Aliases for SOCS4 Gene
External Ids for SOCS4 Gene
Previous HGNC Symbols for SOCS4 Gene
Previous GeneCards Identifiers for SOCS4 Gene
The protein encoded by this gene contains a SH2 domain and a SOCS BOX domain. The protein thus belongs to the suppressor of cytokine signaling (SOCS), also known as STAT-induced STAT inhibitor (SSI), protein family. SOCS family members are known to be cytokine-inducible negative regulators of cytokine signaling. Two alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for SOCS4 Gene
SOCS4 (Suppressor Of Cytokine Signaling 4) is a Protein Coding gene. Diseases associated with SOCS4 include Borderline Glaucoma and Endometrial Stromal Sarcoma. Among its related pathways are IL-2 Pathway and PEDF Induced Signaling. Gene Ontology (GO) annotations related to this gene include protein kinase inhibitor activity. An important paralog of this gene is SOCS5.
UniProtKB/Swiss-Prot Summary for SOCS4 Gene
SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. Substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Inhibits EGF signaling by mediating the degradation of the Tyr-phosphorylated EGF receptor/EGFR.