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This gene is a member of the iron/manganese superoxide dismutase family. It encodes a mitochondrial protein that forms a homotetramer and binds one manganese ion per subunit. This protein binds to the superoxide byproducts of oxidative phosphorylation and converts them to hydrogen peroxide and diatomic oxygen. Mutations in this gene have been associated with idiopathic cardiomy... See more...
Aliases for SOD2 Gene
Aliases for SOD2 Gene
- Superoxide Dismutase 2 2 3 5
- Superoxide Dismutase [Mn], Mitochondrial 3 4
- Superoxide Dismutase 2, Mitochondrial 2 3
- EC 1.15.1.1 4 50
- GClnc1 2 3
- Epididymis Secretory Sperm Binding Protein 3
- Manganese-Containing Superoxide Dismutase 3
- Gastric Cancer–Associated LncRNA 1 2
- Gastric Cancer-Associated LncRNA 1 3
External Ids for SOD2 Gene
- HGNC: 11180
- NCBI Entrez Gene: 6648
- Ensembl: ENSG00000112096
- OMIM®: 147460
- UniProtKB/Swiss-Prot: P04179
Previous GeneCards Identifiers for SOD2 Gene
- GC06M159539
- GC06M159973
- GC06M160009
- GC06M160012
- GC06M160070
- GC06M160020
- GC06M160102
- GC06M157570
Summaries for SOD2 Gene
-
This gene is a member of the iron/manganese superoxide dismutase family. It encodes a mitochondrial protein that forms a homotetramer and binds one manganese ion per subunit. This protein binds to the superoxide byproducts of oxidative phosphorylation and converts them to hydrogen peroxide and diatomic oxygen. Mutations in this gene have been associated with idiopathic cardiomyopathy (IDC), premature aging, sporadic motor neuron disease, and cancer. Alternative splicing of this gene results in multiple transcript variants. A related pseudogene has been identified on chromosome 1. [provided by RefSeq, Apr 2016]
GeneCards Summary for SOD2 Gene
SOD2 (Superoxide Dismutase 2) is a Protein Coding gene. Diseases associated with SOD2 include Microvascular Complications Of Diabetes 6 and Gastric Cancer. Among its related pathways are Apoptosis and survival_Anti-apoptotic action of nuclear ESR1 and ESR2 and Folate Metabolism. Gene Ontology (GO) annotations related to this gene include identical protein binding and oxygen binding.
UniProtKB/Swiss-Prot Summary for SOD2 Gene
-
Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.
Additional gene information for SOD2 Gene
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SOD2 Gene
Genomics for SOD2 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for SOD2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around SOD2 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SOD2
- Top Transcription factor binding sites by QIAGEN in the SOD2 gene promoter:
-
- AP-2alpha
- AP-2alpha isoform 2
- ATF-2
- c-Jun
Genomic Locations for SOD2 Gene
Latest Assembly
- chr6:159,669,069-159,762,529
- (GRCh38/hg38)
- Size:
- 93,461 bases
- Orientation:
- Minus strand
Previous Assembly
- chr6:160,090,101-160,183,313
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 93,213 bases
- Orientation:
- Minus strand
Genomic View for SOD2 Gene
Genes around SOD2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 6q25.3 by HGNC
- 6q25.3 by Entrez Gene
- 6q25.3 by Ensembl
SOD2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for SOD2 Gene
Proteins for SOD2 Gene
-
Protein details for SOD2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P04179-SODM_HUMAN
- Recommended name:
- Superoxide dismutase [Mn], mitochondrial
- Protein Accession:
- P04179
- B2R7R1
- B3KUK2
- B4DL20
- B4E3K9
- E1P5A9
- P78434
- Q16792
- Q5TCM1
- Q96EE6
- Q9P2Z3
Protein attributes for SOD2 Gene
- Size:
- 222 amino acids
- Molecular mass:
- 24750 Da
- Cofactor:
- Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
- Quaternary structure:
-
- Homotetramer.
Three dimensional structures from OCA and Proteopedia for SOD2 Gene
Protein Expression for SOD2 Gene
Selected DME Specific Peptides for SOD2 Gene
- P04179:
-
- LPDLPYDY
- WEHAYYL
- IKRDFGS
- EEKYQEAL
- GGGHINH
- EALAKGDVT
- DYGALEP
- KHHAAYV
- KFKEKLTA
- FGSFDKF
- ALQPALKF
- YVNNLNVTEEKY
- KHSLPDL
- NQDPLQGTTGL
- KGDVTAQ
- KNVRPDYLKAIW
- YKNVRPDY
- LHHSKHHA
- DVWEHAYY
- LSPNGGG
- GSGWGWL
Post-translational modifications for SOD2 Gene
- Nitrated under oxidative stress. Nitration coupled with oxidation inhibits the catalytic activity.
- Acetylation at Lys-122 decreases enzymatic activity. Deacetylated by SIRT3 upon exposure to ionizing radiations or after long fasting (By similarity).
