21873635 |
ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | · | 6c | · | 6d | · | 6e | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | ^ | 11 | ^ | 12 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | |||||||||||||||||||||||||||||||||||
SP2: | - | ||||||||||||||||||||||||||||||||||||||
SP3: | - | - | - | ||||||||||||||||||||||||||||||||||||
SP4: | - | - | - | ||||||||||||||||||||||||||||||||||||
SP5: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||
SP6: | - | ||||||||||||||||||||||||||||||||||||||
SP7: | - | - |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | SP2 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | SP2 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | SP2 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Sp2 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Sp2 30 17 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | SP2 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | SP2 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | SP2 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | sp2 30 |
|
||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.13441 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | LOC100537519 30 |
|
||
sp2 31 31 |
|
OneToMany | |||
Fruit Fly (Drosophila melanogaster) |
Insecta | CG5669 32 |
|
|
|
Worm (Caenorhabditis elegans) |
Secernentea | T22C8.5 32 |
|
|
|
sptf-2 31 |
|
ManyToMany |
Disorder | Aliases | PubMed IDs |
---|---|---|
ciliary dyskinesia, primary, 10 |
|
|
ciliary dyskinesia, primary, 9 |
|
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