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Aliases for SORCS2 Gene

Aliases for SORCS2 Gene

  • Sortilin Related VPS10 Domain Containing Receptor 2 2 3 5
  • VPS10 Domain-Containing Receptor SorCS2 3 4
  • Sortilin-Related VPS10 Domain Containing Receptor 2 2
  • VPS10 Domain Receptor Protein 3
  • KIAA1329 4

External Ids for SORCS2 Gene

Previous GeneCards Identifiers for SORCS2 Gene

  • GC04P007099
  • GC04P007315
  • GC04P007258
  • GC04P007259
  • GC04P007312

Summaries for SORCS2 Gene

Entrez Gene Summary for SORCS2 Gene

  • This gene encodes one family member of vacuolar protein sorting 10 (VPS10) domain-containing receptor proteins. The VPS10 domain name comes from the yeast carboxypeptidase Y sorting receptor Vps10 protein. Members of this gene family are large with many exons but the CDS lengths are usually less than 3700 nt. Very large introns typically separate the exons encoding the VPS10 domain; the remaining exons are separated by much smaller-sized introns. These genes are strongly expressed in the central nervous system. [provided by RefSeq, Jul 2008]

GeneCards Summary for SORCS2 Gene

SORCS2 (Sortilin Related VPS10 Domain Containing Receptor 2) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include neuropeptide receptor activity. An important paralog of this gene is SORCS1.

Additional gene information for SORCS2 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SORCS2 Gene

Genomics for SORCS2 Gene

GeneHancer (GH) Regulatory Elements for SORCS2 Gene

Promoters and enhancers for SORCS2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04J007192 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE 600.7 +0.6 563 2.2 CTCF RAD21 GLIS2 ZIC2 REST SMARCA5 ZBTB26 ZBTB17 SMC3 ZNF423 SORCS2 GC04M007198
GH04J007191 Enhancer 0.2 ENCODE 600.7 -1.6 -1583 0 SORCS2 GC04P007155
GH04J007190 Enhancer 0.2 ENCODE 600.7 -1.3 -1293 0.5 SORCS2 GC04P007155
GH04J007211 Enhancer 0.9 Ensembl ENCODE 18.7 +20.3 20339 2.4 CEBPG NCOA3 SP1 SP5 ZIC2 CEBPA FOXA2 GABPA CEBPB MAX SORCS2 GC04M007198 LOC105374371
GH04J007159 Enhancer 0.9 Ensembl ENCODE 11.6 -31.6 -31637 2.6 ZNF652 ZNF24 SP1 HNF1A ZNF644 GATAD2A RXRB FOXA2 SOX13 ZNF205 SORCS2 GC04P007155
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SORCS2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SORCS2 gene promoter:
  • E47
  • GATA-1
  • HOXA3
  • Meis-1
  • Meis-1a
  • Meis-1b
  • Nkx2-5
  • RP58
  • USF-1
  • USF1

Genomic Locations for SORCS2 Gene

Genomic Locations for SORCS2 Gene
550,300 bases
Plus strand
550,300 bases
Plus strand

Genomic View for SORCS2 Gene

Genes around SORCS2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SORCS2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SORCS2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SORCS2 Gene

Proteins for SORCS2 Gene

  • Protein details for SORCS2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    VPS10 domain-containing receptor SorCS2
    Protein Accession:
    Secondary Accessions:
    • Q9P2L7

    Protein attributes for SORCS2 Gene

    1159 amino acids
    Molecular mass:
    128152 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for SORCS2 Gene

neXtProt entry for SORCS2 Gene

Post-translational modifications for SORCS2 Gene

  • Glycosylation at posLast=362362, isoforms=65, isoforms=328, posLast=902902, posLast=158158, isoforms=891, isoforms=830, and isoforms=600
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect
    • SORC2_HUMAN (1896)

Other Protein References for SORCS2 Gene

No data available for DME Specific Peptides for SORCS2 Gene

Domains & Families for SORCS2 Gene

Gene Families for SORCS2 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for SORCS2 Gene

