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This gene encodes an SH3 domain-containing adaptor protein. The presence of SH3 domains play a role in this protein's ability to bind other cytoplasmic molecules and contribute to cystoskeletal organization, cell adhesion and migration, signaling, and gene expression. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, No... See more...
Aliases for SORBS3 Gene
Aliases for SORBS3 Gene
External Ids for SORBS3 Gene
- HGNC: 30907
- Entrez Gene: 10174
- Ensembl: ENSG00000120896
- OMIM: 610795
- UniProtKB: O60504
Previous GeneCards Identifiers for SORBS3 Gene
- GC08P022466
- GC08P022409
- GC08P020951
Summaries for SORBS3 Gene
-
This gene encodes an SH3 domain-containing adaptor protein. The presence of SH3 domains play a role in this protein's ability to bind other cytoplasmic molecules and contribute to cystoskeletal organization, cell adhesion and migration, signaling, and gene expression. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
GeneCards Summary for SORBS3 Gene
SORBS3 (Sorbin And SH3 Domain Containing 3) is a Protein Coding gene. Diseases associated with SORBS3 include Cardiomyopathy, Dilated, 1P and Schizophrenia 18. Among its related pathways are Cardiac conduction and Smooth Muscle Contraction. Gene Ontology (GO) annotations related to this gene include transcription factor binding and vinculin binding. An important paralog of this gene is SORBS1.
UniProtKB/Swiss-Prot Summary for SORBS3 Gene
-
Vinexin alpha isoform promotes up-regulation of actin stress fiber formation. Vinexin beta isoform plays a role in cell spreading and enhances the activation of JNK/SAPK in response to EGF stimulation by using its third SH3 domain.
Additional gene information for SORBS3 Gene
- HGNC(30907)
- Entrez Gene(10174)
- Ensembl(ENSG00000120896)
- OMIM(610795)
- UniProtKB(O60504)
- Open Targets Platform(ENSG00000120896)
- Search for SORBS3 at DataMed
- Search for SORBS3 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SORBS3 Gene
Genomics for SORBS3 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for SORBS3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around SORBS3 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SORBS3
- Top Transcription factor binding sites by QIAGEN in the SORBS3 gene promoter:
-
- E2F
- E2F-1
- E2F-2
- E2F-3a
- E2F-4
- E2F-5
Genomic Locations for SORBS3 Gene
Genomic Locations for SORBS3 Gene
- chr8:22,544,986-22,575,788
- (GRCh38/hg38)
- Size:
- 30,803 bases
- Orientation:
- Plus strand
- chr8:22,402,499-22,433,301
- (GRCh37/hg19)
- Size:
- 30,803 bases
- Orientation:
- Plus strand
Genomic View for SORBS3 Gene
Genes around SORBS3 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 8p21.3 by HGNC
- 8p21.3 by Entrez Gene
- 8p21.3 by Ensembl
SORBS3 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for SORBS3 Gene
Proteins for SORBS3 Gene
-
Protein details for SORBS3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O60504-VINEX_HUMAN
- Recommended name:
- Vinexin
- Protein Accession:
- O60504
- Q5BJE4
- Q6NX54
- Q96FY4
- Q9UQE4
Protein attributes for SORBS3 Gene
- Size:
- 671 amino acids
- Molecular mass:
- 75341 Da
- Quaternary structure:
-
- Interacts with DLG5 through its third SH3 domain (By similarity). Interacts with vinculin by the first two SH3 domains and the proline rich region of vinculin. Binds to SOS (guanine nucleotide exchange factor of RAS and RAC), through its third SH3 domain. The formation of this complex is down-regulated by phosphorylation of SOS. Interacts with INPPL1/SHIP2, SAFB2, SOCS7 and SRCIN1. Interacts with FASLG. Interacts with MAPK1/ERK2 (By similarity).
