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The protein encoded by this gene is a zinc finger transcription factor that binds to GC-rich motifs of many promoters. The encoded protein is involved in many cellular processes, including cell differentiation, cell growth, apoptosis, immune responses, response to DNA damage, and chromatin remodeling. Post-translational modifications such as phosphorylation, acetylation, glycosylation, and proteolytic processing significantly affect the activity of this protein, which can be an activator or a repressor. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2014]
SP1 (Sp1 Transcription Factor) is a Protein Coding gene. Diseases associated with SP1 include Huntington Disease and Cytomegalovirus Infection. Among its related pathways are Transcriptional activity of SMAD2/SMAD3-SMAD4 heterotrimer and Transcriptional misregulation in cancer. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is SP4.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000976 | transcription regulatory region sequence-specific DNA binding | IDA, IBA | 18293083 |
GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding | IDA | 14979875 |
GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding | IDA,ISS | -- |
GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific | ISA | -- |
GO:0000987 | proximal promoter sequence-specific DNA binding | ISS | 10362258 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000790 | nuclear chromatin | IDA,ISA | -- |
GO:0005634 | nucleus | IEA,IC | 3139301 |
GO:0005654 | nucleoplasm | IDA,TAS | -- |
GO:0005719 | nuclear euchromatin | IDA | 14701757 |
GO:0005737 | cytoplasm | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | IL-2 Pathway |
Prolactin Signaling
.54
ErbB2-ErbB3 Heterodimers
.49
|
HMGB1 Pathway
.36
|
2 | Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) | ||
3 | Transcriptional activity of SMAD2/SMAD3-SMAD4 heterotrimer | ||
4 | Aldosterone synthesis and secretion |
.41
|
|
5 | Regulation of cholesterol biosynthesis by SREBP (SREBF) |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006355 | regulation of transcription, DNA-templated | IDA | 12169688 |
GO:0006357 | regulation of transcription by RNA polymerase II | IEA | -- |
GO:0010628 | positive regulation of gene expression | IMP | 23802567 |
GO:0016032 | viral process | IEA | -- |
GO:0032869 | cellular response to insulin stimulus | IEA | -- |
ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | · | 4c | · | 4d | ^ | 5 | ^ | 6 | ^ | 7 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | |||||||||||||||||||
SP2: | - | ||||||||||||||||||||
SP3: | - | - | - | ||||||||||||||||||
SP4: |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | SP1 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | SP1 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | SP1 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Sp1 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Sp1 30 17 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | SP1 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | SP1 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | sp1 30 |
|
||
MGC76006 30 |
|
||||
Zebrafish (Danio rerio) |
Actinopterygii | sp1 30 31 |
|
OneToOne | |
Fruit Fly (Drosophila melanogaster) |
Insecta | Spps 31 |
|
OneToMany | |
Worm (Caenorhabditis elegans) |
Secernentea | sptf-3 31 |
|
OneToMany |