The protein encoded by this gene contains a SH2 domain and a SOCS BOX domain. The protein thus belongs to the suppressor of cytokine signaling (SOCS) family, also known as STAT-induced STAT inhibitor (SSI) protein family. SOCS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The specific function of this protein has not yet been deter... See more...

Aliases for SOCS5 Gene

Aliases for SOCS5 Gene

  • Suppressor Of Cytokine Signaling 5 2 3 4 5
  • SOCS-5 2 3 4
  • CISH6 2 3 4
  • CIS6 2 3 4
  • Cytokine-Inducible SH2-Containing Protein 5 3 4
  • Cytokine-Inducible SH2 Protein 6 3 4
  • KIAA0671 2 4
  • Cish5 2 3
  • CIS-6 3 4
  • SOCS5 5
  • CISH5 4

External Ids for SOCS5 Gene

Previous GeneCards Identifiers for SOCS5 Gene

  • GC02P046943
  • GC02P047094
  • GC02P046900
  • GC02P046837
  • GC02P046926
  • GC02P046663

Summaries for SOCS5 Gene

Entrez Gene Summary for SOCS5 Gene

  • The protein encoded by this gene contains a SH2 domain and a SOCS BOX domain. The protein thus belongs to the suppressor of cytokine signaling (SOCS) family, also known as STAT-induced STAT inhibitor (SSI) protein family. SOCS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The specific function of this protein has not yet been determined. Two alternatively spliced transcript variants encoding an identical protein have been reported. [provided by RefSeq, Jul 2008]

GeneCards Summary for SOCS5 Gene

SOCS5 (Suppressor Of Cytokine Signaling 5) is a Protein Coding gene. Diseases associated with SOCS5 include Allergic Conjunctivitis and Conjunctivitis. Among its related pathways are Development IGF-1 receptor signaling and IL-2 Pathway. Gene Ontology (GO) annotations related to this gene include receptor tyrosine kinase binding and epidermal growth factor receptor binding. An important paralog of this gene is SOCS4.

UniProtKB/Swiss-Prot Summary for SOCS5 Gene

  • SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Inhibits for instance EGF signaling by mediating the degradation of the EGF receptor/EGFR. Involved in the regulation of T-helper cell differentiation by inhibiting of the IL4 signaling pathway which promotes differentiation into the Th2 phenotype. Can also partially inhibit IL6 and LIF signaling.

Gene Wiki entry for SOCS5 Gene

Additional gene information for SOCS5 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SOCS5 Gene

Genomics for SOCS5 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for SOCS5 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SOCS5 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SOCS5

Top Transcription factor binding sites by QIAGEN in the SOCS5 gene promoter:
  • NF-AT
  • NF-AT1
  • NF-AT2
  • NF-AT3
  • NF-AT4
  • PPAR-gamma2

Genomic Locations for SOCS5 Gene

Genomic Locations for SOCS5 Gene
chr2:46,698,952-46,780,245
(GRCh38/hg38)
Size:
81,294 bases
Orientation:
Plus strand
chr2:46,926,091-46,990,268
(GRCh37/hg19)
Size:
64,178 bases
Orientation:
Plus strand

Genomic View for SOCS5 Gene

Genes around SOCS5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SOCS5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SOCS5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SOCS5 Gene

Proteins for SOCS5 Gene

  • Protein details for SOCS5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75159-SOCS5_HUMAN
    Recommended name:
    Suppressor of cytokine signaling 5
    Protein Accession:
    O75159
    Secondary Accessions:
    • Q53SD4
    • Q8IYZ4

    Protein attributes for SOCS5 Gene

    Size:
    536 amino acids
    Molecular mass:
    61246 Da
    Quaternary structure:
    • Interacts with IL4R; inhibits IL4 signaling (By similarity). Interacts with EGFR. Interacts with ELOB and ELOC; mediates EGFR ubiquitination and degradation.
    SequenceCaution:
    • Sequence=BAA31646.2; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for SOCS5 Gene

Post-translational modifications for SOCS5 Gene

Other Protein References for SOCS5 Gene

No data available for DME Specific Peptides for SOCS5 Gene

Domains & Families for SOCS5 Gene

Gene Families for SOCS5 Gene

Protein Domains for SOCS5 Gene

InterPro:
Blocks:
  • SOCS protein, C-terminal
ProtoNet:

Suggested Antigen Peptide Sequences for SOCS5 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ75616, highly similar to Homo sapiens suppressor of cytokine signaling 5 (SOCS5), transcript variant 1, mRNA (Q53SD4_HUMAN)
  • Cytokine-inducible SH2-containing protein 5 (SOCS5_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O75159

UniProtKB/Swiss-Prot:

SOCS5_HUMAN :
  • The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes.
Domain:
  • The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes.
genes like me logo Genes that share domains with SOCS5: view

Function for SOCS5 Gene

Molecular function for SOCS5 Gene

UniProtKB/Swiss-Prot Function:
SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Inhibits for instance EGF signaling by mediating the degradation of the EGF receptor/EGFR. Involved in the regulation of T-helper cell differentiation by inhibiting of the IL4 signaling pathway which promotes differentiation into the Th2 phenotype. Can also partially inhibit IL6 and LIF signaling.
UniProtKB/Swiss-Prot Induction:
Up-regulated by EGF (at protein level).

Phenotypes From GWAS Catalog for SOCS5 Gene

Gene Ontology (GO) - Molecular Function for SOCS5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005154 epidermal growth factor receptor binding IEA --
GO:0005515 protein binding IPI 15590694
GO:0030971 receptor tyrosine kinase binding IPI 15590694
GO:0046935 1-phosphatidylinositol-3-kinase regulator activity IBA 21873635
genes like me logo Genes that share ontologies with SOCS5: view
genes like me logo Genes that share phenotypes with SOCS5: view

Animal Models for SOCS5 Gene

MGI Knock Outs for SOCS5:

Animal Model Products

CRISPR Products

miRNA for SOCS5 Gene

miRTarBase miRNAs that target SOCS5

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SOCS5

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SOCS5 Gene

Localization for SOCS5 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SOCS5 gene
Compartment Confidence
cytosol 5
nucleus 4
plasma membrane 3
extracellular 2
cytoskeleton 2
mitochondrion 2
peroxisome 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SOCS5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0005942 phosphatidylinositol 3-kinase complex IBA 21873635
genes like me logo Genes that share ontologies with SOCS5: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for SOCS5 Gene

Pathways & Interactions for SOCS5 Gene

PathCards logo

SuperPathways for SOCS5 Gene

SuperPathway Contained pathways
1 IL-2 Pathway
.54
.49
.34
2 PEDF Induced Signaling
.61
.47
3 TGF-Beta Pathway
.57
.41
4 Cytokine Signaling in Immune system
5 Development IGF-1 receptor signaling
.38
genes like me logo Genes that share pathways with SOCS5: view

Pathways by source for SOCS5 Gene

1 GeneGo (Thomson Reuters) pathway for SOCS5 Gene
  • Immune response IL-4 signaling pathway
8 Qiagen pathways for SOCS5 Gene
  • Growth Hormone Signaling
  • IL-4 Pathway
  • IL-6 Pathway
  • IL-9 Pathway
  • JAK-STAT Pathway

UniProtKB/Swiss-Prot O75159-SOCS5_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for SOCS5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007173 epidermal growth factor receptor signaling pathway IEA --
GO:0007175 negative regulation of epidermal growth factor-activated receptor activity IDA 15590694
GO:0007259 JAK-STAT cascade IEA --
GO:0009968 negative regulation of signal transduction NAS 10773671
GO:0016567 protein ubiquitination IEA --
genes like me logo Genes that share ontologies with SOCS5: view

No data available for SIGNOR curated interactions for SOCS5 Gene

Drugs & Compounds for SOCS5 Gene

No Compound Related Data Available

Transcripts for SOCS5 Gene

mRNA/cDNA for SOCS5 Gene

2 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SOCS5

Alternative Splicing Database (ASD) splice patterns (SP) for SOCS5 Gene

No ASD Table

Relevant External Links for SOCS5 Gene

GeneLoc Exon Structure for
SOCS5

Expression for SOCS5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SOCS5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SOCS5 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SOCS5

SOURCE GeneReport for Unigene cluster for SOCS5 Gene:

Hs.468426

Evidence on tissue expression from TISSUES for SOCS5 Gene

  • Nervous system(4.8)
  • Spleen(2.7)
  • Liver(2.6)
  • Heart(2.5)
  • Muscle(2.3)
  • Blood(2.3)
  • Kidney(2.3)
  • Lymph node(2.3)
  • Bone marrow(2.3)
  • Intestine(2.3)
  • Lung(2.2)
  • Adrenal gland(2.2)
  • Skin(2.2)
genes like me logo Genes that share expression patterns with SOCS5: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SOCS5 Gene

Orthologs for SOCS5 Gene

This gene was present in the common ancestor of animals.