Three dimensional structures from OCA and Proteopedia for SORBS3 Gene
Protein Expression for SORBS3 Gene
Post-translational modifications for SORBS3 Gene
- Phosphorylated at Ser-530 by MAPK1/ERK2 during cell spreading.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for SORBS3 Gene
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for SORBS3
- Novus Biologicals Antibodies for SORBS3
-
Abcam antibodies for SORBS3
- Invitrogen Antibodies for SORBS3 (AFLGC-SORBS3)
-
Biorbyt antibodies for SORBS3
-
Boster Bio Antibodies for SORBS3
-
Santa Cruz Biotechnology (SCBT) Antibodies for SORBS3
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for SORBS3
- Origene Custom Protein Services for SORBS3
- ProSpec Recombinant Proteins for SORBS3
-
Abcam proteins for SORBS3
Assay Products
-
Signalway ELISA kits for SORBS3
No data available for DME Specific Peptides for SORBS3 Gene
Domains & Families for SORBS3 Gene
Gene Families for SORBS3 Gene
- Human Protein Atlas (HPA):
-
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for SORBS3 Gene
- InterPro:
- Blocks:
-
- Sorbin-like
- ProtoNet:
Suggested Antigen Peptide Sequences for SORBS3 Gene
- GenScript: Design optimal peptide antigens:
-
- SORBS3 protein (Q9BT70_HUMAN)
- Sorbin and SH3 domain-containing protein 3 (VINEX_HUMAN)
No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for SORBS3 Gene
Function for SORBS3 Gene
Molecular function for SORBS3 Gene
- UniProtKB/Swiss-Prot Function:
- Vinexin alpha isoform promotes up-regulation of actin stress fiber formation. Vinexin beta isoform plays a role in cell spreading and enhances the activation of JNK/SAPK in response to EGF stimulation by using its third SH3 domain.
Phenotypes From GWAS Catalog for SORBS3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005200 | structural constituent of cytoskeleton | TAS | 9885244 |
| GO:0005515 | protein binding | IEA,IPI | 12660241 |
| GO:0008134 | transcription factor binding | IEA | -- |
| GO:0017166 | vinculin binding | IPI | 9885244 |
Phenotypes for SORBS3 Gene
- MGI mutant phenotypes for SORBS3:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for SORBS3:
-
- Increased vaccinia virus (VACV) infection
- no effect
- Decreased viability
- Decreased viability ratio
- Negative genetic interaction between BLM-/- and BLM+/+
- Decreased cilium length after serum starvation
- Strongly decreased CFP-tsO45G cell surface transport
- Decreased cell migration
- Decreased nuclei size in G2M
- Inconclusive
- Negative genetic interaction between MUS81-/- and MUS81+/+
- Negative genetic interaction between PTTG1-/- and PTTG1+/+
- Decreased cilium length
Animal Models for SORBS3 Gene
- MGI Knock Outs for SORBS3:
-
- Sorbs3 Sorbs3<tm1Kiok>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for SORBS3 - Select products 50% OFF >
- * SORBS3 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for SORBS3
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SORBS3
-
Santa Cruz Biotechnology (SCBT) CRISPR for SORBS3
miRNA for SORBS3 Gene
- miRTarBase miRNAs that target SORBS3
-
- hsa-miR-1229-3p (MIRT036259)
- hsa-miR-877-5p (MIRT037354)
- hsa-miR-744-5p (MIRT037629)
- hsa-miR-4433b-5p (MIRT715100)
- hsa-miR-1260b (MIRT715101)
- hsa-miR-1260a (MIRT715102)
- hsa-miR-466 (MIRT715103)
- hsa-miR-4672 (MIRT715104)
- hsa-miR-3941 (MIRT715105)
- hsa-miR-4433a-5p (MIRT715106)
- hsa-miR-600 (MIRT715107)
- hsa-miR-6748-3p (MIRT715108)
- hsa-miR-1224-3p (MIRT715109)
- hsa-miR-1228-3p (MIRT715110)
- hsa-miR-603 (MIRT715111)
- hsa-miR-362-3p (MIRT715112)
- hsa-miR-329-3p (MIRT715113)
- hsa-miR-8485 (MIRT715114)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for SORBS3
- Browse OriGene Inhibitory RNA Products For SORBS3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SORBS3
Clone Products
- Applied Biological Materials (abm): Clones for SORBS3 - Select products 50% OFF >
- * SORBS3 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG209995
- MG222348
- MR209995
- MR209995L3
- MR209995L4
- MR222348
- MR222348L3
- MR222348L4
- MR229269
- MR230863
- MR230864
- RC209459
- RC209459L3
- RC209459L4
- RC210669
- RC210669L1
- RC210669L2
- RC210669L3
- RC210669L4
- RG209459
- RG210669
- RR208054
- RR208054L3
- RR208054L4
- MR209995L3V
- MR209995L4V
- MR222348L3V
- MR222348L4V
- RC209459L3V
- RC209459L4V
- RC210669L1V
- RC210669L2V
- RC210669L3V
- RC210669L4V
- RR208054L3V
- RR208054L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for SORBS3
- Addgene plasmids for SORBS3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SORBS3
Cell Line Products
-
Horizon Cell Lines for SORBS3
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SORBS3 Gene
Localization for SORBS3 Gene
Subcellular locations from UniProtKB/Swiss-Prot for SORBS3 Gene
- [Isoform Alpha]: Cell junction. Cytoplasm, cytoskeleton. Note=Localized at cell-extracellular matrix junctions (By similarity). Both isoforms were localized at focal adhesion and cell-cell adhesion sites. {ECO:0000250}.