- Polyubiquitinated; leading to proteasomal degradation. Deubiquitinated by USP36 which increases protein stability.
-
Ubiquitination at Lys130
- NX_P04179 (NX_P04179-1)
- Modification sites at PhosphoSitePlus
Other Protein References for SOD2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
- LifeSpan BioSciences SOD2 / Mn SOD Antibody (LS-B3694) and SOD2 / Mn SOD Antibody (LS-B5924)
- G Biosciences Immunotag™ sod2 Antibody and Immunotag™ SOD2 Antibody
- GeneTex Anti-SOD2 antibody and Anti-SOD2 antibody [GT1433]
- NSJ Bioreagents SOD2 Antibody Superoxide Dismutase 2
- Novus Biologicals Antibodies for SOD2
-
Abcam antibodies for SOD2
- Invitrogen Antibodies for SOD2 (AFLGC-SOD2)
-
Santa Cruz Biotechnology (SCBT) Antibodies for SOD2
- Sino Biological Antibodies for SOD2
Protein products for research
- G Biosciences Human SOD2/Mn-SOD, Liquid (BAN0913) and Human SOD2/Mn-SOD, Liquid (BAN0662)
- Search Origene for MassSpec and Protein Over-expression Lysates for SOD2
- Origene Custom Protein Services for SOD2
- Sino Biological Recombinant Proteins for SOD2
- Browse Sino Biological Cell Lysates
- ProSpec Recombinant Proteins for SOD2
-
Abcam proteins for SOD2
Assay products for research
- Novus Biologicals ELISA Kits for SOD2
- antibodies-online: Show 67 available SOD2 Elisa Kits ranked by validation data
- Compare Top SOD2 Elisa Kits
-
Quality Products:
- ABIN1117275
- ABIN414541
- ABIN858364
- ABIN2685499
- ABIN5522479
- ABIN1572476
- ABIN510553
- ABIN5593195
- ABIN5659004
- ABIN2951593
- ABIN852261
- ABIN1884503
- ABIN5522480
- ABIN628166
- ABIN2951595
- ABIN6211042
- ABIN5070732
- ABIN585516
- ABIN1117274
- ABIN431919
- ABIN852262
- ABIN5522481
- ABIN1572477
- ABIN627354
- ABIN5593196
- ABIN5659005
- ABIN6254528
- ABIN2539276
- ABIN852267
- ABIN5696502
- ABIN628515
- ABIN6211043
-
Abcam assays for SOD2
Domains & Families for SOD2 Gene
Gene Families for SOD2 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
- Cancer-related genes
- Disease related genes
- Enzymes
- Plasma proteins
- Potential drug targets
Protein Domains for SOD2 Gene
- InterPro:
- Blocks:
-
- Manganese and iron superoxide dismutase
Suggested Antigen Peptide Sequences for SOD2 Gene
- GenScript: Design optimal peptide antigens:
-
- Superoxide dismutase (B3KUK2_HUMAN)
- Superoxide dismutase (B4DL20_HUMAN)
- Superoxide dismutase (B4E3K9_HUMAN)
- Superoxide dismutase (Q4ZJI1_HUMAN)
- Superoxide dismutase 2, mitochondrial (Q5TCM0_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P04179- Family:
-
- Belongs to the iron/manganese superoxide dismutase family.
Function for SOD2 Gene
Molecular function for SOD2 Gene
- UniProtKB/Swiss-Prot Function:
- Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=2 H(+) + 2 superoxide = H2O2 + O2; Xref=Rhea:RHEA:20696, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240, ChEBI:CHEBI:18421; EC=1.15.1.1;.
- UniProtKB/Swiss-Prot Induction:
- Expression is regulated by KRIT1.
- GENATLAS Biochemistry:
- manganese superoxide dismutase 2,mitochondrial,catabolic pathway of activated oxygen species,free radical detoxification,susceptibility factor for non familial idiopathy dilated cardiomyopathy in Japanese
Enzyme Numbers (IUBMB) for SOD2 Gene
Phenotypes From GWAS Catalog for SOD2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003677 | DNA binding | IEA | -- |
| GO:0004784 | superoxide dismutase activity | IEA,IDA | 12551919 |
| GO:0005515 | protein binding | IPI | 32296183 |
| GO:0016491 | oxidoreductase activity | IEA | -- |
| GO:0019825 | oxygen binding | IEA | -- |
Phenotypes for SOD2 Gene
- MGI mutant phenotypes for SOD2:
-
inferred from 8 alleles
- nervous system phenotype
- muscle phenotype
- homeostasis/metabolism phenotype
- growth/size/body region phenotype
- cellular phenotype
- cardiovascular system phenotype
- behavior/neurological phenotype
- immune system phenotype
- mortality/aging
- renal/urinary system phenotype
- liver/biliary system phenotype
- hematopoietic system phenotype
- neoplasm
- reproductive system phenotype
- vision/eye phenotype
- hearing/vestibular/ear phenotype
- integument phenotype
- pigmentation phenotype
- adipose tissue phenotype
- GenomeRNAi human phenotypes for SOD2:
Animal Models for SOD2 Gene
Animal Models for research
-
Taconic Biosciences Mouse Models for SOD2
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for SOD2 - Starting at $85 >
- * SOD2 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for SOD2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SOD2
-
Santa Cruz Biotechnology (SCBT) CRISPR for SOD2
miRNA for SOD2 Gene
- miRTarBase miRNAs that target SOD2
-
- hsa-miR-222-3p (MIRT000135)
- rno-miR-145-5p (MIRT000503)
- hsa-miR-377-3p (MIRT000993)
- hsa-miR-17-3p (MIRT005745)
- hsa-miR-30a-5p (MIRT028409)
- hsa-miR-769-3p (MIRT039083)
- hsa-miR-342-3p (MIRT043729)
- bta-miR-17-5p (MIRT053867)
- bta-miR-221 (MIRT053992)
- hsa-miR-4325 (MIRT167960)
- hsa-miR-212-3p (MIRT437838)
- hsa-miR-20a-5p (MIRT439566)
- hsa-miR-106b-5p (MIRT439567)
- hsa-miR-222-5p (MIRT442899)
- hsa-miR-4662a-5p (MIRT442900)
- hsa-miR-3129-5p (MIRT442901)
- hsa-miR-199b-3p (MIRT442902)
- hsa-miR-199a-3p (MIRT442903)
- hsa-miR-936 (MIRT442905)
- hsa-miR-6749-3p (MIRT451853)
- hsa-miR-4738-3p (MIRT451854)
- hsa-miR-6731-3p (MIRT451855)
- hsa-miR-6826-5p (MIRT451856)
- hsa-miR-6873-5p (MIRT451857)
- hsa-miR-6124 (MIRT451858)
- hsa-miR-583 (MIRT451859)
- hsa-miR-6859-5p (MIRT451860)
- hsa-miR-3916 (MIRT451861)
- hsa-miR-3125 (MIRT451862)
- hsa-miR-4531 (MIRT451863)
- hsa-miR-7847-3p (MIRT451864)
- hsa-miR-4764-5p (MIRT451865)
- hsa-miR-5192 (MIRT451866)
- hsa-miR-4644 (MIRT451867)
- hsa-miR-4306 (MIRT451868)
- hsa-miR-185-5p (MIRT451869)
- hsa-miR-5703 (MIRT451870)
- hsa-miR-4434 (MIRT451871)
- hsa-miR-4516 (MIRT451872)
- hsa-miR-1287-5p (MIRT451873)
- hsa-miR-3135b (MIRT451874)
- hsa-miR-3605-5p (MIRT451875)
- hsa-miR-539-5p (MIRT451876)
- hsa-miR-764 (MIRT451877)
- hsa-miR-4657 (MIRT451878)
- hsa-miR-4491 (MIRT451879)
- hsa-miR-1265 (MIRT451880)
- hsa-miR-3914 (MIRT451881)
- hsa-miR-552-3p (MIRT451882)
- hsa-miR-4446-5p (MIRT451883)
- hsa-miR-4482-3p (MIRT451884)
- hsa-miR-7159-3p (MIRT451885)
- hsa-miR-5006-3p (MIRT451886)
- hsa-miR-4755-5p (MIRT451887)
- hsa-miR-211-5p (MIRT451888)
- hsa-miR-204-5p (MIRT451889)
- hsa-miR-3659 (MIRT451890)
- hsa-miR-623 (MIRT451891)
- hsa-miR-6780b-3p (MIRT451892)
- hsa-miR-4780 (MIRT451893)
- hsa-miR-197-3p (MIRT498666)
- hsa-miR-6892-5p (MIRT498667)
- hsa-miR-3148 (MIRT498668)
- hsa-miR-1252-5p (MIRT498669)
- hsa-miR-203a-3p (MIRT498670)
- hsa-miR-7843-5p (MIRT498671)
- hsa-miR-6879-5p (MIRT498672)
- hsa-miR-6735-5p (MIRT498673)
- hsa-miR-4632-5p (MIRT498674)
- hsa-miR-4436b-3p (MIRT498675)
- hsa-miR-3646 (MIRT498676)
- hsa-miR-651-3p (MIRT498677)
