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Aliases for SOX14 Gene

Aliases for SOX14 Gene

  • SRY-Box 14 2 2 3 5
  • SRY (Sex Determining Region Y)-Box 14 2 3
  • HMG Box Transcription Factor SOX-14 2 3
  • SOX28 3 4
  • Transcription Factor SOX-14 3
  • Protein SOX-28 4
  • SRY Box 14 2

External Ids for SOX14 Gene

Previous GeneCards Identifiers for SOX14 Gene

  • GC03P134468
  • GC03P138275
  • GC03P138765
  • GC03P138804
  • GC03P138966
  • GC03P137483
  • GC03P134858

Summaries for SOX14 Gene

Entrez Gene Summary for SOX14 Gene

  • This intronless gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. Mutations in this gene are suggested to be responsible for the limb defects associated with blepharophimosis, ptosis, epicanthus inversus syndrome (BPES) and Mobius syndrome. [provided by RefSeq, Jul 2008]

GeneCards Summary for SOX14 Gene

SOX14 (SRY-Box 14) is a Protein Coding gene. Diseases associated with SOX14 include Epicanthus. Among its related pathways are Circadian rythm related genes and ERK Signaling. Gene Ontology (GO) annotations related to this gene include sequence-specific DNA binding and chromatin binding. An important paralog of this gene is SOX21.

UniProtKB/Swiss-Prot for SOX14 Gene

  • Acts as a negative regulator of transcription.

Gene Wiki entry for SOX14 Gene

Additional gene information for SOX14 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SOX14 Gene

Genomics for SOX14 Gene

GeneHancer (GH) Regulatory Elements for SOX14 Gene

Promoters and enhancers for SOX14 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03I137764 Promoter/Enhancer 1.1 EPDnew ENCODE 550.8 0.0 -40 0.2 SIN3A PATZ1 GLIS1 TCF7 CTBP2 ZNF143 EZH2 TCF7L2 SOX14 NPM1P17
GH03I137769 Enhancer 0.5 ENCODE 0.8 +4.4 4414 0.1 CTBP1 SIN3A TCF7L2 EZH2 LINC01210 SOX14
GH03I137767 Enhancer 0.4 ENCODE 0.8 +3.6 3560 0.2 POU5F1 SIN3A EZH2 SOX14 LINC01210
GH03I137768 Enhancer 0.4 ENCODE 0.8 +3.1 3130 0.2 BACH1 EZH2 SOX14 LINC01210
GH03I137770 Enhancer 0.4 Ensembl 0.4 +6.6 6617 0.2 SUZ12 ZNF341 EZH2 LINC01210 SOX14
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SOX14 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SOX14 gene promoter:

Genomic Locations for SOX14 Gene

Genomic Locations for SOX14 Gene
2,055 bases
Plus strand

Genomic View for SOX14 Gene

Genes around SOX14 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SOX14 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SOX14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SOX14 Gene

Proteins for SOX14 Gene

  • Protein details for SOX14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transcription factor SOX-14
    Protein Accession:
    Secondary Accessions:
    • B2RAC0
    • Q3KPH7

    Protein attributes for SOX14 Gene

    240 amino acids
    Molecular mass:
    26485 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SOX14 Gene

Post-translational modifications for SOX14 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SOX14 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SOX14 Gene

Domains & Families for SOX14 Gene

Gene Families for SOX14 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for SOX14 Gene

Suggested Antigen Peptide Sequences for SOX14 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SOX14: view

No data available for UniProtKB/Swiss-Prot for SOX14 Gene

Function for SOX14 Gene

Molecular function for SOX14 Gene

GENATLAS Biochemistry:
SRY related HMG box gene 14,predominantly expressed in fetal brain,spinal cord,thymus,potentially involved in regulation of nervous system development,modulator of LINE retroposons promoter activity
UniProtKB/Swiss-Prot Function:
Acts as a negative regulator of transcription.

Phenotypes From GWAS Catalog for SOX14 Gene

Gene Ontology (GO) - Molecular Function for SOX14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IEA --
GO:0003677 DNA binding IEA --
GO:0003682 chromatin binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0043565 sequence-specific DNA binding ISS --
genes like me logo Genes that share ontologies with SOX14: view
genes like me logo Genes that share phenotypes with SOX14: view

Animal Models for SOX14 Gene

MGI Knock Outs for SOX14:

miRNA for SOX14 Gene

miRTarBase miRNAs that target SOX14

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SOX14 Gene

Localization for SOX14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SOX14 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SOX14 gene
Compartment Confidence
nucleus 4

Gene Ontology (GO) - Cellular Components for SOX14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005634 nucleus IEA --
GO:0044798 nuclear transcription factor complex IEA --
genes like me logo Genes that share ontologies with SOX14: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SOX14 Gene

