This gene encodes a member of the superoxide dismutase (SOD) protein family. SODs are antioxidant enzymes that catalyze the conversion of superoxide radicals into hydrogen peroxide and oxygen, which may protect the brain, lungs, and other tissues from oxidative stress. Proteolytic processing of the encoded protein results in the formation of two distinct homotetramers that diff... See more...

Aliases for SOD3 Gene

Aliases for SOD3 Gene

  • Superoxide Dismutase 3 2 3 5
  • Extracellular Superoxide Dismutase [Cu-Zn] 3 4
  • Superoxide Dismutase 3, Extracellular 2 3
  • EC 1.15.1.1 4 52
  • EC-SOD 3 4
  • Testicular Tissue Protein Li 175 3

External Ids for SOD3 Gene

Previous GeneCards Identifiers for SOD3 Gene

  • GC04P024921
  • GC04P024484
  • GC04P024546
  • GC04P024472
  • GC04P024139

Summaries for SOD3 Gene

Entrez Gene Summary for SOD3 Gene

  • This gene encodes a member of the superoxide dismutase (SOD) protein family. SODs are antioxidant enzymes that catalyze the conversion of superoxide radicals into hydrogen peroxide and oxygen, which may protect the brain, lungs, and other tissues from oxidative stress. Proteolytic processing of the encoded protein results in the formation of two distinct homotetramers that differ in their ability to interact with the extracellular matrix (ECM). Homotetramers consisting of the intact protein, or type C subunit, exhibit high affinity for heparin and are anchored to the ECM. Homotetramers consisting of a proteolytically cleaved form of the protein, or type A subunit, exhibit low affinity for heparin and do not interact with the ECM. A mutation in this gene may be associated with increased heart disease risk. [provided by RefSeq, Oct 2015]

GeneCards Summary for SOD3 Gene

SOD3 (Superoxide Dismutase 3) is a Protein Coding gene. Diseases associated with SOD3 include Asbestosis and Myocardial Stunning. Among its related pathways are Detoxification of Reactive Oxygen Species and NRF2 pathway. Gene Ontology (GO) annotations related to this gene include heparin binding and superoxide dismutase activity. An important paralog of this gene is CCS.

UniProtKB/Swiss-Prot Summary for SOD3 Gene

  • Protect the extracellular space from toxic effect of reactive oxygen intermediates by converting superoxide radicals into hydrogen peroxide and oxygen.

Gene Wiki entry for SOD3 Gene

Additional gene information for SOD3 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SOD3 Gene

Genomics for SOD3 Gene

GeneHancer (GH) Regulatory Elements for SOD3 Gene

Promoters and enhancers for SOD3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04J024794 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE CraniofacialAtlas 505.3 +5.4 5382 3 CTCF JUND FOS CTBP1 NCOR1 FOXA2 POLR2A NR2F2 TAL1 HDAC2 SOD3 lnc-PI4K2B-7 lnc-LGI2-5
GH04J024762 Enhancer 0.8 Ensembl ENCODE 17.1 -25.4 -25432 3 CTBP1 SIN3A FOS PBX2 GATA3 FOXA1 PKNOX1 DPF2 BHLHE40 ESR1 SOD3 ENSG00000251638 LINC02473
GH04J024744 Enhancer 0.7 Ensembl ENCODE 16.4 -45.9 -45911 2.8 FOXA2 NANOG PBX2 GATA3 FOXA1 MEIS2 PKNOX1 FOXJ2 SOD3 MIR573 ENSG00000251638 LINC02473
GH04J024855 Enhancer 0.8 Ensembl ENCODE 11.3 +67.6 67602 3 JUND FOS BCL11A CBFB POLR2A BATF IRF4 POU2F2 IKZF1 ATF2 SOD3 LGI2 piR-35674-389 lnc-LGI2-3 CCDC149
GH04J024849 Enhancer 0.8 Ensembl ENCODE 11.5 +62.1 62085 4.4 TCF12 JUND FOS ZNF623 SKI FOXA2 FOSL2 SMAD4 THRB ATF2 SOD3 LGI2 lnc-LGI2-3 piR-35674-389 CCDC149
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SOD3 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SOD3

Top Transcription factor binding sites by QIAGEN in the SOD3 gene promoter:
  • Chx10
  • E47
  • Gfi-1
  • Nkx5-1
  • POU2F1
  • POU2F1a
  • RORalpha1
  • SRF
  • SRF (504 AA)
  • STAT5B

Genomic Locations for SOD3 Gene

Genomic Locations for SOD3 Gene
chr4:24,789,912-24,800,845
(GRCh38/hg38)
Size:
10,934 bases
Orientation:
Plus strand
chr4:24,791,534-24,802,467
(GRCh37/hg19)
Size:
10,934 bases
Orientation:
Plus strand

Genomic View for SOD3 Gene

Genes around SOD3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SOD3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SOD3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SOD3 Gene

Proteins for SOD3 Gene

  • Protein details for SOD3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P08294-SODE_HUMAN
    Recommended name:
    Extracellular superoxide dismutase [Cu-Zn]
    Protein Accession:
    P08294
    Secondary Accessions:
    • Q5U781
    • Q6FHA2

    Protein attributes for SOD3 Gene

    Size:
    240 amino acids
    Molecular mass:
    25851 Da
    Cofactor:
    Name=Cu cation; Xref=ChEBI:CHEBI:23378;
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    • Homotetramer.

    Three dimensional structures from OCA and Proteopedia for SOD3 Gene

neXtProt entry for SOD3 Gene

Selected DME Specific Peptides for SOD3 Gene

P08294:
  • GRAVVVH
  • HVHQFGD
  • RLACCVVG

Post-translational modifications for SOD3 Gene

  • Glycosylation at Asn107, Lys229, and Lys230
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect

Other Protein References for SOD3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for SOD3 Gene

Gene Families for SOD3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted secreted proteins

Protein Domains for SOD3 Gene

Suggested Antigen Peptide Sequences for SOD3 Gene

GenScript: Design optimal peptide antigens:
  • Extracellular superoxide dismutase [Cu-Zn] (SODE_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P08294

UniProtKB/Swiss-Prot:

SODE_HUMAN :
  • Belongs to the Cu-Zn superoxide dismutase family.
Family:
  • Belongs to the Cu-Zn superoxide dismutase family.
genes like me logo Genes that share domains with SOD3: view

Function for SOD3 Gene

Molecular function for SOD3 Gene

UniProtKB/Swiss-Prot Function:
Protect the extracellular space from toxic effect of reactive oxygen intermediates by converting superoxide radicals into hydrogen peroxide and oxygen.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=2 H(+) + 2 superoxide = H2O2 + O2; Xref=Rhea:RHEA:20696, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240, ChEBI:CHEBI:18421; EC=1.15.1.1;.
GENATLAS Biochemistry:
superoxide dismutase 3,extracellular,predominantly expressed in heart,placenta,pancreas,lung,catabolic pathway of activated oxygen species,free radical detoxification

Enzyme Numbers (IUBMB) for SOD3 Gene

Phenotypes From GWAS Catalog for SOD3 Gene

Gene Ontology (GO) - Molecular Function for SOD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004784 superoxide dismutase activity IBA,TAS 21873635
GO:0005507 copper ion binding IBA 21873635
GO:0005515 protein binding IPI 15528465
GO:0008201 heparin binding IEA --
GO:0016209 antioxidant activity IEA --
genes like me logo Genes that share ontologies with SOD3: view
genes like me logo Genes that share phenotypes with SOD3: view

Animal Models for SOD3 Gene

MGI Knock Outs for SOD3:
  • Sod3 Sod3<tm1Mrkl>

Animal Model Products

CRISPR Products

miRNA for SOD3 Gene

miRTarBase miRNAs that target SOD3

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SOD3 Gene

Localization for SOD3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SOD3 Gene

