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The protein encoded by this gene is a zinc finger transcription factor that binds to GC-rich motifs of many promoters. The encoded protein is involved in many cellular processes, including cell differentiation, cell growth, apoptosis, immune responses, response to DNA damage, and chromatin remodeling. Post-translational modifications such as phosphorylation, acetylation, glycos... See more...
Aliases for SP1 Gene
Aliases for SP1 Gene
External Ids for SP1 Gene
- HGNC: 11205
- NCBI Entrez Gene: 6667
- Ensembl: ENSG00000185591
- OMIM®: 189906
- UniProtKB/Swiss-Prot: P08047
Previous GeneCards Identifiers for SP1 Gene
- GC12P053801
- GC12P053490
- GC12P052060
- GC12P050814
- GC12P053773
Summaries for SP1 Gene
-
The protein encoded by this gene is a zinc finger transcription factor that binds to GC-rich motifs of many promoters. The encoded protein is involved in many cellular processes, including cell differentiation, cell growth, apoptosis, immune responses, response to DNA damage, and chromatin remodeling. Post-translational modifications such as phosphorylation, acetylation, glycosylation, and proteolytic processing significantly affect the activity of this protein, which can be an activator or a repressor. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2014]
GeneCards Summary for SP1 Gene
SP1 (Sp1 Transcription Factor) is a Protein Coding gene. Diseases associated with SP1 include Huntington Disease and Embryonal Carcinoma. Among its related pathways are Toll-Like receptor Signaling Pathways and G-Beta Gamma Signaling. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is SP4.
UniProtKB/Swiss-Prot Summary for SP1 Gene
-
Transcription factor that can activate or repress transcription in response to physiological and pathological stimuli. Binds with high affinity to GC-rich motifs and regulates the expression of a large number of genes involved in a variety of processes such as cell growth, apoptosis, differentiation and immune responses. Highly regulated by post-translational modifications (phosphorylations, sumoylation, proteolytic cleavage, glycosylation and acetylation). Binds also the PDGFR-alpha G-box promoter. May have a role in modulating the cellular response to DNA damage. Implicated in chromatin remodeling. Plays an essential role in the regulation of FE65 gene expression. In complex with ATF7IP, maintains telomerase activity in cancer cells by inducing TERT and TERC gene expression. Isoform 3 is a stronger activator of transcription than isoform 1. Positively regulates the transcription of the core clock component ARNTL/BMAL1 (PubMed:10391891, PubMed:11371615, PubMed:11904305, PubMed:14593115, PubMed:16377629, PubMed:16478997, PubMed:16943418, PubMed:17049555, PubMed:18171990, PubMed:18199680, PubMed:18239466, PubMed:18513490, PubMed:18619531, PubMed:19193796, PubMed:20091743, PubMed:21798247, PubMed:21046154). Plays a role in the recruitment of SMARCA4/BRG1 on the c-FOS promoter. Plays a role in protecting cells against oxidative stress following brain injury by regulating the expression of RNF112 (By similarity).
Additional gene information for SP1 Gene
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SP1 Gene
Genomics for SP1 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for SP1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around SP1 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SP1
- Top Transcription factor binding sites by QIAGEN in the SP1 gene promoter:
-
- AP-1
- ATF-2
- c-Jun
- STAT1
Genomic Locations for SP1 Gene
Latest Assembly
- chr12:53,380,176-53,416,446
- (GRCh38/hg38)
- Size:
- 36,271 bases
- Orientation:
- Plus strand
Previous Assembly
- chr12:53,773,960-53,810,230
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 36,271 bases
- Orientation:
- Plus strand
Genomic View for SP1 Gene
Genes around SP1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 12q13.13 by HGNC
- 12q13.13 by Entrez Gene
- 12q13.13 by Ensembl
SP1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for SP1 Gene
Proteins for SP1 Gene
-
Protein details for SP1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P08047-SP1_HUMAN
- Recommended name:
- Transcription factor Sp1
- Protein Accession:
- P08047
- E4Z9M7
- G5E9M8
- Q86TN8
- Q9H3Q5
- Q9NR51
- Q9NY21
- Q9NYE7
Protein attributes for SP1 Gene
- Size:
- 785 amino acids
- Molecular mass:
- 80693 Da
- Quaternary structure:
-
- Interacts with ATF7IP, ATF7IP2, BAHD1, POGZ, HCFC1, AATF and PHC2. Interacts with HLTF; the interaction may be required for basal transcriptional activity of HLTF. Interacts (deacetylated form) with EP300; the interaction enhances gene expression. Interacts with HDAC1 and JUN. Interacts with ELF1; the interaction is inhibited by glycosylation of SP1. Interaction with NFYA; the interaction is inhibited by glycosylation of SP1. Interacts with ATF7IP and TBP. Interacts with MEIS2 isoform 4 and PBX1 isoform PBX1a. Interacts with EGR1 (PubMed:10391891, PubMed:10976766, PubMed:12021324, PubMed:12847090, PubMed:12855699, PubMed:15691849, PubMed:16478997, PubMed:19106100, PubMed:19285002, PubMed:19302979, PubMed:19666599, PubMed:20121949, PubMed:21746878, PubMed:7592727, PubMed:9466902). Interacts with SMARCA4/BRG1. Interacts with RNF112 in an oxidative stress-regulated manner (By similarity). Interacts with ZBTB7A; ZBTB7A prevents the binding to GC-rich motifs in promoters and represses the transcriptional activity of SP1 (PubMed:12004059). Interacts with DDX3X; this interaction potentiates SP1-induced CDKN1A/WAF1/CIP1 transcription (PubMed:16818630).
