Aliases for SORBS3 Gene
Aliases for SORBS3 Gene
External Ids for SORBS3 Gene
- HGNC: 30907
- Entrez Gene: 10174
- Ensembl: ENSG00000120896
- OMIM: 610795
- UniProtKB: O60504
Previous GeneCards Identifiers for SORBS3 Gene
- GC08P022466
- GC08P022409
- GC08P020951
Summaries for SORBS3 Gene
-
This gene encodes an SH3 domain-containing adaptor protein. The presence of SH3 domains play a role in this protein's ability to bind other cytoplasmic molecules and contribute to cystoskeletal organization, cell adhesion and migration, signaling, and gene expression. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
GeneCards Summary for SORBS3 Gene
SORBS3 (Sorbin And SH3 Domain Containing 3) is a Protein Coding gene. Among its related pathways are Cardiac conduction and Smooth Muscle Contraction. Gene Ontology (GO) annotations related to this gene include transcription factor binding and vinculin binding. An important paralog of this gene is SORBS1.
UniProtKB/Swiss-Prot for SORBS3 Gene
-
Vinexin alpha isoform promotes up-regulation of actin stress fiber formation. Vinexin beta isoform plays a role in cell spreading and enhances the activation of JNK/SAPK in response to EGF stimulation by using its third SH3 domain.
Additional gene information for SORBS3 Gene
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SORBS3 Gene
Genomics for SORBS3 Gene
GeneHancer (GH) Regulatory Elements for SORBS3 Gene
Promoters and enhancers for SORBS3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around SORBS3 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the SORBS3 gene promoter:
-
- E2F-2
- E2F
- E2F-1
- E2F-5
- E2F-3a
- E2F-4
Regulatory Element Products
Genomic Locations for SORBS3 Gene
Genomic Locations for SORBS3 Gene
- chr8:22,544,986-22,575,788
- (GRCh38/hg38)
- Size:
- 30,803 bases
- Orientation:
- Plus strand
- chr8:22,402,499-22,433,301
- (GRCh37/hg19)
- Size:
- 30,803 bases
- Orientation:
- Plus strand
Genomic View for SORBS3 Gene
Genes around SORBS3 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 8p21.3 by Entrez Gene
- 8p21.3 by HGNC
- 8p21.3 by Ensembl
SORBS3 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for SORBS3 Gene
Proteins for SORBS3 Gene
-
Protein details for SORBS3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O60504-VINEX_HUMAN
- Recommended name:
- Vinexin
- Protein Accession:
- O60504
- Q5BJE4
- Q6NX54
- Q96FY4
- Q9UQE4
Protein attributes for SORBS3 Gene
- Size:
- 671 amino acids
- Molecular mass:
- 75341 Da
- Quaternary structure:
-
- Interacts with DLG5 through its third SH3 domain (By similarity). Interacts with vinculin by the first two SH3 domains and the proline rich region of vinculin. Binds to SOS (guanine nucleotide exchange factor of RAS and RAC), through its third SH3 domain. The formation of this complex is down-regulated by phosphorylation of SOS. Interacts with INPPL1/SHIP2, SAFB2, SOCS7 and SRCIN1. Interacts with FASLG. Interacts with MAPK1/ERK2 (By similarity).
Three dimensional structures from OCA and Proteopedia for SORBS3 Gene
Protein Expression for SORBS3 Gene
Post-translational modifications for SORBS3 Gene
- Phosphorylated at Ser-530 by MAPK1/ERK2 during cell spreading.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for SORBS3 Gene
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for SORBS3
- Novus Biologicals Antibodies for SORBS3
-
Abcam antibodies for SORBS3
- Invitrogen Antibodies for SORBS3 (AFLGC-SORBS3)
- GeneTex SORBS3 Antibody for SORBS3
-
Boster Bio Antibodies for SORBS3
-
Santa Cruz Biotechnology (SCBT) Antibodies for SORBS3
Protein Products
-
OriGene Purified Proteins for SORBS3
- Search Origene for MassSpec and Protein Over-expression Lysates for SORBS3
- Origene Custom Protein Services for SORBS3
- ProSpec Recombinant Proteins for SORBS3
- Search GeneTex for Proteins for SORBS3
-
Abcam proteins for SORBS3
Assay Products
No data available for DME Specific Peptides for SORBS3 Gene
Domains & Families for SORBS3 Gene
Gene Families for SORBS3 Gene
- Human Protein Atlas (HPA):
-
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for SORBS3 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for SORBS3 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for SORBS3 Gene
Function for SORBS3 Gene
Molecular function for SORBS3 Gene
- UniProtKB/Swiss-Prot Function:
- Vinexin alpha isoform promotes up-regulation of actin stress fiber formation. Vinexin beta isoform plays a role in cell spreading and enhances the activation of JNK/SAPK in response to EGF stimulation by using its third SH3 domain.
