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Aliases for SOX12 Gene

Aliases for SOX12 Gene

  • SRY-Box 12 2 3 5
  • SRY (Sex Determining Region Y)-Box 12 2 3
  • SOX22 3 4
  • SRY (Sex Determining Region Y)-Box 22 2
  • SRY-Related HMG-Box Gene 22 3
  • Transcription Factor SOX-12 3
  • SOX-22 Protein 3
  • Protein SOX-22 4
  • SRY Box 12 2

External Ids for SOX12 Gene

Previous HGNC Symbols for SOX12 Gene

  • SOX22

Previous GeneCards Identifiers for SOX12 Gene

  • GC20P000294
  • GC20P000301
  • GC20P000254

Summaries for SOX12 Gene

Entrez Gene Summary for SOX12 Gene

  • Members of the SOX family of transcription factors are characterized by the presence of a DNA-binding high mobility group (HMG) domain, homologous to the HMG box of sex-determining region Y (SRY). Forming a subgroup of the HMG domain superfamily, SOX proteins have been implicated in cell fate decisions in a diverse range of developmental processes. SOX transcription factors have diverse tissue-specific expression patterns during early development and have been proposed to act as target-specific transcription factors and/or as chromatin structure regulatory elements. The protein encoded by this gene was identified as a SOX family member based on conserved domains, and its expression in various tissues suggests a role in both differentiation and maintenance of several cell types. [provided by RefSeq, Jan 2013]

GeneCards Summary for SOX12 Gene

SOX12 (SRY-Box 12) is a Protein Coding gene. Among its related pathways are ERK Signaling. Gene Ontology (GO) annotations related to this gene include transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding and RNA polymerase II transcription coactivator activity. An important paralog of this gene is SOX4.

UniProtKB/Swiss-Prot for SOX12 Gene

  • Binds to the sequence 5-AACAAT-3.

Gene Wiki entry for SOX12 Gene

Additional gene information for SOX12 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SOX12 Gene

Genomics for SOX12 Gene

GeneHancer (GH) Regulatory Elements for SOX12 Gene

Promoters and enhancers for SOX12 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH20I000323 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 550.8 +0.9 936 7 HDGF PKNOX1 CLOCK FOXA2 MLX ARNT ZFP64 ARID4B SIN3A FEZF1 SOX12 TBC1D20 ACTG1P3 ZCCHC3 C20orf96 NRSN2-AS1 NRSN2 DEFB132 RBCK1 DEFB129
GH20I000377 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 18.8 +55.5 55495 6.4 CLOCK MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 TRIB3 GC20P000382 GC20P000390 GC20P000389 GC20P000387 GC20P000386 GC20P000385 GC20P000384 SOX12 TBC1D20
GH20I000345 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 11.3 +22.1 22115 3.7 MLX ZFP64 FEZF1 DMAP1 SLC30A9 ZNF213 E2F8 ZNF143 MCM3 SP3 NRSN2 NRSN2-AS1 LOC101929937 GC20M000344 ACTG1P3 TBC1D20 RBCK1 SOX12 SLC52A3
GH20I001117 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 11 +793.5 793471 2.7 MLX ZFP64 YBX1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 PSMF1 LOC105372493 TBC1D20 RBCK1 ACTG1P3 ENSG00000229728 SOX12
GH20I000645 Enhancer 1.4 Ensembl ENCODE dbSUPER 12.4 +320.7 320651 2.3 FOXA2 MLX ARID4B SIN3A DMAP1 ZNF2 ZNF48 ETS1 SLC30A9 POLR2B SRXN1 TCF15 SOX12 CSNK2A1 SCRT2 NRSN2 SLC52A3 GC20M000621 GC20M000631 ENSG00000270299
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SOX12 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SOX12 gene promoter:

Genomic Locations for SOX12 Gene

Genomic Locations for SOX12 Gene
4,658 bases
Plus strand

Genomic View for SOX12 Gene

Genes around SOX12 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SOX12 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SOX12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SOX12 Gene

Proteins for SOX12 Gene

  • Protein details for SOX12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transcription factor SOX-12
    Protein Accession:
    Secondary Accessions:
    • Q5D038
    • Q9NUD4

    Protein attributes for SOX12 Gene

    315 amino acids
    Molecular mass:
    34122 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAB69627.1; Type=Frameshift; Positions=135, 201; Evidence={ECO:0000305};

neXtProt entry for SOX12 Gene

Post-translational modifications for SOX12 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SOX12 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SOX12 Gene

Domains & Families for SOX12 Gene

Gene Families for SOX12 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for SOX12 Gene

Suggested Antigen Peptide Sequences for SOX12 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SOX12: view

No data available for UniProtKB/Swiss-Prot for SOX12 Gene

Function for SOX12 Gene

Molecular function for SOX12 Gene

UniProtKB/Swiss-Prot Function:
Binds to the sequence 5-AACAAT-3.

