Aliases for SOX11 Gene
External Ids for SOX11 Gene
Previous GeneCards Identifiers for SOX11 Gene
This intronless gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. The protein may function in the developing nervous system and play a role in tumorigenesis. [provided by RefSeq, Jul 2008]
GeneCards Summary for SOX11 Gene
SOX11 (SRY-Box Transcription Factor 11) is a Protein Coding gene. Diseases associated with SOX11 include Coffin-Siris Syndrome 9 and Coffin-Siris Syndrome 1. Among its related pathways are Preimplantation Embryo and ERK Signaling. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and RNA polymerase II core promoter sequence-specific DNA binding. An important paralog of this gene is SOX4.
UniProtKB/Swiss-Prot Summary for SOX11 Gene
Transcription factor that acts as a transcriptional activator (PubMed:24886874). Binds cooperatively with POU3F2/BRN2 or POU3F1/OCT6 to gene promoters, which enhances transcriptional activation (By similarity). Acts as a transcriptional activator of TEAD2 by binding to its gene promoter and first intron (By similarity). Plays a redundant role with SOX4 and SOX12 in cell survival of developing tissues such as the neural tube, branchial arches and somites, thereby contributing to organogenesis (By similarity).