- (Microbial infection) Interacts with varicella-zoster virus IE62 protein.
- (Microbial infection) Interacts with SV40 VP2/3 proteins. Interacts with SV40 major capsid protein VP1; this interaction leads to a cooperativity between the 2 proteins in DNA binding.
- (Microbial infection) Interacts with HIV-1 Vpr; the interaction is inhibited by SP1 O-glycosylation.
- SequenceCaution:
-
- Sequence=AAH43224.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
- Miscellaneous:
-
- In the hepatoma cell line Hep-G2, SP1 precursor mRNA may undergo homotype trans-splicing leading to the duplication of exons 2 and 3.
Three dimensional structures from OCA and Proteopedia for SP1 Gene
Protein Expression for SP1 Gene
Post-translational modifications for SP1 Gene
- Phosphorylated on multiple serine and threonine residues. Phosphorylation is coupled to ubiquitination, sumoylation and proteolytic processing. Phosphorylation on Ser-59 enhances proteolytic cleavage. Phosphorylation on Ser-7 enhances ubiquitination and protein degradation. Hyperphosphorylation on Ser-101 in response to DNA damage has no effect on transcriptional activity. MAPK1/MAPK3-mediated phosphorylation on Thr-453 and Thr-739 enhances VEGF transcription but, represses FGF2-triggered PDGFR-alpha transcription. Also implicated in the repression of RECK by ERBB2. Hyperphosphorylated on Thr-278 and Thr-739 during mitosis by MAPK8 shielding SP1 from degradation by the ubiquitin-dependent pathway. Phosphorylated in the zinc-finger domain by calmodulin-activated PKCzeta. Phosphorylation on Ser-641 by PKCzeta is critical for TSA-activated LHR gene expression through release of its repressor, p107. Phosphorylation on Thr-668, Ser-670 and Thr-681 is stimulated by angiotensin II via the AT1 receptor inducing increased binding to the PDGF-D promoter. This phosphorylation is increased in injured artey wall. Ser-59 and Thr-681 can both be dephosphorylated by PP2A during cell-cycle interphase. Dephosphorylation on Ser-59 leads to increased chromatin association during interphase and increases the transcriptional activity. On insulin stimulation, sequentially glycosylated and phosphorylated on several C-terminal serine and threonine residues.
- Acetylated. Acetylation/deacetylation events affect transcriptional activity. Deacetylation leads to an increase in the expression the 12(s)-lipooxygenase gene though recruitment of p300 to the promoter.
- Ubiquitinated. Ubiquitination occurs on the C-terminal proteolytically-cleaved peptide and is triggered by phosphorylation.
- Sumoylated with SUMO1. Sumoylation modulates proteolytic cleavage of the N-terminal repressor domain. Sumoylation levels are attenuated during tumorigenesis. Phosphorylation mediates SP1 desumoylation.
- Proteolytic cleavage in the N-terminal repressor domain is prevented by sumoylation. The C-terminal cleaved product is susceptible to degradation.
