Aliases for SP1 Gene
Aliases for SP1 Gene
External Ids for SP1 Gene
- HGNC: 11205
- Entrez Gene: 6667
- Ensembl: ENSG00000185591
- OMIM: 189906
- UniProtKB: P08047
Previous GeneCards Identifiers for SP1 Gene
- GC12P053801
- GC12P053490
- GC12P052060
- GC12P050814
- GC12P053773
Summaries for SP1 Gene
-
The protein encoded by this gene is a zinc finger transcription factor that binds to GC-rich motifs of many promoters. The encoded protein is involved in many cellular processes, including cell differentiation, cell growth, apoptosis, immune responses, response to DNA damage, and chromatin remodeling. Post-translational modifications such as phosphorylation, acetylation, glycosylation, and proteolytic processing significantly affect the activity of this protein, which can be an activator or a repressor. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2014]
GeneCards Summary for SP1 Gene
SP1 (Sp1 Transcription Factor) is a Protein Coding gene. Diseases associated with SP1 include Huntington Disease and Keratoconus. Among its related pathways are Gene Expression and Integrated Breast Cancer Pathway. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is SP4.
UniProtKB/Swiss-Prot for SP1 Gene
-
Transcription factor that can activate or repress transcription in response to physiological and pathological stimuli. Binds with high affinity to GC-rich motifs and regulates the expression of a large number of genes involved in a variety of processes such as cell growth, apoptosis, differentiation and immune responses. Highly regulated by post-translational modifications (phosphorylations, sumoylation, proteolytic cleavage, glycosylation and acetylation). Binds also the PDGFR-alpha G-box promoter. May have a role in modulating the cellular response to DNA damage. Implicated in chromatin remodeling. Plays an essential role in the regulation of FE65 gene expression. In complex with ATF7IP, maintains telomerase activity in cancer cells by inducing TERT and TERC gene expression. Isoform 3 is a stronger activator of transcription than isoform 1. Positively regulates the transcription of the core clock component ARNTL/BMAL1 (PubMed:10391891, PubMed:11371615, PubMed:11904305, PubMed:14593115, PubMed:16377629, PubMed:16478997, PubMed:16943418, PubMed:17049555, PubMed:18171990, PubMed:18199680, PubMed:18239466, PubMed:18513490, PubMed:18619531, PubMed:19193796, PubMed:20091743, PubMed:21798247). Plays a role in the recruitment of SMARCA4/BRG1 on the c-FOS promoter. Plays a role in protecting cells against oxidative stress following brain injury by regulating the expression of RNF112 (By similarity).
Additional gene information for SP1 Gene
- Monarch Initiative
- Search for SP1 at DataMed
- Search for SP1 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SP1 Gene
Genomics for SP1 Gene
GeneHancer (GH) Regulatory Elements for SP1 Gene
Promoters and enhancers for SP1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around SP1 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the SP1 gene promoter:
-
- AP-1
- STAT1
- ATF-2
- c-Jun
Regulatory Element Products
Genomic Locations for SP1 Gene
Genomic Locations for SP1 Gene
- chr12:53,380,176-53,416,446
- (GRCh38/hg38)
- Size:
- 36,271 bases
- Orientation:
- Plus strand
- chr12:53,773,960-53,810,230
- (GRCh37/hg19)
- Size:
- 36,271 bases
- Orientation:
- Plus strand
Genomic View for SP1 Gene
Genes around SP1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 12q13.13 by Entrez Gene
- 12q13.13 by HGNC
- 12q13.13 by Ensembl
SP1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for SP1 Gene
Proteins for SP1 Gene
-
Protein details for SP1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P08047-SP1_HUMAN
- Recommended name:
- Transcription factor Sp1
- Protein Accession:
- P08047
- E4Z9M7
- G5E9M8
- Q86TN8
- Q9H3Q5
- Q9NR51
- Q9NY21
- Q9NYE7
