Aliases for SOCS3 Gene
External Ids for SOCS3 Gene
Previous GeneCards Identifiers for SOCS3 Gene
This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene is induced by various cytokines, including IL6, IL10, and interferon (IFN)-gamma. The protein encoded by this gene can bind to JAK2 kinase, and inhibit the activity of JAK2 kinase. Studies of the mouse counterpart of this gene suggested the roles of this gene in the negative regulation of fetal liver hematopoiesis, and placental development. [provided by RefSeq, Jul 2008]
GeneCards Summary for SOCS3 Gene
SOCS3 (Suppressor Of Cytokine Signaling 3) is a Protein Coding gene. Diseases associated with SOCS3 include Dermatitis, Atopic, 4 and Primary Polycythemia. Among its related pathways are Interleukin-6 family signaling and Development_Leptin signaling via JAK/STAT and MAPK cascades. Gene Ontology (GO) annotations related to this gene include protein kinase inhibitor activity. An important paralog of this gene is CISH.
UniProtKB/Swiss-Prot Summary for SOCS3 Gene
SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS3 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway. Inhibits cytokine signal transduction by binding to tyrosine kinase receptors including gp130, LIF, erythropoietin, insulin, IL12, GCSF and leptin receptors. Binding to JAK2 inhibits its kinase activity. Suppresses fetal liver erythropoiesis. Regulates onset and maintenance of allergic responses mediated by T-helper type 2 cells. Regulates IL-6 signaling in vivo (By similarity). Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize IL6ST (By similarity).