Aliases for SOWAHD Gene

Aliases for SOWAHD Gene

  • Sosondowah Ankyrin Repeat Domain Family Member D 2 3 5
  • Ankyrin Repeat Domain-Containing Protein SOWAHD 3 4
  • Ankyrin Repeat Domain-Containing Protein 58 3 4
  • Protein Sosondowah Homolog D 3 4
  • Ankyrin Repeat Domain 58 2 3
  • ANKRD58 3 4

External Ids for SOWAHD Gene

Previous HGNC Symbols for SOWAHD Gene

  • ANKRD58

Previous GeneCards Identifiers for SOWAHD Gene

  • GC0XP118893

Summaries for SOWAHD Gene

GeneCards Summary for SOWAHD Gene

SOWAHD (Sosondowah Ankyrin Repeat Domain Family Member D) is a Protein Coding gene. An important paralog of this gene is SOWAHC.

Additional gene information for SOWAHD Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SOWAHD Gene

Genomics for SOWAHD Gene

GeneHancer (GH) Regulatory Elements for SOWAHD Gene

Promoters and enhancers for SOWAHD Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XJ119753 Promoter/Enhancer 1.8 FANTOM5 Ensembl ENCODE CraniofacialAtlas 507.6 -1.2 -1178 7.6 CTCF SIN3A USF1 SP1 EP300 ZIC2 KDM6A ZNF423 ZBTB26 RFX1 SOWAHD RNF113A NDUFA1 MIR766 UPF3B SEPTIN6 ZBTB33 HSALNG0139786 piR-50406
GH0XJ119734 Enhancer 0.6 Ensembl 13 -23.5 -23487 1.8 ZIC2 ZNF423 RBM25 NFIC POLR2A SPI1 BCOR ZNF768 GLIS1 ZMYM3 MIR766 SOWAHD UPF3B piR-50406 lnc-SEPT6-1
GH0XJ119625 Enhancer 0.4 Ensembl 11.8 -133.0 -133011 2.4 SPI1 NR2C1 PRDM4 piR-60051-114 MIR766 UBE2A SOWAHD lnc-NKRF-1 NKRF SEPTIN6
GH0XJ119612 Enhancer 0.3 Ensembl 11.9 -145.0 -144987 0.8 POLR2A UBE2A MIR766 CXorf56 SOWAHD NKRF piR-60051-114
GH0XJ119750 Enhancer 0.2 Ensembl 0.4 -7.6 -7587 0.4 piR-50406 SOWAHD
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SOWAHD on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SOWAHD

Genomic Locations for SOWAHD Gene

Genomic Locations for SOWAHD Gene
chrX:119,758,588-119,760,202
(GRCh38/hg38)
Size:
1,615 bases
Orientation:
Plus strand
chrX:118,892,576-118,894,165
(GRCh37/hg19)
Size:
1,590 bases
Orientation:
Plus strand

Genomic View for SOWAHD Gene

Genes around SOWAHD on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SOWAHD Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SOWAHD Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SOWAHD Gene

Proteins for SOWAHD Gene

  • Protein details for SOWAHD Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NJG2-SWAHD_HUMAN
    Recommended name:
    Ankyrin repeat domain-containing protein SOWAHD
    Protein Accession:
    A6NJG2

    Protein attributes for SOWAHD Gene

    Size:
    315 amino acids
    Molecular mass:
    33803 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SOWAHD Gene

Post-translational modifications for SOWAHD Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SOWAHD Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SOWAHD Gene

Domains & Families for SOWAHD Gene

Gene Families for SOWAHD Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for SOWAHD Gene

Suggested Antigen Peptide Sequences for SOWAHD Gene

GenScript: Design optimal peptide antigens:
  • Ankyrin repeat domain-containing protein 58 (ANR58_HUMAN)

Graphical View of Domain Structure for InterPro Entry

A6NJG2

UniProtKB/Swiss-Prot:

