Aliases for SOCS7 Gene

Aliases for SOCS7 Gene

  • Suppressor Of Cytokine Signaling 7 2 3 4 5
  • NAP4 2 3 4
  • Nck, Ash And Phospholipase C Gamma-Binding Protein 3 4
  • Nck, Ash And Phospholipase C Binding Protein 2 3
  • NCK-Associated Protein 4 2 3
  • NCKAP4 2 3
  • SOCS-7 3 4
  • NAP-4 3 4
  • Nck-Associated Protein 4 4
  • SOCS7 5
  • SOCS6 4

External Ids for SOCS7 Gene

Previous GeneCards Identifiers for SOCS7 Gene

  • GC14P049305
  • GC14P053483
  • GC17P036869
  • GC17P033761
  • GC17P036508
  • GC17P032304
  • GC17P038353

Summaries for SOCS7 Gene

GeneCards Summary for SOCS7 Gene

SOCS7 (Suppressor Of Cytokine Signaling 7) is a Protein Coding gene. Diseases associated with SOCS7 include Uvulitis. Among its related pathways are Prolactin Signaling Pathway and JAK-STAT signaling pathway. Gene Ontology (GO) annotations related to this gene include SH3 domain binding and protein kinase inhibitor activity. An important paralog of this gene is SOCS6.

UniProtKB/Swiss-Prot Summary for SOCS7 Gene

  • Regulates signaling cascades probably through protein ubiquitination and/or sequestration. Functions in insulin signaling and glucose homeostasis through IRS1 ubiquitination and subsequent proteasomal degradation. Inhibits also prolactin, growth hormone and leptin signaling by preventing STAT3 and STAT5 activation, sequestering them in the cytoplasm and reducing their binding to DNA. May be a substrate recognition component of a SCF-like E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity).

Gene Wiki entry for SOCS7 Gene

Additional gene information for SOCS7 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SOCS7 Gene

Genomics for SOCS7 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for SOCS7 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J038350 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 600.7 +0.8 845 4.2 SP1 CREB1 GATAD2A PRDM10 ZNF629 TFE3 SOX13 IKZF1 NFKBIZ KDM1A SOCS7 piR-61505 GPR179 ARHGAP23 piR-33746
GH17J038507 Promoter/Enhancer 1.2 ENCODE CraniofacialAtlas 10.8 +157.4 157381 2.9 CTCF IKZF1 JUND MTA2 RBFOX2 PATZ1 REST RAD21 ZNF501 POLR2A SOCS7 piR-34105-003 piR-58327-004 ARHGAP23 SRCIN1
GH17J038323 Enhancer 0.9 FANTOM5 Ensembl ENCODE 12.6 -26.0 -26044 4.4 FOXA1 PRDM1 RFX1 CTBP1 RBM22 SPI1 ATF4 GABPA SSRP1 CEBPG SOCS7 MRPL45 TBC1D3 lnc-GPR179-1 piR-45035-087 GPR179
GH17J038483 Enhancer 1 Ensembl ENCODE 11.4 +133.2 133157 2.4 SP1 CTCF PRDM10 POLR2A BACH1 LARP7 ZNF143 PHF21A PKNOX1 REST MED1 ARHGAP23 SOCS7 SNORA21 CDK12 RPL23 piR-35871-004 piR-36428-004 SRCIN1
GH17J038320 Enhancer 0.8 Ensembl ENCODE 12 -30.9 -30940 1.6 FOXA1 CTBP1 CTCF ZNF217 SIN3A GATA3 DPF2 ELF1 ZNF687 ZBTB33 piR-45035-087 GPR179 SOCS7 MRPL45 NONHSAG021648.2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SOCS7 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SOCS7

Top Transcription factor binding sites by QIAGEN in the SOCS7 gene promoter:
  • ATF-2
  • c-Jun
  • c-Myb
  • Egr-2
  • GATA-1
  • MAZR
  • POU2F1
  • POU2F1a
  • SEF-1 (1)
  • STAT3

Genomic Locations for SOCS7 Gene

Genomic Locations for SOCS7 Gene
chr17:38,351,844-38,405,593
(GRCh38/hg38)
Size:
53,750 bases
Orientation:
Plus strand
chr17:36,508,007-36,561,846
(GRCh37/hg19)
Size:
53,840 bases
Orientation:
Plus strand

Genomic View for SOCS7 Gene

Genes around SOCS7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SOCS7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SOCS7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SOCS7 Gene

Proteins for SOCS7 Gene

  • Protein details for SOCS7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14512-SOCS7_HUMAN
    Recommended name:
    Suppressor of cytokine signaling 7
    Protein Accession:
    O14512
    Secondary Accessions:
    • A2VCU2
    • Q0IJ63