Protein attributes for SP1 Gene
- Size:
- 785 amino acids
- Molecular mass:
- 80693 Da
- Quaternary structure:
-
- Interacts with ATF7IP, ATF7IP2, BAHD1, POGZ, HCFC1, AATF and PHC2. Interacts with varicella-zoster virus IE62 protein. Interacts with HIV-1 Vpr; the interaction is inhibited by SP1 O-glycosylation. Interacts with SV40 VP2/3 proteins. Interacts with SV40 major capsid protein VP1; this interaction leads to a cooperativity between the 2 proteins in DNA binding. Interacts with HLTF; the interaction may be required for basal transcriptional activity of HLTF. Interacts (deacetylated form) with EP300; the interaction enhances gene expression. Interacts with HDAC1 and JUN. Interacts with ELF1; the interaction is inhibited by glycosylation of SP1. Interaction with NFYA; the interaction is inhibited by glycosylation of SP1. Interacts with ATF7IP and TBP. Interacts with MEIS2 isoform 4 and PBX1 isoform PBX1a. Interacts with EGR1 (PubMed:10391891, PubMed:10976766, PubMed:12021324, PubMed:12847090, PubMed:12855699, PubMed:15691849, PubMed:16478997, PubMed:19106100, PubMed:19285002, PubMed:19302979, PubMed:19666599, PubMed:20121949, PubMed:21746878, PubMed:7592727, PubMed:9466902). Interacts with SMARCA4/BRG1. Interacts with RNF112 in an oxidative stress-regulated manner (By similarity).
- Miscellaneous:
-
- In the hepatoma cell line Hep-G2, SP1 precursor mRNA may undergo homotype trans-splicing leading to the duplication of exons 2 and 3.
- SequenceCaution:
-
- Sequence=AAH43224.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
Three dimensional structures from OCA and Proteopedia for SP1 Gene
Protein Expression for SP1 Gene
Post-translational modifications for SP1 Gene
- Phosphorylated on multiple serine and threonine residues. Phosphorylation is coupled to ubiquitination, sumoylation and proteolytic processing. Phosphorylation on Ser-59 enhances proteolytic cleavage. Phosphorylation on Ser-7 enhances ubiquitination and protein degradation. Hyperphosphorylation on Ser-101 in response to DNA damage has no effect on transcriptional activity. MAPK1/MAPK3-mediated phosphorylation on Thr-453 and Thr-739 enhances VEGF transcription but, represses FGF2-triggered PDGFR-alpha transcription. Also implicated in the repression of RECK by ERBB2. Hyperphosphorylated on Thr-278 and Thr-739 during mitosis by MAPK8 shielding SP1 from degradation by the ubiquitin-dependent pathway. Phosphorylated in the zinc-finger domain by calmodulin-activated PKCzeta. Phosphorylation on Ser-641 by PKCzeta is critical for TSA-activated LHR gene expression through release of its repressor, p107. Phosphorylation on Thr-668, Ser-670 and Thr-681 is stimulated by angiotensin II via the AT1 receptor inducing increased binding to the PDGF-D promoter. This phosphorylation is increased in injured artey wall. Ser-59 and Thr-681 can both be dephosphorylated by PP2A during cell-cycle interphase. Dephosphorylation on Ser-59 leads to increased chromatin association during interphase and increases the transcriptional activity. On insulin stimulation, sequentially glycosylated and phosphorylated on several C-terminal serine and threonine residues.
- Acetylated. Acetylation/deacetylation events affect transcriptional activity. Deacetylation leads to an increase in the expression the 12(s)-lipooxygenase gene though recruitment of p300 to the promoter.
- Ubiquitinated. Ubiquitination occurs on the C-terminal proteolytically-cleaved peptide and is triggered by phosphorylation.
- Sumoylated with SUMO1. Sumoylation modulates proteolytic cleavage of the N-terminal repressor domain. Sumoylation levels are attenuated during tumorigenesis. Phosphorylation mediates SP1 desumoylation.
- Proteolytic cleavage in the N-terminal repressor domain is prevented by sumoylation. The C-terminal cleaved product is susceptible to degradation.
