This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including IL2, IL3 erythropoietin (EPO), CSF2/GM-CSF, and interferon (IFN)-gamma. The protein ... See more...

Aliases for SOCS1 Gene

Aliases for SOCS1 Gene

  • Suppressor Of Cytokine Signaling 1 2 3 4 5
  • SOCS-1 2 3 4
  • SSI-1 2 3 4
  • TIP3 2 3 4
  • JAB 2 3 4
  • STAT-Induced STAT Inhibitor 1 3 4
  • Tec-Interacting Protein 3 3 4
  • TIP-3 3 4
  • SSI1 3 4
  • Cytokine-Inducible SH2 Protein 1 3
  • STAT Induced SH3 Protein 1 3
  • JAK Binding Protein 3
  • JAK-Binding Protein 4
  • CISH1 3
  • SOCS1 5
  • Cish1 2
  • CIS1 3

External Ids for SOCS1 Gene

Previous GeneCards Identifiers for SOCS1 Gene

  • GC16M011499
  • GC16M011314

Summaries for SOCS1 Gene

Entrez Gene Summary for SOCS1 Gene

  • This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including IL2, IL3 erythropoietin (EPO), CSF2/GM-CSF, and interferon (IFN)-gamma. The protein encoded by this gene functions downstream of cytokine receptors, and takes part in a negative feedback loop to attenuate cytokine signaling. Knockout studies in mice suggested the role of this gene as a modulator of IFN-gamma action, which is required for normal postnatal growth and survival. [provided by RefSeq, Jul 2008]

GeneCards Summary for SOCS1 Gene

SOCS1 (Suppressor Of Cytokine Signaling 1) is a Protein Coding gene. Diseases associated with SOCS1 include Coronary Heart Disease 1 and Diabetes Mellitus, Noninsulin-Dependent. Among its related pathways are Signaling by GPCR and Immune response IFN alpha/beta signaling pathway. Gene Ontology (GO) annotations related to this gene include protein kinase binding and insulin-like growth factor receptor binding. An important paralog of this gene is SOCS2.

UniProtKB/Swiss-Prot Summary for SOCS1 Gene

  • SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS1 is involved in negative regulation of cytokines that signal through the JAK/STAT3 pathway. Through binding to JAKs, inhibits their kinase activity. In vitro, also suppresses Tec protein-tyrosine activity. Appears to be a major regulator of signaling by interleukin 6 (IL6) and leukemia inhibitory factor (LIF). Regulates interferon-gamma mediated sensory neuron survival (By similarity). Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize JAK2. SOCS1 appears to be a negative regulator in IGF1R signaling pathway.

Gene Wiki entry for SOCS1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SOCS1 Gene

Genomics for SOCS1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for SOCS1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SOCS1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SOCS1

Top Transcription factor binding sites by QIAGEN in the SOCS1 gene promoter:
  • AP-1
  • ATF-2
  • CREB
  • deltaCREB
  • STAT3

Genomic Locations for SOCS1 Gene

Genomic Locations for SOCS1 Gene
chr16:11,254,408-11,256,204
(GRCh38/hg38)
Size:
1,797 bases
Orientation:
Minus strand
chr16:11,348,262-11,350,039
(GRCh37/hg19)
Size:
1,778 bases
Orientation:
Minus strand

Genomic View for SOCS1 Gene

Genes around SOCS1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SOCS1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SOCS1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SOCS1 Gene

Proteins for SOCS1 Gene

  • Protein details for SOCS1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15524-SOCS1_HUMAN
    Recommended name:
    Suppressor of cytokine signaling 1
    Protein Accession:
    O15524
    Secondary Accessions:
    • O15097
    • Q9NSA7