- O-glycosylated; Contains 8 N-acetylglucosamine side chains. Levels are controlled by insulin and the SP1 phosphorylation states. Insulin-mediated O-glycosylation locates SP1 to the nucleus, where it is sequentially deglycosylated and phosphorylated. O-glycosylation affects transcriptional activity through disrupting the interaction with a number of transcription factors including ELF1 and NFYA. Also inhibits interaction with the HIV1 promoter. Inhibited by peroxisomome proliferator receptor gamma (PPARgamma).
-
Glycosylation at Ser491, Ser612, Thr640, Ser641, Ser698, and Ser702
- NX_P08047 (NX_P08047-1)
- Modification sites at PhosphoSitePlus
-
Glycosylation from GlyConnect
- SP1_HUMAN (605)
Other Protein References for SP1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
- LifeSpan BioSciences SP1 Antibody and SP1 Monoclonal Antibody
- GeneTex Anti-SP1 antibody and Anti-SP1 antibody [GT2574]
- NSJ Bioreagents Specificity Protein 1 Antibody / SP1
-
Custom Antibody ServicesOriGene Antibodies for SP1
- Novus Biologicals Antibodies for SP1
-
Abcam antibodies for SP1
- Invitrogen Antibodies for SP1 (AFLGC-SP1)
- antibodies-online: Show 124 available SP1 Antibodies ranked by validation data
- Compare Top SP1 Antibodies
-
Recommended
- 227 WB Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 8 IHC (p) Antibodies (anti-human)
- 4 IHC Antibodies (anti-human)
- 93 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 3 IHC Antibodies (anti-rat)
- 129 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 6 IHC (p) Antibodies (anti-mouse)
- 4 IHC Antibodies (anti-mouse)
-
Boster Bio Antibodies for SP1
-
Custom Antibody ServicesProSci Antibodies for SP1
- Sp1 transcription factor [15-659]
- trans-acting transcription factor 1 [28-632]
- trans-acting transcription factor 1 [28-633]
- trans-acting transcription factor 1 [43-573]
- Sp1 transcription factor [45-151]
- Sp1 transcription factor [29-891]
- Sp1 transcription factor [48-798]
- Transcription factor Sp1 [55-854]
- Sp1 transcription factor [79-481]
-
Santa Cruz Biotechnology (SCBT) Antibodies for SP1
- Sino Biological Antibodies for SP1
Protein products for research
-
OriGene Purified Proteins for SP1
- Search Origene for MassSpec and Protein Over-expression Lysates for SP1
- Origene Custom Protein Services for SP1
- Novus Biologicals proteins for SP1
- antibodies-online: Show 9 available SP1 Proteins ranked by validation data
- Compare Top SP1 Proteins
-
Abcam proteins for SP1
Assay products for research
- G Biosciences Immunotag™ Transcription factor Sp1 ELISA Kit
-
Abcam assays for SP1
No data available for DME Specific Peptides for SP1 Gene
Domains & Families for SP1 Gene
Gene Families for SP1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Predicted intracellular proteins
- Transcription factors
Protein Domains for SP1 Gene
- InterPro:
Suggested Antigen Peptide Sequences for SP1 Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA, FLJ92269 (B2R4Y6_HUMAN)
- Specificity protien 1 (C4PGM0_HUMAN)
- Transcription factor Sp1 (E4Z9M7_HUMAN)
- Pregnancy-specific protein (Q15403_HUMAN)
- Transcription factor Sp1 (SP1_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P08047UniProtKB/Swiss-Prot:
SP1_HUMAN :- The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.
- Belongs to the Sp1 C2H2-type zinc-finger protein family.
- Domain:
-
- The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.
- Family:
-
- Belongs to the Sp1 C2H2-type zinc-finger protein family.
Function for SP1 Gene
Molecular function for SP1 Gene
- UniProtKB/Swiss-Prot Function:
- Transcription factor that can activate or repress transcription in response to physiological and pathological stimuli. Binds with high affinity to GC-rich motifs and regulates the expression of a large number of genes involved in a variety of processes such as cell growth, apoptosis, differentiation and immune responses. Highly regulated by post-translational modifications (phosphorylations, sumoylation, proteolytic cleavage, glycosylation and acetylation). Binds also the PDGFR-alpha G-box promoter. May have a role in modulating the cellular response to DNA damage. Implicated in chromatin remodeling. Plays an essential role in the regulation of FE65 gene expression. In complex with ATF7IP, maintains telomerase activity in cancer cells by inducing TERT and TERC gene expression. Isoform 3 is a stronger activator of transcription than isoform 1. Positively regulates the transcription of the core clock component ARNTL/BMAL1 (PubMed:10391891, PubMed:11371615, PubMed:11904305, PubMed:14593115, PubMed:16377629, PubMed:16478997, PubMed:16943418, PubMed:17049555, PubMed:18171990, PubMed:18199680, PubMed:18239466, PubMed:18513490, PubMed:18619531, PubMed:19193796, PubMed:20091743, PubMed:21798247, PubMed:21046154). Plays a role in the recruitment of SMARCA4/BRG1 on the c-FOS promoter. Plays a role in protecting cells against oxidative stress following brain injury by regulating the expression of RNF112 (By similarity).
