Aliases for SOD1 Gene
External Ids for SOD1 Gene
Previous HGNC Symbols for SOD1 Gene
Previous GeneCards Identifiers for SOD1 Gene
The protein encoded by this gene binds copper and zinc ions and is one of two isozymes responsible for destroying free superoxide radicals in the body. The encoded isozyme is a soluble cytoplasmic protein, acting as a homodimer to convert naturally-occuring but harmful superoxide radicals to molecular oxygen and hydrogen peroxide. The other isozyme is a mitochondrial protein. In addition, this protein contains an antimicrobial peptide that displays antibacterial, antifungal, and anti-MRSA activity against E. coli, E. faecalis, S. aureus, S. aureus MRSA LPV+, S. agalactiae, and yeast C. krusei. Mutations in this gene have been implicated as causes of familial amyotrophic lateral sclerosis. Rare transcript variants have been reported for this gene. [provided by RefSeq, Jul 2020]
GeneCards Summary for SOD1 Gene
SOD1 (Superoxide Dismutase 1) is a Protein Coding gene. Diseases associated with SOD1 include Amyotrophic Lateral Sclerosis 1 and Spastic Tetraplegia And Axial Hypotonia, Progressive. Among its related pathways are Pathways of neurodegeneration - multiple diseases and AGE/RAGE pathway. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and enzyme binding. An important paralog of this gene is CCS.
UniProtKB/Swiss-Prot Summary for SOD1 Gene
Destroys radicals which are normally produced within the cells and which are toxic to biological systems.