Phenotypes From GWAS Catalog for SORBS3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005200 | structural constituent of cytoskeleton | TAS | 9885244 |
| GO:0005515 | protein binding | IEA,IPI | 12660241 |
| GO:0008134 | transcription factor binding | IEA | -- |
| GO:0017166 | vinculin binding | IPI | 9885244 |
Phenotypes for SORBS3 Gene
- MGI mutant phenotypes for SORBS3:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for SORBS3:
-
- Decreased viability ratio
- Negative genetic interaction between PTTG1-/- and PTTG1+/+
- Negative genetic interaction between BLM-/- and BLM+/+
- Negative genetic interaction between MUS81-/- and MUS81+/+
- Increased cilium length
- Increased cilium length after serum starvation
- Decreased cell migration
- Decreased viability
- no effect
- Increased vaccinia virus (VACV) infection
- Mildly decreased CFP-tsO45G cell surface transport
- Decreased NF-kappaB reporter expression
- Increased cell number in S
- Increased viability
Animal Models for SORBS3 Gene
- MGI Knock Outs for SORBS3:
-
- Sorbs3 Sorbs3<tm1Kiok>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for SORBS3
-
CRISPR Products
-
OriGene CRISPR knockouts for SORBS3
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SORBS3
- genomics-online: gRNA clones - Search results for 86 available Vinexin gene related products
- Overview of 86 available Vinexin gene related products
- Applied Biological Materials CRISPR for SORBS3
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for SORBS3
- GenScript: Design CRISPR guide RNA sequences for SORBS3
miRNA for SORBS3 Gene
- miRTarBase miRNAs that target SORBS3
-
- hsa-mir-1229-3p (MIRT036259)
- hsa-mir-877-5p (MIRT037354)
- hsa-mir-744-5p (MIRT037629)
- hsa-mir-4433b-5p (MIRT715100)
- hsa-mir-1260b (MIRT715101)
- hsa-mir-1260a (MIRT715102)
- hsa-mir-466 (MIRT715103)
- hsa-mir-4672 (MIRT715104)
- hsa-mir-3941 (MIRT715105)
- hsa-mir-4433a-5p (MIRT715106)
- hsa-mir-600 (MIRT715107)
- hsa-mir-6748-3p (MIRT715108)
- hsa-mir-1224-3p (MIRT715109)
- hsa-mir-1228-3p (MIRT715110)
- hsa-mir-603 (MIRT715111)
- hsa-mir-362-3p (MIRT715112)
- hsa-mir-329-3p (MIRT715113)
- hsa-mir-8485 (MIRT715114)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for SORBS3
- Browse OriGene Inhibitory RNA Products For SORBS3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SORBS3
- genomics-online: shRNA clones - Search results for 86 available Vinexin gene related products
- Overview of 86 available Vinexin gene related products
Clone Products
-
OriGene ORF clones in human for SORBS3
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for SORBS3
- Addgene plasmids for SORBS3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SORBS3
- Applied Biological Materials Clones for SORBS3
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for SORBS3
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SORBS3 Gene
Localization for SORBS3 Gene
Subcellular locations from UniProtKB/Swiss-Prot for SORBS3 Gene
- Isoform Alpha: Cell junction. Cytoplasm, cytoskeleton. Note=Localized at cell-extracellular matrix junctions (By similarity). Both isoforms were localized at focal adhesion and cell-cell adhesion sites. {ECO:0000250}.