    Protein attributes for SOCS7 Gene

    Size:
    581 amino acids
    Molecular mass:
    62969 Da
    Quaternary structure:
    • Interacts with phosphorylated IRS4 and PIK3R1 (By similarity). Interacts, via the third proline-rich region, with the second SH3 domain of the adapter protein NCK1. Also interacts with GRB2, INSR, IRS1, PLCG1, SORBS3/vinexin, and phosphorylated STAT3 and STAT5. Interacts with SEPT6.
    SequenceCaution:
    • Sequence=AAI28608.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. The N-terminus may be contaminated with vector sequence.; Evidence={ECO:0000305}; Sequence=BAA22432.1; Type=Erroneous termination; Note=Extended C-terminus.; Evidence={ECO:0000305};

    Alternative splice isoforms for SOCS7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SOCS7 Gene

Post-translational modifications for SOCS7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SOCS7 Gene

No data available for DME Specific Peptides for SOCS7 Gene

Domains & Families for SOCS7 Gene

Gene Families for SOCS7 Gene

Protein Domains for SOCS7 Gene

InterPro:
Blocks:
  • SOCS protein, C-terminal
ProtoNet:

Suggested Antigen Peptide Sequences for SOCS7 Gene

GenScript: Design optimal peptide antigens:
  • Nck-associated protein 4 (SOCS7_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O14512

UniProtKB/Swiss-Prot:

SOCS7_HUMAN :
  • The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes (By similarity). It is required for IRS1 ubiquitination and subsequent proteasomal degradation.
Domain:
  • The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes (By similarity). It is required for IRS1 ubiquitination and subsequent proteasomal degradation.
genes like me logo Genes that share domains with SOCS7: view

Function for SOCS7 Gene

Molecular function for SOCS7 Gene

UniProtKB/Swiss-Prot Function:
Regulates signaling cascades probably through protein ubiquitination and/or sequestration. Functions in insulin signaling and glucose homeostasis through IRS1 ubiquitination and subsequent proteasomal degradation. Inhibits also prolactin, growth hormone and leptin signaling by preventing STAT3 and STAT5 activation, sequestering them in the cytoplasm and reducing their binding to DNA. May be a substrate recognition component of a SCF-like E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity).
UniProtKB/Swiss-Prot Induction:
By IL6/interleukin-6, prolactin and growth hormone.

Phenotypes From GWAS Catalog for SOCS7 Gene

Gene Ontology (GO) - Molecular Function for SOCS7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 20598684
GO:0017124 SH3 domain binding NAS 9344857
GO:0046935 1-phosphatidylinositol-3-kinase regulator activity IBA 21873635
genes like me logo Genes that share ontologies with SOCS7: view
genes like me logo Genes that share phenotypes with SOCS7: view

Animal Models for SOCS7 Gene

MGI Knock Outs for SOCS7:

Animal Model Products

CRISPR Products

miRNA for SOCS7 Gene

miRTarBase miRNAs that target SOCS7

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SOCS7

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SOCS7 Gene

Localization for SOCS7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SOCS7 Gene

Cytoplasm. Cell membrane. Peripheral membrane protein. Cytoplasmic side. Nucleus. Note=Mostly cytoplasmic, but shuttles between the cytoplasm and the nucleus. Rapidly relocalizes to the nucleus after UV irradiation. Cytoplasmic location depends upon SEPT7 presence.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SOCS7 gene
Compartment Confidence
plasma membrane 5
nucleus 5
cytosol 5
extracellular 2
cytoskeleton 2
mitochondrion 2
peroxisome 1
endoplasmic reticulum 1
endosome 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for SOCS7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IDA --
GO:0005886 plasma membrane IEA --
GO:0005942 phosphatidylinositol 3-kinase complex IBA 21873635
genes like me logo Genes that share ontologies with SOCS7: view

Pathways & Interactions for SOCS7 Gene

genes like me logo Genes that share pathways with SOCS7: view

Pathways by source for SOCS7 Gene

1 BioSystems pathway for SOCS7 Gene

UniProtKB/Swiss-Prot O14512-SOCS7_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for SOCS7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0009968 negative regulation of signal transduction IEA --
GO:0016567 protein ubiquitination IEA --
GO:0035556 intracellular signal transduction IEA --
GO:0040008 regulation of growth IEA --
genes like me logo Genes that share ontologies with SOCS7: view

No data available for SIGNOR curated interactions for SOCS7 Gene

Drugs & Compounds for SOCS7 Gene

No Compound Related Data Available

Transcripts for SOCS7 Gene

mRNA/cDNA for SOCS7 Gene

1 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SOCS7

Alternative Splicing Database (ASD) splice patterns (SP) for SOCS7 Gene

No ASD Table

Relevant External Links for SOCS7 Gene

GeneLoc Exon Structure for
SOCS7

Expression for SOCS7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SOCS7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SOCS7 Gene

This gene is overexpressed in Testis (x17.9) and Brain - Cerebellar Hemisphere (x4.4).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SOCS7

SOURCE GeneReport for Unigene cluster for SOCS7 Gene:

Hs.514132

mRNA Expression by UniProt/SwissProt for SOCS7 Gene:

O14512-SOCS7_HUMAN
Tissue specificity: Expressed in brain and leukocytes. Also in fetal lung fibroblasts and fetal brain.