- UniProtKB/Swiss-Prot Induction:
- By insulin.
- GENATLAS Biochemistry:
- transcription factor Sp-1,GT box binding protein
Phenotypes From GWAS Catalog for SP1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000976 | transcription regulatory region sequence-specific DNA binding | IDA | 18293083 |
| GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding | IDA | 14979875 |
| GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding | ISS | -- |
| GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific | ISA | -- |
| GO:0000987 | proximal promoter sequence-specific DNA binding | ISS | 10362258 |
Phenotypes for SP1 Gene
- MGI mutant phenotypes for SP1:
-
inferred from 1 alleles
- homeostasis/metabolism phenotype
- growth/size/body region phenotype
- cardiovascular system phenotype
- respiratory system phenotype
- mortality/aging
- liver/biliary system phenotype
- hematopoietic system phenotype
- vision/eye phenotype
- limbs/digits/tail phenotype
- skeleton phenotype
- integument phenotype
- embryo phenotype
- craniofacial phenotype
- GenomeRNAi human phenotypes for SP1:
-
- Increased vaccinia virus (VACV) infection
- Decreased viability
- shRNA abundance <= 25%
- Decreased shRNA abundance (Z-score < -2)
- no effect
- Decreased viability after Maraba virus infection
- Resistant to vaccinia virus (VACV-A4L) infection
- Increased shRNA abundance (Z-score > 2)
- Increased viability with MLN4924 (a NAE inhibitor)
- Synthetic lethal with MLN4924 (a NAE inhibitor)
- Downregulation of NFkappaB pathway
- Decreased viability with paclitaxel
Animal Models for SP1 Gene
- MGI Knock Outs for SP1:
-
- Sp1 Sp1<tm1Phi>
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for SP1 - Starting at $85 >
- * SP1 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for SP1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SP1
-
Santa Cruz Biotechnology (SCBT) CRISPR for SP1
miRNA for SP1 Gene
- miRTarBase miRNAs that target SP1
-
- hsa-miR-29b-3p (MIRT000445)
- hsa-miR-27a-3p (MIRT002403)
- hsa-miR-124-3p (MIRT002660)
- hsa-miR-218-5p (MIRT004246)
- rno-miR-34a-5p (MIRT006050)
- rno-miR-93-5p (MIRT006051)
- hsa-miR-21-5p (MIRT006236)
- hsa-miR-375 (MIRT006775)
- hsa-miR-149-5p (MIRT007014)
- hsa-miR-22-3p (MIRT007329)
- mmu-miR-301b-3p (MIRT007839)
- mmu-miR-19b-3p (MIRT012339)
- mmu-miR-24-3p (MIRT013803)
- hsa-miR-335-5p (MIRT017513)
- hsa-miR-16-5p (MIRT031577)
- hsa-miR-1-3p (MIRT035536)
- hsa-miR-133a-3p (MIRT035537)
- hsa-miR-625-5p (MIRT039599)
- hsa-miR-99b-5p (MIRT044192)
- hsa-miR-186-5p (MIRT045067)
- hsa-miR-125a-5p (MIRT045732)
- hsa-let-7f-5p (MIRT051372)
- hsa-let-7b-5p (MIRT052264)
- hsa-let-7a-5p (MIRT052453)
- hsa-miR-200b-3p (MIRT053570)
- hsa-miR-200c-3p (MIRT053573)
- hsa-miR-145-5p (MIRT053757)
- hsa-miR-133b (MIRT053758)
- hsa-miR-155-5p (MIRT135364)
- hsa-miR-4530 (MIRT135381)
- hsa-miR-6734-5p (MIRT135386)
- hsa-miR-4667-5p (MIRT187418)
- hsa-miR-4700-5p (MIRT187419)
- hsa-miR-8089 (MIRT187422)
- hsa-miR-129-5p (MIRT187423)
- hsa-miR-4276 (MIRT187456)
- hsa-miR-4428 (MIRT232387)
- hsa-miR-4533 (MIRT232388)
- hsa-miR-4747-5p (MIRT232390)
- hsa-miR-5196-5p (MIRT232391)
- hsa-miR-190a-3p (MIRT232415)
- hsa-miR-31-3p (MIRT248248)
- hsa-miR-296-5p (MIRT248249)
- hsa-miR-518a-5p (MIRT248250)
- hsa-miR-527 (MIRT248251)
