Aliases for SOCS2 Gene
Aliases for SOCS2 Gene
External Ids for SOCS2 Gene
- HGNC: 19382
- Entrez Gene: 8835
- Ensembl: ENSG00000120833
- OMIM: 605117
- UniProtKB: O14508
Previous GeneCards Identifiers for SOCS2 Gene
- GC12P094485
- GC12P093896
- GC12P092466
- GC12P093963
- GC12P091030
Summaries for SOCS2 Gene
-
This gene encodes a member of the suppressor of cytokine signaling (SOCS) family. SOCS family members are cytokine-inducible negative regulators of cytokine receptor signaling via the Janus kinase/signal transducer and activation of transcription pathway (the JAK/STAT pathway). SOCS family proteins interact with major molecules of signaling complexes to block further signal transduction, in part, by proteasomal depletion of receptors or signal-transducing proteins via ubiquitination. The expression of this gene can be induced by a subset of cytokines, including erythropoietin, GM-CSF, IL10, interferon (IFN)-gamma and by cytokine receptors such as growth horomone receptor. The protein encoded by this gene interacts with the cytoplasmic domain of insulin-like growth factor-1 receptor (IGF1R) and is thought to be involved in the regulation of IGF1R mediated cell signaling. This gene has pseudogenes on chromosomes 20 and 22. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]
GeneCards Summary for SOCS2 Gene
SOCS2 (Suppressor Of Cytokine Signaling 2) is a Protein Coding gene. Diseases associated with SOCS2 include Essential Thrombocythemia and Vertebral Artery Occlusion. Among its related pathways are Common Cytokine Receptor Gamma-Chain Family Signaling Pathways and Regulation of lipid metabolism Insulin signaling-generic cascades. Gene Ontology (GO) annotations related to this gene include SH3/SH2 adaptor activity and insulin-like growth factor receptor binding. An important paralog of this gene is CISH.
UniProtKB/Swiss-Prot for SOCS2 Gene
-
SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS2 appears to be a negative regulator in the growth hormone/IGF1 signaling pathway. Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Additional gene information for SOCS2 Gene
- Monarch Initiative
- Search for SOCS2 at DataMed
- Search for SOCS2 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SOCS2 Gene
Genomics for SOCS2 Gene
GeneHancer (GH) Regulatory Elements for SOCS2 Gene
Promoters and enhancers for SOCS2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around SOCS2 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the SOCS2 gene promoter:
-
- PPAR-gamma2
- PPAR-gamma1
- STAT5B
- GATA-1
- ITF-2
- Tal-1beta
Regulatory Element Products
Genomic Locations for SOCS2 Gene
Genomic Locations for SOCS2 Gene
- chr12:93,569,814-93,626,236
- (GRCh38/hg38)
- Size:
- 56,423 bases
- Orientation:
- Plus strand
- chr12:93,963,590-93,977,263
- (GRCh37/hg19)
- Size:
- 13,674 bases
- Orientation:
- Plus strand
Genomic View for SOCS2 Gene
Genes around SOCS2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 12q22 by Entrez Gene
- 12q by HGNC
- 12q22 by Ensembl
SOCS2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for SOCS2 Gene
Proteins for SOCS2 Gene
-
Protein details for SOCS2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O14508-SOCS2_HUMAN
- Recommended name:
- Suppressor of cytokine signaling 2
- Protein Accession:
- O14508
- A8K3D1
- O14542
- O95102
- Q9UKS5
Protein attributes for SOCS2 Gene
- Size:
- 198 amino acids
- Molecular mass:
- 22172 Da
- Quaternary structure:
-
- Interacts with IGF1 receptor, prolactin receptor and growth hormone (GH) receptor. Associates with the Elongin BC complex.
Protein Expression for SOCS2 Gene
Post-translational modifications for SOCS2 Gene
Other Protein References for SOCS2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for SOCS2 (SOCS-2)
- Novus Biologicals Antibodies for SOCS2
- Invitrogen Antibodies for SOCS2
- GeneTex SOCS2 Antibody for SOCS2
Protein Products
-
OriGene Purified Proteins for SOCS2
- Search Origene for MassSpec and Protein Over-expression Lysates for SOCS2
- Origene Custom Protein Services for SOCS2
- GeneTex Proteins for SOCS2
Assay Products
No data available for DME Specific Peptides for SOCS2 Gene
Domains & Families for SOCS2 Gene
Gene Families for SOCS2 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for SOCS2 Gene
- Blocks:
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for SOCS2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
O14508UniProtKB/Swiss-Prot:
SOCS2_HUMAN :- The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes.
- Domain:
-
- The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes.
Function for SOCS2 Gene
Molecular function for SOCS2 Gene
- UniProtKB/Swiss-Prot Function:
- SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS2 appears to be a negative regulator in the growth hormone/IGF1 signaling pathway. Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
- UniProtKB/Swiss-Prot Induction:
- By a subset of cytokines, including EPO/erythropoietin and CSF2/GM-CSF.
- GENATLAS Biochemistry:
- suppressor of cytokine signaling 2. Involved in the interleukin-6 induced receptor phosphorylation and in the negative regulation of cytokine induced STAT factor signaling,putative candidate for asthma and atopy susceptibility
Phenotypes From GWAS Catalog for SOCS2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004860 | protein kinase inhibitor activity | IBA | -- |
| GO:0005070 | SH3/SH2 adaptor activity | TAS | 9344848 |
| GO:0005131 | growth hormone receptor binding | NAS | 12135564 |
| GO:0005159 | insulin-like growth factor receptor binding | IPI | 9727029 |
| GO:0005515 | protein binding | IPI | 11781573 |
Phenotypes for SOCS2 Gene
- MGI mutant phenotypes for SOCS2:
-
inferred from 4 alleles
- respiratory system phenotype
- limbs/digits/tail phenotype
- digestive/alimentary phenotype
- homeostasis/metabolism phenotype
- integument phenotype
- endocrine/exocrine gland phenotype
- liver/biliary system phenotype
- reproductive system phenotype
- skeleton phenotype
- renal/urinary system phenotype
- adipose tissue phenotype
- hematopoietic system phenotype
- immune system phenotype
- growth/size/body region phenotype
- GenomeRNAi human phenotypes for SOCS2:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for SOCS2
-
CRISPR Products
-
OriGene CRISPR knockouts for SOCS2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SOCS2
- genomics-online: gRNA clones - Search results for 154 available SOCS2 gene related products
- Overview of 154 available SOCS2 gene related products
- Applied Biological Materials CRISPR for SOCS2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for SOCS2
- GenScript: Design CRISPR guide RNA sequences for SOCS2
miRNA for SOCS2 Gene
- miRTarBase miRNAs that target SOCS2
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for SOCS2
- Browse OriGene Inhibitory RNA Products For SOCS2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SOCS2
- genomics-online: shRNA clones - Search results for 154 available SOCS2 gene related products
- Overview of 154 available SOCS2 gene related products
Clone Products
-
GenScript: Next-day shipping of latest version cDNA ORF clones for SOCS2 in any vector
- NM_003877.4
- XM_011538935.1
- XM_017020151.1
- XM_017020154.1
- NM_001270471.1
- NM_001270468.1
- NM_001270471.1
- NM_001270468.1
- XM_011538936.1
- XM_017020147.1
- XM_017020148.1
- NM_001270469.1
- XM_017020152.1
- NM_001270470.1
- XM_017020155.1
- XM_017020149.1
- XM_017020156.1
- NM_001270467.1
- XM_017020156.1
- NM_001270467.1
- XM_017020150.1
- XM_017020153.1
- XM_011538929.1
- Sino Biological Human cDNA Clone for SOCS2
- VectorBuilder custom plasmid, inducible vectors for SOCS2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for SOCS2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SOCS2
- Applied Biological Materials Clones for SOCS2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for SOCS2
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SOCS2 Gene
Localization for SOCS2 Gene
| Compartment | Confidence |
|---|---|
| cytosol | 5 |
| nucleus | 3 |
| plasma membrane | 2 |
| extracellular | 2 |
| mitochondrion | 1 |
- Endoplasmic reticulum (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IBA,NAS | 9727029 |
| GO:0005829 | cytosol | TAS | -- |
No data available for Subcellular locations from UniProtKB/Swiss-Prot for SOCS2 Gene
Pathways & Interactions for SOCS2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Prolactin Signaling Pathway | ||
| 2 | IL-2 Pathway |
.34
|
|
| 3 | PEDF Induced Signaling |
.61
|
.47
|
| 4 | Common Cytokine Receptor Gamma-Chain Family Signaling Pathways |
.36
|
|
| 5 | TGF-Beta Pathway |
.57
|
.40
|
Pathways by source for SOCS2 Gene
1 Sino Biological pathway for SOCS2 Gene
1 GeneTex pathway for SOCS2 Gene
4 BioSystems pathways for SOCS2 Gene
3 Reactome pathways for SOCS2 Gene
4 KEGG pathways for SOCS2 Gene
2 GeneGo (Thomson Reuters) pathways for SOCS2 Gene
1 R&D Systems pathway for SOCS2 Gene
8 Qiagen pathways for SOCS2 Gene
1 Cell Signaling Technology pathway for SOCS2 Gene
UniProtKB/Swiss-Prot O14508-SOCS2_HUMAN
- Pathway: Protein modification; protein ubiquitination.
