Aliases for SORBS1 Gene
External Ids for SORBS1 Gene
Previous HGNC Symbols for SORBS1 Gene
Previous GeneCards Identifiers for SORBS1 Gene
This gene encodes a CBL-associated protein which functions in the signaling and stimulation of insulin. Mutations in this gene may be associated with human disorders of insulin resistance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]
GeneCards Summary for SORBS1 Gene
SORBS1 (Sorbin And SH3 Domain Containing 1) is a Protein Coding gene. Diseases associated with SORBS1 include Erythematosquamous Dermatosis and Body Mass Index Quantitative Trait Locus 11. Among its related pathways are Adherens junction and PPAR signaling pathway. Gene Ontology (GO) annotations related to this gene include protein kinase binding and cytoskeletal protein binding. An important paralog of this gene is SORBS2.
UniProtKB/Swiss-Prot Summary for SORBS1 Gene
Plays a role in tyrosine phosphorylation of CBL by linking CBL to the insulin receptor. Required for insulin-stimulated glucose transport. Involved in formation of actin stress fibers and focal adhesions (By similarity).