Free for academic non-profit institutions. Other users need a Commercial license
Aliases for SOCS7 Gene
Aliases for SOCS7 Gene
External Ids for SOCS7 Gene
- HGNC: 29846
- Entrez Gene: 30837
- Ensembl: ENSG00000274211
- OMIM: 608788
- UniProtKB: O14512
Previous GeneCards Identifiers for SOCS7 Gene
- GC14P049305
- GC14P053483
- GC17P036869
- GC17P033761
- GC17P036508
- GC17P032304
- GC17P038353
Summaries for SOCS7 Gene
GeneCards Summary for SOCS7 Gene
SOCS7 (Suppressor Of Cytokine Signaling 7) is a Protein Coding gene. Diseases associated with SOCS7 include Uvulitis. Among its related pathways are Prolactin Signaling Pathway and JAK-STAT signaling pathway. Gene Ontology (GO) annotations related to this gene include SH3 domain binding and protein kinase inhibitor activity. An important paralog of this gene is SOCS6.
UniProtKB/Swiss-Prot Summary for SOCS7 Gene
-
Regulates signaling cascades probably through protein ubiquitination and/or sequestration. Functions in insulin signaling and glucose homeostasis through IRS1 ubiquitination and subsequent proteasomal degradation. Inhibits also prolactin, growth hormone and leptin signaling by preventing STAT3 and STAT5 activation, sequestering them in the cytoplasm and reducing their binding to DNA. May be a substrate recognition component of a SCF-like E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity).
Additional gene information for SOCS7 Gene
- HGNC(29846)
- Entrez Gene(30837)
- Ensembl(ENSG00000274211)
- OMIM(608788)
- UniProtKB(O14512)
- Open Targets Platform(ENSG00000274211)
- Search for SOCS7 at DataMed
- Search for SOCS7 at HumanCyc
No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SOCS7 Gene
Genomics for SOCS7 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for SOCS7 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around SOCS7 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SOCS7
- Top Transcription factor binding sites by QIAGEN in the SOCS7 gene promoter:
-
- ATF-2
- c-Jun
- c-Myb
- Egr-2
- GATA-1
- MAZR
- POU2F1
- POU2F1a
- SEF-1 (1)
- STAT3
Genomic Locations for SOCS7 Gene
Genomic Locations for SOCS7 Gene
- chr17:38,351,844-38,405,593
- (GRCh38/hg38)
- Size:
- 53,750 bases
- Orientation:
- Plus strand
- chr17:36,508,007-36,561,846
- (GRCh37/hg19)
- Size:
- 53,840 bases
- Orientation:
- Plus strand
Genomic View for SOCS7 Gene
Genes around SOCS7 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17q12 by HGNC
- 17q12 by Entrez Gene
- 17q12 by Ensembl
SOCS7 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for SOCS7 Gene
Proteins for SOCS7 Gene
-
Protein details for SOCS7 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O14512-SOCS7_HUMAN
- Recommended name:
- Suppressor of cytokine signaling 7
- Protein Accession:
- O14512
- A2VCU2
- Q0IJ63
Protein attributes for SOCS7 Gene
- Size:
- 581 amino acids
- Molecular mass:
- 62969 Da
- Quaternary structure:
-
- Interacts with phosphorylated IRS4 and PIK3R1 (By similarity). Interacts, via the third proline-rich region, with the second SH3 domain of the adapter protein NCK1. Also interacts with GRB2, INSR, IRS1, PLCG1, SORBS3/vinexin, and phosphorylated STAT3 and STAT5. Interacts with SEPT6.