Interacting Proteins for SOCS2 Gene
Selected Interacting proteins:
O14508-SOCS2_HUMAN
ENSP00000339428
for SOCS2 Gene via
IID
UniProtKB
MINT
STRING
GPS-Prot Interaction Network for SOCS2
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001558 | regulation of cell growth | NAS | 9727029 |
| GO:0006469 | negative regulation of protein kinase activity | IBA | -- |
| GO:0007259 | JAK-STAT cascade | TAS | 9266833 |
| GO:0007595 | lactation | IEA | -- |
| GO:0009966 | regulation of signal transduction | NAS | 9727029 |
No data available for SIGNOR curated interactions for SOCS2 Gene
Transcripts for SOCS2 Gene
mRNA/cDNA for SOCS2 Gene
- (15) REFSEQ mRNAs :
- (9) Additional mRNA sequences :
- (217) Selected AceView cDNA sequences:
- (12) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000340600 2761 bps (uc001tcw.3)
- ENST00000536696 1065 bps (uc021rbx.3)
- ENST00000547229 462 bps (uc058rtm.1)
- ENST00000548091 744 bps (uc058rtj.1)
- ENST00000548537 3733 bps (uc058rtk.1)
Unigene Clusters for SOCS2 Gene
CRISPR Products
-
OriGene CRISPR knockouts for SOCS2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SOCS2
- genomics-online: gRNA clones - Search results for 154 available SOCS2 gene related products
- Overview of 154 available SOCS2 gene related products
- Applied Biological Materials CRISPR for SOCS2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for SOCS2
- GenScript: Design CRISPR guide RNA sequences for SOCS2
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for SOCS2
- Browse OriGene Inhibitory RNA Products For SOCS2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SOCS2
- genomics-online: shRNA clones - Search results for 154 available SOCS2 gene related products
- Overview of 154 available SOCS2 gene related products
Clone Products
-
GenScript: Next-day shipping of latest version cDNA ORF clones for SOCS2 in any vector
- NM_003877.4
- XM_011538935.1
- XM_017020151.1
- XM_017020154.1
- NM_001270471.1
- NM_001270468.1
- NM_001270471.1
- NM_001270468.1
- XM_011538936.1
- XM_017020147.1
- XM_017020148.1
- NM_001270469.1
- XM_017020152.1
- NM_001270470.1
- XM_017020155.1
- XM_017020149.1
- XM_017020156.1
- NM_001270467.1
- XM_017020156.1
- NM_001270467.1
- XM_017020150.1
- XM_017020153.1
- XM_011538929.1
- Sino Biological Human cDNA Clone for SOCS2
- VectorBuilder custom plasmid, inducible vectors for SOCS2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for SOCS2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SOCS2
- Applied Biological Materials Clones for SOCS2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | · | 5c | ^ | 6 | ^ | 7a | · | 7b | · | 7c | · | 7d | ^ | 8a | · | 8b | · | 8c | · | 8d | · | 8e | ^ | 9a | · | 9b | ^ | 10 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | |||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | ||||||||||||||||||||||||||||||||||||
| SP7: | - | - | |||||||||||||||||||||||||||||||||||||
| SP8: | - | ||||||||||||||||||||||||||||||||||||||
| SP9: | - | ||||||||||||||||||||||||||||||||||||||
| SP10: |
Expression for SOCS2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Cardiovascular System)
- T Helper Cells Thymus
- Double Negative 2 Thymocytes Thymus
- Hematopoietic Stem Cells Hematopoietic Bone Marrow
-
Thymus (Hematopoietic System)
- T Helper Cells Thymus
- Double Negative 2 Thymocytes Thymus
- Mesenchymal Stem Cells (Uncategorized)
-
Peripheral Nervous System (Nervous System)
- Schwann Precursor Cells Peripheral Nerve Domain
-
Limb (Muscoskeletal System)
- Mesenchymal Condensate Cells Zeugopod
-
Bone (Muscoskeletal System)
- Mesenchymal Condensate Cells Zeugopod
-
Cartilage (Muscoskeletal System)
- Mesenchymal Condensate Cells Zeugopod
- Epiblast (Early Embryonic Tissues)
- Neural Crest (Gastrulation Derivatives)
- Umbilical Cord (Extraembryonic Tissues)
- Eye (Sensory Organs)
-
Uterus (Reproductive System)
-
Prostate (Endocrine System)
-
Ovary (Reproductive System)