GenScript: Design optimal peptide antigens:
  • VPS10 domain-containing receptor SorCS2 (SORC2_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the VPS10-related sortilin family. SORCS subfamily.
  • Belongs to the VPS10-related sortilin family. SORCS subfamily.
genes like me logo Genes that share domains with SORCS2: view

Function for SORCS2 Gene

Phenotypes From GWAS Catalog for SORCS2 Gene

Gene Ontology (GO) - Molecular Function for SORCS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008188 neuropeptide receptor activity NAS 11499680
genes like me logo Genes that share ontologies with SORCS2: view
genes like me logo Genes that share phenotypes with SORCS2: view

Animal Models for SORCS2 Gene

MGI Knock Outs for SORCS2:

Animal Model Products

  • Taconic Biosciences Mouse Models for SORCS2

CRISPR Products

miRNA for SORCS2 Gene

miRTarBase miRNAs that target SORCS2

Clone Products

  • Applied Biological Materials (abm): Clones for SORCS2 - Now 50% OFF >
  • * SORCS2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * SORCS2 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SORCS2 Gene

Localization for SORCS2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SORCS2 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SORCS2 gene
Compartment Confidence
plasma membrane 3
endosome 1
golgi apparatus 1
mitochondrion 0
endoplasmic reticulum 0
cytosol 0
lysosome 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SORCS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane IEA --
GO:0014069 postsynaptic density IEA --
GO:0016020 membrane NAS,IEA 11499680
GO:0016021 integral component of membrane IEA,IBA 21873635
GO:0031901 early endosome membrane IEA --
genes like me logo Genes that share ontologies with SORCS2: view

Pathways & Interactions for SORCS2 Gene

PathCards logo

SuperPathways for SORCS2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SORCS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006886 intracellular protein transport IEA --
GO:0007218 neuropeptide signaling pathway NAS 11499680
GO:0060292 long-term synaptic depression IEA --
genes like me logo Genes that share ontologies with SORCS2: view

No data available for Pathways by source and SIGNOR curated interactions for SORCS2 Gene

Drugs & Compounds for SORCS2 Gene

(1) Drugs for SORCS2 Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Atazanavir Approved, Investigational Pharma HIV protease inhibitor,highly potent 0
genes like me logo Genes that share compounds with SORCS2: view

Transcripts for SORCS2 Gene

mRNA/cDNA for SORCS2 Gene

Unigene Clusters for SORCS2 Gene

Sortilin-related VPS10 domain containing receptor 2:
Representative Sequences:

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for SORCS2 - Now 50% OFF >
  • * SORCS2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * SORCS2 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

Alternative Splicing Database (ASD) splice patterns (SP) for SORCS2 Gene

No ASD Table

Relevant External Links for SORCS2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SORCS2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SORCS2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SORCS2 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (44.7) and Retina (14.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SORCS2 Gene

NURSA nuclear receptor signaling pathways regulating expression of SORCS2 Gene:


SOURCE GeneReport for Unigene cluster for SORCS2 Gene:


mRNA Expression by UniProt/SwissProt for SORCS2 Gene:

Tissue specificity: Highly expressed in brain and kidney. Detected at low levels in heart, liver, small intestine, skeletal muscle and thymus.

Evidence on tissue expression from TISSUES for SORCS2 Gene

  • Nervous system(4.5)
genes like me logo Genes that share expression patterns with SORCS2: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for SORCS2 Gene

Orthologs for SORCS2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SORCS2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SORCS2 35 34
  • 99.02 (n)
(Canis familiaris)
Mammalia SORCS2 34 35
  • 88.69 (n)
(Bos Taurus)
Mammalia SORCS2 35 34
  • 87.64 (n)
(Ornithorhynchus anatinus)
Mammalia SORCS2 35
  • 85 (a)
(Rattus norvegicus)
Mammalia Sorcs2 34
  • 84.65 (n)
(Mus musculus)
Mammalia Sorcs2 17 34 35
  • 84.13 (n)
(Monodelphis domestica)
Mammalia SORCS2 35
  • 82 (a)
(Gallus gallus)
Aves -- 35
  • 79 (a)
-- 35
  • 75 (a)
  • 73.84 (n)
(Anolis carolinensis)
Reptilia SORCS2 35
  • 70 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia sorcs2 34
  • 70.59 (n)
(Danio rerio)
Actinopterygii sorcs2 34
  • 68.36 (n)
  • 65 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 35
  • 19 (a)
-- 35
  • 19 (a)
-- 35
  • 17 (a)
-- 35
  • 14 (a)
PEP1 37 35
  • 11 (a)
VTH2 35
  • 10 (a)
-- 35
  • 10 (a)
VTH1 35
  • 10 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 25 (a)
Species where no ortholog for SORCS2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SORCS2 Gene