- SequenceCaution:
-
- Sequence=AAI28608.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. The N-terminus may be contaminated with vector sequence.; Evidence={ECO:0000305}; Sequence=BAA22432.1; Type=Erroneous termination; Note=Extended C-terminus.; Evidence={ECO:0000305};
Post-translational modifications for SOCS7 Gene
Other Protein References for SOCS7 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for SOCS7
-
Abcam antibodies for SOCS7
- Invitrogen Antibodies for SOCS7 (AFLGC-SOCS7)
-
Boster Bio Antibodies for SOCS7
-
Santa Cruz Biotechnology (SCBT) Antibodies for SOCS7
Protein Products
-
OriGene Purified Proteins for SOCS7
- Search Origene for MassSpec and Protein Over-expression Lysates for SOCS7
- Origene Custom Protein Services for SOCS7
- Novus Biologicals proteins for SOCS7
-
Abcam proteins for SOCS7
No data available for DME Specific Peptides for SOCS7 Gene
Domains & Families for SOCS7 Gene
Gene Families for SOCS7 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for SOCS7 Gene
- InterPro:
- Blocks:
-
- SOCS protein, C-terminal
- ProtoNet:
Suggested Antigen Peptide Sequences for SOCS7 Gene
- GenScript: Design optimal peptide antigens:
-
- Nck-associated protein 4 (SOCS7_HUMAN)
Graphical View of Domain Structure for InterPro Entry
O14512UniProtKB/Swiss-Prot:
SOCS7_HUMAN :- The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes (By similarity). It is required for IRS1 ubiquitination and subsequent proteasomal degradation.
- Domain:
-
- The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes (By similarity). It is required for IRS1 ubiquitination and subsequent proteasomal degradation.
Function for SOCS7 Gene
Molecular function for SOCS7 Gene
- UniProtKB/Swiss-Prot Function:
- Regulates signaling cascades probably through protein ubiquitination and/or sequestration. Functions in insulin signaling and glucose homeostasis through IRS1 ubiquitination and subsequent proteasomal degradation. Inhibits also prolactin, growth hormone and leptin signaling by preventing STAT3 and STAT5 activation, sequestering them in the cytoplasm and reducing their binding to DNA. May be a substrate recognition component of a SCF-like E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity).
- UniProtKB/Swiss-Prot Induction:
- By IL6/interleukin-6, prolactin and growth hormone.
Phenotypes From GWAS Catalog for SOCS7 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 20598684 |
| GO:0017124 | SH3 domain binding | NAS | 9344857 |
| GO:0046935 | 1-phosphatidylinositol-3-kinase regulator activity | IBA | 21873635 |
Phenotypes for SOCS7 Gene
- MGI mutant phenotypes for SOCS7:
- inferred from 5 alleles
- GenomeRNAi human phenotypes for SOCS7:
Animal Models for SOCS7 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for SOCS7 - Select products 50% OFF >
- * SOCS7 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for SOCS7
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SOCS7
-
Santa Cruz Biotechnology (SCBT) CRISPR for SOCS7
miRNA for SOCS7 Gene
- miRTarBase miRNAs that target SOCS7
-
- hsa-miR-145-5p (MIRT007248)
- mmu-miR-26a-5p (MIRT011265)