- Isoform Beta: Cell junction. Nucleus. Cytoplasm, cytoskeleton. Note=Localized at cell-extracellular matrix junctions (By similarity). Both isoforms were localized at focal adhesion and cell-cell adhesion sites, vinexin beta was also found in the nucleus. {ECO:0000250}.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
| cytoskeleton | 4 |
- Focal adhesion sites (2)
- Nucleoplasm (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA | -- |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005829 | cytosol | TAS | -- |
| GO:0005856 | cytoskeleton | IEA | -- |
| GO:0005925 | colocalizes_with focal adhesion | IDA | 9885244 |
Pathways & Interactions for SORBS3 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Cardiac conduction | ||
| 2 | Smooth Muscle Contraction | ||
Pathways by source for SORBS3 Gene
2 Reactome pathways for SORBS3 Gene
Interacting Proteins for SORBS3 Gene
Selected Interacting proteins:
O60504-VINEX_HUMAN
ENSP00000240123
for SORBS3 Gene via
UniProtKB
STRING
MINT
IID
GPS-Prot Interaction Network for SORBS3
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000122 | negative regulation of transcription by RNA polymerase II | IEA | -- |
| GO:0006936 | muscle contraction | TAS | -- |
| GO:0007015 | actin filament organization | IEA | -- |
| GO:0007155 | cell adhesion | IEA,TAS | 9885244 |
| GO:0031589 | cell-substrate adhesion | IEA | -- |
Transcripts for SORBS3 Gene
mRNA/cDNA for SORBS3 Gene
- (7) REFSEQ mRNAs :
- (7) Additional mRNA sequences :
- (306) Selected AceView cDNA sequences:
- (22) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000522037 718 bps (uc064kzu.1)
- ENST00000523941 568 bps (uc064kzv.1)
- ENST00000240123 3459 bps (uc003xbv.4)
- ENST00000517500 1228 bps (uc064kzw.1)
- ENST00000517535 3067 bps (uc064kzx.1)
Unigene Clusters for SORBS3 Gene
- Sorbin and SH3 domain containing 3:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for SORBS3
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SORBS3
- genomics-online: gRNA clones - Search results for 86 available Vinexin gene related products
- Overview of 86 available Vinexin gene related products
- Applied Biological Materials CRISPR for SORBS3
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for SORBS3
- GenScript: Design CRISPR guide RNA sequences for SORBS3
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for SORBS3
- Browse OriGene Inhibitory RNA Products For SORBS3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SORBS3
- genomics-online: shRNA clones - Search results for 86 available Vinexin gene related products
- Overview of 86 available Vinexin gene related products
Clone Products
-
OriGene ORF clones in human for SORBS3
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for SORBS3
- Addgene plasmids for SORBS3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SORBS3
- Applied Biological Materials Clones for SORBS3
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | · | 4c | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | · | 7c | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | ^ | 11 | ^ | 12a | · | 12b | ^ | 13a | · | 13b | ^ | 14a | · | 14b | · | 14c | ^ | 15a | · | 15b | · |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
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| SP10: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP12: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
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| SP16: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP17: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP18: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP19: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP20: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP21: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP22: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP23: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP24: | - | - | - | - | - |
| ExUns: | 15c | · | 15d | · | 15e | · | 15f | ^ | 16a | · | 16b | · | 16c | ^ | 17a | · | 17b | · | 17c | ^ | 18 | ^ | 19a | · | 19b | ^ | 20a | · | 20b | · | 20c | ^ | 21a | · | 21b | · | 21c | ^ | 22a | · | 22b | · | 22c | · | 22d | · | 22e | · | 22f | · | 22g | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP12: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP13: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP14: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP15: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP16: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP17: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP18: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP19: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP20: | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP21: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP22: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP23: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP24: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
