Aliases for SOHLH1 Gene
External Ids for SOHLH1 Gene
Previous HGNC Symbols for SOHLH1 Gene
Previous GeneCards Identifiers for SOHLH1 Gene
This gene encodes one of testis-specific transcription factors which are essential for spermatogenesis, oogenesis and folliculogenesis. This gene is located on chromosome 9. Mutations in this gene are associated with nonobstructive azoospermia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2013]
GeneCards Summary for SOHLH1 Gene
SOHLH1 (Spermatogenesis And Oogenesis Specific Basic Helix-Loop-Helix 1) is a Protein Coding gene. Diseases associated with SOHLH1 include Ovarian Dysgenesis 5 and Spermatogenic Failure 32. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and protein dimerization activity. An important paralog of this gene is SOHLH2.
UniProtKB/Swiss-Prot Summary for SOHLH1 Gene
Transcription regulator of both male and female germline differentiation. Suppresses genes involved in spermatogonial stem cells maintenance, and induces genes important for spermatogonial differentiation. Coordinates oocyte differentiation without affecting meiosis I (By similarity).