Secreted, extracellular space. Note=99% of EC-SOD is anchored to heparan sulfate proteoglycans in the tissue interstitium, and 1% is located in the vasculature in equilibrium between the plasma and the endothelium.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SOD3 gene
Compartment Confidence
extracellular 5
golgi apparatus 4
mitochondrion 3
peroxisome 3
nucleus 3
plasma membrane 2
cytoskeleton 2
endoplasmic reticulum 2
cytosol 2
lysosome 2
endosome 1

Gene Ontology (GO) - Cellular Components for SOD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region HDA,TAS --
GO:0005615 extracellular space IBA 21873635
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0005796 Golgi lumen TAS --
genes like me logo Genes that share ontologies with SOD3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SOD3 Gene

Pathways & Interactions for SOD3 Gene

genes like me logo Genes that share pathways with SOD3: view

Gene Ontology (GO) - Biological Process for SOD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001666 response to hypoxia IEA --
GO:0006801 superoxide metabolic process IEA --
GO:0006979 response to oxidative stress IEA --
GO:0019430 removal of superoxide radicals IBA 21873635
GO:0034599 cellular response to oxidative stress TAS --
genes like me logo Genes that share ontologies with SOD3: view

No data available for SIGNOR curated interactions for SOD3 Gene

Drugs & Compounds for SOD3 Gene

(28) Drugs for SOD3 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Iron Approved, Experimental Pharma 1496
Copper Approved, Investigational Pharma 236
Oxygen Approved, Vet_approved Pharma 0
Zinc Approved, Investigational Pharma 2822
Manganese Approved Nutra 51

(21) Additional Compounds for SOD3 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
superoxide
  • (O2)(.-)
  • Dioxide(1-)
  • Hyperoxid
  • Hyperoxide
  • O2(.-)
11062-77-4
Hydrogen Ion
  • H+
  • H(+)
  • Hydrogen cation
  • Hydron
  • Proton
genes like me logo Genes that share compounds with SOD3: view

Transcripts for SOD3 Gene

mRNA/cDNA for SOD3 Gene

1 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SOD3 Gene

No ASD Table

Relevant External Links for SOD3 Gene

GeneLoc Exon Structure for
SOD3

Expression for SOD3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SOD3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SOD3 Gene

This gene is overexpressed in Artery - Aorta (x7.8), Esophagus - Muscularis (x4.5), and Artery - Coronary (x4.5).

Protein differential expression in normal tissues from HIPED for SOD3 Gene

This gene is overexpressed in Prostate (8.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SOD3 Gene



Protein tissue co-expression partners for SOD3 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SOD3

SOURCE GeneReport for Unigene cluster for SOD3 Gene:

Hs.2420

mRNA Expression by UniProt/SwissProt for SOD3 Gene:

P08294-SODE_HUMAN
Tissue specificity: Expressed in blood vessels, heart, lung, kidney and placenta. Major SOD isoenzyme in extracellular fluids such as plasma, lymph and synovial fluid.

Evidence on tissue expression from TISSUES for SOD3 Gene

  • Blood(4.5)
  • Liver(4.3)
  • Intestine(4.2)
  • Bone marrow(4)
  • Nervous system(2.9)
  • Lung(2.8)
  • Heart(2.6)
  • Kidney(2.5)
  • Muscle(2.4)
genes like me logo Genes that share expression patterns with SOD3: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for SOD3 Gene

Orthologs for SOD3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SOD3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SOD3 31 30
  • 100 (n)
OneToOne
dog
(Canis familiaris)
Mammalia SOD3 31 30
  • 83.25 (n)
OneToOne
cow
(Bos Taurus)
Mammalia SOD3 30
  • 83.19 (n)
ECSOD 31
  • 70 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sod3 17 31 30
  • 76.76 (n)
rat
(Rattus norvegicus)
Mammalia Sod3 30
  • 76.13 (n)
oppossum
(Monodelphis domestica)
Mammalia SOD3 31
  • 50 (a)
OneToOne
chicken
(Gallus gallus)
Aves SOD3 31 30
  • 57.14 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SOD3 31
  • 45 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sod3 30
  • 53.72 (n)
zebrafish
(Danio rerio)
Actinopterygii sod3a 31 30
  • 54.48 (n)
OneToMany
sod3b 31 31
  • 47 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Sod3 31
  • 31 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea sod-4 31
  • 25 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SOD1 31
  • 36 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5360 31
  • 39 (a)
OneToMany
Species where no ortholog for SOD3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SOD3 Gene

