Aliases for SOCS6 Gene
External Ids for SOCS6 Gene
Previous HGNC Symbols for SOCS6 Gene
Previous GeneCards Identifiers for SOCS6 Gene
The protein encoded by this gene contains a SH2 domain and a CIS homolog domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by GM-CSF and EPO in hematopoietic cells. A high expression level of this gene was found in factor-independent chronic myelogenous leukemia (CML) and erythroleukemia (HEL) cell lines. [provided by RefSeq, Jul 2008]
GeneCards Summary for SOCS6 Gene
SOCS6 (Suppressor Of Cytokine Signaling 6) is a Protein Coding gene. Diseases associated with SOCS6 include Somatization Disorder and Borderline Glaucoma. Among its related pathways are RET signaling and IL10 Signaling Pathway. Gene Ontology (GO) annotations related to this gene include protein kinase inhibitor activity. An important paralog of this gene is SOCS7.
UniProtKB/Swiss-Prot Summary for SOCS6 Gene
SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Regulates KIT degradation by ubiquitination of the tyrosine-phosphorylated receptor.