Evidence on tissue expression from TISSUES for SOCS7 Gene

  • Nervous system(4.8)
  • Blood(2.3)
  • Spleen(2.2)
  • Heart(2.2)
  • Liver(2.2)
  • Kidney(2.1)
  • Intestine(2.1)
  • Muscle(2.1)
  • Lymph node(2.1)
  • Skin(2.1)
  • Pancreas(2)
genes like me logo Genes that share expression patterns with SOCS7: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for SOCS7 Gene

Orthologs for SOCS7 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SOCS7 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia SOCS7 30
  • 99.91 (n)
Cow
(Bos Taurus)
Mammalia SOCS7 30
  • 94.57 (n)
Dog
(Canis familiaris)
Mammalia SOCS7 30
  • 94 (n)
Rat
(Rattus norvegicus)
Mammalia Socs7 30
  • 91.58 (n)
Mouse
(Mus musculus)
Mammalia Socs7 30 17
  • 91.12 (n)
Chicken
(Gallus gallus)
Aves SOCS7 30
  • 83.97 (n)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia socs7 30
  • 74 (n)
Str.2599 30
Zebrafish
(Danio rerio)
Actinopterygii socs7 30
  • 68.09 (n)
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10743 30
Species where no ortholog for SOCS7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for SOCS7 Gene

ENSEMBL:
Gene Tree for SOCS7 (if available)
TreeFam:
Gene Tree for SOCS7 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SOCS7: view image

Paralogs for SOCS7 Gene

Paralogs for SOCS7 Gene

(1) SIMAP similar genes for SOCS7 Gene using alignment to 3 proteins:

  • SOCS7_HUMAN
  • J3KSN6_HUMAN
  • J9JID8_HUMAN
genes like me logo Genes that share paralogs with SOCS7: view

Variants for SOCS7 Gene

Additional dbSNP identifiers (rs#s) for SOCS7 Gene

Structural Variations from Database of Genomic Variants (DGV) for SOCS7 Gene

Variant ID Type Subtype PubMed ID
esv2758688 CNV gain+loss 17122850
esv33106 CNV gain 17666407
nsv1129385 OTHER inversion 24896259
nsv1146669 OTHER inversion 26484159
nsv2041 CNV insertion 18451855
nsv428341 CNV gain+loss 18775914
nsv469701 CNV loss 16826518

Variation tolerance for SOCS7 Gene

Residual Variation Intolerance Score: 13% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.52; 64.71% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SOCS7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SOCS7

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SOCS7 Gene

Disorders for SOCS7 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SOCS7 Gene - From: DISEASES

Disorder Aliases PubMed IDs
uvulitis
  • acute uvulitis
- elite association - COSMIC cancer census association via MalaCards
Search SOCS7 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for SOCS7

genes like me logo Genes that share disorders with SOCS7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SOCS7 Gene

Publications for SOCS7 Gene

  1. Suppressor of cytokine signaling 7 inhibits prolactin, growth hormone, and leptin signaling by interacting with STAT5 or STAT3 and attenuating their nuclear translocation. (PMID: 15677474) Martens N … Gertler A (The Journal of biological chemistry 2005) 3 4 23
  2. Expression of SOCS genes in normal and leukemic human leukocytes stimulated by prolactin, growth hormone and cytokines. (PMID: 10969179) Dogusan Z … Hooghe R (Journal of neuroimmunology 2000) 3 4 23
  3. A novel ligand for an SH3 domain of the adaptor protein Nck bears an SH2 domain and nuclear signaling motifs. (PMID: 9344857) Matuoka K … Takenawa T (Biochemical and biophysical research communications 1997) 2 3 4
  4. Septins regulate actin organization and cell-cycle arrest through nuclear accumulation of NCK mediated by SOCS7. (PMID: 17803907) Kremer BE … Macara IG (Cell 2007) 3 4
  5. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PMID: 16625196) Zody MC … Nusbaum C (Nature 2006) 3 4

Products for SOCS7 Gene

Sources for SOCS7 Gene