- hsa-miR-615-3p (MIRT040011)
- hsa-miR-17-5p (MIRT286941)
- hsa-miR-19a-5p (MIRT286942)
- hsa-miR-19b-1-5p (MIRT286943)
- hsa-miR-19b-2-5p (MIRT286944)
- hsa-miR-20a-5p (MIRT286945)
- hsa-miR-93-5p (MIRT286947)
- hsa-miR-106a-5p (MIRT286948)
- hsa-miR-186-3p (MIRT286950)
- hsa-miR-106b-5p (MIRT286951)
- hsa-miR-20b-5p (MIRT286954)
- hsa-miR-519c-3p (MIRT286955)
- hsa-miR-526b-3p (MIRT286956)
- hsa-miR-519b-3p (MIRT286957)
- hsa-miR-519d-3p (MIRT286958)
- hsa-miR-520g-3p (MIRT286959)
- hsa-miR-520h (MIRT286960)
- hsa-miR-519a-3p (MIRT286961)
- hsa-miR-2052 (MIRT286965)
- hsa-miR-3149 (MIRT467383)
- hsa-miR-4715-3p (MIRT467384)
- hsa-miR-411-5p (MIRT467385)
- hsa-miR-4775 (MIRT467386)
- hsa-miR-6832-5p (MIRT467387)
- hsa-miR-4735-5p (MIRT467388)
- hsa-miR-6872-3p (MIRT467389)
- hsa-miR-590-3p (MIRT467390)
- hsa-miR-136-5p (MIRT554051)
- hsa-miR-6083 (MIRT554052)
- hsa-miR-548o-3p (MIRT554053)
- hsa-miR-1323 (MIRT554054)
- hsa-miR-3074-3p (MIRT554055)
- hsa-miR-362-3p (MIRT554056)
- hsa-miR-329-3p (MIRT554057)
- hsa-miR-448 (MIRT614736)
- hsa-miR-1224-5p (MIRT614737)
- hsa-miR-8064 (MIRT614738)
- hsa-miR-4751 (MIRT614739)
- hsa-miR-5004-5p (MIRT614740)
- hsa-miR-502-3p (MIRT614741)
- hsa-miR-501-3p (MIRT614742)
- hsa-miR-1197 (MIRT614743)
- hsa-miR-4643 (MIRT614744)
- hsa-miR-8485 (MIRT614745)
- hsa-miR-199a-3p (MIRT732843)
- hsa-let-7a-5p (MIRT735583)
- hsa-let-7b-5p (MIRT735608)
- hsa-let-7c-5p (MIRT735635)
- hsa-let-7d-5p (MIRT735663)
- hsa-let-7e-5p (MIRT735690)
- hsa-let-7f-5p (MIRT735721)
- hsa-let-7g-5p (MIRT735753)
- hsa-let-7i-5p (MIRT735781)
- hsa-miR-1247-3p (MIRT736399)
- hsa-miR-1273h-3p (MIRT736844)
- hsa-miR-1292-5p (MIRT737140)
- hsa-miR-17-3p (MIRT738009)
- hsa-miR-185-5p (MIRT738267)
- hsa-miR-1909-3p (MIRT738378)
- hsa-miR-191-5p (MIRT738561)
- hsa-miR-214-5p (MIRT739014)
- hsa-miR-2355-5p (MIRT739159)
- hsa-miR-2467-3p (MIRT739304)
- hsa-miR-3153 (MIRT740400)
- hsa-miR-3202 (MIRT741176)
- hsa-miR-328-5p (MIRT741301)
- hsa-miR-3616-3p (MIRT741684)
- hsa-miR-3665 (MIRT742066)
- hsa-miR-3678-3p (MIRT742171)
- hsa-miR-3911 (MIRT742851)
- hsa-miR-3927-3p (MIRT743029)
- hsa-miR-3934-5p (MIRT743107)
- hsa-miR-4261 (MIRT743477)
- hsa-miR-4306 (MIRT743924)
- hsa-miR-432-5p (MIRT744091)
- hsa-miR-4418 (MIRT744160)
- hsa-miR-4421 (MIRT744258)
- hsa-miR-4436b-3p (MIRT744480)
- hsa-miR-4443 (MIRT744595)
- hsa-miR-4446-3p (MIRT744627)
- hsa-miR-4458 (MIRT744769)
- hsa-miR-4476 (MIRT745051)
- hsa-miR-4481 (MIRT745127)
- hsa-miR-4489 (MIRT745262)
- hsa-miR-4492 (MIRT745301)
- hsa-miR-4498 (MIRT745382)
- hsa-miR-4500 (MIRT745489)
- hsa-miR-4524a-3p (MIRT745857)
- hsa-miR-4532 (MIRT745992)
- hsa-miR-4632-5p (MIRT746289)
- hsa-miR-4644 (MIRT746396)
- hsa-miR-4648 (MIRT746471)
- hsa-miR-4684-3p (MIRT746946)
- hsa-miR-4690-5p (MIRT747080)
- hsa-miR-4694-5p (MIRT747162)
- hsa-miR-4738-5p (MIRT748025)
- hsa-miR-4745-5p (MIRT748198)
- hsa-miR-4779 (MIRT748769)
- hsa-miR-5001-5p (MIRT749375)
- hsa-miR-5091 (MIRT749662)
- hsa-miR-509-3-5p (MIRT749677)
- hsa-miR-509-5p (MIRT749713)
- hsa-miR-5192 (MIRT749955)
- hsa-miR-5580-5p (MIRT750933)