- O-glycosylated; Contains 8 N-acetylglucosamine side chains. Levels are controlled by insulin and the SP1 phosphorylation states. Insulin-mediated O-glycosylation locates SP1 to the nucleus, where it is sequentially deglycosylated and phosphorylated. O-glycosylation affects transcriptional activity through disrupting the interaction with a number of transcription factors including ELF1 and NFYA. Also inhibits interaction with the HIV1 promoter. Inhibited by peroxisomome proliferator receptor gamma (PPARgamma).
- Glycosylation at posLast=702702, isoforms=2, 3698, posLast=641641, posLast=640640, posLast=612612, and isoforms=2, 3491
- Modification sites at PhosphoSitePlus
-
Glycosylation from GlyConnect
- SP1_HUMAN (605)
Other Protein References for SP1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for SP1
- Novus Biologicals Antibodies for SP1
- Invitrogen Antibodies for SP1
- antibodies-online: Search results for 288 available SP1 Antibodies ranked by validation data
- Compare Top SP1 Antibodies
-
Recommended
- 236 WB Antibodies (anti-human)
- 24 IF (p) Antibodies (anti-human)
- 7 IHC (p) Antibodies (anti-human)
- 1 IF/ICC Antibody (anti-human)
- 89 WB Antibodies (anti-rat)
- 24 IF (p) Antibodies (anti-rat)
- 1 IHC (p) Antibody (anti-rat)
- 125 WB Antibodies (anti-mouse)
- 24 IF (p) Antibodies (anti-mouse)
- 3 IHC (p) Antibodies (anti-mouse)
- GeneTex SP1 Antibody for SP1
-
Santa Cruz Biotechnology (SCBT) Antibodies for SP1
Protein Products
-
OriGene Purified Proteins for SP1
- Search Origene for MassSpec and Protein Over-expression Lysates for SP1
- Origene Custom Protein Services for SP1
- Novus Biologicals proteins for SP1
- Search GeneTex for Proteins for SP1
Assay Products
No data available for DME Specific Peptides for SP1 Gene
Domains & Families for SP1 Gene
Gene Families for SP1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Predicted intracellular proteins
- Transcription factors
Protein Domains for SP1 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for SP1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P08047- Family:
-
- Belongs to the Sp1 C2H2-type zinc-finger protein family.
Function for SP1 Gene
Molecular function for SP1 Gene
- UniProtKB/Swiss-Prot Function:
- Transcription factor that can activate or repress transcription in response to physiological and pathological stimuli. Binds with high affinity to GC-rich motifs and regulates the expression of a large number of genes involved in a variety of processes such as cell growth, apoptosis, differentiation and immune responses. Highly regulated by post-translational modifications (phosphorylations, sumoylation, proteolytic cleavage, glycosylation and acetylation). Binds also the PDGFR-alpha G-box promoter. May have a role in modulating the cellular response to DNA damage. Implicated in chromatin remodeling. Plays an essential role in the regulation of FE65 gene expression. In complex with ATF7IP, maintains telomerase activity in cancer cells by inducing TERT and TERC gene expression. Isoform 3 is a stronger activator of transcription than isoform 1. Positively regulates the transcription of the core clock component ARNTL/BMAL1 (PubMed:10391891, PubMed:11371615, PubMed:11904305, PubMed:14593115, PubMed:16377629, PubMed:16478997, PubMed:16943418, PubMed:17049555, PubMed:18171990, PubMed:18199680, PubMed:18239466, PubMed:18513490, PubMed:18619531, PubMed:19193796, PubMed:20091743, PubMed:21798247). Plays a role in the recruitment of SMARCA4/BRG1 on the c-FOS promoter. Plays a role in protecting cells against oxidative stress following brain injury by regulating the expression of RNF112 (By similarity).
- UniProtKB/Swiss-Prot Induction:
- By insulin.
- GENATLAS Biochemistry:
- transcription factor Sp-1,GT box binding protein
Phenotypes From GWAS Catalog for SP1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding | IDA | 14979875 |
| GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding | ISS | -- |
| GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding | NAS | 19274049 |
| GO:0000982 | transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | IDA | 21659522 |
| GO:0000987 | proximal promoter sequence-specific DNA binding | ISS | 10362258 |
Phenotypes for SP1 Gene
- MGI mutant phenotypes for SP1:
-
inferred from 1 alleles
- cardiovascular system phenotype
- respiratory system phenotype
- limbs/digits/tail phenotype
- vision/eye phenotype
- homeostasis/metabolism phenotype
- integument phenotype
- mortality/aging
- craniofacial phenotype
- liver/biliary system phenotype
- skeleton phenotype
- embryo phenotype
- hematopoietic system phenotype
- growth/size/body region phenotype
- GenomeRNAi human phenotypes for SP1:
-
- Decreased shRNA abundance (Z-score < -2)
- Increased shRNA abundance (Z-score > 2)
- Decreased viability with paclitaxel
- Decreased viability
- no effect
- Increased vaccinia virus (VACV) infection
- Resistant to vaccinia virus (VACV-A4L) infection
- Downregulation of NFkappaB pathway
- Decreased viability after Maraba virus infection
- shRNA abundance <= 50%
- Synthetic lethal with MLN4924 (a NAE inhibitor)
Animal Models for SP1 Gene
- MGI Knock Outs for SP1:
-
- Sp1 Sp1<tm1Phi>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for SP1
-
CRISPR Products
-
OriGene CRISPR knockouts for SP1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SP1
- genomics-online: gRNA clones - Search results for 106 available SP1 gene related products
- Overview of 106 available SP1 gene related products
- Applied Biological Materials CRISPR for SP1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for SP1
- GenScript: Design CRISPR guide RNA sequences for SP1
miRNA for SP1 Gene
- miRTarBase miRNAs that target SP1
-
- hsa-mir-29b-3p (MIRT000445)
- hsa-mir-27a-3p (MIRT002403)
- hsa-mir-124-3p (MIRT002660)
- hsa-mir-218-5p (MIRT004246)
- hsa-mir-21-5p (MIRT006236)
- hsa-mir-375 (MIRT006775)
- hsa-mir-149-5p (MIRT007014)
- hsa-mir-22-3p (MIRT007329)
- hsa-mir-335-5p (MIRT017513)
- hsa-mir-16-5p (MIRT031577)
- hsa-mir-1-3p (MIRT035536)
- hsa-mir-133a-3p (MIRT035537)
- hsa-mir-625-5p (MIRT039599)
- hsa-mir-99b-5p (MIRT044192)
- hsa-mir-186-5p (MIRT045067)
- hsa-mir-125a-5p (MIRT045732)
- hsa-let-7f-5p (MIRT051372)
- hsa-let-7b-5p (MIRT052264)
- hsa-let-7a-5p (MIRT052453)
- hsa-mir-200b-3p (MIRT053570)
- hsa-mir-200c-3p (MIRT053573)
- hsa-mir-145-5p (MIRT053757)
- hsa-mir-133b (MIRT053758)
- hsa-mir-155-5p (MIRT135364)
- hsa-mir-4530 (MIRT135381)
- hsa-mir-6734-5p (MIRT135386)
- hsa-mir-4667-5p (MIRT187418)
- hsa-mir-4700-5p (MIRT187419)
- hsa-mir-8089 (MIRT187422)
- hsa-mir-129-5p (MIRT187423)
- hsa-mir-4276 (MIRT187456)
- hsa-mir-4428 (MIRT232387)
- hsa-mir-4533 (MIRT232388)
- hsa-mir-4747-5p (MIRT232390)
- hsa-mir-5196-5p (MIRT232391)
- hsa-mir-190a-3p (MIRT232415)
- hsa-mir-31-3p (MIRT248248)
- hsa-mir-296-5p (MIRT248249)
- hsa-mir-518a-5p (MIRT248250)
- hsa-mir-527 (MIRT248251)
- hsa-mir-4749-3p (MIRT248254)
- hsa-mir-7160-3p (MIRT248255)
- hsa-mir-374a-5p (MIRT273589)
- hsa-mir-374b-5p (MIRT273591)