Pathways & Interactions for SOX14 Gene

genes like me logo Genes that share pathways with SOX14: view

Pathways by source for SOX14 Gene

1 BioSystems pathway for SOX14 Gene
1 Qiagen pathway for SOX14 Gene

Gene Ontology (GO) - Biological Process for SOX14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II ISS --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007399 nervous system development TAS 9925951
GO:0007601 visual perception IEA --
genes like me logo Genes that share ontologies with SOX14: view

No data available for SIGNOR curated interactions for SOX14 Gene

Drugs & Compounds for SOX14 Gene

No Compound Related Data Available

Transcripts for SOX14 Gene

mRNA/cDNA for SOX14 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(5) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SOX14 Gene

SRY (sex determining region Y)-box 14:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SOX14 Gene

No ASD Table

Relevant External Links for SOX14 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SOX14 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SOX14 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SOX14 Gene

This gene is overexpressed in Brain - Hypothalamus (x23.7), Brain - Substantia nigra (x14.9), and Prostate (x8.2).

Protein differential expression in normal tissues from HIPED for SOX14 Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SOX14 Gene

Protein tissue co-expression partners for SOX14 Gene

NURSA nuclear receptor signaling pathways regulating expression of SOX14 Gene:


SOURCE GeneReport for Unigene cluster for SOX14 Gene:


Evidence on tissue expression from TISSUES for SOX14 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with SOX14: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SOX14 Gene

Orthologs for SOX14 Gene

This gene was present in the common ancestor of animals.

Orthologs for SOX14 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SOX14 33
  • 99.72 (n)
(Bos Taurus)
Mammalia SOX14 33
  • 96.67 (n)
(Canis familiaris)
Mammalia SOX14 33
  • 96.25 (n)
(Mus musculus)
Mammalia Sox14 33 16 34
  • 95.42 (n)
(Rattus norvegicus)
Mammalia Sox14 33
  • 95.42 (n)
(Monodelphis domestica)
Mammalia SOX14 34
  • 95 (a)
(Gallus gallus)
Aves SOX14 33 34
  • 84.44 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia sox14 33
  • 77.13 (n)
(Danio rerio)
Actinopterygii sox14 33 34
  • 77.73 (n)
-- 33
fruit fly
(Drosophila melanogaster)
Insecta Sox21a 35 34
  • 90 (a)
Sox21b 35
  • 88 (a)
D 35
  • 87 (a)
(Caenorhabditis elegans)
Secernentea sox-3 34
  • 39 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 34 (a)
Species where no ortholog for SOX14 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SOX14 Gene

Gene Tree for SOX14 (if available)
Gene Tree for SOX14 (if available)

Paralogs for SOX14 Gene

(13) SIMAP similar genes for SOX14 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SOX14: view

Variants for SOX14 Gene

Sequence variations from dbSNP and Humsavar for SOX14 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs869025252 likely-benign, Anophthalmia - microphthalmia 137,765,506(+) AA/A frameshift, stop_lost, terminator_codon_variant
rs1000159882 -- 137,765,112(+) C/T coding_sequence_variant, synonymous_variant
rs1000507646 -- 137,763,570(+) T/A upstream_transcript_variant
rs1001392390 -- 137,764,274(+) G/T upstream_transcript_variant
rs1001827458 -- 137,762,742(+) T/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for SOX14 Gene

Variant ID Type Subtype PubMed ID
nsv1142374 CNV tandem duplication 24896259
nsv428422 CNV gain+loss 18775914
nsv955354 CNV deletion 24416366

Variation tolerance for SOX14 Gene

Residual Variation Intolerance Score: 40% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.24; 5.46% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SOX14 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SOX14 Gene

Disorders for SOX14 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SOX14 Gene - From: GeneCards

Disorder Aliases PubMed IDs
- elite association - COSMIC cancer census association via MalaCards
Search SOX14 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for SOX14

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with SOX14: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SOX14 Gene

Publications for SOX14 Gene

  1. Fine mapping of the neurally expressed gene SOX14 to human 3q23, relative to three congenital diseases. (PMID: 10830911) Hargrave M … Koopman P (Human genetics 2000) 3 4 22 58
  2. Characterisation and mapping of the human SOX14 gene. (PMID: 9925951) Arsic N … Stevanovic M (Cytogenetics and cell genetics 1998) 2 3 4 58
  3. Analysis of copy number variation in 8,842 Korean individuals reveals 39 genes associated with hepatic biomarkers AST and ALT. (PMID: 20797317) Kim HY … Kim H (BMB reports 2010) 3 44 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. The isolation and high-resolution chromosomal mapping of human SOX14 and SOX21; two members of the SOX gene family related to SOX1, SOX2, and SOX3. (PMID: 10441749) Malas S … Episkopou V (Mammalian genome : official journal of the International Mammalian Genome Society 1999) 3 4 58

Products for SOX14 Gene

Sources for SOX14 Gene

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