    Protein attributes for SOCS1 Gene

    Size:
    211 amino acids
    Molecular mass:
    23551 Da
    Quaternary structure:
    • Interacts with multiple activated signaling proteins of the tyrosine kinase signaling pathway including JAK family kinases, TEC, KIT, GRB2 and VAV. Binding to JAKs is mediated through the KIR and SH2 domains to a phosphorylated tyrosine residue within the JAK JH1 domain. Binds the SH3 domain of GRB2 via diproline determinants in the N-terminus, and the N-terminal regulatory domain of VAV (By similarity). Interacts with the Elongin BC complex (ELOB and ELOC). Component of an ECS CBC(SOCS1) E3 ubiquitin-protein ligase complex which contains Elongin BC, CUL5, RBX1 and SOCS1 (By similarity). Interacts (via SH2 domain and SOCS box) with TRIM8 (By similarity). Interacts with AXL, CUL2 and FGFR3. Interacts with INSR (By similarity). Interacts with TRIM8 (PubMed:12163497).

neXtProt entry for SOCS1 Gene

Post-translational modifications for SOCS1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SOCS1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for SOCS1
  • Boster Bio Antibodies for SOCS1
  • Santa Cruz Biotechnology (SCBT) Antibodies for SOCS1

No data available for DME Specific Peptides for SOCS1 Gene

Domains & Families for SOCS1 Gene

Gene Families for SOCS1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted intracellular proteins

Protein Domains for SOCS1 Gene

InterPro:
Blocks:
  • SOCS protein, C-terminal
ProtoNet:

Suggested Antigen Peptide Sequences for SOCS1 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ45719 fis, clone FELNG2001953, highly similar to Suppressor of cytokine signaling 1 (Q4JHT5_HUMAN)
  • Suppressor of cytokine signalling protein (Q9NSA8_HUMAN)
  • Tec-interacting protein 3 (SOCS1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O15524

UniProtKB/Swiss-Prot:

SOCS1_HUMAN :
  • The ESS and SH2 domains are required for JAK phosphotyrosine binding. Further interaction with the KIR domain is necessary for signal and kinase inhibition.
  • Belongs to the SOCS1 family.
Domain:
  • The ESS and SH2 domains are required for JAK phosphotyrosine binding. Further interaction with the KIR domain is necessary for signal and kinase inhibition.
  • The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes. The Elongin BC complex binding domain is also known as BC-box with the consensus [APST]-L-x(3)-C-x(3)-[AILV] and is part of the SOCS box (By similarity).
Family:
  • Belongs to the SOCS1 family.
genes like me logo Genes that share domains with SOCS1: view

Function for SOCS1 Gene

Molecular function for SOCS1 Gene

UniProtKB/Swiss-Prot Function:
SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS1 is involved in negative regulation of cytokines that signal through the JAK/STAT3 pathway. Through binding to JAKs, inhibits their kinase activity. In vitro, also suppresses Tec protein-tyrosine activity. Appears to be a major regulator of signaling by interleukin 6 (IL6) and leukemia inhibitory factor (LIF). Regulates interferon-gamma mediated sensory neuron survival (By similarity). Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize JAK2. SOCS1 appears to be a negative regulator in IGF1R signaling pathway.
UniProtKB/Swiss-Prot Induction:
By a subset of cytokines including those belonging to the interferon, interleukin and colony-stimulating factor families.

Phenotypes From GWAS Catalog for SOCS1 Gene

Gene Ontology (GO) - Molecular Function for SOCS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004860 protein kinase inhibitor activity TAS 9202125
GO:0005159 insulin-like growth factor receptor binding IPI 9727029
GO:0005515 protein binding IPI 16273093
GO:0019210 kinase inhibitor activity IEA,ISS --
GO:0019901 protein kinase binding IPI 9727029
genes like me logo Genes that share ontologies with SOCS1: view
genes like me logo Genes that share phenotypes with SOCS1: view

Animal Models for SOCS1 Gene

MGI Knock Outs for SOCS1:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SOCS1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SOCS1 Gene

Localization for SOCS1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SOCS1 Gene

