Aliases for SOD2 Gene
External Ids for SOD2 Gene
Previous GeneCards Identifiers for SOD2 Gene
This gene is a member of the iron/manganese superoxide dismutase family. It encodes a mitochondrial protein that forms a homotetramer and binds one manganese ion per subunit. This protein binds to the superoxide byproducts of oxidative phosphorylation and converts them to hydrogen peroxide and diatomic oxygen. Mutations in this gene have been associated with idiopathic cardiomyopathy (IDC), premature aging, sporadic motor neuron disease, and cancer. Alternative splicing of this gene results in multiple transcript variants. A related pseudogene has been identified on chromosome 1. [provided by RefSeq, Apr 2016]
GeneCards Summary for SOD2 Gene
SOD2 (Superoxide Dismutase 2) is a Protein Coding gene. Diseases associated with SOD2 include Microvascular Complications Of Diabetes 6 and Ischemia. Among its related pathways are FoxO family signaling and Detoxification of Reactive Oxygen Species. Gene Ontology (GO) annotations related to this gene include identical protein binding and oxygen binding. An important paralog of this gene is ENSG00000285441.
UniProtKB/Swiss-Prot Summary for SOD2 Gene
Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.