- [Isoform Beta]: Cell junction. Nucleus. Cytoplasm, cytoskeleton. Note=Localized at cell-extracellular matrix junctions (By similarity). Both isoforms were localized at focal adhesion and cell-cell adhesion sites, vinexin beta was also found in the nucleus. {ECO:0000250}.
| Compartment | Confidence |
|---|---|
| cytosol | 5 |
| cytoskeleton | 4 |
| nucleus | 4 |
| plasma membrane | 2 |
| extracellular | 1 |
| mitochondrion | 1 |
| lysosome | 1 |
- Cytosol (2)
- Focal adhesion sites (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA | -- |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005829 | cytosol | TAS | -- |
| GO:0005856 | cytoskeleton | IEA | -- |
| GO:0005925 | colocalizes_with focal adhesion | IDA | 9885244 |
Pathways & Interactions for SORBS3 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Cardiac conduction | ||
| 2 | Smooth Muscle Contraction | ||
Pathways by source for SORBS3 Gene
2 Reactome pathways for SORBS3 Gene
Interacting Proteins for SORBS3 Gene
Selected Interacting proteins:
O60504-VINEX_HUMAN
ENSP00000240123
for SORBS3 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for SORBS3
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000122 | negative regulation of transcription by RNA polymerase II | IEA | -- |
| GO:0006936 | muscle contraction | TAS | -- |
| GO:0007015 | actin filament organization | IEA | -- |
| GO:0007155 | cell adhesion | IEA,TAS | 9885244 |
| GO:0031589 | cell-substrate adhesion | IEA | -- |
Transcripts for SORBS3 Gene
mRNA/cDNA for SORBS3 Gene
- 2 REFSEQ mRNAs :
- 11 NCBI additional mRNA sequence :
- 22 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000240123 3459 nts (view in UCSC)
- ENST00000517500 1228 nts (view in UCSC)
- ENST00000517535 3067 nts (view in UCSC)
- ENST00000517962 885 nts (view in UCSC)
- ENST00000518512 755 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for SORBS3 - Select products 50% OFF >
- * SORBS3 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for SORBS3
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SORBS3
-
Santa Cruz Biotechnology (SCBT) CRISPR for SORBS3
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for SORBS3
- Browse OriGene Inhibitory RNA Products For SORBS3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SORBS3
Clone Products
- Applied Biological Materials (abm): Clones for SORBS3 - Select products 50% OFF >
- * SORBS3 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG209995
- MG222348
- MR209995
- MR209995L3
- MR209995L4
- MR222348
- MR222348L3
- MR222348L4
- MR229269
- MR230863
- MR230864
- RC209459
- RC209459L3
- RC209459L4
- RC210669
- RC210669L1
- RC210669L2
- RC210669L3
- RC210669L4
- RG209459
- RG210669
- RR208054
- RR208054L3
- RR208054L4
- MR209995L3V
- MR209995L4V
- MR222348L3V
- MR222348L4V
- RC209459L3V
- RC209459L4V
- RC210669L1V
- RC210669L2V
- RC210669L3V
- RC210669L4V
- RR208054L3V
- RR208054L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for SORBS3
- Addgene plasmids for SORBS3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SORBS3
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | · | 4c | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | · | 7c | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | ^ | 11 | ^ | 12a | · | 12b | ^ | 13a | · | 13b | ^ | 14a | · | 14b | · | 14c | ^ | 15a | · | 15b | · |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP2: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP12: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP13: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP14: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP15: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP16: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP17: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP18: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP19: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP20: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP21: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP22: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP23: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP24: | - | - | - | - | - |
| ExUns: | 15c | · | 15d | · | 15e | · | 15f | ^ | 16a | · | 16b | · | 16c | ^ | 17a | · | 17b | · | 17c | ^ | 18 | ^ | 19a | · | 19b | ^ | 20a | · | 20b | · | 20c | ^ | 21a | · | 21b | · | 21c | ^ | 22a | · | 22b | · | 22c | · | 22d | · | 22e | · | 22f | · | 22g | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP12: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP13: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP14: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP15: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP16: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP17: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP18: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP19: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP20: | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP21: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP22: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP23: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP24: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
