This gene encodes a member of the Sp subfamily of Sp/XKLF transcription factors. Sp family proteins are sequence-specific DNA-binding proteins characterized by an amino-terminal trans-activation domain and three carboxy-terminal zinc finger motifs. This protein contains the least conserved DNA-binding domain within the Sp subfamily of proteins, and its DNA sequence specificity ... See more...

Aliases for SP2 Gene

Aliases for SP2 Gene

  • Sp2 Transcription Factor 2 3 5
  • Transcription Factor Sp2 3 4
  • KIAA0048 2 4
  • SP2 5

External Ids for SP2 Gene

Previous GeneCards Identifiers for SP2 Gene

  • GC17P045680
  • GC17P048454
  • GC17P046315
  • GC17P046449
  • GC17P046448
  • GC17P043328
  • GC17P045973
  • GC17P041342

Summaries for SP2 Gene

Entrez Gene Summary for SP2 Gene

  • This gene encodes a member of the Sp subfamily of Sp/XKLF transcription factors. Sp family proteins are sequence-specific DNA-binding proteins characterized by an amino-terminal trans-activation domain and three carboxy-terminal zinc finger motifs. This protein contains the least conserved DNA-binding domain within the Sp subfamily of proteins, and its DNA sequence specificity differs from the other Sp proteins. It localizes primarily within subnuclear foci associated with the nuclear matrix, and can activate or in some cases repress expression from different promoters. [provided by RefSeq, Jul 2008]

GeneCards Summary for SP2 Gene

SP2 (Sp2 Transcription Factor) is a Protein Coding gene. Diseases associated with SP2 include Ciliary Dyskinesia, Primary, 10 and Ciliary Dyskinesia, Primary, 9. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity, RNA polymerase II-specific and histone deacetylase binding. An important paralog of this gene is SP4.

UniProtKB/Swiss-Prot Summary for SP2 Gene

  • Binds to GC box promoters elements and selectively activates mRNA synthesis from genes that contain functional recognition sites.

Gene Wiki entry for SP2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SP2 Gene

Genomics for SP2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for SP2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SP2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SP2

Top Transcription factor binding sites by QIAGEN in the SP2 gene promoter:
  • AP-1
  • ATF-2
  • c-Jun
  • CREB
  • deltaCREB
  • GR
  • GR-alpha
  • GR-beta
  • LCR-F1
  • p53

Genomic Locations for SP2 Gene

Genomic Locations for SP2 Gene
chr17:47,896,032-47,932,271
(GRCh38/hg38)
Size:
36,240 bases
Orientation:
Plus strand
chr17:45,973,516-46,006,323
(GRCh37/hg19)
Size:
32,808 bases
Orientation:
Plus strand

Genomic View for SP2 Gene

Genes around SP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SP2 Gene

Proteins for SP2 Gene

  • Protein details for SP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q02086-SP2_HUMAN
    Recommended name:
    Transcription factor Sp2
    Protein Accession:
    Q02086
    Secondary Accessions:
    • A6NK74

    Protein attributes for SP2 Gene

    Size:
    613 amino acids
    Molecular mass:
    64900 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH16680.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH33814.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA05923.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SP2 Gene

Post-translational modifications for SP2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SP2 Gene

Domains & Families for SP2 Gene

Gene Families for SP2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for SP2 Gene

InterPro:
Blocks:
  • C2H2-type zinc finger signature
ProtoNet:

Suggested Antigen Peptide Sequences for SP2 Gene

GenScript: Design optimal peptide antigens:
  • Transcription factor Sp2 (SP2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q02086

UniProtKB/Swiss-Prot:

SP2_HUMAN :
  • The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors. In SP2, the motif is inactive.
  • Belongs to the Sp1 C2H2-type zinc-finger protein family.
Domain:
  • The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors. In SP2, the motif is inactive.
Family:
  • Belongs to the Sp1 C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with SP2: view

Function for SP2 Gene

Molecular function for SP2 Gene

UniProtKB/Swiss-Prot Function:
Binds to GC box promoters elements and selectively activates mRNA synthesis from genes that contain functional recognition sites.
GENATLAS Biochemistry:
transcription factor SP2,linked to RARA and HOXb genes

Phenotypes From GWAS Catalog for SP2 Gene

Gene Ontology (GO) - Molecular Function for SP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000976 transcription regulatory region sequence-specific DNA binding IBA 21873635
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA 10744779
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific ISA --
GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific IDA 10744779
GO:0003676 nucleic acid binding IEA --
genes like me logo Genes that share ontologies with SP2: view
genes like me logo Genes that share phenotypes with SP2: view

Animal Models for SP2 Gene

MGI Knock Outs for SP2:
  • Sp2 Sp2<tm1.2Sus>

Animal Model Products

CRISPR Products

miRNA for SP2 Gene

miRTarBase miRNAs that target SP2

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SP2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SP2 Gene

Localization for SP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SP2 Gene

Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SP2 gene
Compartment Confidence
nucleus 5
plasma membrane 2
extracellular 2
cytoskeleton 2
mitochondrion 2
cytosol 2
peroxisome 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (4)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin ISA --
GO:0005634 nucleus IBA 21873635
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with SP2: view

