Aliases for SOGA1 Gene

Aliases for SOGA1 Gene

  • Suppressor Of Glucose, Autophagy Associated 1 2 3 5
  • Suppressor Of Glucose By Autophagy 2 3 4
  • KIAA0889 2 3 4
  • SOGA 2 3 4
  • Suppressor Of Glucose, Autophagy-Associated Protein 1 3 4
  • Suppressor Of Glucose From Autophagy 2 3
  • SOGA Family Member 1 3 4
  • Protein SOGA1 3 4
  • C20orf117 3 4
  • Chromosome 20 Open Reading Frame 117 2
  • DJ132F21.1 2
  • FLJ44670 2
  • SOGA1 5

External Ids for SOGA1 Gene

Previous HGNC Symbols for SOGA1 Gene

  • C20orf117
  • KIAA0889

Previous GeneCards Identifiers for SOGA1 Gene

  • GC20M035407

Summaries for SOGA1 Gene

GeneCards Summary for SOGA1 Gene

SOGA1 (Suppressor Of Glucose, Autophagy Associated 1) is a Protein Coding gene. An important paralog of this gene is MTCL1.

UniProtKB/Swiss-Prot Summary for SOGA1 Gene

  • Regulates autophagy by playing a role in the reduction of glucose production in an adiponectin- and insulin-dependent manner.

Gene Wiki entry for SOGA1 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SOGA1 Gene

Genomics for SOGA1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for SOGA1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SOGA1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SOGA1

Genomic Locations for SOGA1 Gene

Latest Assembly
chr20:36,777,447-36,863,538
(GRCh38/hg38)
Size:
86,092 bases
Orientation:
Minus strand

Previous Assembly
chr20:35,405,850-35,491,941
(GRCh37/hg19 by Entrez Gene)
Size:
86,092 bases
Orientation:
Minus strand

chr20:35,405,845-35,492,089
(GRCh37/hg19 by Ensembl)
Size:
86,245 bases
Orientation:
Minus strand

Genomic View for SOGA1 Gene

Genes around SOGA1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SOGA1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SOGA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SOGA1 Gene

Proteins for SOGA1 Gene

  • Protein details for SOGA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O94964-SOGA1_HUMAN
    Recommended name:
    Protein SOGA1
    Protein Accession:
    O94964
    Secondary Accessions:
    • A6NK10
    • Q14DB2
    • Q5JW51
    • Q6ZTG8

    Protein attributes for SOGA1 Gene

    Size:
    1423 amino acids
    Molecular mass:
    159760 Da
    Quaternary structure:
    • The C-terminal 25 kDa form occurs as a monomer.
    SequenceCaution:
    • Sequence=BAA74912.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};

    Alternative splice isoforms for SOGA1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SOGA1 Gene

Post-translational modifications for SOGA1 Gene

  • Proteolytically cleaved in primary hepatocytes into a C-terminal 80 kDa form (By similarity). Proteolytically cleaved into a C-terminal SOGA 25 kDa form that is detected in plasma.
  • Ubiquitination at Lys809, Lys867, Lys878, and Lys886
  • Modification sites at PhosphoSitePlus

Other Protein References for SOGA1 Gene

No data available for DME Specific Peptides for SOGA1 Gene

Domains & Families for SOGA1 Gene

Gene Families for SOGA1 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for SOGA1 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

O94964

UniProtKB/Swiss-Prot:

SOGA1_HUMAN :
  • Belongs to the SOGA family.
Family:
  • Belongs to the SOGA family.
genes like me logo Genes that share domains with SOGA1: view

No data available for Suggested Antigen Peptide Sequences for SOGA1 Gene

Function for SOGA1 Gene

Molecular function for SOGA1 Gene

UniProtKB/Swiss-Prot Function:
Regulates autophagy by playing a role in the reduction of glucose production in an adiponectin- and insulin-dependent manner.
UniProtKB/Swiss-Prot Induction:
Up-regulated in the plasma by adiponectin in healthy fasting female.

Phenotypes From GWAS Catalog for SOGA1 Gene

Gene Ontology (GO) - Molecular Function for SOGA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with SOGA1: view
genes like me logo Genes that share phenotypes with SOGA1: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SOGA1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SOGA1 Gene

Localization for SOGA1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SOGA1 Gene

[C-terminal 80 kDa form]: Secreted. Note=Secreted in primary hepatocyte-conditioned media. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SOGA1 gene
Compartment Confidence
extracellular 5
nucleus 3
cytosol 3
golgi apparatus 2
plasma membrane 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoli (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SOGA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IEA,IDA 20813965
GO:0070062 extracellular exosome HDA 19056867
genes like me logo Genes that share ontologies with SOGA1: view

Pathways & Interactions for SOGA1 Gene

PathCards logo

SuperPathways for SOGA1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SOGA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008286 insulin receptor signaling pathway ISS 20813965
GO:0010506 regulation of autophagy IEA,ISS --
GO:0045721 negative regulation of gluconeogenesis ISS 20813965
genes like me logo Genes that share ontologies with SOGA1: view