ENSEMBL:
Gene Tree for SOD3 (if available)
TreeFam:
Gene Tree for SOD3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SOD3: view image

Paralogs for SOD3 Gene

Paralogs for SOD3 Gene

(1) SIMAP similar genes for SOD3 Gene using alignment to 2 proteins:

  • SODE_HUMAN
  • M0R1V4_HUMAN
genes like me logo Genes that share paralogs with SOD3: view

Variants for SOD3 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for SOD3 Gene

SODE_HUMAN-P08294
The variant Gly-231 which is found in about 2.2% of individual displays a 10-fold increased plasma EC-SOD content due to reduced heparin-binding affinity and thus the impairment of its binding ability to endothelial cell surface.

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SOD3 Gene

SNP ID Clinical significance and condition Chr 04 pos Variation AA Info Type
708784 Benign: not provided 24,799,792(+) G/A MISSENSE_VARIANT
713304 Benign: not provided 24,799,614(+) G/A SYNONYMOUS_VARIANT
714475 Likely Benign: not provided 24,799,638(+) C/T SYNONYMOUS_VARIANT
775951 Benign: not provided 24,799,530(+) G/C SYNONYMOUS_VARIANT
rs1799895 Pathogenic: Superoxide dismutase, elevated extracellular. - 24,800,212(+) C/Gp.Arg231Gly MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for SOD3 Gene

Structural Variations from Database of Genomic Variants (DGV) for SOD3 Gene

Variant ID Type Subtype PubMed ID
nsv829887 CNV gain+loss 17160897

Variation tolerance for SOD3 Gene

Gene Damage Index Score: 7.32; 81.44% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SOD3 Gene

Human Gene Mutation Database (HGMD)
SOD3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SOD3

SNP Genotyping and Copy Number Assay Products

Disorders for SOD3 Gene

MalaCards: The human disease database

(15) MalaCards diseases for SOD3 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
asbestosis
  • idiopathic interstitial pneumonitis - from asbestos exposure
myocardial stunning
diabetic polyneuropathy
  • diabetes mellitus with polyneuropathy
heart disease
  • congenital heart disease
pulmonary fibrosis
  • fibrosis of lung
- elite association - COSMIC cancer census association via MalaCards
Search SOD3 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for SOD3

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with SOD3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SOD3 Gene

Publications for SOD3 Gene

  1. The structure of human extracellular copper-zinc superoxide dismutase at 1.7 A resolution: insights into heparin and collagen binding. (PMID: 19289127) Antonyuk SV … Hasnain SS (Journal of molecular biology 2009) 3 4 23 54
  2. Manganese and extracellular superoxide dismutase polymorphisms and risk for asbestosis. (PMID: 19636420) Franko A … Dolzan V (Journal of biomedicine & biotechnology 2009) 3 23 41 54
  3. Association of extracellular superoxide dismutase (SOD3) Ala40Thr gene polymorphism with pre-eclampsia complicated by severe fetal growth restriction. (PMID: 19108943) Rosta K … Vér A (European journal of obstetrics, gynecology, and reproductive biology 2009) 3 23 41 54
  4. Extracellular superoxide dismutase haplotypes are associated with acute lung injury and mortality. (PMID: 18948423) Arcaroli JJ … Crapo JD (American journal of respiratory and critical care medicine 2009) 3 23 41 54
  5. A haplotype-based case-control study examining human extracellular superoxide dismutase gene and essential hypertension. (PMID: 18971527) Naganuma T … Usami R (Hypertension research : official journal of the Japanese Society of Hypertension 2008) 3 23 41 54

Products for SOD3 Gene

Sources for SOD3 Gene