SWAHD_HUMAN :
  • Belongs to the SOWAH family.
Family:
  • Belongs to the SOWAH family.
genes like me logo Genes that share domains with SOWAHD: view

Function for SOWAHD Gene

genes like me logo Genes that share phenotypes with SOWAHD: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SOWAHD

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SOWAHD Gene

Localization for SOWAHD Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SOWAHD gene
Compartment Confidence
mitochondrion 2
cytosol 1
peroxisome 0
nucleus 0

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for SOWAHD Gene

Pathways & Interactions for SOWAHD Gene

PathCards logo

SuperPathways for SOWAHD Gene

No Data Available

Interacting Proteins for SOWAHD Gene

;

Gene Ontology (GO) - Biological Process for SOWAHD Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SOWAHD Gene

Drugs & Compounds for SOWAHD Gene

No Compound Related Data Available

Transcripts for SOWAHD Gene

mRNA/cDNA for SOWAHD Gene

1 REFSEQ mRNAs :
1 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SOWAHD

Alternative Splicing Database (ASD) splice patterns (SP) for SOWAHD Gene

No ASD Table

Relevant External Links for SOWAHD Gene

GeneLoc Exon Structure for
SOWAHD

Expression for SOWAHD Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SOWAHD Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SOWAHD Gene

This gene is overexpressed in Whole Blood (x12.3), Spleen (x8.2), Testis (x5.2), and Small Intestine - Terminal Ileum (x4.4).

Protein differential expression in normal tissues from HIPED for SOWAHD Gene

This gene is overexpressed in Bone (40.3), Pancreas (10.4), and Testis (9.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SOWAHD Gene



Protein tissue co-expression partners for SOWAHD Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SOWAHD

SOURCE GeneReport for Unigene cluster for SOWAHD Gene:

Hs.355223
genes like me logo Genes that share expression patterns with SOWAHD: view

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SOWAHD Gene

Orthologs for SOWAHD Gene

This gene was present in the common ancestor of animals.

Orthologs for SOWAHD Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SOWAHD 30
  • 96.84 (n)
cow
(Bos Taurus)
Mammalia SOWAHD 31 30
  • 83.07 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Sowahd 17 31 30
  • 70.85 (n)
rat
(Rattus norvegicus)
Mammalia Sowahd 30
  • 69.52 (n)
chicken
(Gallus gallus)
Aves SOWAHD 31
  • 40 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SOWAHD 31
  • 27 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii SOWAHD 31
  • 25 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta sowah 31
  • 8 (a)
OneToMany
Species where no ortholog for SOWAHD was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SOWAHD Gene

ENSEMBL:
Gene Tree for SOWAHD (if available)
TreeFam:
Gene Tree for SOWAHD (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SOWAHD: view image

Paralogs for SOWAHD Gene

Paralogs for SOWAHD Gene

genes like me logo Genes that share paralogs with SOWAHD: view

Variants for SOWAHD Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SOWAHD Gene

SNP ID Clinical significance and condition Chr 0X pos Variation AA Info Type
rs12841259 - p.Thr254Ala

Additional dbSNP identifiers (rs#s) for SOWAHD Gene

Structural Variations from Database of Genomic Variants (DGV) for SOWAHD Gene

Variant ID Type Subtype PubMed ID
nsv7056 CNV deletion 18451855

Variation tolerance for SOWAHD Gene

Gene Damage Index Score: 0.67; 14.23% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SOWAHD Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SOWAHD

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SOWAHD Gene

Disorders for SOWAHD Gene

Additional Disease Information for SOWAHD

No disorders were found for SOWAHD Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SOWAHD Gene

Publications for SOWAHD Gene

  1. An ancient genomic regulatory block conserved across bilaterians and its dismantling in tetrapods by retrogene replacement. (PMID: 22234889) Maeso I … Garcia-Fernàndez J (Genome research 2012) 2 3 54
  2. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross MT … Bentley DR (Nature 2005) 3 4 54

Products for SOWAHD Gene

Sources for SOWAHD Gene