Nucleus. Cytoplasmic vesicle. Note=Detected in perinuclear cytoplasmic vesicles upon interaction with FGFR3.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SOCS1 gene
Compartment Confidence
nucleus 5
cytosol 5
plasma membrane 3
extracellular 3
cytoskeleton 2
mitochondrion 2
endoplasmic reticulum 2
endosome 2
lysosome 2
golgi apparatus 2
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (3)
  • Cytoplasmic bodies (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SOCS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm TAS 9202126
GO:0005829 cytosol TAS --
GO:0005942 phosphatidylinositol 3-kinase complex IBA 21873635
genes like me logo Genes that share ontologies with SOCS1: view

Pathways & Interactions for SOCS1 Gene

genes like me logo Genes that share pathways with SOCS1: view

Pathways by source for SOCS1 Gene

7 GeneGo (Thomson Reuters) pathways for SOCS1 Gene
  • Development EPO-induced Jak-STAT pathway
  • Development Prolactin receptor signaling
  • Development_Thrombopoetin signaling via JAK-STAT pathway
  • Immune response IFN alpha/beta signaling pathway
  • Immune response IFN gamma signaling pathway
8 Qiagen pathways for SOCS1 Gene
  • Growth Hormone Signaling
  • IL-4 Pathway
  • IL-6 Pathway
  • IL-9 Pathway
  • JAK-STAT Pathway
1 Cell Signaling Technology pathway for SOCS1 Gene
1 GeneTex pathway for SOCS1 Gene

UniProtKB/Swiss-Prot O15524-SOCS1_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

SIGNOR curated interactions for SOCS1 Gene

Inactivates:
Is activated by:

Gene Ontology (GO) - Biological Process for SOCS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001932 regulation of protein phosphorylation IEA,ISS --
GO:0006469 negative regulation of protein kinase activity IEA --
GO:0007259 JAK-STAT cascade IEA --
GO:0009968 negative regulation of signal transduction IEA --
GO:0010533 regulation of activation of Janus kinase activity IEA --
genes like me logo Genes that share ontologies with SOCS1: view

Drugs & Compounds for SOCS1 Gene

(5) Drugs for SOCS1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(7) Additional Compounds for SOCS1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SOCS1: view

Transcripts for SOCS1 Gene

mRNA/cDNA for SOCS1 Gene

1 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SOCS1

Alternative Splicing Database (ASD) splice patterns (SP) for SOCS1 Gene

No ASD Table

Relevant External Links for SOCS1 Gene

GeneLoc Exon Structure for
SOCS1

Expression for SOCS1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SOCS1 Gene

Protein differential expression in normal tissues from HIPED for SOCS1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SOCS1 Gene



Protein tissue co-expression partners for SOCS1 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SOCS1

SOURCE GeneReport for Unigene cluster for SOCS1 Gene:

Hs.50640

mRNA Expression by UniProt/SwissProt for SOCS1 Gene:

O15524-SOCS1_HUMAN
Tissue specificity: Expressed in all tissues with high expression in spleen, small intestine and peripheral blood leukocytes.

Evidence on tissue expression from TISSUES for SOCS1 Gene

  • Lung(3.6)
  • Blood(3.2)
  • Skin(3.1)
  • Lymph node(3)
  • Spleen(2.9)
  • Intestine(2.9)
  • Liver(2.9)
  • Nervous system(2.8)
  • Kidney(2.7)
  • Bone marrow(2.7)
  • Heart(2.7)
  • Muscle(2.6)
  • Pancreas(2.4)
  • Stomach(2.4)
  • Thyroid gland(2.4)
  • Bone(2.1)
genes like me logo Genes that share expression patterns with SOCS1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for SOCS1 Gene

Orthologs for SOCS1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SOCS1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia SOCS1 30 31
  • 99.21 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia SOCS1 30 31
  • 95.24 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia SOCS1 30 31
  • 94.15 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Socs1 30
  • 88.63 (n)
Mouse
(Mus musculus)
Mammalia Socs1 30 17 31
  • 88.47 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia SOCS1 31
  • 73 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia SOCS1 31
  • 41 (a)
OneToOne
Chicken
(Gallus gallus)
Aves SOCS1 30 31
  • 63.77 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia SOCS1 31
  • 62 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia socs1 30
  • 55.77 (n)
Zebrafish
(Danio rerio)
Actinopterygii socs1a 30 31
  • 52.99 (n)
OneToMany
socs1b 31
  • 38 (a)
OneToMany
Species where no ortholog for SOCS1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for SOCS1 Gene