- hsa-miR-500a-3p (MIRT503377)
- hsa-miR-6804-3p (MIRT503378)
- hsa-miR-7977 (MIRT503379)
- hsa-miR-506-5p (MIRT503380)
- hsa-miR-892c-5p (MIRT503381)
- hsa-miR-502-3p (MIRT503382)
- hsa-miR-501-3p (MIRT503383)
- hsa-miR-3144-3p (MIRT514691)
- hsa-miR-4266 (MIRT514692)
- hsa-miR-633 (MIRT514693)
- hsa-miR-3944-5p (MIRT514694)
- hsa-miR-4424 (MIRT514695)
- hsa-miR-4495 (MIRT514696)
- hsa-miR-875-5p (MIRT514697)
- hsa-miR-6888-5p (MIRT514698)
- hsa-miR-1179 (MIRT514699)
- hsa-miR-1252-3p (MIRT514700)
- hsa-miR-202-3p (MIRT525720)
- hsa-miR-98-5p (MIRT525721)
- hsa-miR-4500 (MIRT525722)
- hsa-miR-4458 (MIRT525723)
- hsa-let-7i-5p (MIRT525724)
- hsa-let-7g-5p (MIRT525725)
- hsa-let-7f-5p (MIRT525726)
- hsa-let-7e-5p (MIRT525727)
- hsa-let-7d-5p (MIRT525728)
- hsa-let-7c-5p (MIRT525729)
- hsa-let-7b-5p (MIRT525730)
- hsa-miR-7162-3p (MIRT525731)
- hsa-let-7a-5p (MIRT525732)
- hsa-miR-6753-5p (MIRT525733)
- hsa-miR-1911-3p (MIRT525734)
- hsa-miR-527 (MIRT525735)
- hsa-miR-518a-5p (MIRT525736)
- hsa-miR-5591-3p (MIRT525737)
- hsa-miR-524-5p (MIRT525738)
- hsa-miR-520d-5p (MIRT525739)
- hsa-miR-409-5p (MIRT525740)
- hsa-miR-671-5p (MIRT525741)
- hsa-miR-6730-5p (MIRT525742)
- hsa-miR-519d-5p (MIRT525743)
- hsa-miR-125b-1-3p (MIRT525744)
- hsa-miR-9500 (MIRT525745)
- hsa-miR-4474-5p (MIRT525746)
- hsa-miR-4684-3p (MIRT525747)
- hsa-miR-593-3p (MIRT525748)
- hsa-miR-301b-5p (MIRT525749)
- hsa-miR-146a-3p (MIRT525750)
- hsa-miR-301a-5p (MIRT525751)
- hsa-miR-483-3p (MIRT525752)
- hsa-miR-4803 (MIRT525753)
- hsa-miR-3671 (MIRT525754)
- hsa-miR-376c-5p (MIRT525755)
- hsa-miR-376b-5p (MIRT525756)
- hsa-miR-144-5p (MIRT525757)
- hsa-miR-5590-3p (MIRT525758)
- hsa-miR-142-5p (MIRT525759)
- hsa-miR-6849-5p (MIRT525760)
- hsa-miR-3681-5p (MIRT525761)
- hsa-miR-93-5p (MIRT525762)
- hsa-miR-526b-3p (MIRT525763)
- hsa-miR-519d-3p (MIRT525764)
- hsa-miR-20b-5p (MIRT525765)
- hsa-miR-17-5p (MIRT525766)
- hsa-miR-106a-5p (MIRT525767)
- hsa-miR-6783-3p (MIRT525768)
- hsa-miR-1343-3p (MIRT525769)
- hsa-miR-4638-3p (MIRT525770)
- hsa-miR-8067 (MIRT525771)
- hsa-miR-6508-5p (MIRT525772)
- hsa-miR-4254 (MIRT525773)
- hsa-miR-3690 (MIRT525774)
- hsa-miR-577 (MIRT525775)
- hsa-miR-10a-3p (MIRT525776)
- hsa-miR-3121-3p (MIRT525777)
- hsa-miR-6509-5p (MIRT525778)
- hsa-miR-4298 (MIRT525779)
- hsa-miR-1302 (MIRT525780)
- hsa-miR-183-3p (MIRT525781)
- hsa-miR-331-5p (MIRT525782)
- hsa-miR-5681b (MIRT525783)
- hsa-miR-425-5p (MIRT525784)
- hsa-miR-4678 (MIRT525785)
- hsa-miR-513b-5p (MIRT525786)
- hsa-miR-4765 (MIRT525787)
- hsa-miR-1236-5p (MIRT525788)
- hsa-miR-2116-3p (MIRT525789)
- hsa-miR-3611 (MIRT525790)
- hsa-miR-561-5p (MIRT525791)
- hsa-miR-6861-3p (MIRT525792)
- hsa-miR-6515-3p (MIRT525793)
- hsa-miR-6757-5p (MIRT525794)
- hsa-miR-3123 (MIRT525795)
- hsa-miR-6816-3p (MIRT525796)
- hsa-miR-5191 (MIRT525797)
- hsa-miR-490-5p (MIRT525798)
- hsa-miR-6876-5p (MIRT525799)
- hsa-miR-4476 (MIRT525800)
- hsa-miR-450b-3p (MIRT525801)
- hsa-miR-638 (MIRT525802)
- hsa-miR-4713-3p (MIRT525803)
- hsa-miR-4695-3p (MIRT525804)
- hsa-miR-4786-3p (MIRT525805)
- hsa-miR-6758-3p (MIRT525806)
- hsa-miR-340-5p (MIRT525807)
- hsa-miR-503-3p (MIRT525808)
- hsa-miR-6861-5p (MIRT525809)
- hsa-miR-186-3p (MIRT525810)
- hsa-miR-885-5p (MIRT525811)
- hsa-miR-3159 (MIRT525812)
- hsa-miR-551b-5p (MIRT525813)
- hsa-miR-4433a-3p (MIRT549774)
- hsa-miR-4459 (MIRT549775)
- hsa-miR-4646-3p (MIRT559919)
- hsa-miR-4433b-5p (MIRT559920)
- hsa-miR-339-5p (MIRT559921)
- hsa-miR-670-3p (MIRT559922)
- hsa-miR-4752 (MIRT559923)
- hsa-miR-6833-5p (MIRT559924)
- hsa-miR-644a (MIRT559925)
- hsa-miR-3190-3p (MIRT559926)
- hsa-miR-8053 (MIRT559927)
- hsa-miR-6717-5p (MIRT559928)
- hsa-miR-6077 (MIRT559929)
- hsa-miR-7-5p (MIRT559930)
- hsa-miR-145-3p (MIRT559931)
- hsa-miR-4289 (MIRT559932)
- hsa-miR-4302 (MIRT559933)
- mmu-miR-668-3p (MIRT577644)
- mmu-miR-1192 (MIRT577645)
- mmu-miR-495-3p (MIRT577646)
- mmu-miR-3065-5p (MIRT577647)
- mmu-miR-713 (MIRT597200)
- mmu-miR-3082-5p (MIRT597201)
- mmu-miR-1195 (MIRT597202)
- mmu-miR-3089-5p (MIRT597203)
- mmu-miR-759 (MIRT603303)
- hsa-miR-1263 (MIRT609365)
- hsa-miR-150-3p (MIRT609366)
- hsa-miR-3941 (MIRT609367)
- hsa-miR-5689 (MIRT609368)
- hsa-miR-9-5p (MIRT609369)
- hsa-miR-4789-3p (MIRT609370)
- hsa-miR-603 (MIRT609371)
- hsa-miR-362-3p (MIRT609372)
- hsa-miR-329-3p (MIRT609373)
- hsa-miR-8485 (MIRT609374)
- hsa-miR-4668-5p (MIRT617348)
- hsa-miR-410-3p (MIRT617349)
- hsa-miR-614 (MIRT617350)
- hsa-miR-23c (MIRT642820)
- hsa-miR-23b-3p (MIRT642821)
- hsa-miR-23a-3p (MIRT642822)
- hsa-miR-130a-5p (MIRT642823)
- hsa-miR-5189-3p (MIRT642824)
- hsa-miR-6832-3p (MIRT642825)
- hsa-miR-8080 (MIRT689870)
- hsa-miR-6771-3p (MIRT689871)
- hsa-miR-548as-3p (MIRT689872)
- hsa-miR-505-3p (MIRT689873)
- hsa-miR-7159-5p (MIRT689874)
- hsa-miR-610 (MIRT689875)
- hsa-miR-4272 (MIRT689876)
- hsa-miR-200b-5p (MIRT689877)
- hsa-miR-200a-5p (MIRT689878)
- hsa-miR-421 (MIRT689879)
- hsa-miR-4709-5p (MIRT689880)
- hsa-miR-1285-5p (MIRT689881)
- hsa-miR-5683 (MIRT689882)
- hsa-miR-548t-3p (MIRT689883)
- hsa-miR-548ap-3p (MIRT689884)
- hsa-miR-548aa (MIRT689885)
- hsa-miR-4445-3p (MIRT689886)
- hsa-miR-544a (MIRT689887)
- hsa-miR-6788-5p (MIRT689888)
- hsa-miR-30c-2-3p (MIRT689889)
- hsa-miR-30c-1-3p (MIRT689890)
- hsa-miR-8085 (MIRT689891)
- hsa-miR-6731-5p (MIRT689892)
- hsa-miR-6878-5p (MIRT689893)
- hsa-miR-548x-5p (MIRT689894)
- hsa-miR-548g-5p (MIRT689895)
- hsa-miR-548aj-5p (MIRT689896)
- hsa-miR-4793-3p (MIRT689897)
- hsa-miR-3130-3p (MIRT689898)
- hsa-miR-1283 (MIRT689899)
- hsa-miR-4742-5p (MIRT689900)
- hsa-miR-545-3p (MIRT689901)
- hsa-miR-759 (MIRT689902)
- hsa-miR-4714-3p (MIRT689903)
- hsa-miR-4698 (MIRT689904)
- hsa-miR-6871-5p (MIRT689905)
- hsa-miR-548p (MIRT689906)
- hsa-miR-5586-3p (MIRT689907)
- hsa-miR-181c-3p (MIRT689908)
- hsa-miR-3120-3p (MIRT689909)
- hsa-miR-4282 (MIRT689910)
- mmu-miR-21a-5p (MIRT732635)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for SOD2
- Browse OriGene Inhibitory RNA Products For SOD2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SOD2
Clone products for research
- Applied Biological Materials (abm): Clones for SOD2 - Starting at $45 >
- * SOD2 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
-
- MG201642
- MG202568
- MR201642
- MR201642L1
- MR201642L2
- MR201642L3
- MR201642L4
- MR202568
- MR202568L3
- MR202568L4
- RC202330
- RC202330L1
- RC202330L2
- RC202330L3
- RC202330L4
- RC212924
- RC212924L1
- RC212924L2
- RC212924L3
- RC212924L4
- RC212981
- RC212981L3
- RC212981L4
- RG202330
- RG212924
- RG212981
- RR213719
- RR213719L3
- RR213719L4
- MR201642L1V
- MR201642L2V
- MR201642L3V
- MR201642L4V
- MR202568L3V
- MR202568L4V
- RC202330L1V
- RC202330L2V
- RC202330L3V
- RC202330L4V
- RC212924L1V
- RC212924L2V
- RC212924L3V
- RC212924L4V
- RC212981L3V
- RC212981L4V
- RR213719L3V
- RR213719L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for SOD2
- Addgene plasmids for SOD2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SOD2
Cell Lines for research
-
Horizon Cell Lines for SOD2
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SOD2 Gene
Localization for SOD2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for SOD2 Gene
- Mitochondrion matrix.
| Compartment | Confidence |
|---|---|
| mitochondrion | 5 |
| extracellular | 4 |
| nucleus | 3 |
| cytosol | 3 |
| plasma membrane | 2 |
| cytoskeleton | 2 |
| peroxisome | 2 |
| endoplasmic reticulum | 2 |
| lysosome | 2 |
| endosome | 1 |
| golgi apparatus | 1 |
- Mitochondria (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005739 | mitochondrion | IEA,IDA | 12551919 |
| GO:0005759 | mitochondrial matrix | IEA,TAS | 10511315 |
| GO:0042645 | mitochondrial nucleoid | IEA | -- |
| GO:0070062 | extracellular exosome | HDA | 23533145 |
Pathways & Interactions for SOD2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Folate Metabolism | ||
| 2 | Longevity regulating pathway | ||
| 3 | Neurodegenerative Diseases | ||
| 4 | Detoxification of Reactive Oxygen Species | ||
| 5 | Glucose / Energy Metabolism | ||
Pathways by source for SOD2 Gene
7 BioSystems pathways for SOD2 Gene
5 Reactome pathways for SOD2 Gene
1 GeneGo (Thomson Reuters) pathway for SOD2 Gene
- Apoptosis and survival_Anti-apoptotic action of nuclear ESR1 and ESR2
1 Qiagen pathway for SOD2 Gene
- PEDF Induced Signaling
1 Cell Signaling Technology pathway for SOD2 Gene
Interacting Proteins for SOD2 Gene
Selected Interacting proteins:
P04179-SODM_HUMAN
ENSP00000446252
for SOD2 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for SOD2
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000303 | response to superoxide | IMP | 16179351 |
| GO:0001315 | age-dependent response to reactive oxygen species | IMP | 14980699 |
| GO:0001666 | response to hypoxia | IEA | -- |
| GO:0001836 | release of cytochrome c from mitochondria | ISS | -- |
| GO:0003069 | acetylcholine-mediated vasodilation involved in regulation of systemic arterial blood pressure | ISS | -- |
Drugs & Compounds for SOD2 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Methotrexate | Approved | Pharma | Folate antagonist,inhibits DFHR | 1884 | ||
| Paclitaxel | Approved, Vet_approved | Pharma | Tubulin and Bcl2 inhibitor, Taxanes | 3989 | ||
| Copper | Approved, Investigational | Pharma | 276 | |||
| Oxygen | Approved, Vet_approved | Pharma | 0 | |||
| Zinc | Approved, Investigational | Pharma | 1706 |
Drug products for research
- G Biosciences Human SOD2/Mn-SOD, Liquid (BAN0913) and Human SOD2/Mn-SOD, Liquid (BAN0662)
Transcripts for SOD2 Gene
mRNA/cDNA for SOD2 Gene
- 9 REFSEQ mRNAs :
- 38 NCBI additional mRNA sequence :
- 15 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000337404 991 nts (view in UCSC)
- ENST00000367054 815 nts (view in UCSC)
- ENST00000367055 990 nts (view in UCSC)
- ENST00000401980 523 nts (view in UCSC)
- ENST00000444946 917 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for SOD2 - Starting at $85 >
- * SOD2 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for SOD2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SOD2
-
Santa Cruz Biotechnology (SCBT) CRISPR for SOD2
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for SOD2
- Browse OriGene Inhibitory RNA Products For SOD2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SOD2
Clone products for research
- Applied Biological Materials (abm): Clones for SOD2 - Starting at $45 >
- * SOD2 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
-
- MG201642
- MG202568
- MR201642
- MR201642L1
- MR201642L2
- MR201642L3
- MR201642L4
- MR202568
- MR202568L3
- MR202568L4
- RC202330
- RC202330L1
- RC202330L2
- RC202330L3
- RC202330L4
- RC212924
- RC212924L1
- RC212924L2
- RC212924L3
- RC212924L4
- RC212981
- RC212981L3
- RC212981L4
- RG202330
- RG212924
- RG212981
- RR213719
- RR213719L3
- RR213719L4
- MR201642L1V
- MR201642L2V
- MR201642L3V
- MR201642L4V
- MR202568L3V
- MR202568L4V
- RC202330L1V
- RC202330L2V
- RC202330L3V
- RC202330L4V
- RC212924L1V
- RC212924L2V
- RC212924L3V
- RC212924L4V
- RC212981L3V
- RC212981L4V
- RR213719L3V
- RR213719L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for SOD2
- Addgene plasmids for SOD2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SOD2
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8a | · | 8b | · | 8c | · | 8d | · | 8e | · | 8f | ^ | 9 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | |||||||||||||||||||||||||||