Orthologs for SOCS5 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia SOCS5 30 31
  • 99.69 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia SOCS5 30 31
  • 92.72 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia SOCS5 30 31
  • 92.29 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia SOCS5 31
  • 92 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Socs5 30 17 31
  • 87.56 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Socs5 30
  • 87.38 (n)
Chicken
(Gallus gallus)
Aves SOCS5 30 31
  • 81.65 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia SOCS5 31
  • 86 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia socs5 30
  • 74.03 (n)
Str.4500 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.11517 30
Zebrafish
(Danio rerio)
Actinopterygii socs5b 30 31
  • 64.96 (n)
OneToMany
socs5a 31
  • 63 (a)
OneToMany
socs9 31
  • 51 (a)
OneToMany
Fruit Fly
(Drosophila melanogaster)
Insecta Socs36E 31 32
  • 26 (a)
OneToMany
Species where no ortholog for SOCS5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for SOCS5 Gene

ENSEMBL:
Gene Tree for SOCS5 (if available)
TreeFam:
Gene Tree for SOCS5 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SOCS5: view image

Paralogs for SOCS5 Gene

Paralogs for SOCS5 Gene

(2) SIMAP similar genes for SOCS5 Gene using alignment to 1 proteins:

  • SOCS5_HUMAN
genes like me logo Genes that share paralogs with SOCS5: view

Variants for SOCS5 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SOCS5 Gene

SNP ID Clinical significance and condition Chr 02 pos Variation AA Info Type
711818 Benign: not provided 46,759,670(+) C/A SYNONYMOUS_VARIANT
720047 Benign: not provided 46,758,587(+) C/T SYNONYMOUS_VARIANT
784983 Benign: not provided 46,760,006(+) C/T SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for SOCS5 Gene

Structural Variations from Database of Genomic Variants (DGV) for SOCS5 Gene

Variant ID Type Subtype PubMed ID
esv25338 CNV loss 19812545
esv2578626 CNV insertion 19546169
esv2639866 CNV deletion 19546169
esv2760650 CNV loss 21179565
esv3590615 CNV loss 21293372
nsv1013079 CNV loss 25217958
nsv1072938 CNV deletion 25765185
nsv1126548 CNV deletion 24896259
nsv961404 CNV duplication 23825009

Variation tolerance for SOCS5 Gene

Residual Variation Intolerance Score: 6.79% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.81; 16.93% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SOCS5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SOCS5

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SOCS5 Gene

Disorders for SOCS5 Gene

MalaCards: The human disease database

(2) MalaCards diseases for SOCS5 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
allergic conjunctivitis
  • conjunctivitis allergic
conjunctivitis
  • madras eye
- elite association - COSMIC cancer census association via MalaCards
Search SOCS5 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for SOCS5

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with SOCS5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SOCS5 Gene

Publications for SOCS5 Gene

  1. Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S … Poustka A (Genome research 2001) 2 3 4
  2. Cloning and expression of CIS6, chromosome assignment to 3p22 and 2p21 by in situ hybridization. (PMID: 10773671) Magrangeas F … Minvielle S (Cytogenetics and cell genetics 2000) 3 4 23
  3. Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9734811) Ishikawa K … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1998) 2 3 4
  4. Genome-wide association study of smoking behaviours in patients with COPD. (PMID: 21685187) Siedlinski M … ECLIPSE Investigators (Thorax 2011) 3 41
  5. A multiplex MALDI-TOF MS approach facilitates genotyping of DNA from formalin-fixed paraffin-embedded tumour specimens. (PMID: 20802378) Horn H … Schaeffeler E (Pharmacogenetics and genomics 2010) 3 41

Products for SOCS5 Gene

  • Signalway Proteins for SOCS5

Sources for SOCS5 Gene