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Aliases for SOD2 Gene

Aliases for SOD2 Gene

  • Superoxide Dismutase 2 2 3 5
  • Superoxide Dismutase 2, Mitochondrial 2 3
  • Manganese-Containing Superoxide Dismutase 3
  • Superoxide Dismutase [Mn], Mitochondrial 3
  • Mangano-Superoxide Dismutase 3
  • Mn Superoxide Dismutase 3
  • Indophenoloxidase B 3
  • EC 4
  • Mn-SOD 3
  • IPO-B 3
  • MNSOD 3
  • MVCD6 3
  • IPOB 3

External Ids for SOD2 Gene

Previous GeneCards Identifiers for SOD2 Gene

  • GC06M159539
  • GC06M159973
  • GC06M160009
  • GC06M160012
  • GC06M160070
  • GC06M160020
  • GC06M160102
  • GC06M157570

Summaries for SOD2 Gene

Entrez Gene Summary for SOD2 Gene

  • This gene is a member of the iron/manganese superoxide dismutase family. It encodes a mitochondrial protein that forms a homotetramer and binds one manganese ion per subunit. This protein binds to the superoxide byproducts of oxidative phosphorylation and converts them to hydrogen peroxide and diatomic oxygen. Mutations in this gene have been associated with idiopathic cardiomyopathy (IDC), premature aging, sporadic motor neuron disease, and cancer. Alternative splicing of this gene results in multiple transcript variants. A related pseudogene has been identified on chromosome 1. [provided by RefSeq, Apr 2016]

GeneCards Summary for SOD2 Gene

SOD2 (Superoxide Dismutase 2) is a Protein Coding gene. Diseases associated with SOD2 include Microvascular Complications Of Diabetes 6 and Aging. Among its related pathways are FoxO signaling pathway and Longevity regulating pathway. Gene Ontology (GO) annotations related to this gene include identical protein binding and oxygen binding. An important paralog of this gene is ENSG00000285441.

UniProtKB/Swiss-Prot for SOD2 Gene

  • Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.

Gene Wiki entry for SOD2 Gene

Additional gene information for SOD2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SOD2 Gene

Genomics for SOD2 Gene

GeneHancer (GH) Regulatory Elements for SOD2 Gene

Promoters and enhancers for SOD2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J159690 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 662.5 +51.8 51787 5.8 HDGF PKNOX1 FOXA2 MLX ARNT ZFP64 ARID4B SIN3A FEZF1 DMAP1 SOD2 MRPL18 WTAP PNLDC1 ACAT2 SNORA29 TCP1 SNORA20 LOC105378085 GC06M159698
GH06J159725 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 650.4 +16.9 16922 5.4 CLOCK MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 WTAP GC06M159725 SOD2 MRPL18 TCP1 PNLDC1 ACAT2 SNORA29 SNORA20 LOC729603
GH06J159680 Promoter/Enhancer 0.9 EPDnew ENCODE dbSUPER 650.2 +63.8 63810 0.8 SOD2 MRPL18 PNLDC1 SNORA29 TCP1 LOC105378085 GC06M159668 PIR54448 GC06M159698 ENSG00000285441
GH06J159688 Promoter/Enhancer 0.7 EPDnew dbSUPER 662.5 +57.0 56978 0.1 SOD2 WTAP ACAT2 SNORA29 MRPL18 TCP1 SNORA20 GC06M159698 GC06M159668 PIR54448
GH06J159684 Promoter 0.6 EPDnew 650.2 +60.2 60232 0.1 ZNF362 SOD2 SNORA29 TCP1 PNLDC1 GC06M159668 GC06M159698 PIR54448 ENSG00000285441
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SOD2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SOD2 gene promoter:
  • c-Jun
  • ATF-2
  • AP-2alpha isoform 2
  • AP-2alpha

Genomic Locations for SOD2 Gene

Genomic Locations for SOD2 Gene
76,130 bases
Minus strand
93,473 bases
Minus strand

Genomic View for SOD2 Gene

Genes around SOD2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SOD2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SOD2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SOD2 Gene

Proteins for SOD2 Gene

  • Protein details for SOD2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Superoxide dismutase [Mn], mitochondrial
    Protein Accession:
    Secondary Accessions:
    • B2R7R1
    • B3KUK2
    • B4DL20
    • B4E3K9
    • E1P5A9
    • P78434
    • Q16792
    • Q5TCM1
    • Q96EE6
    • Q9P2Z3
    • B2R7R1
    • B3KUK2
    • B4DL20
    • B4E3K9
    • E1P5A9
    • P78434
    • Q16792
    • Q5TCM1
    • Q96EE6
    • Q9P2Z3

    Protein attributes for SOD2 Gene

    222 amino acids
    Molecular mass:
    24750 Da
    Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    • Homotetramer.
    • Homotetramer.

