Free for academic non-profit institutions. Other users need a Commercial license
This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including IL2, IL3 erythropoietin (EPO), CSF2/GM-CSF, and interferon (IFN)-gamma. The protein encoded by this gene functions downstream of cytokine receptors, and takes part in a negative feedback loop to attenuate cytokine signaling. Knockout studies in mice suggested the role of this gene as a modulator of IFN-gamma action, which is required for normal postnatal growth and survival. [provided by RefSeq, Jul 2008]
SOCS1 (Suppressor Of Cytokine Signaling 1) is a Protein Coding gene. Diseases associated with SOCS1 include Lipoprotein Quantitative Trait Locus and Anemia, Autoimmune Hemolytic. Among its related pathways are Signaling by GPCR and Interleukin-4 and 13 signaling. Gene Ontology (GO) annotations related to this gene include protein kinase binding and insulin-like growth factor receptor binding. An important paralog of this gene is SOCS7.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004860 | protein kinase inhibitor activity | TAS | 9202125 |
GO:0005159 | insulin-like growth factor receptor binding | IPI | 9727029 |
GO:0005515 | protein binding | IPI | 16273093 |
GO:0019210 | kinase inhibitor activity | IEA,ISS | -- |
GO:0019901 | protein kinase binding | IPI | 9727029 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IEA | -- |
GO:0005654 | nucleoplasm | IDA | -- |
GO:0005737 | cytoplasm | TAS | 9202126 |
GO:0005829 | cytosol | TAS | -- |
GO:0005942 | phosphatidylinositol 3-kinase complex | IBA | 21873635 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Activated TLR4 signalling | ||
2 | Prolactin Signaling Pathway |
Development Prolactin receptor signaling
.38
|
|
3 | IL-2 Pathway |
Prolactin Signaling
.54
Growth Hormone Signaling
.49
|
IL-4 Pathway
.34
|
4 | Class I MHC mediated antigen processing and presentation | ||
5 | Immune response IFN alpha/beta signaling pathway |
Immune response IFN alpha/beta signaling pathway
.74
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001817 | regulation of cytokine production | IEA | -- |
GO:0001932 | regulation of protein phosphorylation | IEA,ISS | -- |
GO:0006469 | negative regulation of protein kinase activity | IEA | -- |
GO:0007259 | JAK-STAT cascade | IEA | -- |
GO:0009968 | negative regulation of signal transduction | IEA | -- |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | SOCS1 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | SOCS1 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | SOCS1 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Socs1 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Socs1 30 17 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | SOCS1 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | SOCS1 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | SOCS1 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | SOCS1 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | socs1 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | socs1a 30 31 |
|
OneToMany | |
socs1b 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 16 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
977212 | Likely Pathogenic: Autoimmune thrombocytopenia | 11,255,111(-) |
G/C NM_003745.1(SOCS1):c.368C>G (p.Pro123Arg) |
MISSENSE | |
977213 | Likely Pathogenic: Autoimmune hemolytic anemia; Autoimmune thrombocytopenia | 11,255,454(-) |
CT/C NM_003745.1(SOCS1):c.24del (p.Ala9fs) |
FRAMESHIFT | |
977214 | Likely Pathogenic: Autoimmune hemolytic anemia; Autoimmune thrombocytopenia | 11,254,998(-) |
T/TGCGGC NM_003745.1(SOCS1):c.476_480dup (p.Met161fs) |
FRAMESHIFT | |
977215 | Likely Pathogenic: Systemic lupus erythematosus | 11,255,415(-) |
G/A NM_003745.1(SOCS1):c.64C>T (p.Arg22Trp) |
MISSENSE | |
977216 | Likely Pathogenic: Systemic lupus erythematosus | 11,255,019(-) |
A/G NM_003745.1(SOCS1):c.460T>C (p.Tyr154His) |
MISSENSE |
Disorder | Aliases | PubMed IDs |
---|---|---|
lipoprotein quantitative trait locus |
|
|
anemia, autoimmune hemolytic |
|
|
type 2 diabetes mellitus |
|
|
thrombocytopenia due to platelet alloimmunization |
|
|
thrombocytopenic purpura, autoimmune |
|
|