Aliases for SOCS6 Gene
External Ids for SOCS6 Gene
Previous HGNC Symbols for SOCS6 Gene
Previous GeneCards Identifiers for SOCS6 Gene
The protein encoded by this gene contains a SH2 domain and a CIS homolog domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by GM-CSF and EPO in hematopoietic cells. A high expression level of this gene was found in factor-independent chronic myelogenous leukemia (CML) and erythroleukemia (HEL) cell lines. [provided by RefSeq, Jul 2008]
GeneCards Summary for SOCS6 Gene
SOCS6 (Suppressor Of Cytokine Signaling 6) is a Protein Coding gene. Diseases associated with SOCS6 include Somatization Disorder and Articulation Disorder. Among its related pathways are Signaling by GPCR and Common Cytokine Receptor Gamma-Chain Family Signaling Pathways. Gene Ontology (GO) annotations related to this gene include protein kinase inhibitor activity. An important paralog of this gene is SOCS7.
UniProtKB/Swiss-Prot Summary for SOCS6 Gene
SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Regulates KIT degradation by ubiquitination of the tyrosine-phosphorylated receptor.