| ExUns: | 23a | · | 23b | ^ | 24 | ^ | 25a | · | 25b | · | 25c | ^ | 26a | · | 26b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||
| SP2: | - | ||||||||||||||
| SP3: | |||||||||||||||
| SP4: | |||||||||||||||
| SP5: | - | ||||||||||||||
| SP6: | |||||||||||||||
| SP7: | |||||||||||||||
| SP8: | |||||||||||||||
| SP9: | |||||||||||||||
| SP10: | |||||||||||||||
| SP11: | |||||||||||||||
| SP12: | |||||||||||||||
| SP13: | |||||||||||||||
| SP14: | |||||||||||||||
| SP15: | - | - | - | ||||||||||||
| SP16: | |||||||||||||||
| SP17: | |||||||||||||||
| SP18: | |||||||||||||||
| SP19: | |||||||||||||||
| SP20: | |||||||||||||||
| SP21: | |||||||||||||||
| SP22: | |||||||||||||||
| SP23: | |||||||||||||||
| SP24: |
Relevant External Links for SORBS3 Gene
- GeneLoc Exon Structure for
- SORBS3
Expression for SORBS3 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Brain (Nervous System)
- Myelinating Oligodendrocyte Cells Forebrain White Matter
-
Glial Cells
- Myelinating Oligodendrocyte Cells Forebrain White Matter
-
Uterus (Reproductive System)
-
Prostate (Endocrine System)
-
Placenta (Extraembryonic Tissues)
-
Spleen (Hematopoietic System)
-
Gall Bladder (Hepatobiliary System)
-
Lung (Respiratory System)
-
Kidney (Urinary System)
-
Fibroblasts (Uncategorized)
-
Testis (Reproductive System)
-
Liver (Hepatobiliary System)
-
Ovary (Reproductive System)
-
Adipose (Muscoskeletal System)
This gene is overexpressed in Gallbladder (6.2).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SORBS3 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SORBS3
SOURCE GeneReport for Unigene cluster for SORBS3 Gene:
Hs.528572mRNA Expression by UniProt/SwissProt for SORBS3 Gene:
O60504-VINEX_HUMAN
Tissue specificity:
Both isoforms are expressed in different tissues like heart, placenta, brain, skeletal muscle and pancreas. Isoform beta is especially found in liver.
Evidence on tissue expression from TISSUES for SORBS3 Gene
- Nervous system(4.7)
- Liver(4.5)
- Muscle(2.5)
- Skin(2.5)
- Kidney(2.4)
- Lung(2.4)
- Heart(2.3)
- Intestine(2.1)
Primer Products
-
OriGene qPCR primer pairs for SORBS3
-
OriGene qPCR primer pairs and template standards for SORBS3
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for SORBS3 Gene
Orthologs for SORBS3 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | SORBS3 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | SORBS3 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Sorbs3 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Sorbs3 30 17 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | SORBS3 30 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | SORBS3 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | SORBS3 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | SORBS3 31 |
|
OneToOne | |
| Zebrafish (Danio rerio) |
Actinopterygii | sorbs3 30 31 |
|
OneToOne | |
| Fruit Fly (Drosophila melanogaster) |
Insecta | CAP 31 |
|
OneToMany |
- Species where no ortholog for SORBS3 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for SORBS3 Gene
- ENSEMBL:
- Gene Tree for SORBS3 (if available)
- TreeFam:
- Gene Tree for SORBS3 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for SORBS3: view image
Paralogs for SORBS3 Gene
Paralogs for SORBS3 Gene
(17) SIMAP similar genes for SORBS3 Gene using alignment to 15 proteins:
- VINEX_HUMAN
- E5RH58_HUMAN
- E5RHI2_HUMAN
- E5RHS8_HUMAN
- E5RIA0_HUMAN
- E5RJP2_HUMAN
- E7EQH0_HUMAN
- H0YAT3_HUMAN
- H0YAU6_HUMAN
- H0YAZ3_HUMAN
- H0YB51_HUMAN
- H0YB85_HUMAN
- H0YBA2_HUMAN
- H0YBL2_HUMAN
- Q9BT70_HUMAN
Variants for SORBS3 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SORBS3 Gene
| SNP ID | Clinical significance and condition | Chr 08 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 713944 | Benign: not provided | 22,564,469(+) | C/T | MISSENSE_VARIANT | |
| 717653 | Likely Benign: not provided | 22,566,459(+) | C/G | MISSENSE_VARIANT | |
| 719494 | Likely Benign: not provided | 22,554,875(+) | C/T | MISSENSE_VARIANT | |
| 719715 | Likely Benign: not provided | 22,566,399(+) | C/G | SYNONYMOUS_VARIANT,FIVE_PRIME_UTR_VARIANT | |
| 720868 | Benign: not provided | 22,571,077(+) | G/A | SYNONYMOUS_VARIANT |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv451n21 | CNV | loss | 19592680 |
| esv2759604 | CNV | loss | 17122850 |
| nsv1075125 | CNV | deletion | 25765185 |
| nsv1075546 | CNV | deletion | 25765185 |
Residual Variation Intolerance Score:
95.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
5.22;