Gene Tree for SORCS2 (if available)
Gene Tree for SORCS2 (if available)
Evolutionary constrained regions (ECRs) for SORCS2: view image

Paralogs for SORCS2 Gene

Paralogs for SORCS2 Gene

(2) SIMAP similar genes for SORCS2 Gene using alignment to 4 proteins:

  • H0Y9I2_HUMAN
genes like me logo Genes that share paralogs with SORCS2: view

Variants for SORCS2 Gene

Sequence variations from dbSNP and Humsavar for SORCS2 Gene

SNP ID Clin Chr 04 pos Variation AA Info Type
rs1000001444 -- 7,334,513(+) GGGGGG/GGGGG intron_variant
rs1000003750 -- 7,423,490(+) C/T intron_variant
rs10000132 -- 7,397,942(+) T/C/G intron_variant
rs1000017277 -- 7,709,896(+) C/G intron_variant
rs10000185 -- 7,508,031(+) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SORCS2 Gene

Variant ID Type Subtype PubMed ID
dgv1458e212 CNV loss 25503493
dgv2724n106 CNV deletion 24896259
dgv2725n106 CNV deletion 24896259
dgv2726n106 CNV deletion 24896259
dgv2727n106 CNV deletion 24896259
dgv2728n106 CNV tandem duplication 24896259
dgv2924e59 CNV duplication 20981092
dgv2925e59 CNV duplication 20981092
dgv2926e59 CNV duplication 20981092
dgv2928e59 CNV duplication 20981092
dgv641n27 CNV loss 19166990
dgv642n27 CNV loss 19166990
dgv814e201 CNV deletion 23290073
dgv859n67 CNV gain 20364138
dgv8942n54 CNV loss 21841781
dgv8943n54 CNV loss 21841781
dgv8944n54 CNV gain 21841781
dgv8945n54 CNV gain 21841781
dgv8946n54 CNV loss 21841781
dgv8947n54 CNV loss 21841781
dgv8948n54 CNV gain+loss 21841781
dgv8949n54 CNV loss 21841781
dgv8950n54 CNV loss 21841781
dgv8951n54 CNV loss 21841781
dgv8952n54 CNV loss 21841781
dgv8953n54 CNV loss 21841781
dgv8954n54 CNV loss 21841781
dgv8955n54 CNV loss 21841781
dgv921e199 CNV deletion 23128226
esv1005726 CNV insertion 20482838
esv1005920 CNV deletion 20482838
esv1007737 CNV insertion 20482838
esv1009076 CNV insertion 20482838
esv1010050 CNV deletion 20482838
esv1046425 CNV deletion 17803354
esv1111596 CNV deletion 17803354
esv1161122 CNV insertion 17803354
esv1258015 CNV deletion 17803354
esv1317344 CNV deletion 17803354
esv1352937 CNV deletion 17803354
esv1391135 CNV deletion 17803354
esv1514799 CNV deletion 17803354
esv1533109 CNV deletion 17803354
esv2024202 CNV deletion 18987734
esv2351379 CNV deletion 18987734
esv23563 CNV gain 19812545
esv23725 CNV gain 19812545
esv24474 CNV loss 19812545
esv24504 CNV gain+loss 19812545
esv25539 CNV loss 19812545
esv25923 CNV gain 19812545
esv2656824 CNV deletion 23128226
esv2658823 CNV deletion 23128226
esv2668075 CNV deletion 23128226
esv2671770 CNV deletion 23128226
esv2672283 CNV deletion 23128226
esv2673985 CNV deletion 23128226
esv2678075 CNV deletion 23128226
esv2678974 CNV deletion 23128226
esv26887 CNV loss 19812545
esv26900 CNV loss 19812545
esv27263 CNV loss 19812545
esv2727026 CNV deletion 23290073
esv2727027 CNV deletion 23290073
esv2727030 CNV deletion 23290073
esv2727031 CNV deletion 23290073
esv2727032 CNV deletion 23290073
esv2727033 CNV deletion 23290073
esv2727034 CNV deletion 23290073
esv2727035 CNV deletion 23290073
esv2727036 CNV deletion 23290073
esv2727037 CNV deletion 23290073
esv2727038 CNV deletion 23290073
esv2727039 CNV deletion 23290073
esv2727042 CNV deletion 23290073
esv2727044 CNV deletion 23290073
esv2727045 CNV deletion 23290073
esv2727046 CNV deletion 23290073
esv2727047 CNV deletion 23290073
esv2727048 CNV deletion 23290073
esv2727049 CNV deletion 23290073
esv2727050 CNV deletion 23290073
esv2727052 CNV deletion 23290073
esv2727053 CNV deletion 23290073
esv2727054 CNV deletion 23290073
esv2727055 CNV deletion 23290073
esv2727056 CNV deletion 23290073
esv2727057 CNV deletion 23290073
esv2727058 CNV deletion 23290073
esv2727059 CNV deletion 23290073
esv2727060 CNV deletion 23290073
esv2727061 CNV deletion 23290073
esv2727063 CNV deletion 23290073
esv2727064 CNV deletion 23290073
esv2727065 CNV deletion 23290073
esv2727066 CNV deletion 23290073
esv2727067 CNV deletion 23290073
esv2727068 CNV deletion 23290073