- hsa-mir-6752-3p (MIRT273594)
- hsa-mir-31-5p (MIRT273599)
- hsa-mir-202-3p (MIRT273603)
- hsa-mir-605-3p (MIRT273604)
- hsa-mir-922 (MIRT273605)
- hsa-mir-3153 (MIRT273606)
- hsa-mir-4257 (MIRT273607)
- hsa-mir-2467-3p (MIRT273612)
- hsa-mir-6126 (MIRT273613)
- hsa-mir-6733-5p (MIRT273614)
- hsa-mir-6739-5p (MIRT273615)
- hsa-mir-6835-3p (MIRT273616)
- hsa-mir-7977 (MIRT273618)
- hsa-mir-369-3p (MIRT338134)
- hsa-mir-410-3p (MIRT338135)
- hsa-mir-5011-5p (MIRT338138)
- hsa-mir-5692c (MIRT338139)
- hsa-mir-5692b (MIRT338140)
- hsa-mir-24-3p (MIRT338141)
- hsa-mir-4668-5p (MIRT338144)
- hsa-mir-8485 (MIRT338165)
- hsa-mir-1277-5p (MIRT338170)
- hsa-mir-3127-3p (MIRT384633)
- hsa-mir-4691-5p (MIRT384635)
- hsa-mir-6756-3p (MIRT384636)
- hsa-mir-6792-3p (MIRT384637)
- hsa-mir-216a-3p (MIRT405400)
- hsa-mir-128-3p (MIRT405401)
- hsa-mir-3681-3p (MIRT405404)
- hsa-mir-5582-5p (MIRT405406)
- hsa-mir-6124 (MIRT405407)
- hsa-mir-330-3p (MIRT437801)
- hsa-mir-33a-5p (MIRT437803)
- hsa-mir-150-5p (MIRT437824)
- hsa-mir-711 (MIRT437892)
- hsa-mir-223-3p (MIRT438229)
- hsa-mir-6738-5p (MIRT467367)
- hsa-mir-5194 (MIRT467368)
- hsa-mir-1914-3p (MIRT467369)
- hsa-mir-423-5p (MIRT467370)
- hsa-mir-3184-5p (MIRT467371)
- hsa-mir-5190 (MIRT467372)
- hsa-mir-6794-5p (MIRT467373)
- hsa-mir-4716-3p (MIRT467374)
- hsa-mir-6083 (MIRT510726)
- hsa-mir-2110 (MIRT565498)
- hsa-mir-1200 (MIRT565499)
- hsa-mir-378a-5p (MIRT565500)
- hsa-mir-7159-5p (MIRT565501)
- hsa-mir-6780b-5p (MIRT565502)
- hsa-mir-4725-3p (MIRT565503)
- hsa-mir-4271 (MIRT565504)
- hsa-mir-4493 (MIRT565505)
- hsa-mir-6852-5p (MIRT565506)
- hsa-mir-3140-5p (MIRT565507)
- hsa-mir-6791-5p (MIRT565508)
- hsa-mir-4292 (MIRT565509)
- hsa-mir-4308 (MIRT565510)
- hsa-mir-3065-5p (MIRT565511)
- hsa-mir-6871-5p (MIRT565512)
- hsa-mir-5590-5p (MIRT612415)
- hsa-mir-6749-3p (MIRT612416)
- hsa-mir-211-5p (MIRT612417)
- hsa-mir-204-5p (MIRT612418)
- hsa-mir-2355-5p (MIRT612419)
- hsa-mir-4685-3p (MIRT612420)
- hsa-mir-4287 (MIRT612421)
- hsa-mir-6832-3p (MIRT612422)
- hsa-mir-6793-3p (MIRT612423)
- hsa-mir-186-3p (MIRT612424)
- hsa-mir-141-5p (MIRT612425)
- hsa-mir-466 (MIRT634298)
- hsa-mir-4672 (MIRT634299)
- hsa-mir-3941 (MIRT634300)
- hsa-mir-603 (MIRT634301)
- hsa-mir-362-3p (MIRT634302)
- hsa-mir-329-3p (MIRT634303)
- hsa-mir-3692-3p (MIRT638227)
- hsa-mir-5006-3p (MIRT666153)
- hsa-mir-4755-5p (MIRT666154)
- hsa-mir-670-5p (MIRT666155)
- hsa-mir-4312 (MIRT666156)
- hsa-mir-6859-3p (MIRT666157)
- hsa-mir-627-3p (MIRT666158)
- hsa-mir-1248 (MIRT666159)
- hsa-mir-6747-3p (MIRT666160)
- hsa-mir-216b-3p (MIRT666161)
- hsa-mir-670-3p (MIRT666162)
- hsa-mir-520f-5p (MIRT686791)
- hsa-mir-6796-3p (MIRT686792)
- hsa-mir-27b-3p (MIRT686793)
- hsa-mir-29c-3p (MIRT732873)
- hsa-mir-612 (MIRT733905)
- hsa-mir-324-5p (MIRT733944)
- hsa-mir-429 (MIRT734667)
- hsa-mir-326 (MIRT735460)
- hsa-mir-137 (MIRT735500)
- hsa-mir-892b (MIRT735506)
- bta-mir-128 (MIRT735507)
Transcription Factor Targets for SP1 Gene
Targeted motifs for SP1 Gene
HOMER Transcription Factor Regulatory Elements motif SP1
- Consensus sequence: GGCCCCGCCCCC Submotif: canonical Cell Type: NA
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for SP1
- Browse OriGene Inhibitory RNA Products For SP1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SP1