    Three dimensional structures from OCA and Proteopedia for SOD2 Gene

    Alternative splice isoforms for SOD2 Gene


neXtProt entry for SOD2 Gene

Post-translational modifications for SOD2 Gene

  • Nitrated under oxidative stress. Nitration coupled with oxidation inhibits the catalytic activity.
  • Acetylation at Lys-122 decreases enzymatic activity. Deacetylated by SIRT3 upon exposure to ionizing radiations or after long fasting (By similarity).
  • Polyubiquitinated; leading to proteasomal degradation. Deubiquitinated by USP36 which increases protein stability.
  • Ubiquitination at posLast=130130
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SOD2 Gene

Domains & Families for SOD2 Gene

Gene Families for SOD2 Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Disease related genes
  • Enzymes
  • Plasma proteins
  • Potential drug targets
  • Predicted intracellular proteins

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the iron/manganese superoxide dismutase family.
  • Belongs to the iron/manganese superoxide dismutase family.
genes like me logo Genes that share domains with SOD2: view

Function for SOD2 Gene

Molecular function for SOD2 Gene

UniProtKB/Swiss-Prot Function:
Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.
UniProtKB/Swiss-Prot CatalyticActivity:
2 superoxide + 2 H(+) = O(2) + H(2)O(2).
UniProtKB/Swiss-Prot Induction:
Expression is regulated by KRIT1.
GENATLAS Biochemistry:
manganese superoxide dismutase 2,mitochondrial,catabolic pathway of activated oxygen species,free radical detoxification,susceptibility factor for non familial idiopathy dilated cardiomyopathy in Japanese

Enzyme Numbers (IUBMB) for SOD2 Gene

Phenotypes From GWAS Catalog for SOD2 Gene

Gene Ontology (GO) - Molecular Function for SOD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004784 superoxide dismutase activity TAS --
GO:0016491 oxidoreductase activity IEA --
GO:0030145 manganese ion binding TAS 10511315
GO:0042802 identical protein binding IPI 19822147
GO:0046872 metal ion binding IEA,IBA --
genes like me logo Genes that share ontologies with SOD2: view
genes like me logo Genes that share phenotypes with SOD2: view

Animal Models for SOD2 Gene

MGI Knock Outs for SOD2:
  • Sod2 Sod2<tm1.1Kskk>
  • Sod2 Sod2<tm1Cje>
  • Sod2 Sod2<tm1Leb>
  • Sod2 Sod2<tm1(tetO-Sod2)Evbo>
  • Sod2 Sod2<tm1(rtTA*M2,tetO)Jsg>

Animal Model Products

CRISPR Products

miRNA for SOD2 Gene

miRTarBase miRNAs that target SOD2

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SOD2

Clone Products

  • Addgene plasmids for SOD2

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SOD2 Gene

Localization for SOD2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SOD2 Gene

Mitochondrion matrix.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SOD2 gene
Compartment Confidence
extracellular 5
mitochondrion 5
nucleus 2
cytosol 2
plasma membrane 1
cytoskeleton 1
peroxisome 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for SOD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA 12551919
GO:0005743 mitochondrial inner membrane IBA --
GO:0005759 mitochondrial matrix TAS 10511315
GO:0070062 extracellular exosome HDA 23533145
genes like me logo Genes that share ontologies with SOD2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SOD2 Gene

Pathways & Interactions for SOD2 Gene

genes like me logo Genes that share pathways with SOD2: view

Gene Ontology (GO) - Biological Process for SOD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000303 response to superoxide IMP 16179351
GO:0001315 age-dependent response to reactive oxygen species IMP 14980699
GO:0001836 release of cytochrome c from mitochondria ISS --
GO:0003069 acetylcholine-mediated vasodilation involved in regulation of systemic arterial blood pressure ISS --
GO:0006357 regulation of transcription by RNA polymerase II IMP 9393747
genes like me logo Genes that share ontologies with SOD2: view

