Free for academic non-profit institutions. Other users need a Commercial license
This gene encodes a member of the Sp subfamily of Sp/XKLF transcription factors. Sp family proteins are sequence-specific DNA-binding proteins characterized by an amino-terminal trans-activation domain and three carboxy-terminal zinc finger motifs. This protein contains the least conserved DNA-binding domain within the Sp subfamily of proteins, and its DNA sequence specificity ... See more...
Aliases for SP2 Gene
External Ids for SP2 Gene
- HGNC: 11207
- Entrez Gene: 6668
- Ensembl: ENSG00000167182
- OMIM: 601801
- UniProtKB: Q02086
Previous GeneCards Identifiers for SP2 Gene
- GC17P045680
- GC17P048454
- GC17P046315
- GC17P046449
- GC17P046448
- GC17P043328
- GC17P045973
- GC17P041342
Summaries for SP2 Gene
-
This gene encodes a member of the Sp subfamily of Sp/XKLF transcription factors. Sp family proteins are sequence-specific DNA-binding proteins characterized by an amino-terminal trans-activation domain and three carboxy-terminal zinc finger motifs. This protein contains the least conserved DNA-binding domain within the Sp subfamily of proteins, and its DNA sequence specificity differs from the other Sp proteins. It localizes primarily within subnuclear foci associated with the nuclear matrix, and can activate or in some cases repress expression from different promoters. [provided by RefSeq, Jul 2008]
GeneCards Summary for SP2 Gene
SP2 (Sp2 Transcription Factor) is a Protein Coding gene. Diseases associated with SP2 include Myasthenic Syndrome, Congenital, 3B, Fast-Channel and Retinitis Pigmentosa 18. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity, RNA polymerase II-specific and histone deacetylase binding. An important paralog of this gene is SP4.
UniProtKB/Swiss-Prot Summary for SP2 Gene
-
Binds to GC box promoters elements and selectively activates mRNA synthesis from genes that contain functional recognition sites.
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SP2 Gene
Genomics for SP2 Gene
GeneHancer (GH) Regulatory Elements for SP2 Gene
Promoters and enhancers for SP2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around SP2 on UCSC Golden Path with GeneCards custom track
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SP2
- Top Transcription factor binding sites by QIAGEN in the SP2 gene promoter:
-
- AP-1
- ATF-2
- c-Jun
- CREB
- deltaCREB
- GR
- GR-alpha
- GR-beta
- LCR-F1
- p53
Genomic Locations for SP2 Gene
Genomic Locations for SP2 Gene
- chr17:47,896,054-47,932,271
- (GRCh38/hg38)
- Size:
- 36,218 bases
- Orientation:
- Plus strand
- chr17:45,973,516-46,006,323
- (GRCh37/hg19)
- Size:
- 32,808 bases
- Orientation:
- Plus strand
Genomic View for SP2 Gene
Genes around SP2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17q21.32 by HGNC
- 17q21.32 by Entrez Gene
- 17q21.32 by Ensembl
SP2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for SP2 Gene
Proteins for SP2 Gene
-
Protein details for SP2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q02086-SP2_HUMAN
- Recommended name:
- Transcription factor Sp2
- Protein Accession:
- Q02086
- A6NK74
Protein attributes for SP2 Gene
- Size:
- 613 amino acids
- Molecular mass:
- 64900 Da
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=AAH16680.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH33814.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA05923.2; Type=Erroneous initiation; Evidence={ECO:0000305};
Protein Expression for SP2 Gene
Post-translational modifications for SP2 Gene
Other Protein References for SP2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ SP2 Antibody
- Creative Diagnostics Anti-SP2 monoclonal antibody
-
Custom Antibody ServicesOriGene Antibodies for SP2
- Novus Biologicals Antibodies for SP2
- Invitrogen Antibodies for SP2 (AFLGC-SP2)
- antibodies-online: Show 25 available Sp2 Antibodies ranked by validation data
-
Santa Cruz Biotechnology (SCBT) Antibodies for SP2
Protein Products
-
OriGene Purified Proteins for SP2
- Search Origene for MassSpec and Protein Over-expression Lysates for SP2
- Origene Custom Protein Services for SP2
- antibodies-online: Search results for available Sp2 related products ranked by validation data
-
Abcam proteins for SP2
Assay Products
- antibodies-online: Search results for available Sp2 related products ranked by validation data
-
Boster Bio ELISA Kits for SP2
No data available for DME Specific Peptides for SP2 Gene
Domains & Families for SP2 Gene
Gene Families for SP2 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Plasma proteins
- Predicted intracellular proteins
- Transcription factors
Protein Domains for SP2 Gene
- Blocks:
-
- C2H2-type zinc finger signature
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for SP2 Gene
- GenScript: Design optimal peptide antigens:
-
- Transcription factor Sp2 (SP2_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q02086UniProtKB/Swiss-Prot:
SP2_HUMAN :- The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors. In SP2, the motif is inactive.