- genomics-online: shRNA clones - Search results for 106 available SP1 gene related products
- Overview of 106 available SP1 gene related products
Clone Products
- Sino Biological Human cDNA Clone for SP1
- VectorBuilder custom plasmid, inducible vectors for SP1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for SP1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for SP1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SP1
- Applied Biological Materials Clones for SP1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for SP1
No data available for Enzyme Numbers (IUBMB) and Human Phenotype Ontology for SP1 Gene
Localization for SP1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for SP1 Gene
- Nucleus. Cytoplasm. Note=Nuclear location is governed by glycosylated/phosphorylated states. Insulin promotes nuclear location, while glucagon favors cytoplasmic location.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| extracellular | 2 |
| mitochondrion | 2 |
| peroxisome | 2 |
| plasma membrane | 1 |
| cytoskeleton | 1 |
| endoplasmic reticulum | 1 |
| cytosol | 1 |
- Nucleoplasm (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000790 | nuclear chromatin | IDA | 15831516 |
| GO:0005634 | nucleus | IC,IEA | 3139301 |
| GO:0005654 | nucleoplasm | TAS,IDA | -- |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0017053 | transcriptional repressor complex | IDA | 16691198 |
Pathways & Interactions for SP1 Gene
Pathways by source for SP1 Gene
35 BioSystems pathways for SP1 Gene
17 Reactome pathways for SP1 Gene
1 PharmGKB pathway for SP1 Gene
12 KEGG pathways for SP1 Gene
15 GeneGo (Thomson Reuters) pathways for SP1 Gene
11 Qiagen pathways for SP1 Gene
2 Cell Signaling Technology pathways for SP1 Gene
Interacting Proteins for SP1 Gene
Selected Interacting proteins:
P08047-SP1_HUMAN
ENSP00000329357
for SP1 Gene via
IID
MINT
UniProtKB
STRING
GPS-Prot Interaction Network for SP1
SIGNOR curated interactions for SP1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IDA,IEA | 12169688 |
| GO:0006357 | regulation of transcription by RNA polymerase II | IBA,IEA | -- |
| GO:0010628 | positive regulation of gene expression | IMP | 23802567 |
| GO:0016032 | viral process | IEA | -- |
Transcripts for SP1 Gene
mRNA/cDNA for SP1 Gene
- (4) REFSEQ mRNAs :
- (13) Additional mRNA sequences :
- (358) Selected AceView cDNA sequences:
- (4) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000551969 602 bps (uc058opn.1)
- ENST00000548560 1061 bps (uc058opo.1)
- ENST00000426431 7603 bps (uc010sog.3)
- ENST00000327443 2846 bps (uc001scw.4)
Unigene Clusters for SP1 Gene
- Sp1 transcription factor:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for SP1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SP1
- genomics-online: gRNA clones - Search results for 106 available SP1 gene related products
- Overview of 106 available SP1 gene related products
- Applied Biological Materials CRISPR for SP1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for SP1
- GenScript: Design CRISPR guide RNA sequences for SP1
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for SP1
- Browse OriGene Inhibitory RNA Products For SP1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SP1
- genomics-online: shRNA clones - Search results for 106 available SP1 gene related products
- Overview of 106 available SP1 gene related products
Clone Products
- Sino Biological Human cDNA Clone for SP1
- VectorBuilder custom plasmid, inducible vectors for SP1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for SP1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for SP1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SP1
- Applied Biological Materials Clones for SP1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | · | 4c | · | 4d | ^ | 5 | ^ | 6 | ^ | 7 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||||||
| SP2: | - | ||||||||||||||||||||
| SP3: | - | - | - | ||||||||||||||||||
| SP4: |
Expression for SP1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Eye (Sensory Organs)
- Fetal Corneal Basal Epithelial Cells Corneal Epithelium
- Keratocytes Corneal Stroma
- Endothelial Cells Corneal Endothelium
- Keratoblasts Corneal Stroma
-
Epithelial Cells
- Fetal Corneal Basal Epithelial Cells Corneal Epithelium
-
Fibroblasts
- Keratocytes Corneal Stroma
-
Somite (Muscoskeletal System)
- Mononuclear Myocytes Cervical Epaxial Myotome
-
Skeletal Muscle (Muscoskeletal System)
- Mononuclear Myocytes Cervical Epaxial Myotome
-
Endothelium (Cardiovascular System)
- Endothelial Cells Corneal Endothelium
mRNA differential expression in normal tissues according to GTEx for SP1 Gene
This gene is overexpressed in Whole Blood (x4.3).
This gene is overexpressed in CD8 Tcells (15.8), Lung (9.8), and Fetal gut (8.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SP1 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of SP1 Gene:
SP1SOURCE GeneReport for Unigene cluster for SP1 Gene:
Hs.649191mRNA Expression by UniProt/SwissProt for SP1 Gene:
P08047-SP1_HUMAN
Tissue specificity:
Up-regulated in adenocarcinomas of the stomach (at protein level). Isoform 3 is ubiquitously expressed at low levels.
Evidence on tissue expression from TISSUES for SP1 Gene
- Nervous system(4.7)
- Intestine(4.5)
- Kidney(2.5)
- Lung(2.5)
- Muscle(2.5)
- Liver(2.4)
- Skin(2.4)
- Heart(2.2)
- Adrenal gland(2.1)
- Blood(2.1)
- Stomach(2)
Primer Products
-
OriGene qPCR primer pairs and template standards for SP1
-
OriGene qPCR primer pairs for SP1
- genomics-online: primer clones - Search results for 106 available SP1 gene related products
- Overview of 106 available SP1 gene related products
Gene Expression Assay Products
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for SP1 Gene
Orthologs for SP1 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | SP1 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | SP1 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | SP1 34 33 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Sp1 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Sp1 16 34 33 |
|
||
| chicken (Gallus gallus) |
Aves | SP1 34 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | SP1 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | sp1 33 |
|
||
| MGC76006 33 |
|
||||
| zebrafish (Danio rerio) |
Actinopterygii | sp1 34 33 33 |
|
OneToOne | |
| fruit fly (Drosophila melanogaster) |
Insecta | Spps 34 |
|
OneToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | sptf-3 34 |
|
OneToMany |
- Species where no ortholog for SP1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Evolution for SP1 Gene
- ENSEMBL:
- Gene Tree for SP1 (if available)