Gene Ontology (GO) - Molecular Function for SOX12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000976 transcription regulatory region sequence-specific DNA binding ISS --
GO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding ISS,IEA --
GO:0001105 RNA polymerase II transcription coactivator activity ISS --
GO:0003677 DNA binding NAS 9215677
genes like me logo Genes that share ontologies with SOX12: view
genes like me logo Genes that share phenotypes with SOX12: view

Animal Models for SOX12 Gene

MGI Knock Outs for SOX12:

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SOX12 Gene

Localization for SOX12 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SOX12 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SOX12 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for SOX12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0032993 protein-DNA complex IEA --
genes like me logo Genes that share ontologies with SOX12: view

Pathways & Interactions for SOX12 Gene

SuperPathways for SOX12 Gene

SuperPathway Contained pathways
1 ERK Signaling
genes like me logo Genes that share pathways with SOX12: view

Pathways by source for SOX12 Gene

1 Qiagen pathway for SOX12 Gene

Interacting Proteins for SOX12 Gene

Gene Ontology (GO) - Biological Process for SOX12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II NAS 9215677
GO:0006366 transcription by RNA polymerase II IEA --
GO:0021510 spinal cord development IEA,ISS --
genes like me logo Genes that share ontologies with SOX12: view

No data available for SIGNOR curated interactions for SOX12 Gene

Drugs & Compounds for SOX12 Gene

No Compound Related Data Available

Transcripts for SOX12 Gene

mRNA/cDNA for SOX12 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(127) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SOX12 Gene

SRY (sex determining region Y)-box 12:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SOX12 Gene

No ASD Table

Relevant External Links for SOX12 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SOX12 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SOX12 Gene

Protein differential expression in normal tissues from HIPED for SOX12 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SOX12 Gene

Protein tissue co-expression partners for SOX12 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SOX12 Gene:


SOURCE GeneReport for Unigene cluster for SOX12 Gene:


mRNA Expression by UniProt/SwissProt for SOX12 Gene:

Tissue specificity: Expressed most abundantly in the CNS. Also expressed in fetal brain and kidney and adult heart, pancreas, testis and ovary. Other tissues were only weakly positive.

Evidence on tissue expression from TISSUES for SOX12 Gene

  • Nervous system(4.4)
genes like me logo Genes that share expression patterns with SOX12: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for SOX12 Gene

Orthologs for SOX12 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SOX12 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SOX12 33 34
  • 96.4 (n)
(Canis familiaris)
Mammalia SOX12 33 34
  • 94.9 (n)
(Rattus norvegicus)
Mammalia Sox12 33
  • 91.3 (n)
(Mus musculus)
Mammalia Sox12 33 16 34
  • 90.98 (n)
(Monodelphis domestica)
Mammalia SOX12 34
  • 72 (a)
(Gallus gallus)
Aves LOC777179 33
  • 81.66 (n)
(Anolis carolinensis)
Reptilia SOX12 34
  • 54 (a)
(Danio rerio)
Actinopterygii sox12 34
  • 38 (a)
fruit fly
(Drosophila melanogaster)
Insecta Sox14 34
  • 14 (a)
(Caenorhabditis elegans)
Secernentea sem-2 34
  • 20 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ROX1 36
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10865 34
  • 18 (a)
Species where no ortholog for SOX12 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for SOX12 Gene

Gene Tree for SOX12 (if available)
Gene Tree for SOX12 (if available)

Paralogs for SOX12 Gene

(5) SIMAP similar genes for SOX12 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SOX12: view

Variants for SOX12 Gene

Sequence variations from dbSNP and Humsavar for SOX12 Gene

SNP ID Clin Chr 20 pos Variation AA Info Type
rs1000287490 -- 326,462(+) G/C coding_sequence_variant, missense_variant
rs1000716575 -- 330,513(+) G/C downstream_transcript_variant
rs1000771318 -- 327,071(+) T/C 3_prime_UTR_variant
rs1000835030 -- 329,257(+) G/A 3_prime_UTR_variant
rs1000896166 -- 325,407(+) C/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for SOX12 Gene

Variant ID Type Subtype PubMed ID
dgv4219n100 CNV gain 25217958
esv3893263 CNV loss 25118596
nsv1133498 CNV deletion 24896259

Variation tolerance for SOX12 Gene

Gene Damage Index Score: 2.38; 42.13% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SOX12 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SOX12 Gene

Disorders for SOX12 Gene

Additional Disease Information for SOX12

No disorders were found for SOX12 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SOX12 Gene

Publications for SOX12 Gene

  1. SOX22 is a new member of the SOX gene family, mainly expressed in human nervous tissue. (PMID: 9215677) Jay P … Berta P (Human molecular genetics 1997) 2 3 4 22 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P … Rogers J (Nature 2001) 3 4 58
  4. SOX12: a novel potential target for acute myeloid leukaemia. (PMID: 27858992) Wan H … Zhong H (British journal of haematology 2017) 3 58
  5. SOXC and MiR17-92 gene expression profiling defines two subgroups with different clinical outcome in mantle cell lymphoma. (PMID: 26998831) Roisman A … Slavutsky I (Genes, chromosomes & cancer 2016) 3 58

Products for SOX12 Gene

Sources for SOX12 Gene

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