No data available for Pathways by source and SIGNOR curated interactions for SOGA1 Gene

Drugs & Compounds for SOGA1 Gene

No Compound Related Data Available

Transcripts for SOGA1 Gene

mRNA/cDNA for SOGA1 Gene

3 REFSEQ mRNAs :
15 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SOGA1

Alternative Splicing Database (ASD) splice patterns (SP) for SOGA1 Gene

No ASD Table

Relevant External Links for SOGA1 Gene

GeneLoc Exon Structure for
SOGA1

Expression for SOGA1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SOGA1 Gene

mRNA differential expression in normal tissues according to GTEx for SOGA1 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x6.9) and Brain - Cerebellum (x6.5).

Protein differential expression in normal tissues from HIPED for SOGA1 Gene

This gene is overexpressed in Lung (33.1) and Adrenal (28.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SOGA1 Gene



Protein tissue co-expression partners for SOGA1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SOGA1

SOURCE GeneReport for Unigene cluster for SOGA1 Gene:

Hs.460807

Evidence on tissue expression from TISSUES for SOGA1 Gene

  • Nervous system(4.6)
genes like me logo Genes that share expression patterns with SOGA1: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SOGA1 Gene

Orthologs for SOGA1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SOGA1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia SOGA1 30 31
  • 99.32 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia SOGA1 30 31
  • 90.11 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia SOGA1 30 31
  • 88.9 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Soga1 30
  • 87.69 (n)
Mouse
(Mus musculus)
Mammalia Soga1 30 17 31
  • 87.28 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia SOGA1 31
  • 67 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 36 (a)
ManyToMany
-- 31
  • 27 (a)
ManyToMany
Chicken
(Gallus gallus)
Aves SOGA1 30 31
  • 76.03 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia SOGA1 31
  • 67 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia soga1 30
  • 65.31 (n)
Zebrafish
(Danio rerio)
Actinopterygii soga1 30 31
  • 57.83 (n)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta CG18304 31
  • 12 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea tag-241 31
  • 12 (a)
OneToMany
Species where no ortholog for SOGA1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for SOGA1 Gene

ENSEMBL:
Gene Tree for SOGA1 (if available)
TreeFam:
Gene Tree for SOGA1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SOGA1: view image

Paralogs for SOGA1 Gene

Paralogs for SOGA1 Gene

(3) SIMAP similar genes for SOGA1 Gene using alignment to 3 proteins:

  • SOGA1_HUMAN
  • H0YDM2_HUMAN
  • I3L0I1_HUMAN
genes like me logo Genes that share paralogs with SOGA1: view

Variants for SOGA1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SOGA1 Gene

SNP ID Clinical significance and condition Chr 20 pos Variation AA Info Type
930802 Uncertain Significance: not provided 36,802,909(-) C/A
NM_080627.4(SOGA1):c.3286G>T (p.Glu1096Ter)
NONSENSE
rs112654834 Benign: not provided 36,816,191(-) C/T
NM_080627.4(SOGA1):c.1251G>A (p.Leu417=)
SYNONYMOUS
rs34459518 Benign: not provided. - 36,794,389(-) C/Gp.Gln993His
NM_080627.4(SOGA1):c.3693G>C (p.Gln1231His)
MISSENSE
rs546997200 Likely Benign: not provided 36,862,874(-) C/A
NM_080627.4(SOGA1):c.471G>T (p.Gly157=)
SYNONYMOUS

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for SOGA1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for SOGA1 Gene

Variant ID Type Subtype PubMed ID
dgv2247n106 CNV deletion 24896259
esv2722381 CNV deletion 23290073
esv2722382 CNV deletion 23290073
esv29717 CNV loss 19812545
esv3567957 CNV loss 25503493
esv3645741 CNV gain 21293372
esv3645742 CNV gain 21293372
esv3645744 CNV loss 21293372
esv3645745 CNV gain 21293372
nsv1057192 CNV loss 25217958
nsv1057845 CNV gain 25217958
nsv475979 CNV novel sequence insertion 20440878
nsv7341 OTHER inversion 18451855

Variation tolerance for SOGA1 Gene

Gene Damage Index Score: 5.05; 68.72% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SOGA1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SOGA1

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SOGA1 Gene

Disorders for SOGA1 Gene

Additional Disease Information for SOGA1

No disorders were found for SOGA1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SOGA1 Gene

Publications for SOGA1 Gene

  1. Adiponectin lowers glucose production by increasing SOGA. (PMID: 20813965) Cowherd RB … Combs TP (The American journal of pathology 2010) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  4. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P … Rogers J (Nature 2001) 3 4
  5. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10048485) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1998) 3 4

Products for SOGA1 Gene

Sources for SOGA1 Gene