| SP2: | - | - | - | ||||||||||||||||||||||||||||||
| SP3: | - | - | - | ||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | - | ||||||||||||||||||||||||||
| SP5: | - | - | |||||||||||||||||||||||||||||||
| SP6: | - | ||||||||||||||||||||||||||||||||
| SP7: | - | - | |||||||||||||||||||||||||||||||
| SP8: |
Relevant External Links for SOD2 Gene
- GeneLoc Exon Structure for
- SOD2
Expression for SOD2 Gene
mRNA differential expression in normal tissues according to GTEx for SOD2 Gene
This gene is overexpressed in Muscle - Skeletal (x16.8).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SOD2 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SOD2
SOURCE GeneReport for Unigene cluster for SOD2 Gene:
Hs.487046Evidence on tissue expression from TISSUES for SOD2 Gene
- Nervous system(5)
- Lung(4.9)
- Liver(4.9)
- Heart(4.8)
- Intestine(4.7)
- Muscle(4.2)
- Blood(4.1)
- Kidney(3.9)
- Bone marrow(3.4)
- Spleen(3.3)
- Stomach(3.3)
- Pancreas(3.2)
- Adrenal gland(3)
- Skin(2.9)
- Lymph node(2.8)
- Bone(2.6)
- Eye(2.6)
- Thyroid gland(2.5)
- Gall bladder(2.1)
Primer products for research
-
OriGene qPCR primer pairs for SOD2
-
OriGene qPCR primer pairs and template standards for SOD2
Gene Expression Assays for research
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SOD2 Gene
Orthologs for SOD2 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | SOD2 29 30 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | SOD2 29 30 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | SOD2 29 30 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | SOD2 30 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | SOD2 30 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Sod2 29 16 30 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Sod2 29 |
|
||
| Chicken (Gallus gallus) |
Aves | SOD2 29 30 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | SOD2 30 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | sod2 29 |
|
||
| Str.15249 29 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.23883 29 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | sod2 29 30 |
|
OneToOne | |
| Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.13830 29 |
|
||
| African malaria mosquito (Anopheles gambiae) |
Insecta | MNSOD1 29 |
|
||
| Fruit Fly (Drosophila melanogaster) |
Insecta | Sod2 29 30 31 |
|
OneToOne | |
| Worm (Caenorhabditis elegans) |
Secernentea | sod-2 29 30 31 |
|
OneToMany | |
| sod-3 30 31 |
|
OneToMany | |||
| A. gosspyii yeast (Eremothecium gossypii) |
Saccharomycetes | AGOS_ADR160W 29 |
|
||
| K. Lactis Yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0E03609g 29 |
|
||
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | SOD2 29 30 32 32 |
|
OneToOne | |
| Thale Cress (Arabidopsis thaliana) |
eudicotyledons | MSD1 29 |
|
||
| Alicante grape (Vitis vinifera) |
eudicotyledons | Vvi.7748 29 |
|
||
| Rice (Oryza sativa) |
Liliopsida | Os05g0323900 29 |
|
||
| Os.4610 29 |
|
||||
| Corn (Zea mays) |
Liliopsida | Zm.1987 29 |
|
||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.2788 30 |
|
OneToOne | |
| Bread mold (Neurospora crassa) |
Ascomycetes | NCU09560 29 |
|
||
| Fission Yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | SPAC1486.01 29 |
|
||
| Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.2423 29 |
|
- Species where no ortholog for SOD2 was found in the sources mined by GeneCards:
-
- Actinobacteria (Mycobacterium tuberculosis)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for SOD2 Gene
- ENSEMBL:
- Gene Tree for SOD2 (if available)
- TreeFam:
- Gene Tree for SOD2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for SOD2: view image
- Alliance of Genome Resources:
- Additional Orthologs for SOD2
Paralogs for SOD2 Gene
(1) SIMAP similar genes for SOD2 Gene using alignment to 14 proteins:
- SODM_HUMAN
- F5GXZ9_HUMAN
- F5GYZ5_HUMAN
- F5H3C5_HUMAN
- F5H4R2_HUMAN
- G5E9P6_HUMAN
- G8JLJ2_HUMAN
- Q4ZJI1_HUMAN
- Q6LE88_HUMAN
- Q71UR9_HUMAN
- Q7Z7M4_HUMAN
- Q7Z7M5_HUMAN
- Q7Z7M6_HUMAN
- Q7Z7M7_HUMAN
Pseudogenes.org Pseudogenes for SOD2 Gene
No data available for Paralogs for SOD2 Gene
Variants for SOD2 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SOD2 Gene
| SNP ID | Clinical significance and condition | Chr 06 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 981493 | Uncertain Significance: not provided | 159,682,620(-) |
C/A NM_000636.4(SOD2):c.542G>T (p.Gly181Val) |
MISSENSE | |
| rs200264201 | Benign: not provided | 159,692,671(-) |
C/T NM_000636.4(SOD2):c.216G>A (p.Ala72=) |
SYNONYMOUS | |
| rs4880 | Drug Response: SUPEROXIDE DISMUTASE 2 POLYMORPHISM; Microvascular complications of diabetes 6; cyclophosphamide response - Efficacy | 159,692,840(-) |
A/Gp.Val16Ala NM_000636.4(SOD2):c.47T>C (p.Val16Ala) |
MISSENSE_VARIANT,FIVE_PRIME_UTR | |
| rs557996027 | Benign: not provided | 159,682,583(-) |
A/G NM_000636.4(SOD2):c.579T>C (p.Tyr193=) |
SYNONYMOUS | |
| rs1141718 | -- |
p.Ile82Thr |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2759483 | CNV | gain | 17122850 |
| esv33081 | CNV | gain | 17666407 |
Residual Variation Intolerance Score:
43.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
8.35;
85.37% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for SOD2 Gene
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SOD2 Gene
Disorders for SOD2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| microvascular complications of diabetes 6 |
|
|
| gastric cancer |
|
|
| ischemia |
|
|
| extrinsic allergic alveolitis |
|
|
| aging |
|
|
Search SOD2 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
SODM_HUMAN- Microvascular complications of diabetes 6 (MVCD6) [MIM:612634]: Pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new-onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis. {ECO:0000269 PubMed:12624725, ECO:0000269 PubMed:18989629}. Note=Disease susceptibility is associated with variants affecting the gene represented in this entry.
Additional Disease Information for SOD2
- Human Genome Epidemiology Navigator
- (HuGE)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for Genatlas for SOD2 Gene
Publications for SOD2 Gene
- The polymorphism of manganese superoxide dismutase is associated with diabetic nephropathy in Japanese type 2 diabetic patients. (PMID: 12624725) Nomiyama T … Kawamori R (Journal of human genetics 2003) 3 4 22 40 72
- A functional polymorphism in the manganese superoxide dismutase gene and diabetic nephropathy. (PMID: 17192491) Möllsten A … Dahlquist G (Diabetes 2007) 3 22 40 72
- Genotype-activity relationship for Mn-superoxide dismutase, glutathione peroxidase 1 and catalase in humans. (PMID: 16538174) Bastaki M … Holland N (Pharmacogenetics and genomics 2006) 3 22 40 72
- The mitochondrial superoxide dismutase A16V polymorphism in the cardiomyopathy associated with hereditary haemochromatosis. (PMID: 15591282) Valenti L … Fargion S (Journal of medical genetics 2004) 3 22 40 72
- Missense polymorphisms in three oxidative-stress enzymes (GSTP1, SOD2, and GPX1) and dyskinesias in Russian psychiatric inpatients from Siberia. (PMID: 20041472) Al Hadithy AF … Loonen AJ (Human psychopharmacology 2010) 3 22 40
ExternalLinks
Products for SOD2 Gene
- Custom Antibody ServicesOriGene Antibodies for SOD2
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for SOD2
- Origene Custom Protein Services for SOD2
- Origene shrna, sirna, and RNAi products in human, mouse, rat for SOD2
- Browse OriGene Inhibitory RNA Products For SOD2
- OriGene qPCR primer pairs for SOD2
- OriGene qPCR primer pairs and template standards for SOD2
- OriGene CRISPR knockouts for SOD2