No data available for SIGNOR curated interactions for SOD2 Gene

Drugs & Compounds for SOD2 Gene

(85) Drugs for SOD2 Gene - From: DrugBank, PharmGKB, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Methotrexate Approved Pharma Folate antagonist,inhibits DFHR 1603
Paclitaxel Approved, Vet_approved Pharma Tubulin and Bcl2 inhibitor, Taxanes 3027
Copper Approved, Investigational Pharma 202
Oxygen Approved, Vet_approved Pharma 0
Zinc Approved, Investigational Pharma 2430

(70) Additional Compounds for SOD2 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • (O2)(.-)
  • Dioxide(1-)
  • Hyperoxid
  • Hyperoxide
  • O2(.-)
  • FE (II) ion
  • Fe(II)
  • Fe(2+)
  • Ferrous ion
  • Iron ion(2+)
Hydrogen Ion
  • H+
  • H(+)
  • Hydrogen cation
  • Hydron
  • Proton
genes like me logo Genes that share compounds with SOD2: view

Transcripts for SOD2 Gene

Unigene Clusters for SOD2 Gene

Superoxide dismutase 2, mitochondrial:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SOD2

Clone Products

  • Addgene plasmids for SOD2

Alternative Splicing Database (ASD) splice patterns (SP) for SOD2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c · 8d · 8e · 8f ^ 9
SP1: - - - - - -
SP2: - - -
SP3: - - -
SP4: - - - - - - -
SP5: - -
SP6: -
SP7: - -

Relevant External Links for SOD2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SOD2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SOD2 Gene

mRNA differential expression in normal tissues according to GTEx for SOD2 Gene

This gene is overexpressed in Muscle - Skeletal (x16.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SOD2 Gene

Protein tissue co-expression partners for SOD2 Gene

NURSA nuclear receptor signaling pathways regulating expression of SOD2 Gene:


SOURCE GeneReport for Unigene cluster for SOD2 Gene:


Evidence on tissue expression from TISSUES for SOD2 Gene

  • Nervous system(5)
  • Liver(4.9)
  • Lung(4.9)
  • Heart(4.7)
  • Intestine(4.6)
  • Muscle(4.1)
  • Blood(3.8)
  • Kidney(3.6)
  • Bone marrow(3)
  • Stomach(2.9)
  • Pancreas(2.7)
  • Spleen(2.6)
  • Adrenal gland(2.5)
  • Lymph node(2.2)
  • Skin(2.2)
  • Eye(2.1)
  • Gall bladder(2.1)
  • Bone(2)
genes like me logo Genes that share expression patterns with SOD2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SOD2 Gene

Orthologs for SOD2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SOD2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SOD2 34 33
  • 99.83 (n)
(Canis familiaris)
Mammalia SOD2 34 33
  • 88.59 (n)
(Bos Taurus)
Mammalia SOD2 34 33
  • 88.29 (n)
(Ornithorhynchus anatinus)
Mammalia SOD2 34
  • 88 (a)
(Monodelphis domestica)
Mammalia SOD2 34
  • 88 (a)
(Mus musculus)
Mammalia Sod2 16 34 33
  • 86.94 (n)
(Rattus norvegicus)
Mammalia Sod2 33
  • 86.04 (n)
(Gallus gallus)
Aves SOD2 34 33
  • 79.73 (n)
(Anolis carolinensis)
Reptilia SOD2 34
  • 81 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia sod2 33
  • 72.82 (n)
Str.15249 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.23883 33
(Danio rerio)
Actinopterygii sod2 34 33 33
  • 72.58 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13830 33
African malaria mosquito
(Anopheles gambiae)
Insecta MNSOD1 33
  • 63.62 (n)
fruit fly
(Drosophila melanogaster)
Insecta Sod2 34 35 33
  • 62.87 (n)
(Caenorhabditis elegans)
Secernentea sod-2 34 35 33
  • 61.84 (n)
sod-3 34 35
  • 61 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADR160W 33
  • 55.61 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E03609g 33
  • 55.4 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SOD2 36 34 33
  • 55.07 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons MSD1 33
  • 60.66 (n)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.7748 33
(Oryza sativa)
Liliopsida Os05g0323900 33
  • 62.48 (n)
Os.4610 33
(Zea mays)
Liliopsida Zm.1987 33
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2788 34
  • 71 (a)
Cin.2423 33
bread mold
(Neurospora crassa)
Ascomycetes NCU09560 33
  • 57.01 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC1486.01 33
  • 56.54 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2423 33
Species where no ortholog for SOD2 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SOD2 Gene

