SOCS4 Gene (Protein Coding)

Suppressor Of Cytokine Signaling 4

GC14P055027
GIFtS:
38
The protein encoded by this gene contains a SH2 domain and a SOCS BOX domain. The protein thus belongs to the suppressor of cytokine signaling (SOCS), also known as STAT-induced STAT inhibitor (SSI), protein family. SOCS family members are known to be cytokine-inducible negative regulators of cytokine signaling. Two alternatively spliced transcript variants encoding the same pr... See more...

Aliases for SOCS4 Gene

Aliases for SOCS4 Gene

  • Suppressor Of Cytokine Signaling 4 2 3 4 5
  • Suppressor Of Cytokine Signaling 7 2 3 4
  • SOCS-4 3 4
  • SOCS-7 3 4
  • SOCS7 3 4
  • SH2 Domain Containing SOCS Box Protein 3
  • SOCS4 5

External Ids for SOCS4 Gene

Previous HGNC Symbols for SOCS4 Gene

  • SOCS7

Previous GeneCards Identifiers for SOCS4 Gene

  • GC14P052833
  • GC18P068015
  • GC18P067741
  • GC18P066105
  • GC14P053484
  • GC14P054563
  • GC14P055493
  • GC14P035656

Summaries for SOCS4 Gene

Entrez Gene Summary for SOCS4 Gene

  • The protein encoded by this gene contains a SH2 domain and a SOCS BOX domain. The protein thus belongs to the suppressor of cytokine signaling (SOCS), also known as STAT-induced STAT inhibitor (SSI), protein family. SOCS family members are known to be cytokine-inducible negative regulators of cytokine signaling. Two alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for SOCS4 Gene

SOCS4 (Suppressor Of Cytokine Signaling 4) is a Protein Coding gene. Diseases associated with SOCS4 include Borderline Glaucoma and Endometrial Stromal Sarcoma. Among its related pathways are IL10 Signaling Pathway and PEDF Induced Signaling. Gene Ontology (GO) annotations related to this gene include protein kinase inhibitor activity. An important paralog of this gene is SOCS5.

UniProtKB/Swiss-Prot Summary for SOCS4 Gene

  • SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. Substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Inhibits EGF signaling by mediating the degradation of the Tyr-phosphorylated EGF receptor/EGFR.

Additional gene information for SOCS4 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SOCS4 Gene

Genomics for SOCS4 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for SOCS4 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SOCS4 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SOCS4

Top Transcription factor binding sites by QIAGEN in the SOCS4 gene promoter:
  • AML1a
  • AREB6
  • CREB
  • Ik-1
  • POU3F2
  • POU3F2 (N-Oct-5a)
  • POU3F2 (N-Oct-5b)
  • SEF-1 (1)
  • STAT3

Genomic Locations for SOCS4 Gene

Latest Assembly
chr14:55,027,131-55,049,489
(GRCh38/hg38)
Size:
22,359 bases
Orientation:
Plus strand

Previous Assembly
chr14:55,493,954-55,516,207
(GRCh37/hg19 by Entrez Gene)
Size:
22,254 bases
Orientation:
Plus strand

chr14:55,493,948-55,516,206
(GRCh37/hg19 by Ensembl)
Size:
22,259 bases
Orientation:
Plus strand

Genomic View for SOCS4 Gene

Genes around SOCS4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SOCS4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SOCS4 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for SOCS4 Gene

Proteins for SOCS4 Gene

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  • Protein details for SOCS4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WXH5-SOCS4_HUMAN
    Recommended name:
    Suppressor of cytokine signaling 4
    Protein Accession:
    Q8WXH5

    Protein attributes for SOCS4 Gene

    Size:
    440 amino acids
    Molecular mass:
    50623 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for SOCS4 Gene

neXtProt entry for SOCS4 Gene

Post-translational modifications for SOCS4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SOCS4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SOCS4 Gene

Domains & Families for SOCS4 Gene

Gene Families for SOCS4 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for SOCS4 Gene

InterPro:
Blocks:
  • SOCS protein, C-terminal

Suggested Antigen Peptide Sequences for SOCS4 Gene

GenScript: Design optimal peptide antigens:
  • Suppressor of cytokine signaling 7 (SOCS4_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8WXH5

UniProtKB/Swiss-Prot:

SOCS4_HUMAN :
  • The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes.
Domain:
  • The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes.
genes like me logo Genes that share domains with SOCS4: view

Function for SOCS4 Gene

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  4. Inhibitory RNAs for research
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  6. Cell Lines for research

Molecular function for SOCS4 Gene

UniProtKB/Swiss-Prot Function:
SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. Substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Inhibits EGF signaling by mediating the degradation of the Tyr-phosphorylated EGF receptor/EGFR.
UniProtKB/Swiss-Prot Induction:
Up-regulated by EGF.

Phenotypes From GWAS Catalog for SOCS4 Gene

Gene Ontology (GO) - Molecular Function for SOCS4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25814554
GO:0046935 1-phosphatidylinositol-3-kinase regulator activity IBA 21873635
genes like me logo Genes that share ontologies with SOCS4: view
genes like me logo Genes that share phenotypes with SOCS4: view

Animal Models for research

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SOCS4

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SOCS4 Gene

Localization for SOCS4 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SOCS4 gene
Compartment Confidence
nucleus 4
cytosol 3
plasma membrane 2
extracellular 2
cytoskeleton 2
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SOCS4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005942 phosphatidylinositol 3-kinase complex IBA 21873635
genes like me logo Genes that share ontologies with SOCS4: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for SOCS4 Gene

Pathways & Interactions for SOCS4 Gene

PathCards logo

SuperPathways for SOCS4 Gene

SuperPathway Contained pathways
1 IL-2 Pathway
Prolactin Signaling
.54
Growth Hormone Signaling
.49
IL-4 Pathway
.34
2 Type II diabetes mellitus
Type II diabetes mellitus
.35
Type II diabetes mellitus
.33
3 PEDF Induced Signaling
IL-6 Pathway
.61
STAT3 Pathway
.47
4 TGF-Beta Pathway
JAK-STAT Pathway
.57
SOCS Pathway
.40
5 Regulation of lipid metabolism Insulin signaling-generic cascades
Insulin signaling pathway
.32
genes like me logo Genes that share pathways with SOCS4: view

Pathways by source for SOCS4 Gene

1 Sino Biological pathway for SOCS4 Gene
1 BioSystems pathway for SOCS4 Gene
7 Qiagen pathways for SOCS4 Gene
  • Growth Hormone Signaling
  • IL-4 Pathway
  • IL-6 Pathway
  • JAK-STAT Pathway
  • Prolactin Signaling

UniProtKB/Swiss-Prot Q8WXH5-SOCS4_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for SOCS4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007175 negative regulation of epidermal growth factor-activated receptor activity IDA 15590694
GO:0009968 negative regulation of signal transduction IEA --
GO:0016567 protein ubiquitination IEA --
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process IEA --
GO:0035556 intracellular signal transduction IEA --
genes like me logo Genes that share ontologies with SOCS4: view

No data available for SIGNOR curated interactions for SOCS4 Gene

Drugs & Compounds for SOCS4 Gene

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  1. Drug products for research
No Compound Related Data Available

Transcripts for SOCS4 Gene

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mRNA/cDNA for SOCS4 Gene

2 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SOCS4

Alternative Splicing Database (ASD) splice patterns (SP) for SOCS4 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b
SP1:
SP2: -

Relevant External Links for SOCS4 Gene

GeneLoc Exon Structure for
SOCS4

Expression for SOCS4 Gene

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  1. Primer products for research
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mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SOCS4 Gene

mRNA expression in normal human tissues for SOCS4 Gene
mRNA expression by GTEx for SOCS4 GenemRNA expression by BioGPS for SOCS4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SOCS4

SOURCE GeneReport for Unigene cluster for SOCS4 Gene:

Hs.744302

Evidence on tissue expression from TISSUES for SOCS4 Gene

  • Liver(2.5)
  • Spleen(2.4)
  • Nervous system(2.4)
  • Intestine(2.2)
  • Bone marrow(2.2)
  • Lymph node(2.2)
  • Kidney(2.2)
  • Heart(2.1)
  • Blood(2)
genes like me logo Genes that share expression patterns with SOCS4: view

Primer products for research

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SOCS4 Gene

Orthologs for SOCS4 Gene

This gene was present in the common ancestor of animals.

Orthologs for SOCS4 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia SOCS4 29 30
  • 99.77 (n)
 OneToOne
Dog
(Canis familiaris)
 Mammalia SOCS4 29 30
  • 94.02 (n)
 OneToOne
Cow
(Bos Taurus)
 Mammalia SOCS4 29 30
  • 92.41 (n)
 OneToOne
Mouse
(Mus musculus)
 Mammalia Socs4 29 16 30
  • 86.31 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Socs4 29
  • 84.33 (n)
Chicken
(Gallus gallus)
 Aves SOCS4 29 30
  • 74.87 (n)
 OneToOne
Lizard
(Anolis carolinensis)
 Reptilia SOCS4 30
  • 80 (a)
 OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia socs4 29
  • 70.53 (n)
Zebrafish
(Danio rerio)
 Actinopterygii socs9 29
  • 50.2 (n)
socs4 30
  • 49 (a)
 OneToOne
Fruit Fly
(Drosophila melanogaster)
 Insecta Socs36E 30 31
  • 26 (a)
 OneToMany
Species where no ortholog for SOCS4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for SOCS4 Gene

ENSEMBL:
Gene Tree for SOCS4 (if available)
TreeFam:
Gene Tree for SOCS4 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SOCS4: view image
Alliance of Genome Resources:
Additional Orthologs for SOCS4

Paralogs for SOCS4 Gene

Paralogs for SOCS4 Gene

(2) SIMAP similar genes for SOCS4 Gene using alignment to 1 proteins:

  • SOCS4_HUMAN
genes like me logo Genes that share paralogs with SOCS4: view

Variants for SOCS4 Gene

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Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SOCS4 Gene

SNP ID Clinical significance and condition Chr 14 pos Variation AA Info Type
rs35504537 Benign: not provided 55,043,101(+) G/A
NM_199421.2(SOCS4):c.60G>A (p.Arg20=) 		SYNONYMOUS
rs61734083 Benign: not provided 55,043,566(+) G/A
NM_199421.2(SOCS4):c.525G>A (p.Gln175=) 		SYNONYMOUS

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for SOCS4 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for SOCS4 Gene

Variant ID Type Subtype PubMed ID
nsv84529 CNV deletion 16902084

Variation tolerance for SOCS4 Gene

Residual Variation Intolerance Score: 27.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.57; 12.29% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SOCS4 Gene

Human Gene Mutation Database (HGMD)
SOCS4
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SOCS4
Leiden Open Variation Database (LOVD)
SOCS4

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SOCS4 Gene

Disorders for SOCS4 Gene

MalaCards: The human disease database

(3) MalaCards diseases for SOCS4 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
borderline glaucoma
  • preglaucoma
endometrial stromal sarcoma
  • endometrial stromal sarcoma, high grade
diabetes mellitus
  • diabetes
- elite association - COSMIC cancer census association via MalaCards
Search SOCS4 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for SOCS4

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with SOCS4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SOCS4 Gene

Publications for SOCS4 Gene

  1. Risk of meningioma and common variation in genes related to innate immunity. (PMID: 20406964) Rajaraman P … Inskip PD (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2010) 3 40
  2. Higher expression levels of SOCS 1,3,4,7 are associated with earlier tumour stage and better clinical outcome in human breast cancer. (PMID: 20433750) Sasi W … Mokbel K (BMC cancer 2010) 3 22
  3. Polymorphisms in innate immunity genes and risk of childhood leukemia. (PMID: 20438785) Han S … Kang D (Human immunology 2010) 3 40
  4. Structure of the SOCS4-ElonginB/C complex reveals a distinct SOCS box interface and the molecular basis for SOCS-dependent EGFR degradation. (PMID: 17997974) Bullock AN … Knapp S (Structure (London, England : 1993) 2007) 3 4
  5. Suppressors of cytokine signaling 4 and 5 regulate epidermal growth factor receptor signaling. (PMID: 15590694) Kario E … Yarden Y (The Journal of biological chemistry 2005) 3 4

ExternalLinks

View latest publications for SOCS4 gene in Mastermind

Products for SOCS4 Gene

  • Addgene plasmids for SOCS4

Sources for SOCS4 Gene