This gene is overexpressed in Bone (49.8), Liver (9.5), and Heart (9.4).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SOCS2 Gene
NURSA nuclear receptor signaling pathways regulating expression of SOCS2 Gene:
SOCS2SOURCE GeneReport for Unigene cluster for SOCS2 Gene:
Hs.485572mRNA Expression by UniProt/SwissProt for SOCS2 Gene:
O14508-SOCS2_HUMAN
Tissue specificity:
High expression in heart, placenta, lung, kidney and prostate.
Evidence on tissue expression from TISSUES for SOCS2 Gene
- Nervous system(4.8)
- Lung(4.5)
- Liver(3.2)
- Muscle(2.6)
- Eye(2.4)
- Heart(2.4)
- Intestine(2.2)
- Kidney(2.2)
- Stomach(2)
Primer Products
-
OriGene qPCR primer pairs and template standards for SOCS2
-
OriGene qPCR primer pairs for SOCS2
- genomics-online: primer clones - Search results for 154 available SOCS2 gene related products
- Overview of 154 available SOCS2 gene related products
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for SOCS2 Gene
Orthologs for SOCS2 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | SOCS2 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | SOCS2 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | SOCS2 34 33 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Gm9847 34 |
|
OneToMany | |
| Socs2 16 34 33 |
|
||||
| rat (Rattus norvegicus) |
Mammalia | Socs2 33 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | SOCS2 34 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | SOCS2 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | SOCS2 34 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | SOCS2 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | socs2 33 |
|
||
| Str.4310 33 |
|
||||
| zebrafish (Danio rerio) |
Actinopterygii | socs2 34 33 |
|
OneToOne |
- Species where no ortholog for SOCS2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Evolution for SOCS2 Gene
- ENSEMBL:
- Gene Tree for SOCS2 (if available)
- TreeFam:
- Gene Tree for SOCS2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for SOCS2: view image
Paralogs for SOCS2 Gene
(4) SIMAP similar genes for SOCS2 Gene using alignment to 7 proteins:
- SOCS2_HUMAN
- B5BU82_HUMAN
- F8VRV3_HUMAN
- F8VS53_HUMAN
- F8VU91_HUMAN
- S4R3W1_HUMAN
- S4R3Z4_HUMAN
Pseudogenes.org Pseudogenes for SOCS2 Gene
Variants for SOCS2 Gene
| SNP ID | Clin | Chr 12 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000046512 | -- | 93,597,469(+) | C/T | genic_downstream_transcript_variant, intron_variant | |
| rs1000063919 | -- | 93,573,798(+) | G/A | intron_variant | |
| rs1000098416 | -- | 93,597,662(+) | C/G | genic_downstream_transcript_variant, intron_variant | |
| rs1000181770 | -- | 93,583,850(+) | A/T | downstream_transcript_variant, genic_downstream_transcript_variant, intron_variant | |
| rs1000229676 | -- | 93,617,471(+) | G/C | genic_downstream_transcript_variant, intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv7234 | OTHER | inversion | 18451855 |
| nsv559778 | CNV | gain | 21841781 |
| esv25615 | CNV | loss | 19812545 |
| dgv2792n54 | CNV | gain | 21841781 |
| dgv2791n54 | CNV | loss | 21841781 |
Residual Variation Intolerance Score:
43.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.59;
56.25% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for SOCS2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- SOCS2
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SOCS2 Gene
Disorders for SOCS2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| essential thrombocythemia |
|
|
| vertebral artery occlusion |
|
|
Search SOCS2 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for SOCS2
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for SOCS2 Gene
Publications for SOCS2 Gene
- Cloning and functional analysis of new members of STAT induced STAT inhibitor (SSI) family: SSI-2 and SSI-3. (PMID: 9266833) Minamoto S … Kishimoto T (Biochemical and biophysical research communications 1997) 2 3 4 22 58
- Association of single-nucleotide polymorphisms in the suppressor of cytokine signaling 2 (SOCS2) gene with type 2 diabetes in the Japanese. (PMID: 16406727) Kato H … Itakura M (Genomics 2006) 3 22 44 58