- Belongs to the Sp1 C2H2-type zinc-finger protein family.
- Domain:
-
- The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors. In SP2, the motif is inactive.
- Family:
-
- Belongs to the Sp1 C2H2-type zinc-finger protein family.
Function for SP2 Gene
Molecular function for SP2 Gene
- UniProtKB/Swiss-Prot Function:
- Binds to GC box promoters elements and selectively activates mRNA synthesis from genes that contain functional recognition sites.
- GENATLAS Biochemistry:
- transcription factor SP2,linked to RARA and HOXb genes
Phenotypes From GWAS Catalog for SP2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding | IDA | 10744779 |
| GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific | NAS | 19274049 |
| GO:0001227 | DNA-binding transcription repressor activity, RNA polymerase II-specific | IDA | 10744779 |
| GO:0003676 | nucleic acid binding | IEA | -- |
| GO:0003677 | DNA binding | IEA | -- |
Phenotypes for SP2 Gene
- MGI mutant phenotypes for SP2:
- inferred from 5 alleles
- GenomeRNAi human phenotypes for SP2:
Animal Models for SP2 Gene
- MGI Knock Outs for SP2:
-
- Sp2 Sp2<tm1.2Sus>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for SP2 - Select products 50% OFF >
- * SP2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for SP2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SP2
- genomics-online: gRNA clones - Search results for available Sp2 gene related products
-
Santa Cruz Biotechnology (SCBT) CRISPR for SP2
miRNA for SP2 Gene
- miRTarBase miRNAs that target SP2
-
- hsa-mir-29a-3p (MIRT049983)
- hsa-mir-638 (MIRT053760)
- hsa-mir-6773-5p (MIRT467334)
- hsa-mir-6724-5p (MIRT467335)
- hsa-mir-6864-5p (MIRT467336)
- hsa-mir-1294 (MIRT467337)
- hsa-mir-4710 (MIRT467338)
- hsa-mir-6781-5p (MIRT467339)
- hsa-mir-6877-5p (MIRT467340)
- hsa-mir-8085 (MIRT467341)
- hsa-mir-7106-5p (MIRT467342)
- hsa-mir-6731-5p (MIRT467343)
- hsa-mir-4763-3p (MIRT467344)
- hsa-mir-1207-5p (MIRT467345)
- hsa-mir-765 (MIRT467346)
- hsa-mir-6722-3p (MIRT467347)
- hsa-mir-1909-3p (MIRT467348)
- hsa-mir-873-5p (MIRT467349)
- hsa-mir-6134 (MIRT467350)
- hsa-mir-7854-3p (MIRT467351)
- hsa-mir-6133 (MIRT467352)
- hsa-mir-6130 (MIRT467353)
- hsa-mir-6129 (MIRT467354)
- hsa-mir-6127 (MIRT467355)
- hsa-mir-4510 (MIRT467356)
- hsa-mir-3179 (MIRT467357)
- hsa-mir-4419a (MIRT467358)
- hsa-mir-7515 (MIRT467359)
- hsa-mir-7112-5p (MIRT467360)
- hsa-mir-6782-5p (MIRT467361)
- hsa-mir-4756-5p (MIRT467362)
- hsa-mir-4739 (MIRT467363)
- hsa-mir-1321 (MIRT467364)
- hsa-mir-6873-5p (MIRT467365)
- hsa-mir-6760-5p (MIRT467366)
- hsa-mir-5001-3p (MIRT666147)
- hsa-mir-23b-5p (MIRT666148)
- hsa-mir-23a-5p (MIRT666149)
- hsa-mir-24-2-5p (MIRT666150)
- hsa-mir-4772-3p (MIRT666151)
- hsa-mir-24-1-5p (MIRT666152)
- hsa-mir-106a-5p (MIRT783064)
- hsa-mir-106b-5p (MIRT783077)
- hsa-mir-1234-3p (MIRT783189)
- hsa-mir-150-5p (MIRT783886)
- hsa-mir-17-5p (MIRT783939)
- hsa-mir-186-3p (MIRT783990)
- hsa-mir-20a-5p (MIRT784179)
- hsa-mir-20b-5p (MIRT784193)
- hsa-mir-302a-3p (MIRT784428)
- hsa-mir-302b-3p (MIRT784439)
- hsa-mir-302c-3p (MIRT784451)
- hsa-mir-302d-3p (MIRT784466)
- hsa-mir-302e (MIRT784477)
- hsa-mir-372-3p (MIRT785320)
- hsa-mir-373-3p (MIRT785337)
- hsa-mir-4438 (MIRT785881)
- hsa-mir-4731-5p (MIRT786556)
- hsa-mir-5089-5p (MIRT787079)
- hsa-mir-5095 (MIRT787089)
- hsa-mir-512-3p (MIRT787135)
- hsa-mir-519d-3p (MIRT787246)
- hsa-mir-520a-3p (MIRT787262)
- hsa-mir-520b (MIRT787274)
- hsa-mir-520c-3p (MIRT787285)
- hsa-mir-520d-3p (MIRT787298)
- hsa-mir-520e (MIRT787312)
- hsa-mir-520g-3p (MIRT787323)
- hsa-mir-520h (MIRT787333)
- hsa-mir-526b-3p (MIRT787357)
- hsa-mir-5589-5p (MIRT787698)
- hsa-mir-619-5p (MIRT788118)
- hsa-mir-6504-3p (MIRT788244)
- hsa-mir-6506-5p (MIRT788259)
- hsa-mir-6778-3p (MIRT788678)
- hsa-mir-6802-3p (MIRT788819)
- hsa-mir-7107-5p (MIRT789400)
- hsa-mir-7151-3p (MIRT789431)
- hsa-mir-8062 (MIRT789778)
- hsa-mir-93-5p (MIRT789976)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for SP2
- Browse OriGene Inhibitory RNA Products For SP2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SP2