69.93% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for SORBS3 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SORBS3 Gene
Disorders for SORBS3 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| cardiomyopathy, dilated, 1p |
|
|
| schizophrenia 18 |
|
|
| spinocerebellar ataxia, autosomal recessive 3 |
|
|
Search SORBS3 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for SORBS3
- Genetic Association Database
- (GAD)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for SORBS3 Gene
Publications for SORBS3 Gene
- The suppressor of cytokine signaling (SOCS)-7 interacts with the actin cytoskeleton through vinexin. (PMID: 15242778) Martens N … Hooghe-Peters EL (Experimental cell research 2004) 3 4 23
- SAFB2, a new scaffold attachment factor homolog and estrogen receptor corepressor. (PMID: 12660241) Townson SM … Oesterreich S (The Journal of biological chemistry 2003) 3 4 23
- Vinexin forms a signaling complex with Sos and modulates epidermal growth factor-induced c-Jun N-terminal kinase/stress-activated protein kinase activities. (PMID: 10585480) Akamatsu M … Kioka N (The Journal of biological chemistry 1999) 3 4 23
- Vinexin: a novel vinculin-binding protein with multiple SH3 domains enhances actin cytoskeletal organization. (PMID: 9885244) Kioka N … Aota S (The Journal of cell biology 1999) 2 3 4
- Crucial role of vinexin for keratinocyte migration in vitro and epidermal wound healing in vivo. (PMID: 20361963) Kioka N … Ueda K (Experimental cell research 2010) 3 23
ExternalLinks
Products for SORBS3 Gene
- Custom Antibody ServicesOriGene Antibodies for SORBS3
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- OriGene qPCR primer pairs and template standards for SORBS3
- OriGene CRISPR knockouts for SORBS3
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- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- High-throughput Antibody Production Service
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- Epitope Tag Antibodies & Reporter Protein Antibodies
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- Novus Biologicals Antibodies for SORBS3
- Novus Biologicals proteins and lysates for SORBS3
- Browse Antibodies
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- Abcam proteins for SORBS3
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- Browse Primary Antibodies
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- VectorBuilder Custom and pre-made DNA vectors for SORBS3 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for SORBS3 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for SORBS3 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for SORBS3 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for SORBS3
- Addgene plasmids for SORBS3
- antibodies-online: Show 3 available Vinexin Antibodies ranked by validation data
- Compare Top Vinexin Antibodies
- antibodies-online: Search results for available Vinexin related products ranked by validation data
- antibodies-online: Show 4 available Vinexin Proteins ranked by validation data
- Compare Top Vinexin Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for SORBS3
- Search Santa Cruz Biotechnology (SCBT) for SORBS3 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for SORBS3
- Horizon Cell Lines for SORBS3
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SORBS3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SORBS3
- Search GeneCopoeia for miRNA 3'UTR Target clone products for SORBS3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SORBS3
- Boster Bio Antibodies for SORBS3
- Browse Boster Bio ELISA Kits
- Biorbyt antibodies for SORBS3
- Signalway ELISA kits for SORBS3
Sources for SORBS3 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
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- (11) Cell Signaling Technology
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- (24) PharmGKB
- (25) DrugBank
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- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
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- (49) Leiden
- (50) miRBase
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- (53) PubMed
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- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
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- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
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- (90) CYP
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- (104) diseasecard
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- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
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- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
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- (163) LncBase
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- (178) MirGeneDB