esv2727069 CNV deletion 23290073
esv2759221 CNV gain 17122850
esv2831014 CNV deletion 24192839
esv2920 CNV loss 18987735
esv3110 CNV loss 18987735
esv3303379 CNV mobile element insertion 20981092
esv3384638 CNV insertion 20981092
esv34002 CNV loss 18971310
esv34033 CNV loss 18971310
esv34156 CNV loss 18971310
esv34196 OTHER inversion 12058347
esv3563342 CNV deletion 23714750
esv3563343 CNV deletion 23714750
esv3563344 CNV deletion 23714750
esv3563347 CNV deletion 23714750
esv3563351 CNV deletion 23714750
esv3563353 CNV deletion 23714750
esv3563354 CNV deletion 23714750
esv3563356 CNV deletion 23714750
esv3563358 CNV deletion 23714750
esv3599522 CNV loss 21293372
esv3599523 CNV loss 21293372
esv3599527 CNV loss 21293372
esv3599528 CNV loss 21293372
esv3599529 CNV loss 21293372
esv3599531 CNV loss 21293372
esv3599532 CNV loss 21293372
esv3599533 CNV loss 21293372
esv3748 CNV loss 18987735
esv4108 CNV loss 18987735
esv4191 CNV loss 18987735
esv7927 CNV loss 19470904
esv8000 CNV loss 19470904
esv8036 CNV loss 19470904
esv988567 CNV deletion 20482838
esv991612 CNV deletion 20482838
esv993203 CNV gain 20482838
esv999654 CNV deletion 20482838
nsv1003679 CNV gain 25217958
nsv1012289 CNV loss 25217958
nsv1072357 CNV deletion 25765185
nsv1073728 CNV deletion 25765185
nsv1074145 CNV deletion 25765185
nsv1074146 CNV deletion 25765185
nsv1074147 CNV deletion 25765185
nsv1074148 CNV deletion 25765185
nsv1074149 CNV deletion 25765185
nsv1110428 CNV duplication 24896259
nsv1112394 CNV deletion 24896259
nsv1112395 CNV deletion 24896259
nsv1122081 CNV deletion 24896259
nsv1123748 CNV deletion 24896259
nsv1126032 CNV deletion 24896259
nsv1126033 CNV deletion 24896259
nsv1126682 CNV deletion 24896259
nsv1129245 CNV insertion 24896259
nsv1131770 CNV deletion 24896259
nsv1139210 CNV deletion 24896259
nsv1139211 CNV deletion 24896259
nsv1139212 CNV deletion 24896259
nsv1142383 CNV tandem duplication 24896259
nsv1143280 CNV deletion 24896259
nsv1143281 CNV deletion 24896259
nsv1145925 CNV deletion 26484159
nsv1147480 CNV deletion 26484159
nsv1148314 CNV duplication 26484159
nsv1152277 CNV deletion 26484159
nsv1153125 CNV deletion 26484159
nsv1153239 CNV duplication 26484159
nsv290116 CNV deletion 16902084
nsv290990 CNV insertion 16902084
nsv291240 CNV deletion 16902084
nsv291426 CNV deletion 16902084
nsv291540 CNV deletion 16902084
nsv291783 CNV deletion 16902084
nsv292306 CNV deletion 16902084
nsv293826 CNV deletion 16902084
nsv4218 CNV deletion 18451855
nsv4219 CNV deletion 18451855
nsv428436 CNV gain 18775914
nsv461197 CNV loss 19166990
nsv461199 CNV loss 19166990
nsv461203 CNV loss 19166990
nsv461204 CNV loss 19166990
nsv461205 CNV loss 19166990
nsv469758 CNV loss 16826518
nsv470008 CNV loss 18288195
nsv475703 CNV novel sequence insertion 20440878
nsv508272 CNV deletion 20534489
nsv508994 CNV insertion 20534489
nsv508995 CNV insertion 20534489
nsv513120 CNV loss 21212237
nsv517503 CNV loss 19592680
nsv520804 CNV loss 19592680
nsv524838 CNV loss 19592680
nsv526748 CNV loss 19592680
nsv527419 CNV loss 19592680
nsv528667 CNV loss 19592680
nsv593561 CNV loss 21841781
nsv593563 CNV loss 21841781
nsv593564 CNV loss 21841781
nsv593565 CNV loss 21841781
nsv593566 CNV loss 21841781
nsv593569 CNV gain 21841781
nsv593570 CNV loss 21841781
nsv593571 CNV loss 21841781
nsv593572 CNV loss 21841781
nsv593573 CNV gain 21841781
nsv593576 CNV loss 21841781
nsv593577 CNV loss 21841781
nsv593579 CNV gain 21841781
nsv593581 CNV gain+loss 21841781
nsv593588 CNV gain+loss 21841781
nsv593593 CNV loss 21841781
nsv593605 CNV loss 21841781
nsv593611 CNV loss 21841781
nsv593612 CNV loss 21841781
nsv593613 CNV loss 21841781
nsv593616 CNV loss 21841781
nsv593617 CNV loss 21841781
nsv593618 CNV loss 21841781
nsv819855 CNV insertion 19587683
nsv820610 CNV deletion 20802225
nsv820732 CNV deletion 20802225
nsv829850 CNV loss 17160897
nsv949781 CNV deletion 24416366
nsv954410 CNV deletion 24416366

