Aliases for SOCS5 Gene
External Ids for SOCS5 Gene
Previous GeneCards Identifiers for SOCS5 Gene
The protein encoded by this gene contains a SH2 domain and a SOCS BOX domain. The protein thus belongs to the suppressor of cytokine signaling (SOCS) family, also known as STAT-induced STAT inhibitor (SSI) protein family. SOCS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The specific function of this protein has not yet been determined. Two alternatively spliced transcript variants encoding an identical protein have been reported. [provided by RefSeq, Jul 2008]
GeneCards Summary for SOCS5 Gene
SOCS5 (Suppressor Of Cytokine Signaling 5) is a Protein Coding gene. Diseases associated with SOCS5 include Allergic Conjunctivitis and Conjunctivitis. Among its related pathways are IL10 Signaling Pathway and IL4-mediated signaling events. Gene Ontology (GO) annotations related to this gene include receptor tyrosine kinase binding and epidermal growth factor receptor binding. An important paralog of this gene is SOCS4.
UniProtKB/Swiss-Prot Summary for SOCS5 Gene
SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Inhibits for instance EGF signaling by mediating the degradation of the EGF receptor/EGFR. Involved in the regulation of T-helper cell differentiation by inhibiting of the IL4 signaling pathway which promotes differentiation into the Th2 phenotype. Can also partially inhibit IL6 and LIF signaling.