This intronless gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. Mutations in this gene are suggested to be responsible for the limb de... See more...

Aliases for SOX14 Gene

Aliases for SOX14 Gene

  • SRY-Box Transcription Factor 14 2 3 5
  • SRY (Sex Determining Region Y)-Box 14 2 3
  • HMG Box Transcription Factor SOX-14 2 3
  • Transcription Factor SOX-14 3 4
  • SRY-Box 14 2 3
  • SOX28 3 4
  • Protein SOX-28 4

External Ids for SOX14 Gene

Previous GeneCards Identifiers for SOX14 Gene

  • GC03P134468
  • GC03P138275
  • GC03P138765
  • GC03P138804
  • GC03P138966
  • GC03P137483
  • GC03P134858

Summaries for SOX14 Gene

Entrez Gene Summary for SOX14 Gene

  • This intronless gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. Mutations in this gene are suggested to be responsible for the limb defects associated with blepharophimosis, ptosis, epicanthus inversus syndrome (BPES) and Mobius syndrome. [provided by RefSeq, Jul 2008]

GeneCards Summary for SOX14 Gene

SOX14 (SRY-Box Transcription Factor 14) is a Protein Coding gene. Diseases associated with SOX14 include Blepharophimosis and Moebius Syndrome. Among its related pathways are ERK Signaling and Circadian rythm related genes. Gene Ontology (GO) annotations related to this gene include sequence-specific DNA binding and chromatin binding. An important paralog of this gene is SOX21.

UniProtKB/Swiss-Prot Summary for SOX14 Gene

Gene Wiki entry for SOX14 Gene

Additional gene information for SOX14 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SOX14 Gene

Genomics for SOX14 Gene

GeneHancer (GH) Regulatory Elements for SOX14 Gene

Promoters and enhancers for SOX14 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J137763 Promoter 0.7 Ensembl 500.7 -0.4 -391 0.2 HDAC2 EZH2 SUZ12 SIN3A GLIS1 MAFK CTBP2 FOXA1 SP1 RBBP5 SOX14 LINC01210 lnc-SOX14-3
GH03J137764 Enhancer 0.6 ENCODE 500.7 0.0 -48 0.2 TEAD4 TCF7 HDAC2 EZH2 TCF7L2 YY1 SIN3A GLIS1 CTBP2 ZNF143 SOX14 lnc-SOX14-3
GH03J137769 Enhancer 0.5 ENCODE 0.7 +4.4 4406 0.1 HDAC2 CTBP1 EZH2 SIN3A TCF7L2 EGR1 SUZ12 LINC01210 SOX14
GH03J137767 Enhancer 0.4 ENCODE 0.7 +3.6 3552 0.2 NANOG SIN3A EZH2 CHD7 POU5F1 LINC01210 SOX14
GH03J137768 Enhancer 0.4 ENCODE 0.7 +3.1 3122 0.2 EZH2 HDAC2 CHD7 SUZ12 BACH1 LINC01210 SOX14
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SOX14 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SOX14

Top Transcription factor binding sites by QIAGEN in the SOX14 gene promoter:
  • aMEF-2
  • c-Myc
  • Max1
  • MEF-2
  • MEF-2A
  • NF-kappaB
  • NF-kappaB1
  • POU2F1
  • PPAR-alpha
  • RelA

Genomic Locations for SOX14 Gene

Genomic Locations for SOX14 Gene
chr3:137,764,292-137,766,334
(GRCh38/hg38)
Size:
2,043 bases
Orientation:
Plus strand
chr3:137,483,134-137,485,176
(GRCh37/hg19)
Size:
2,043 bases
Orientation:
Plus strand

Genomic View for SOX14 Gene

Genes around SOX14 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SOX14 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SOX14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SOX14 Gene

Proteins for SOX14 Gene

  • Protein details for SOX14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95416-SOX14_HUMAN
    Recommended name:
    Transcription factor SOX-14
    Protein Accession:
    O95416
    Secondary Accessions:
    • B2RAC0
    • Q3KPH7

    Protein attributes for SOX14 Gene

    Size:
    240 amino acids
    Molecular mass:
    26485 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SOX14 Gene

Post-translational modifications for SOX14 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SOX14 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Creative Diagnostics