| ExUns: | 23a | · | 23b | ^ | 24 | ^ | 25a | · | 25b | · | 25c | ^ | 26a | · | 26b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||
| SP2: | - | ||||||||||||||
| SP3: | |||||||||||||||
| SP4: | |||||||||||||||
| SP5: | - | ||||||||||||||
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| SP9: | |||||||||||||||
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| SP11: | |||||||||||||||
| SP12: | |||||||||||||||
| SP13: | |||||||||||||||
| SP14: | |||||||||||||||
| SP15: | - | - | - | ||||||||||||
| SP16: | |||||||||||||||
| SP17: | |||||||||||||||
| SP18: | |||||||||||||||
| SP19: | |||||||||||||||
| SP20: | |||||||||||||||
| SP21: | |||||||||||||||
| SP22: | |||||||||||||||
| SP23: | |||||||||||||||
| SP24: |
Expression for SORBS3 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Brain (Nervous System)
- Myelinating Oligodendrocyte Cells Forebrain White Matter
-
Glial Cells
- Myelinating Oligodendrocyte Cells Forebrain White Matter
-
Uterus (Reproductive System)
-
Prostate (Endocrine System)
-
Placenta (Extraembryonic Tissues)
-
Spleen (Hematopoietic System)
-
Gall Bladder (Hepatobiliary System)
-
Lung (Respiratory System)
-
Kidney (Urinary System)
-
Fibroblasts (Uncategorized)
-
Testis (Reproductive System)
-
Liver (Hepatobiliary System)
-
Ovary (Reproductive System)
-
Adipose (Muscoskeletal System)
This gene is overexpressed in Gallbladder (6.2).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SORBS3 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of SORBS3 Gene:
SORBS3SOURCE GeneReport for Unigene cluster for SORBS3 Gene:
Hs.528572mRNA Expression by UniProt/SwissProt for SORBS3 Gene:
O60504-VINEX_HUMAN
Tissue specificity:
Both isoforms are expressed in different tissues like heart, placenta, brain, skeletal muscle and pancreas. Isoform beta is especially found in liver.
Evidence on tissue expression from TISSUES for SORBS3 Gene
- Nervous system(4.7)
- Liver(4.3)
- Muscle(2.1)
- Kidney(2)
Primer Products
-
OriGene qPCR primer pairs for SORBS3
-
OriGene qPCR primer pairs and template standards for SORBS3
- genomics-online: primer clones - Search results for 86 available Vinexin gene related products
- Overview of 86 available Vinexin gene related products
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for SORBS3 Gene
Orthologs for SORBS3 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | SORBS3 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | SORBS3 34 33 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Sorbs3 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Sorbs3 16 34 33 |
|
||
| dog (Canis familiaris) |
Mammalia | SORBS3 34 33 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | SORBS3 34 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | SORBS3 34 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | SORBS3 34 |
|
OneToOne | |
| zebrafish (Danio rerio) |
Actinopterygii | sorbs3 34 33 |
|
OneToOne | |
| fruit fly (Drosophila melanogaster) |
Insecta | CAP 34 |
|
OneToMany |
- Species where no ortholog for SORBS3 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Evolution for SORBS3 Gene
- ENSEMBL:
- Gene Tree for SORBS3 (if available)
- TreeFam:
- Gene Tree for SORBS3 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for SORBS3: view image
Paralogs for SORBS3 Gene
(17) SIMAP similar genes for SORBS3 Gene using alignment to 15 proteins:
- VINEX_HUMAN
- E5RH58_HUMAN
- E5RHI2_HUMAN
- E5RHS8_HUMAN
- E5RIA0_HUMAN
- E5RJP2_HUMAN
- E7EQH0_HUMAN
- H0YAT3_HUMAN
- H0YAU6_HUMAN
- H0YAZ3_HUMAN
- H0YB51_HUMAN
- H0YB85_HUMAN
- H0YBA2_HUMAN
- H0YBL2_HUMAN
- Q9BT70_HUMAN
Variants for SORBS3 Gene
| SNP ID | Clin | Chr 08 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000008683 | -- | 22,566,224(+) | G/T | 5_prime_UTR_variant, intron_variant | |
| rs1000039262 | -- | 22,552,251(+) | C/A | genic_upstream_transcript_variant, intron_variant | |
| rs1000067775 | -- | 22,565,984(+) | G/A | genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant | |
| rs1000224455 | -- | 22,567,436(+) | A/C/T | intron_variant | |
| rs1000246479 | -- | 22,560,652(+) | T/A | genic_upstream_transcript_variant, intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv451n21 | CNV | loss | 19592680 |
| esv2759604 | CNV | loss | 17122850 |
| nsv1075125 | CNV | deletion | 25765185 |
| nsv1075546 | CNV | deletion | 25765185 |
Residual Variation Intolerance Score:
95.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
5.22;
69.93% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for SORBS3 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SORBS3 Gene