- genomics-online: shRNA clones - Search results for available Sp2 gene related products
Clone Products
- Applied Biological Materials (abm): Clones for SP2 - Select products 50% OFF >
- * SP2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for SP2
- Addgene plasmids for SP2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SP2
- genomics-online: cdna clones - Search results for available Sp2 gene related products
- orf clones - Search results for available Sp2 gene related products
Cell Line Products
-
Horizon Cell Lines for SP2
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SP2 Gene
Localization for SP2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for SP2 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| plasma membrane | 2 |
| extracellular | 2 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| endoplasmic reticulum | 2 |
| cytosol | 2 |
| peroxisome | 1 |
| endosome | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
- Nucleoplasm (4)
- Vesicles (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000790 | nuclear chromatin | ISA | -- |
| GO:0005634 | nucleus | IDA,IBA | 21873635 |
| GO:0005654 | nucleoplasm | IDA | -- |
Pathways & Interactions for SP2 Gene
Interacting Proteins for SP2 Gene
Selected Interacting proteins:
Q02086-SP2_HUMAN
ENSP00000365931
for SP2 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for SP2
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000122 | negative regulation of transcription by RNA polymerase II | IDA | 10744779 |
| GO:0006357 | regulation of transcription by RNA polymerase II | IBA,TAS | 21873635 |
| GO:0006955 | immune response | TAS | 1341900 |
| GO:0035264 | multicellular organism growth | IEA | -- |
No data available for Pathways by source for SP2 Gene
Transcripts for SP2 Gene
mRNA/cDNA for SP2 Gene
- 1 REFSEQ mRNAs :
- 7 NCBI additional mRNA sequence :
- 6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000376741 3026 bps (ENST00000376741.5)
- ENST00000613139 908 bps (ENST00000613139.1)
- ENST00000635868 342 bps (ENST00000635868.1)
- ENST00000637314 531 bps (ENST00000637314.1)
- ENST00000637943 481 bps (ENST00000637943.1)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for SP2 - Select products 50% OFF >
- * SP2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for SP2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SP2
- genomics-online: gRNA clones - Search results for available Sp2 gene related products
-
Santa Cruz Biotechnology (SCBT) CRISPR for SP2
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for SP2
- Browse OriGene Inhibitory RNA Products For SP2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SP2
- genomics-online: shRNA clones - Search results for available Sp2 gene related products
Clone Products
- Applied Biological Materials (abm): Clones for SP2 - Select products 50% OFF >
- * SP2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for SP2
- Addgene plasmids for SP2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SP2
- genomics-online: cdna clones - Search results for available Sp2 gene related products
- orf clones - Search results for available Sp2 gene related products
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | · | 6c | · | 6d | · | 6e | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | ^ | 11 | ^ | 12 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | |||||||||||||||||||||||||||||||||||
| SP2: | - | ||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | ||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | ||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||
| SP6: | - | ||||||||||||||||||||||||||||||||||||||
| SP7: | - | - |
Relevant External Links for SP2 Gene
- GeneLoc Exon Structure for
- SP2
Expression for SP2 Gene
This gene is overexpressed in Blymphocyte (16.0), CD8 Tcells (10.1), Peripheral blood mononuclear cells (9.3), Pancreas (7.4), and Retina (6.9).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SP2 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SP2
SOURCE GeneReport for Unigene cluster for SP2 Gene:
Hs.514276Evidence on tissue expression from TISSUES for SP2 Gene
- Spleen(4.5)
- Bone marrow(4.2)
- Lung(4.2)
Primer Products
-
OriGene qPCR primer pairs for SP2
-
OriGene qPCR primer pairs and template standards for SP2
- genomics-online: primer clones - Search results for available Sp2 gene related products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SP2 Gene
Orthologs for SP2 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | SP2 31 30 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | SP2 31 30 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | SP2 31 30 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Sp2 30 |
|
||
| mouse (Mus musculus) |
Mammalia | Sp2 17 31 30 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | SP2 31 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | SP2 31 30 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | SP2 31 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | sp2 30 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.13441 30 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | LOC100537519 30 |
|
||
| sp2 31 31 |
|
OneToMany | |||
| fruit fly (Drosophila melanogaster) |
Insecta | CG5669 32 |
|
|
|
| worm (Caenorhabditis elegans) |
Secernentea | T22C8.5 32 |
|
|
|
| sptf-2 31 |
|
ManyToMany |
- Species where no ortholog for SP2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Evolution for SP2 Gene
- ENSEMBL:
- Gene Tree for SP2 (if available)
- TreeFam:
- Gene Tree for SP2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for SP2: view image
Paralogs for SP2 Gene
(26) SIMAP similar genes for SP2 Gene using alignment to 2 proteins:
- SP2_HUMAN
- Q9BRW5_HUMAN
Variants for SP2 Gene
Residual Variation Intolerance Score:
5.73% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
6.18;
75.92% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for SP2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- SP2
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SP2 Gene
Disorders for SP2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| myasthenic syndrome, congenital, 3b, fast-channel |
|
|
| retinitis pigmentosa 18 |
|
|
| spastic paraplegia 6, autosomal dominant |
|
|
| hypercholesterolemia, familial, 4 |
|
|
| hemochromatosis type 2 |
|
|
Search SP2 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for SP2
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for SP2 Gene
Publications for SP2 Gene
- Cloning of GT box-binding proteins: a novel Sp1 multigene family regulating T-cell receptor gene expression. (PMID: 1341900) Kingsley C … Winoto A (Molecular and cellular biology 1992) 2 3 4 54
- Sequential use of transcriptional profiling, expression quantitative trait mapping, and gene association implicates MMP20 in human kidney aging. (PMID: 19834535) Wheeler HE … Kim SK (PLoS genetics 2009) 3 41 54
- Sp1 elements in SULT2B1b promoter and 5'-untranslated region of mRNA: Sp1/Sp2 induction and augmentation by histone deacetylase inhibition. (PMID: 15953604) Lee YC … Strott CA (FEBS letters 2005) 3 23 54
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
- Assignment1 of Sp genes to rat chromosome bands 7q36 (Sp1), 10q31-->q32.1 (Sp2), 3q24-->q31 (Sp3) and 6q33 (Sp4) and of the SP2 gene to human chromosome bands 17q21.3-->q22 by in situ hybridization. (PMID: 9730617) Scohy S … Szpirer J (Cytogenetics and cell genetics 1998) 2 3 54
ExternalLinks
Products for SP2 Gene
- Custom Antibody ServicesOriGene Antibodies for SP2
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for SP2
- Search Origene for MassSpec and Protein Over-expression Lysates for SP2
- Origene Custom Protein Services for SP2
- Origene shrna, sirna, and RNAi products in human, mouse, rat for SP2
- Browse OriGene Inhibitory RNA Products For SP2
- OriGene qPCR primer pairs for SP2
- OriGene qPCR primer pairs and template standards for SP2
- OriGene CRISPR knockouts for SP2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For SP2
- Sino Biological Human cDNA Clone for SP2
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for SP2