Variation tolerance for SORCS2 Gene

Residual Variation Intolerance Score: 31.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.45; 77.37% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SORCS2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SORCS2 Gene

Disorders for SORCS2 Gene

Additional Disease Information for SORCS2

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for SORCS2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SORCS2 Gene

Publications for SORCS2 Gene

  1. The genes for the human VPS10 domain-containing receptors are large and contain many small exons. (PMID: 11499680) Hampe W … Schaller HC (Human genetics 2001) 2 3 4 58
  2. A genome-wide association study identifies novel loci associated with circulating IGF-I and IGFBP-3. (PMID: 21216879) Kaplan RC … Wallaschofski H (Human molecular genetics 2011) 3 45 58
  3. Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals. (PMID: 19851296) Oguri M … Yamada Y (American journal of hypertension 2010) 3 45 58
  4. Inherited genetic variant predisposes to aggressive but not indolent prostate cancer. (PMID: 20080650) Xu J … Isaacs WB (Proceedings of the National Academy of Sciences of the United States of America 2010) 3 45 58
  5. Association of genetic variants with hemorrhagic stroke in Japanese individuals. (PMID: 20198315) Yoshida T … Yamada Y (International journal of molecular medicine 2010) 3 45 58

Products for SORCS2 Gene

Sources for SORCS2 Gene

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