ENSEMBL:
Gene Tree for SOCS1 (if available)
TreeFam:
Gene Tree for SOCS1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SOCS1: view image

Paralogs for SOCS1 Gene

Paralogs for SOCS1 Gene

(1) SIMAP similar genes for SOCS1 Gene using alignment to 2 proteins:

  • SOCS1_HUMAN
  • Q4JHT5_HUMAN
genes like me logo Genes that share paralogs with SOCS1: view

Variants for SOCS1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SOCS1 Gene

SNP ID Clinical significance and condition Chr 16 pos Variation AA Info Type
721574 Benign: not provided 11,254,915(-) G/A SYNONYMOUS_VARIANT
rs11549428 Likely Benign: not specified; not provided. - 11,254,849(-) C/Gp.Gln210His MISSENSE_VARIANT
rs1555512165 Uncertain Significance: not provided 11,255,370(-) CG/C FRAMESHIFT_VARIANT
rs587778690 Not Provided: not specified 11,255,339(-) G/GCCGGGA INFRAME_INSERTION
rs587778691 Not Provided: not specified 11,255,329(-) GGGGGCC/G INFRAME_DELETION

Additional dbSNP identifiers (rs#s) for SOCS1 Gene

Structural Variations from Database of Genomic Variants (DGV) for SOCS1 Gene

Variant ID Type Subtype PubMed ID
esv23744 CNV loss 19812545
nsv1040428 CNV gain 25217958
nsv525548 CNV loss 19592680
nsv571453 CNV loss 21841781
nsv827552 CNV gain 20364138

Variation tolerance for SOCS1 Gene

Gene Damage Index Score: 0.50; 10.88% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SOCS1 Gene

Human Gene Mutation Database (HGMD)
SOCS1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SOCS1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SOCS1 Gene

Disorders for SOCS1 Gene

MalaCards: The human disease database

(27) MalaCards diseases for SOCS1 Gene - From: LncRNADisease, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
coronary heart disease 1
  • coronary heart disease, susceptibility to, 1
diabetes mellitus, noninsulin-dependent
  • niddm
myeloproliferative neoplasm
  • campomelic dysplasia
barrett's adenocarcinoma
  • adenocarcinoma arising in barrett's mucosa
n syndrome
  • nsx
- elite association - COSMIC cancer census association via MalaCards
Search SOCS1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for SOCS1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with SOCS1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SOCS1 Gene

Publications for SOCS1 Gene

  1. Suppressor of cytokine signaling 1 gene expression and polymorphisms in systemic lupus erythematosus. (PMID: 20064913) Chan HC … Yen JH (Lupus 2010) 3 23 41
  2. Functional SOCS1 polymorphisms are associated with variation in obesity in whites. (PMID: 19215277) Gylvin T … Pociot F (Diabetes, obesity & metabolism 2009) 3 23 41
  3. Functional polymorphism in the suppressor of cytokine signaling 1 gene associated with adult asthma. (PMID: 17099141) Harada M … Tamari M (American journal of respiratory cell and molecular biology 2007) 3 23 41
  4. Suppressors of cytokine signaling (SOCS) 1 and SOCS3 interact with and modulate fibroblast growth factor receptor signaling. (PMID: 16410555) Ben-Zvi T … Monsonego-Ornan E (Journal of cell science 2006) 3 4 23
  5. TRIM8/GERP RING finger protein interacts with SOCS-1. (PMID: 12163497) Toniato E … Rothman P (The Journal of biological chemistry 2002) 3 4 23

Products for SOCS1 Gene

  • Addgene plasmids for SOCS1

Sources for SOCS1 Gene