- hsa-miR-4749-3p (MIRT248254)
- hsa-miR-7160-3p (MIRT248255)
- hsa-miR-374a-5p (MIRT273589)
- hsa-miR-374b-5p (MIRT273591)
- hsa-miR-6752-3p (MIRT273594)
- hsa-miR-31-5p (MIRT273599)
- hsa-miR-202-3p (MIRT273603)
- hsa-miR-605-3p (MIRT273604)
- hsa-miR-922 (MIRT273605)
- hsa-miR-3153 (MIRT273606)
- hsa-miR-4257 (MIRT273607)
- hsa-miR-2467-3p (MIRT273612)
- hsa-miR-6126 (MIRT273613)
- hsa-miR-6733-5p (MIRT273614)
- hsa-miR-6739-5p (MIRT273615)
- hsa-miR-6835-3p (MIRT273616)
- hsa-miR-7977 (MIRT273618)
- hsa-miR-369-3p (MIRT338134)
- hsa-miR-410-3p (MIRT338135)
- hsa-miR-5011-5p (MIRT338138)
- hsa-miR-5692c (MIRT338139)
- hsa-miR-5692b (MIRT338140)
- hsa-miR-24-3p (MIRT338141)
- hsa-miR-4668-5p (MIRT338144)
- hsa-miR-8485 (MIRT338165)
- hsa-miR-1277-5p (MIRT338170)
- hsa-miR-3127-3p (MIRT384633)
- hsa-miR-4691-5p (MIRT384635)
- hsa-miR-6756-3p (MIRT384636)
- hsa-miR-6792-3p (MIRT384637)
- hsa-miR-216a-3p (MIRT405400)
- hsa-miR-128-3p (MIRT405401)
- hsa-miR-3681-3p (MIRT405404)
- hsa-miR-5582-5p (MIRT405406)
- hsa-miR-6124 (MIRT405407)
- hsa-miR-330-3p (MIRT437801)
- hsa-miR-33a-5p (MIRT437803)
- hsa-miR-150-5p (MIRT437824)
- hsa-miR-711 (MIRT437892)
- hsa-miR-223-3p (MIRT438229)
- hsa-miR-6738-5p (MIRT467367)
- hsa-miR-5194 (MIRT467368)
- hsa-miR-1914-3p (MIRT467369)
- hsa-miR-423-5p (MIRT467370)
- hsa-miR-3184-5p (MIRT467371)
- hsa-miR-5190 (MIRT467372)
- hsa-miR-6794-5p (MIRT467373)
- hsa-miR-4716-3p (MIRT467374)
- hsa-miR-6083 (MIRT510726)
- hsa-miR-2110 (MIRT565498)
- hsa-miR-1200 (MIRT565499)
- hsa-miR-378a-5p (MIRT565500)
- hsa-miR-7159-5p (MIRT565501)
- hsa-miR-6780b-5p (MIRT565502)
- hsa-miR-4725-3p (MIRT565503)
- hsa-miR-4271 (MIRT565504)
- hsa-miR-4493 (MIRT565505)
- hsa-miR-6852-5p (MIRT565506)
- hsa-miR-3140-5p (MIRT565507)
- hsa-miR-6791-5p (MIRT565508)
- hsa-miR-4292 (MIRT565509)
- hsa-miR-4308 (MIRT565510)
- hsa-miR-3065-5p (MIRT565511)
- hsa-miR-6871-5p (MIRT565512)
- mmu-miR-186-5p (MIRT588832)
- hsa-miR-5590-5p (MIRT612415)
- hsa-miR-6749-3p (MIRT612416)
- hsa-miR-211-5p (MIRT612417)
- hsa-miR-204-5p (MIRT612418)
- hsa-miR-2355-5p (MIRT612419)
- hsa-miR-4685-3p (MIRT612420)
- hsa-miR-4287 (MIRT612421)
- hsa-miR-6832-3p (MIRT612422)
- hsa-miR-6793-3p (MIRT612423)
- hsa-miR-186-3p (MIRT612424)
- hsa-miR-141-5p (MIRT612425)
- hsa-miR-466 (MIRT634298)
- hsa-miR-4672 (MIRT634299)
- hsa-miR-3941 (MIRT634300)
- hsa-miR-603 (MIRT634301)
- hsa-miR-362-3p (MIRT634302)
- hsa-miR-329-3p (MIRT634303)
- hsa-miR-3692-3p (MIRT638227)
- hsa-miR-5006-3p (MIRT666153)
- hsa-miR-4755-5p (MIRT666154)
- hsa-miR-670-5p (MIRT666155)
- hsa-miR-4312 (MIRT666156)
- hsa-miR-6859-3p (MIRT666157)
- hsa-miR-627-3p (MIRT666158)
- hsa-miR-1248 (MIRT666159)
- hsa-miR-6747-3p (MIRT666160)
- hsa-miR-216b-3p (MIRT666161)
- hsa-miR-670-3p (MIRT666162)
- hsa-miR-520f-5p (MIRT686791)
- hsa-miR-6796-3p (MIRT686792)
- hsa-miR-27b-3p (MIRT686793)
- mmu-miR-7a-5p (MIRT731319)
- hsa-miR-29c-3p (MIRT732873)
- hsa-miR-612 (MIRT733905)
- hsa-miR-324-5p (MIRT733944)
- hsa-miR-429 (MIRT734667)
- rno-miR-7a-5p (MIRT735053)
- rno-miR-7b (MIRT735054)
- hsa-miR-326 (MIRT735460)
- hsa-miR-137 (MIRT735500)
- hsa-miR-892b (MIRT735506)
- bta-miR-128 (MIRT735507)
Transcription Factor Targets for SP1 Gene
Targeted motifs for SP1 Gene
