Aliases for SOCS1 Gene
External Ids for SOCS1 Gene
Previous GeneCards Identifiers for SOCS1 Gene
This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including IL2, IL3 erythropoietin (EPO), CSF2/GM-CSF, and interferon (IFN)-gamma. The protein encoded by this gene functions downstream of cytokine receptors, and takes part in a negative feedback loop to attenuate cytokine signaling. Knockout studies in mice suggested the role of this gene as a modulator of IFN-gamma action, which is required for normal postnatal growth and survival. [provided by RefSeq, Jul 2008]
GeneCards Summary for SOCS1 Gene
SOCS1 (Suppressor Of Cytokine Signaling 1) is a Protein Coding gene. Diseases associated with SOCS1 include Coronary Heart Disease 1 and Diabetes Mellitus, Noninsulin-Dependent. Among its related pathways are Activated TLR4 signalling and Development EPO-induced Jak-STAT pathway. Gene Ontology (GO) annotations related to this gene include protein kinase binding and insulin-like growth factor receptor binding. An important paralog of this gene is SOCS3.
UniProtKB/Swiss-Prot for SOCS1 Gene
SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS1 is involved in negative regulation of cytokines that signal through the JAK/STAT3 pathway. Through binding to JAKs, inhibits their kinase activity. In vitro, also suppresses Tec protein-tyrosine activity. Appears to be a major regulator of signaling by interleukin 6 (IL6) and leukemia inhibitory factor (LIF). Regulates interferon-gamma mediated sensory neuron survival (By similarity). Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize JAK2. SOCS1 appears to be a negative regulator in IGF1R signaling pathway.