Pathways & Interactions for SP2 Gene

PathCards logo

SuperPathways for SP2 Gene

No Data Available

SIGNOR curated interactions for SP2 Gene

Activates:

Gene Ontology (GO) - Biological Process for SP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IDA 10744779
GO:0006357 regulation of transcription by RNA polymerase II TAS 1341900
GO:0006955 immune response TAS 1341900
GO:0035264 multicellular organism growth IEA --
GO:0045944 positive regulation of transcription by RNA polymerase II IBA 21873635
genes like me logo Genes that share ontologies with SP2: view

No data available for Pathways by source for SP2 Gene

Drugs & Compounds for SP2 Gene

No Compound Related Data Available

Transcripts for SP2 Gene

mRNA/cDNA for SP2 Gene

1 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SP2

Alternative Splicing Database (ASD) splice patterns (SP) for SP2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d · 6e ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12
SP1: - - - -
SP2: -
SP3: - - -
SP4: - - -
SP5: - - - - - -
SP6: -
SP7: - -

Relevant External Links for SP2 Gene

GeneLoc Exon Structure for
SP2

Expression for SP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SP2 Gene

Protein differential expression in normal tissues from HIPED for SP2 Gene

This gene is overexpressed in Blymphocyte (16.0), CD8 Tcells (10.1), Peripheral blood mononuclear cells (9.3), Pancreas (7.4), and Retina (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SP2 Gene



Protein tissue co-expression partners for SP2 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SP2

SOURCE GeneReport for Unigene cluster for SP2 Gene:

Hs.514276

Evidence on tissue expression from TISSUES for SP2 Gene

  • Spleen(4.5)
  • Lung(4.4)
  • Bone marrow(4.4)
  • Nervous system(2.6)
  • Skin(2.5)
  • Blood(2.5)
  • Muscle(2.4)
  • Intestine(2.4)
  • Kidney(2.4)
  • Heart(2.2)
  • Liver(2.1)
  • Lymph node(2.1)
genes like me logo Genes that share expression patterns with SP2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SP2 Gene

Orthologs for SP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SP2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia SP2 30 31
  • 99.51 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia SP2 30 31
  • 92.85 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia SP2 30 31
  • 92.01 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Sp2 30
  • 90.18 (n)
Mouse
(Mus musculus)
Mammalia Sp2 30 17 31
  • 89.16 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia SP2 31
  • 87 (a)
OneToOne
Chicken
(Gallus gallus)
Aves SP2 30 31
  • 77.14 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia SP2 31
  • 79 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia sp2 30
  • 65.7 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.13441 30
Zebrafish
(Danio rerio)
Actinopterygii LOC100537519 30
  • 63.79 (n)
sp2 31 31
  • 61 (a)
OneToMany
Fruit Fly
(Drosophila melanogaster)
Insecta CG5669 32
  • 65 (a)
Worm
(Caenorhabditis elegans)
Secernentea T22C8.5 32
  • 57 (a)
sptf-2 31
  • 47 (a)
ManyToMany
Species where no ortholog for SP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for SP2 Gene

ENSEMBL:
Gene Tree for SP2 (if available)
TreeFam:
Gene Tree for SP2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SP2: view image

Paralogs for SP2 Gene

Paralogs for SP2 Gene

genes like me logo Genes that share paralogs with SP2: view

Variants for SP2 Gene

Additional dbSNP identifiers (rs#s) for SP2 Gene

Structural Variations from Database of Genomic Variants (DGV) for SP2 Gene

Variant ID Type Subtype PubMed ID
esv3640708 CNV loss 21293372
nsv2072 CNV deletion 18451855
nsv518892 CNV loss 19592680

Variation tolerance for SP2 Gene

Residual Variation Intolerance Score: 5.73% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.18; 75.92% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SP2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SP2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SP2 Gene

Disorders for SP2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for SP2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
ciliary dyskinesia, primary, 10
  • cild10
ciliary dyskinesia, primary, 9
  • cild9
- elite association - COSMIC cancer census association via MalaCards
Search SP2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for SP2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with SP2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SP2 Gene

Publications for SP2 Gene

  1. Cloning of GT box-binding proteins: a novel Sp1 multigene family regulating T-cell receptor gene expression. (PMID: 1341900) Kingsley C … Winoto A (Molecular and cellular biology 1992) 2 3 4
  2. Sequential use of transcriptional profiling, expression quantitative trait mapping, and gene association implicates MMP20 in human kidney aging. (PMID: 19834535) Wheeler HE … Kim SK (PLoS genetics 2009) 3 41
  3. Sp1 elements in SULT2B1b promoter and 5'-untranslated region of mRNA: Sp1/Sp2 induction and augmentation by histone deacetylase inhibition. (PMID: 15953604) Lee YC … Strott CA (FEBS letters 2005) 3 23
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  5. Assignment1 of Sp genes to rat chromosome bands 7q36 (Sp1), 10q31-->q32.1 (Sp2), 3q24-->q31 (Sp3) and 6q33 (Sp4) and of the SP2 gene to human chromosome bands 17q21.3-->q22 by in situ hybridization. (PMID: 9730617) Scohy S … Szpirer J (Cytogenetics and cell genetics 1998) 2 3

Products for SP2 Gene

Sources for SP2 Gene