- TreeFam:
- Gene Tree for SP1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for SP1: view image
Paralogs for SP1 Gene
Paralogs for SP1 Gene
(65) SIMAP similar genes for SP1 Gene using alignment to 8 proteins:
- SP1_HUMAN
- B2R4Y6_HUMAN
- E4Z9M7_HUMAN
- G5E9M8_HUMAN
- H3BUU5_HUMAN
- H3BVI2_HUMAN
- L8E7F4_HUMAN
- Q15403_HUMAN
- Sp1
- DHFRP2
- PSG
- PSG3
- PSG7
- PSG6
- PSG11
- WT1
- PSG5
- CEACAM4
- PSG4
- CEACAM3
- PSG2
- DKFZp686O1631
- CEACAM7
- PSG9
- PSG11s
- CEACAM8
- PSG1
- KLF1
- PSG8
- CEACAM6
- kr-znf3
- SP4
- ZNF56
- SP5
- KLF7
- DKFZp686N0199
- KLF9
- GTF3A
- DKFZp686M04222
- CEACAM21
- CEACAM5
- CEACAM1
- ZNF78L1
- ZNF72
- DKFZp781M2392
- KLF6
- KLF13
- ZNF
- SP3
- smap-7
- ZNF692
- KLF4
- PSGII
- DKFZp434J0650
- ZNF697
- ZNF410
- ZFS-6
- ZFS-5
- ZSCAN31
- ZNF702P
- HZF16
- ZNF791
- REST
- ZNF672
- ZIC1
- ZFS-2
- SP9
- A-328A3.4
- ZNF219
- ZNF808
- ZNF600
- ZNF564
- ZNF345
Variants for SP1 Gene
| SNP ID | Clin | Chr 12 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000039371 | -- | 53,413,339(+) | CC/C | 3_prime_UTR_variant | |
| rs1000079005 | -- | 53,401,949(+) | G/A | intron_variant | |
| rs1000109403 | -- | 53,414,741(+) | G/A | 3_prime_UTR_variant | |
| rs1000111602 | -- | 53,406,608(+) | C/T | coding_sequence_variant, missense_variant | |
| rs1000141427 | -- | 53,406,983(+) | C/G | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv558997 | CNV | loss | 21841781 |
| nsv1147435 | CNV | duplication | 26484159 |
| nsv1143562 | CNV | deletion | 24896259 |
| nsv1122735 | CNV | deletion | 24896259 |
| nsv1120262 | CNV | tandem duplication | 24896259 |
Residual Variation Intolerance Score:
6.07% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.39;
27.35% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for SP1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- SP1
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SP1 Gene
Disorders for SP1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| huntington disease |
|
|
| keratoconus |
|
|
| breast cancer |
|
|
| human immunodeficiency virus type 1 |
|
|
| adrenal cortical adenocarcinoma |
|
|
Search SP1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for SP1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for SP1 Gene
Publications for SP1 Gene
- Snail associates with EGR-1 and SP-1 to upregulate transcriptional activation of p15INK4b. (PMID: 20121949) Hu CT … Wu WS (The FEBS journal 2010) 3 4 22 58
- O-GlcNAcylation of Sp1 interrupts Sp1 interaction with NF-Y. (PMID: 19302979) Lim K … Chang HI (Biochemical and biophysical research communications 2009) 3 4 22 58
- Phosphorylation by c-Jun NH2-terminal kinase 1 regulates the stability of transcription factor Sp1 during mitosis. (PMID: 18199680) Chuang JY … Hung JJ (Molecular biology of the cell 2008) 3 4 22 58
- Angiotensin II-inducible platelet-derived growth factor-D transcription requires specific Ser/Thr residues in the second zinc finger region of Sp1. (PMID: 18258854) Tan NY … Khachigian LM (Circulation research 2008) 3 4 22 58
- Phosphorylation of Sp1 in response to DNA damage by ataxia telangiectasia-mutated kinase. (PMID: 18171990) Olofsson BA … Azizkhan-Clifford J (Molecular cancer research : MCR 2007) 3 4 22 58
Products for SP1 Gene
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- OriGene Antibodies for SP1