HOMER Transcription Factor Regulatory Elements motif SP1
- Consensus sequence: GGCCCCGCCCCC Submotif: canonical Cell Type: NA
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for SP1
- Browse OriGene Inhibitory RNA Products For SP1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SP1
Clone products for research
- Applied Biological Materials (abm): Clones for SP1 - Starting at $45 >
- * SP1 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
-
- MG225692
- MR225692
- MR225692L3
- MR225692L4
- RC209154
- RC209154L1
- RC209154L2
- RC209154L3
- RC209154L4
- RC227728
- RC227728L3
- RC227728L4
- RC234799
- RG209154
- RG227728
- RG234799
- RR213136
- RR213136L3
- RR213136L4
- MR225692L3V
- MR225692L4V
- RC209154L1V
- RC209154L2V
- RC209154L3V
- RC209154L4V
- RC227728L3V
- RC227728L4V
- RR213136L3V
- RR213136L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for SP1
- Addgene plasmids for SP1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SP1
Cell Lines for research
-
Horizon Cell Lines for SP1
No data available for Enzyme Numbers (IUBMB) and Human Phenotype Ontology for SP1 Gene
Localization for SP1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for SP1 Gene
- Nucleus. Cytoplasm. Note=Nuclear location is governed by glycosylated/phosphorylated states. Insulin promotes nuclear location, while glucagon favors cytoplasmic location.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| plasma membrane | 2 |
| extracellular | 2 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| peroxisome | 2 |
| endoplasmic reticulum | 2 |
| cytosol | 2 |
| lysosome | 2 |
| endosome | 1 |
| golgi apparatus | 1 |
- Nucleoplasm (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000785 | chromatin | IDA,ISA | -- |
| GO:0000791 | euchromatin | IDA | 14701757 |
| GO:0005634 | nucleus | IEA,IC | 3139301 |
| GO:0005654 | nucleoplasm | IDA,TAS | -- |
| GO:0005737 | cytoplasm | IEA | -- |
Pathways & Interactions for SP1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | IL-2 Pathway |
Prolactin Signaling
.54
ErbB2-ErbB3 Heterodimers
.49
|
HMGB1 Pathway
.36
|
| 2 | Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) | ||
| 3 | Transcriptional activity of SMAD2/SMAD3-SMAD4 heterotrimer | ||
| 4 | Aldosterone synthesis and secretion |
.41
|
|
| 5 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | ||
Pathways by source for SP1 Gene
34 BioSystems pathways for SP1 Gene
17 Reactome pathways for SP1 Gene
1 PharmGKB pathway for SP1 Gene
15 KEGG pathways for SP1 Gene
15 GeneGo (Thomson Reuters) pathways for SP1 Gene
- Cell adhesion Tight junctions
- Cell cycle ESR1 regulation of G1/S transition
- Cell cycle Regulation of G1/S transition (part 1)
- Cell cycle Regulation of G1/S transition (part 2)
- Development Endothelin-1/EDNRA transactivation of EGFR
11 Qiagen pathways for SP1 Gene
- AHR Pathway
- CMV and MAPK Pathways
- ErbB2-ErbB3 Heterodimers
- Estrogen Pathway
- HMGB1 Pathway
2 Cell Signaling Technology pathways for SP1 Gene
Interacting Proteins for SP1 Gene
Selected Interacting proteins:
P08047-SP1_HUMAN
ENSP00000329357
for SP1 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for SP1
SIGNOR curated interactions for SP1 Gene
- Activates:
- Inactivates:
- Is activated by:
- Is inactivated by:
- Other effect:
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006355 | regulation of transcription, DNA-templated | IDA | 12560508 |
| GO:0006357 | regulation of transcription by RNA polymerase II | IEA,IBA | 21873635 |
| GO:0010628 | positive regulation of gene expression | IMP | 23802567 |
| GO:0016032 | viral process | IEA | -- |
| GO:0032869 | cellular response to insulin stimulus | IEA | -- |
Transcripts for SP1 Gene
mRNA/cDNA for SP1 Gene
- 3 REFSEQ mRNAs :
- 24 NCBI additional mRNA sequence :
- 4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000327443 7680 nts (view in UCSC)
- ENST00000426431 7603 nts (view in UCSC)
- ENST00000548560 1061 nts (view in UCSC)
- ENST00000551969 602 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for SP1 - Starting at $85 >
- * SP1 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for SP1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SP1
-
Santa Cruz Biotechnology (SCBT) CRISPR for SP1
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for SP1
- Browse OriGene Inhibitory RNA Products For SP1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SP1
Clone products for research
- Applied Biological Materials (abm): Clones for SP1 - Starting at $45 >
- * SP1 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
-
- MG225692
- MR225692
- MR225692L3
- MR225692L4
- RC209154
- RC209154L1
- RC209154L2
- RC209154L3
- RC209154L4
- RC227728
- RC227728L3
- RC227728L4
- RC234799
- RG209154
- RG227728
- RG234799
- RR213136
- RR213136L3
- RR213136L4
- MR225692L3V
- MR225692L4V
- RC209154L1V
- RC209154L2V
- RC209154L3V
- RC209154L4V
- RC227728L3V
- RC227728L4V
- RR213136L3V
- RR213136L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for SP1
- Addgene plasmids for SP1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SP1
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | · | 4c | · | 4d | ^ | 5 | ^ | 6 | ^ | 7 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||||||
| SP2: | - | ||||||||||||||||||||
| SP3: | - | - | - | ||||||||||||||||||
| SP4: |
Relevant External Links for SP1 Gene
- GeneLoc Exon Structure for
- SP1
Expression for SP1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Eye (Sensory Organs)
- Fetal Corneal Basal Epithelial Cells Corneal Epithelium
- Keratocytes Corneal Stroma
- Endothelial Cells Corneal Endothelium
- Keratoblasts Corneal Stroma
-
Epithelial Cells
- Fetal Corneal Basal Epithelial Cells Corneal Epithelium
-
Fibroblasts
- Keratocytes Corneal Stroma
-
Somite (Muscoskeletal System)
- Mononuclear Myocytes Cervical Epaxial Myotome
-
Skeletal Muscle (Muscoskeletal System)
- Mononuclear Myocytes Cervical Epaxial Myotome
-
Endothelium (Cardiovascular System)
- Endothelial Cells Corneal Endothelium
mRNA differential expression in normal tissues according to GTEx for SP1 Gene
This gene is overexpressed in Whole Blood (x4.3).
This gene is overexpressed in CD8 Tcells (15.8), Lung (9.8), and Fetal gut (8.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SP1 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SP1
SOURCE GeneReport for Unigene cluster for SP1 Gene:
Hs.649191mRNA Expression by UniProt/SwissProt for SP1 Gene:
P08047-SP1_HUMAN
Tissue specificity:
Up-regulated in adenocarcinomas of the stomach (at protein level). Isoform 3 is ubiquitously expressed at low levels.