- Cloning and characterization of novel CIS family genes. (PMID: 9344848) Masuhara M … Yoshimura A (Biochemical and biophysical research communications 1997) 2 3 4 58
- Risk of meningioma and common variation in genes related to innate immunity. (PMID: 20406964) Rajaraman P … Inskip PD (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2010) 3 44 58
- Polymorphisms in innate immunity genes and risk of childhood leukemia. (PMID: 20438785) Han S … Kang D (Human immunology 2010) 3 44 58
Products for SOCS2 Gene
- R&D Systems Antibodies for SOCS2 (SOCS-2)
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Human Proteins and Enzymes
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
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- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for SOCS2
- Search Origene for MassSpec and Protein Over-expression Lysates for SOCS2
- Origene Custom Protein Services for SOCS2
- Origene shrna, sirna, and RNAi products in human, mouse, rat for SOCS2
- Browse OriGene Inhibitory RNA Products For SOCS2
- OriGene qPCR primer pairs and template standards for SOCS2
- OriGene qPCR primer pairs for SOCS2
- OriGene CRISPR knockouts for SOCS2
- OriGene ORF clones in human for SOCS2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For SOCS2
- GenScript: Next-day shipping of latest version cDNA ORF clones for SOCS2 in any vector
- NM_003877.4
- XM_011538935.1
- XM_017020151.1
- XM_017020154.1
- NM_001270471.1
- NM_001270468.1
- NM_001270471.1
- NM_001270468.1
- XM_011538936.1
- XM_017020147.1
- XM_017020148.1
- NM_001270469.1
- XM_017020152.1
- NM_001270470.1
- XM_017020155.1
- XM_017020149.1
- XM_017020156.1
- NM_001270467.1
- XM_017020156.1
- NM_001270467.1
- XM_017020150.1
- XM_017020153.1
- XM_011538929.1
- GenScript Custom Purified and Recombinant Proteins Services for SOCS2
- GenScript Custom Assay Services for SOCS2
- GenScript Custom overexpressing Cell Line Services for SOCS2
- GenScript: Design CRISPR guide RNA sequences for SOCS2
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for SOCS2
- Sino Biological Human cDNA Clone for SOCS2
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for SOCS2
- Novus Biologicals proteins and lysates for SOCS2
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- VectorBuilder custom plasmid, inducible vectors for SOCS2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for SOCS2
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 55 available SOCS2 Antibodies ranked by validation data
- Compare Top SOCS2 Antibodies
- antibodies-online: Search results for 15 available SOCS2 Elisa Kits ranked by validation data
- Compare Top SOCS2 Elisa Kits
- antibodies-online: Search results for 11 available SOCS2 Proteins ranked by validation data
- Compare Top SOCS2 Proteins
- GeneTex SOCS2 Antibody for SOCS2
- GeneTex Proteins for SOCS2
- Horizon Cell Lines for SOCS2
- genomics-online: cdna clones - Search results for 154 available SOCS2 gene related products
- Overview of 154 available SOCS2 gene related products
- orf clones - Search results for 154 available SOCS2 gene related products
- Overview of 154 available SOCS2 gene related products
- genomics-online: gRNA clones - Search results for 154 available SOCS2 gene related products
- Overview of 154 available SOCS2 gene related products
- genomics-online: primer clones - Search results for 154 available SOCS2 gene related products
- Overview of 154 available SOCS2 gene related products
- genomics-online: shRNA clones - Search results for 154 available SOCS2 gene related products
- Overview of 154 available SOCS2 gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SOCS2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SOCS2
- GeneCopoeia miRNA 3'UTR Target clone products for SOCS2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SOCS2
Sources for SOCS2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio
- (169) Biorbyt