Aliases for SORBS3 Gene
External Ids for SORBS3 Gene
Previous GeneCards Identifiers for SORBS3 Gene
This gene encodes an SH3 domain-containing adaptor protein. The presence of SH3 domains play a role in this protein's ability to bind other cytoplasmic molecules and contribute to cystoskeletal organization, cell adhesion and migration, signaling, and gene expression. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
GeneCards Summary for SORBS3 Gene
SORBS3 (Sorbin And SH3 Domain Containing 3) is a Protein Coding gene. Diseases associated with SORBS3 include Schizophrenia 18 and Cardiomyopathy, Dilated, 1P. Among its related pathways are Cardiac conduction and Smooth Muscle Contraction. Gene Ontology (GO) annotations related to this gene include transcription factor binding and vinculin binding. An important paralog of this gene is SORBS1.
UniProtKB/Swiss-Prot Summary for SORBS3 Gene
Vinexin alpha isoform promotes up-regulation of actin stress fiber formation. Vinexin beta isoform plays a role in cell spreading and enhances the activation of JNK/SAPK in response to EGF stimulation by using its third SH3 domain.