- Novus Biologicals proteins and lysates for SP2
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam proteins for SP2
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Invitrogen Antibodies for SP2 (AFLGC-SP2)
- VectorBuilder Custom and pre-made DNA vectors for SP2 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for SP2 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for SP2 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for SP2 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for SP2
- Addgene plasmids for SP2
- antibodies-online: Show 25 available Sp2 Antibodies ranked by validation data
- antibodies-online: Search results for available Sp2 related products ranked by validation data
- antibodies-online: Search results for available Sp2 related products ranked by validation data
- Santa Cruz Biotechnology (SCBT) Antibodies for SP2
- Search Santa Cruz Biotechnology (SCBT) for SP2 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for SP2
- Horizon Cell Lines for SP2
- genomics-online: cdna clones - Search results for available Sp2 gene related products
- orf clones - Search results for available Sp2 gene related products
- genomics-online: gRNA clones - Search results for available Sp2 gene related products
- genomics-online: primer clones - Search results for available Sp2 gene related products
- genomics-online: shRNA clones - Search results for available Sp2 gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SP2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SP2
- Search GeneCopoeia for miRNA 3'UTR Target clone products for SP2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SP2
Sources for SP2 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) H-invDB
- (47) HORDE
- (48) HUGE
- (49) IMGT
- (50) Leiden
- (51) miRBase
- (52) DME
- (53) OriGene
- (54) PubMed
- (55) R&D Systems
- (56) TGDB
- (57) Tocris
- (58) Abcam
- (59) Novus Biologicals
- (60) ProSpec
- (61) Sino Biological
- (62) GenScript
- (63) Qiagen
- (64) OCA
- (65) Proteopedia
- (66) MOPED
- (67) neXtProt
- (68) Reactome
- (69) GeneGo (Thomson Reuters)
- (70) DISEASES
- (71) SIMAP
- (72) GenomeRNAi
- (73) LifeMap
- (74) miRTarBase
- (75) MalaCards
- (76) Invitrogen
- (77) BitterDB
- (78) ESI-BIO
- (79) RefSeq
- (80) BioSystems
- (81) MaxQB
- (82) IUPHAR
- (83) BioGPS
- (84) Illumina
- (85) COMPARTMENTS
- (86) HOMER
- (87) PaxDb
- (88) ApexBio
- (89) Addgene
- (90) antibodies-online
- (91) CYP
- (92) NONCODE
- (93) TreeFam
- (94) PathCards
- (95) GeneReviews
- (96) GeneTex
- (97) Taconic Biosciences
- (98) GTEx
- (99) ProteomicsDB
- (100) SCBT
- (101) DGIdb
- (102) ClinicalTrials
- (103) RVIS
- (104) SIGNOR
- (105) diseasecard
- (106) NIH Rare Diseases
- (107) Orphanet
- (108) UMLS
- (109) GTR
- (110) Disease Ontology
- (111) Genetics Home Reference
- (112) MeSH
- (113) MedlinePlus
- (114) CDC
- (115) NINDS
- (116) NCBI Bookshelf
- (117) ClinVar
- (118) Gene Damage Index
- (119) HPO
- (120) UDN
- (121) VISTA
- (122) FANTOM5
- (123) ENCODE
- (124) ProSci
- (125) Horizon
- (126) The Signaling Pathways Project (SPP)
- (127) IID
- (128) VectorBuilder
- (129) SNPedia
- (130) BRCA Exchange
- (131) CIViC
- (132) ProteoGenix
- (133) dbSUPER
- (134) TISSUES
- (135) Gene ORGANizer
- (136) abm
- (137) Human Protein Atlas
- (138) GWAS Catalog
- (139) Monarch Initiative
- (140) DataMed
- (141) HumanCyc
- (142) genomics-online
- (143) UCNEbase
- (144) EPDnew
- (145) Applied Biosystems
- (146) GlyConnect
- (147) Aminode
- (148) GeneCopoeia
- (149) GPS-Prot
- (150) RNACentral
- (151) LncRNADisease
- (152) LOVD
- (153) miR2Disease
- (154) DiseaseEnhancer
- (155) Boster Bio
- (156) Biorbyt
- (157) Biocompare
- (158) Mastermind
- (159) CTD^2 Dashboard
- (160) CraniofacialAtlas
- (161) GeneImprint
- (162) Synthego
- (163) Bio Basic
- (164) ENA
- (165) GtRNAdb
- (166) LncBase
- (167) LncBook
- (168) LNCipedia
- (169) LncRNAdb
- (170) Modomics
- (171) PDBe
- (172) Rfam
- (173) SILVA
- (174) snOPY
- (175) SRPDB
- (176) GENCODE
- (177) TarBase
- (178) MyBioSource
- (179) Signalway Antibody