- hsa-miR-5584-5p (MIRT750974)
- hsa-miR-5681a (MIRT751153)
- hsa-miR-5699-3p (MIRT751321)
- hsa-miR-593-3p (MIRT751590)
- hsa-miR-6070 (MIRT751673)
- hsa-miR-6132 (MIRT752335)
- hsa-miR-6165 (MIRT752520)
- hsa-miR-640 (MIRT752716)
- hsa-miR-6510-5p (MIRT753098)
- hsa-miR-6515-5p (MIRT753304)
- hsa-miR-664b-5p (MIRT753615)
- hsa-miR-6720-3p (MIRT753740)
- hsa-miR-6722-3p (MIRT753891)
- hsa-miR-6732-5p (MIRT754086)
- hsa-miR-6733-5p (MIRT754124)
- hsa-miR-6735-5p (MIRT754192)
- hsa-miR-6739-5p (MIRT754321)
- hsa-miR-6750-5p (MIRT754577)
- hsa-miR-6799-5p (MIRT756338)
- hsa-miR-6815-3p (MIRT756770)
- hsa-miR-6818-3p (MIRT756836)
- hsa-miR-6822-5p (MIRT756909)
- hsa-miR-6831-5p (MIRT757136)
- hsa-miR-6835-5p (MIRT757190)
- hsa-miR-6836-5p (MIRT757229)
- hsa-miR-6846-5p (MIRT757448)
- hsa-miR-6847-5p (MIRT757491)
- hsa-miR-6848-5p (MIRT757522)
- hsa-miR-6871-5p (MIRT758033)
- hsa-miR-6873-5p (MIRT758085)
- hsa-miR-6876-5p (MIRT758161)
- hsa-miR-6879-5p (MIRT758281)
- hsa-miR-6885-5p (MIRT758548)
- hsa-miR-6888-5p (MIRT758622)
- hsa-miR-6894-5p (MIRT758791)
- hsa-miR-6895-3p (MIRT758796)
- hsa-miR-7154-3p (MIRT759242)
- hsa-miR-7515 (MIRT759396)
- hsa-miR-762 (MIRT759517)
- hsa-miR-765 (MIRT759592)
- hsa-miR-766-5p (MIRT759661)
- hsa-miR-7843-5p (MIRT759781)
- hsa-miR-7847-3p (MIRT759870)
- hsa-miR-92b-5p (MIRT760675)
- hsa-miR-98-5p (MIRT760950)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for SOCS7
- Browse OriGene Inhibitory RNA Products For SOCS7
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SOCS7
Clone Products
- Applied Biological Materials (abm): Clones for SOCS7 - Select products 50% OFF >
- * SOCS7 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for SOCS7
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SOCS7
Cell Line Products
-
Horizon Cell Lines for SOCS7
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SOCS7 Gene
Localization for SOCS7 Gene
Subcellular locations from UniProtKB/Swiss-Prot for SOCS7 Gene
- Cytoplasm. Cell membrane. Peripheral membrane protein. Cytoplasmic side. Nucleus. Note=Mostly cytoplasmic, but shuttles between the cytoplasm and the nucleus. Rapidly relocalizes to the nucleus after UV irradiation. Cytoplasmic location depends upon SEPT7 presence.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| nucleus | 5 |
| cytosol | 5 |
| extracellular | 2 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| peroxisome | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| lysosome | 1 |
- Cytosol (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA | -- |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005829 | cytosol | IDA | -- |
| GO:0005886 | plasma membrane | IEA | -- |
| GO:0005942 | phosphatidylinositol 3-kinase complex | IBA | 21873635 |
Pathways & Interactions for SOCS7 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Prolactin Signaling Pathway | ||
| 2 | JAK-STAT signaling pathway | ||
Pathways by source for SOCS7 Gene
1 BioSystems pathway for SOCS7 Gene
2 KEGG pathways for SOCS7 Gene
UniProtKB/Swiss-Prot O14512-SOCS7_HUMAN
- Pathway: Protein modification; protein ubiquitination.