Gene Tree for SOD2 (if available)
Gene Tree for SOD2 (if available)
Evolutionary constrained regions (ECRs) for SOD2: view image

Paralogs for SOD2 Gene

Paralogs for SOD2 Gene

(1) SIMAP similar genes for SOD2 Gene using alignment to 14 proteins:

  • F5H3C5_HUMAN
  • F5H4R2_HUMAN
  • G5E9P6_HUMAN
  • Q6LE88_HUMAN
  • Q71UR9_HUMAN
  • Q7Z7M4_HUMAN
  • Q7Z7M5_HUMAN
  • Q7Z7M6_HUMAN
  • Q7Z7M7_HUMAN Pseudogenes for SOD2 Gene

genes like me logo Genes that share paralogs with SOD2: view

Variants for SOD2 Gene

Sequence variations from dbSNP and Humsavar for SOD2 Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs4880 benign, risk-factor, drug-response, SUPEROXIDE DISMUTASE 2 POLYMORPHISM, Microvascular complications of diabetes 6, cyclophosphamide response - Efficacy 159,692,840(-) A/G 5_prime_UTR_variant, coding_sequence_variant, missense_variant
rs1000024361 -- 159,731,391(-) C/A genic_upstream_transcript_variant, intron_variant
rs1000045877 -- 159,756,818(-) G/A/T genic_upstream_transcript_variant, intron_variant
rs1000046560 -- 159,714,348(-) C/T genic_upstream_transcript_variant, intron_variant
rs1000138692 -- 159,741,814(-) C/A genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SOD2 Gene

Variant ID Type Subtype PubMed ID
esv2759483 CNV gain 17122850
esv33081 CNV gain 17666407

Variation tolerance for SOD2 Gene

Residual Variation Intolerance Score: 43.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.35; 85.37% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SOD2 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SOD2 Gene

Disorders for SOD2 Gene

MalaCards: The human disease database

(24) MalaCards diseases for SOD2 Gene - From: HGMD, OMIM, ClinVar, GTR, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
microvascular complications of diabetes 6
  • nephropathy, diabetic
diabetic polyneuropathy
  • diabetes mellitus with polyneuropathy
  • acute coronary syndrome
extrinsic allergic alveolitis
  • hp
- elite association - COSMIC cancer census association via MalaCards
Search SOD2 in MalaCards View complete list of genes associated with diseases


  • Microvascular complications of diabetes 6 (MVCD6) [MIM:612634]: Pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new-onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis. {ECO:0000269 PubMed:12624725, ECO:0000269 PubMed:18989629}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Additional Disease Information for SOD2

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with SOD2: view

No data available for Genatlas for SOD2 Gene

Publications for SOD2 Gene

  1. The polymorphism of manganese superoxide dismutase is associated with diabetic nephropathy in Japanese type 2 diabetic patients. (PMID: 12624725) Nomiyama T … Kawamori R (Journal of human genetics 2003) 3 4 22 44 58
  2. Genetic variants in selenoprotein genes increase risk of colorectal cancer. (PMID: 20378690) Méplan C … Hesketh JE (Carcinogenesis 2010) 3 22 44 58
  3. Manganese superoxide dismutase (MnSOD) gene (Ala-9Val, Ile58Thr) polymorphism in patients with age-related macular degeneration (AMD). (PMID: 20357718) Kowalski M … Szemraj J (Medical science monitor : international medical journal of experimental and clinical research 2010) 3 22 44 58
  4. Dietary carotenoid-rich pequi oil reduces plasma lipid peroxidation and DNA damage in runners and evidence for an association with MnSOD genetic variant -Val9Ala. (PMID: 20082261) Miranda-Vilela AL … Grisolia CK (Genetics and molecular research : GMR 2009) 3 22 44 58
  5. Myeloperoxidase and superoxide dismutase 2 polymorphisms comodulate the risk of hepatocellular carcinoma and death in alcoholic cirrhosis. (PMID: 19731237) Nahon P … Beaugrand M (Hepatology (Baltimore, Md.) 2009) 3 22 44 58

Products for SOD2 Gene

  • Addgene plasmids for SOD2

Sources for SOD2 Gene