Aliases for SOCS7 Gene
External Ids for SOCS7 Gene
Previous GeneCards Identifiers for SOCS7 Gene
GeneCards Summary for SOCS7 Gene
SOCS7 (Suppressor Of Cytokine Signaling 7) is a Protein Coding gene. Diseases associated with SOCS7 include Uvulitis. Among its related pathways are Prolactin Signaling Pathway and JAK-STAT signaling pathway. Gene Ontology (GO) annotations related to this gene include SH3 domain binding and protein kinase inhibitor activity. An important paralog of this gene is SOCS6.
UniProtKB/Swiss-Prot Summary for SOCS7 Gene
Regulates signaling cascades probably through protein ubiquitination and/or sequestration. Functions in insulin signaling and glucose homeostasis through IRS1 ubiquitination and subsequent proteasomal degradation. Inhibits also prolactin, growth hormone and leptin signaling by preventing STAT3 and STAT5 activation, sequestering them in the cytoplasm and reducing their binding to DNA. May be a substrate recognition component of a SCF-like E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity).