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The protein encoded by this gene contains a SH2 domain and a SOCS BOX domain. The protein thus belongs to the suppressor of cytokine signaling (SOCS), also known as STAT-induced STAT inhibitor (SSI), protein family. SOCS family members are known to be cytokine-inducible negative regulators of cytokine signaling. Two alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
SOCS4 (Suppressor Of Cytokine Signaling 4) is a Protein Coding gene. Diseases associated with SOCS4 include Borderline Glaucoma and Endometrial Stromal Sarcoma. Among its related pathways are IL-2 Pathway and PEDF Induced Signaling. Gene Ontology (GO) annotations related to this gene include protein kinase inhibitor activity. An important paralog of this gene is SOCS5.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005515 | protein binding | IPI | 25814554 |
GO:0046935 | 1-phosphatidylinositol-3-kinase regulator activity | IBA | 21873635 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005942 | phosphatidylinositol 3-kinase complex | IBA | 21873635 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | IL-2 Pathway |
Prolactin Signaling
.54
Growth Hormone Signaling
.49
|
IL-4 Pathway
.34
|
2 | Type II diabetes mellitus | ||
3 | PEDF Induced Signaling |
IL-6 Pathway
.61
|
STAT3 Pathway
.47
|
4 | TGF-Beta Pathway |
JAK-STAT Pathway
.57
|
SOCS Pathway
.41
|
5 | Regulation of lipid metabolism Insulin signaling-generic cascades |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0007175 | negative regulation of epidermal growth factor-activated receptor activity | IDA | 15590694 |
GO:0009968 | negative regulation of signal transduction | IEA | -- |
GO:0016567 | protein ubiquitination | IEA | -- |
GO:0032436 | positive regulation of proteasomal ubiquitin-dependent protein catabolic process | IEA | -- |
GO:0035556 | intracellular signal transduction | IEA | -- |
ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3a | · | 3b |
---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | |||||||||||
SP2: | - |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | SOCS4 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | SOCS4 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | SOCS4 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Socs4 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Socs4 30 |
|
||
Chicken (Gallus gallus) |
Aves | SOCS4 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | SOCS4 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | socs4 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | socs9 30 |
|
||
socs4 31 |
|
OneToOne | |||
Fruit Fly (Drosophila melanogaster) |
Insecta | Socs36E 31 32 |
|
OneToMany |
Disorder | Aliases | PubMed IDs |
---|---|---|
borderline glaucoma |
|
|
endometrial stromal sarcoma |
|
|