Evidence on tissue expression from TISSUES for SP1 Gene
- Nervous system(4.7)
- Intestine(4.6)
- Kidney(2.9)
- Muscle(2.8)
- Skin(2.8)
- Lung(2.8)
- Heart(2.7)
- Liver(2.7)
- Blood(2.6)
- Lymph node(2.5)
- Spleen(2.5)
- Stomach(2.5)
- Adrenal gland(2.4)
- Pancreas(2.4)
- Bone marrow(2.4)
- Thyroid gland(2.3)
- Eye(2.1)
Primer products for research
-
OriGene qPCR primer pairs for SP1
-
OriGene qPCR primer pairs and template standards for SP1
Gene Expression Assays for research
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for SP1 Gene
Orthologs for SP1 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | SP1 29 30 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | SP1 29 30 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | SP1 29 30 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Sp1 29 |
|
||
| Mouse (Mus musculus) |
Mammalia | Sp1 29 16 30 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | SP1 29 30 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | SP1 30 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | sp1 29 |
|
||
| MGC76006 29 |
|
||||
| Zebrafish (Danio rerio) |
Actinopterygii | sp1 29 30 |
|
OneToOne | |
| Fruit Fly (Drosophila melanogaster) |
Insecta | Spps 30 |
|
OneToMany | |
| Worm (Caenorhabditis elegans) |
Secernentea | sptf-3 30 |
|
OneToMany |
- Species where no ortholog for SP1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Oppossum (Monodelphis domestica)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Platypus (Ornithorhynchus anatinus)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for SP1 Gene
- ENSEMBL:
- Gene Tree for SP1 (if available)
- TreeFam:
- Gene Tree for SP1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for SP1: view image
- Alliance of Genome Resources:
- Additional Orthologs for SP1
Paralogs for SP1 Gene
(65) SIMAP similar genes for SP1 Gene using alignment to 8 proteins:
- SP1_HUMAN
- B2R4Y6_HUMAN
- E4Z9M7_HUMAN
- G5E9M8_HUMAN
- H3BUU5_HUMAN
- H3BVI2_HUMAN
- L8E7F4_HUMAN
- Q15403_HUMAN
- Sp1
- DHFRP2
- PSG
- PSG3
- PSG7
- PSG6
- PSG11
- WT1
- PSG5
- CEACAM4
- PSG4
- CEACAM3
- PSG2
- DKFZp686O1631
- CEACAM7
- PSG9
- PSG11s'
- CEACAM8
- PSG1
- KLF1
- PSG8
- CEACAM6
- kr-znf3
- SP4
- ZNF56
- SP5
- KLF7
- DKFZp686N0199
- KLF9
- GTF3A
- DKFZp686M04222
- CEACAM21
- CEACAM5
- CEACAM1
- ZNF78L1
- ZNF72
- DKFZp781M2392
- KLF6
- KLF13
- ZNF
- SP3
- smap-7
- ZNF692
- KLF4
- PSGII
- DKFZp434J0650
- ZNF697
- ZNF410
- ZFS-6
- ZFS-5
- ZSCAN31
- ZNF702P
- HZF16
- ZNF791
- REST
- ZNF672
- ZIC1
- ZFS-2
- SP9
- A-328A3.4
- ZNF219
- ZNF808
- ZNF600
- ZNF564
- ZNF345
Variants for SP1 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SP1 Gene
| SNP ID | Clinical significance and condition | Chr 12 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs114382555 | Benign: not provided | 53,383,534(+) |
C/A NM_138473.3(SP1):c.1587C>A (p.Leu529=) |
SYNONYMOUS | |
| rs139620478 | Benign: not provided | 53,411,186(+) |
C/T NM_138473.3(SP1):c.2304C>T (p.Asn768=) |
SYNONYMOUS | |
| rs145573092 | Likely Benign: not provided | 53,411,237(+) |
C/T NM_138473.3(SP1):c.2355C>T (p.Phe785=) |
SYNONYMOUS | |
| rs1592554584 | Likely Benign: not provided | 53,382,904(+) |
C/G NM_138473.3(SP1):c.957C>G (p.Ser319=) |
SYNONYMOUS | |
| rs201324612 | Likely Benign: not provided | 53,381,649(+) |
A/G NM_138473.3(SP1):c.8-10A>G |
INTRON |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).