Disorders for SORBS3 Gene
Additional Disease Information for SORBS3
- Genetic Association Database
- (GAD)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for SORBS3 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SORBS3 Gene
Publications for SORBS3 Gene
- The suppressor of cytokine signaling (SOCS)-7 interacts with the actin cytoskeleton through vinexin. (PMID: 15242778) Martens N … Hooghe-Peters EL (Experimental cell research 2004) 3 4 22 58
- SAFB2, a new scaffold attachment factor homolog and estrogen receptor corepressor. (PMID: 12660241) Townson SM … Oesterreich S (The Journal of biological chemistry 2003) 3 4 22 58
- Vinexin: a novel vinculin-binding protein with multiple SH3 domains enhances actin cytoskeletal organization. (PMID: 9885244) Kioka N … Aota S (The Journal of cell biology 1999) 2 3 4 58
- Vinexin forms a signaling complex with Sos and modulates epidermal growth factor-induced c-Jun N-terminal kinase/stress-activated protein kinase activities. (PMID: 10585480) Akamatsu M … Kioka N (The Journal of biological chemistry 1999) 3 4 22 58
- Crucial role of vinexin for keratinocyte migration in vitro and epidermal wound healing in vivo. (PMID: 20361963) Kioka N … Ueda K (Experimental cell research 2010) 3 22 58
Products for SORBS3 Gene
- Browse R&D Systems for Antibodies
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- Custom Antibody ServicesOriGene Antibodies for SORBS3
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- Custom Assay Services
- OriGene Purified Proteins for SORBS3
- Search Origene for MassSpec and Protein Over-expression Lysates for SORBS3
- Origene Custom Protein Services for SORBS3
- Origene shrna, sirna, and RNAi products in human, mouse, rat for SORBS3
- Browse OriGene Inhibitory RNA Products For SORBS3
- OriGene qPCR primer pairs for SORBS3
- OriGene qPCR primer pairs and template standards for SORBS3
- OriGene CRISPR knockouts for SORBS3
- OriGene ORF clones in human for SORBS3
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For SORBS3
- GenScript: Next-day shipping of latest version cDNA ORF clones for SORBS3 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for SORBS3
- GenScript Custom Assay Services for SORBS3
- GenScript Custom overexpressing Cell Line Services for SORBS3
- GenScript: Design CRISPR guide RNA sequences for SORBS3
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for SORBS3
- Sino Biological Human cDNA Clone for SORBS3
- Browse Sino Biological Recombinant Proteins
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- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for SORBS3
- Novus Biologicals lysates and proteins for SORBS3
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies
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- ProSpec Recombinant Proteins for SORBS3
- Invitrogen Antibodies for SORBS3 (AFLGC-SORBS3)
- Cyagen custom Knockout/knockin (KOKI) mouse models for SORBS3
- Addgene plasmids for SORBS3
- antibodies-online: Search results for 27 available Vinexin Antibodies ranked by validation data
- Compare Top Vinexin Antibodies
- antibodies-online: Search results for available Vinexin related products ranked by validation data
- antibodies-online: Search results for 3 available Vinexin Proteins ranked by validation data
- Compare Top Vinexin Proteins
- GeneTex SORBS3 Antibody for SORBS3
- Search GeneTex for Proteins for SORBS3
- Santa Cruz Biotechnology (SCBT) Antibodies for SORBS3
- Search Santa Cruz Biotechnology (SCBT) for SORBS3 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for SORBS3
- Horizon Cell Lines for SORBS3
- genomics-online: cdna clones - Search results for 86 available Vinexin gene related products
- Overview of 86 available Vinexin gene related products
- orf clones - Search results for 86 available Vinexin gene related products
- Overview of 86 available Vinexin gene related products
- genomics-online: gRNA clones - Search results for 86 available Vinexin gene related products
- Overview of 86 available Vinexin gene related products
- genomics-online: primer clones - Search results for 86 available Vinexin gene related products
- Overview of 86 available Vinexin gene related products
- genomics-online: shRNA clones - Search results for 86 available Vinexin gene related products
- Overview of 86 available Vinexin gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SORBS3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SORBS3
- GeneCopoeia miRNA 3'UTR Target clone products for SORBS3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SORBS3
- Boster Bio Antibodies for SORBS3
- Browse Boster Bio ELISA Kits
Sources for SORBS3 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio
- (169) Biorbyt