Interacting Proteins for SOCS7 Gene
Selected Interacting proteins:
O14512-SOCS7_HUMAN
ENSP00000482229
for SOCS7 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for SOCS7
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0008150 | biological_process | ND | -- |
| GO:0009968 | negative regulation of signal transduction | IEA | -- |
| GO:0016567 | protein ubiquitination | IEA | -- |
| GO:0035556 | intracellular signal transduction | IEA | -- |
| GO:0040008 | regulation of growth | IEA | -- |
No data available for SIGNOR curated interactions for SOCS7 Gene
Transcripts for SOCS7 Gene
mRNA/cDNA for SOCS7 Gene
- 1 REFSEQ mRNAs :
- 9 NCBI additional mRNA sequence :
- 5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000612932 8258 nts (view in UCSC)
- ENST00000613678 1827 nts (view in UCSC)
- ENST00000617360 2051 nts (view in UCSC)
- ENST00000617765 480 nts (view in UCSC)
- ENST00000665913 7978 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for SOCS7 - Select products 50% OFF >
- * SOCS7 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for SOCS7
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SOCS7
-
Santa Cruz Biotechnology (SCBT) CRISPR for SOCS7
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for SOCS7
- Browse OriGene Inhibitory RNA Products For SOCS7
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SOCS7
Clone Products
- Applied Biological Materials (abm): Clones for SOCS7 - Select products 50% OFF >
- * SOCS7 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for SOCS7
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SOCS7
Relevant External Links for SOCS7 Gene
- GeneLoc Exon Structure for
- SOCS7
Expression for SOCS7 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Testis (Reproductive System)
- Leydig Cells Testis Interstitium
mRNA differential expression in normal tissues according to GTEx for SOCS7 Gene
This gene is overexpressed in Testis (x17.9) and Brain - Cerebellar Hemisphere (x4.4).
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SOCS7
SOURCE GeneReport for Unigene cluster for SOCS7 Gene:
Hs.514132mRNA Expression by UniProt/SwissProt for SOCS7 Gene:
O14512-SOCS7_HUMAN
Tissue specificity:
Expressed in brain and leukocytes. Also in fetal lung fibroblasts and fetal brain.
Evidence on tissue expression from TISSUES for SOCS7 Gene
- Nervous system(4.8)
- Blood(2.3)
- Spleen(2.2)
- Heart(2.2)
- Liver(2.2)
- Kidney(2.1)
- Intestine(2.1)
- Muscle(2.1)
- Lymph node(2.1)
- Skin(2.1)
- Pancreas(2)
Primer Products
-
OriGene qPCR primer pairs for SOCS7
Gene Expression Assay Products
No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for SOCS7 Gene
Orthologs for SOCS7 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | SOCS7 30 |
|
||
| Cow (Bos Taurus) |
Mammalia | SOCS7 30 |
|
||
| Dog (Canis familiaris) |
Mammalia | SOCS7 30 |
|
||
| Rat (Rattus norvegicus) |
Mammalia | Socs7 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Socs7 30 17 |
|
||
| Chicken (Gallus gallus) |
Aves | SOCS7 30 |
|
||
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | socs7 30 |
|
||
| Str.2599 30 |
|
||||
| Zebrafish (Danio rerio) |
Actinopterygii | socs7 30 |
|
||
| Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.10743 30 |
|
- Species where no ortholog for SOCS7 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Lizard (Anolis carolinensis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Oppossum (Monodelphis domestica)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Platypus (Ornithorhynchus anatinus)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for SOCS7 Gene
- ENSEMBL:
- Gene Tree for SOCS7 (if available)
- TreeFam:
- Gene Tree for SOCS7 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for SOCS7: view image
Paralogs for SOCS7 Gene
Variants for SOCS7 Gene
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2758688 | CNV | gain+loss | 17122850 |
| esv33106 | CNV | gain | 17666407 |
| nsv1129385 | OTHER | inversion | 24896259 |
| nsv1146669 | OTHER | inversion | 26484159 |
| nsv2041 | CNV | insertion | 18451855 |
| nsv428341 | CNV | gain+loss | 18775914 |
| nsv469701 | CNV | loss | 16826518 |
Residual Variation Intolerance Score:
13% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
4.52;
64.71% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for SOCS7 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- SOCS7
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SOCS7 Gene
Disorders for SOCS7 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| uvulitis |
|
|
Search SOCS7 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for SOCS7
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for SOCS7 Gene
Publications for SOCS7 Gene
- Suppressor of cytokine signaling 7 inhibits prolactin, growth hormone, and leptin signaling by interacting with STAT5 or STAT3 and attenuating their nuclear translocation. (PMID: 15677474) Martens N … Gertler A (The Journal of biological chemistry 2005) 3 4 23
- Expression of SOCS genes in normal and leukemic human leukocytes stimulated by prolactin, growth hormone and cytokines. (PMID: 10969179) Dogusan Z … Hooghe R (Journal of neuroimmunology 2000) 3 4 23
- A novel ligand for an SH3 domain of the adaptor protein Nck bears an SH2 domain and nuclear signaling motifs. (PMID: 9344857) Matuoka K … Takenawa T (Biochemical and biophysical research communications 1997) 2 3 4
- Septins regulate actin organization and cell-cycle arrest through nuclear accumulation of NCK mediated by SOCS7. (PMID: 17803907) Kremer BE … Macara IG (Cell 2007) 3 4
- DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PMID: 16625196) Zody MC … Nusbaum C (Nature 2006) 3 4
ExternalLinks
Products for SOCS7 Gene
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for SOCS7
- Search Origene for MassSpec and Protein Over-expression Lysates for SOCS7
- Origene Custom Protein Services for SOCS7
- Origene shrna, sirna, and RNAi products in human, mouse, rat for SOCS7
- Browse OriGene Inhibitory RNA Products For SOCS7
- OriGene qPCR primer pairs for SOCS7
- OriGene CRISPR knockouts for SOCS7
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For SOCS7
- Sino Biological Human cDNA Clone for SOCS7
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for SOCS7
- Novus Biologicals proteins for SOCS7
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for SOCS7
- Abcam proteins for SOCS7
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Invitrogen Antibodies for SOCS7 (AFLGC-SOCS7)
- VectorBuilder Custom and pre-made DNA vectors for SOCS7 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for SOCS7 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for SOCS7 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for SOCS7 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for SOCS7
- antibodies-online: Show 40 available SOCS7 Antibodies ranked by validation data
- Compare Top SOCS7 Antibodies
- antibodies-online: Search results for available SOCS7 related products ranked by validation data
- antibodies-online: Search results for available SOCS7 related products ranked by validation data
- Santa Cruz Biotechnology (SCBT) Antibodies for SOCS7
- Search Santa Cruz Biotechnology (SCBT) for SOCS7 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for SOCS7
- Horizon Cell Lines for SOCS7
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SOCS7
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SOCS7
- Search GeneCopoeia for miRNA 3'UTR Target clone products for SOCS7
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SOCS7
- Boster Bio Antibodies for SOCS7
- Browse Boster Bio ELISA Kits
Sources for SOCS7 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB