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This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including IL2, IL3 erythropoietin (EPO), CSF2/GM-CSF, and interferon (IFN)-gamma. The protein ... See more...
Aliases for SOCS1 Gene
Aliases for SOCS1 Gene
External Ids for SOCS1 Gene
- HGNC: 19383
- Entrez Gene: 8651
- Ensembl: ENSG00000185338
- OMIM: 603597
- UniProtKB: O15524
Previous GeneCards Identifiers for SOCS1 Gene
- GC16M011499
- GC16M011314
Summaries for SOCS1 Gene
-
This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including IL2, IL3 erythropoietin (EPO), CSF2/GM-CSF, and interferon (IFN)-gamma. The protein encoded by this gene functions downstream of cytokine receptors, and takes part in a negative feedback loop to attenuate cytokine signaling. Knockout studies in mice suggested the role of this gene as a modulator of IFN-gamma action, which is required for normal postnatal growth and survival. [provided by RefSeq, Jul 2008]
GeneCards Summary for SOCS1 Gene
SOCS1 (Suppressor Of Cytokine Signaling 1) is a Protein Coding gene. Diseases associated with SOCS1 include Coronary Heart Disease 1 and Diabetes Mellitus, Noninsulin-Dependent. Among its related pathways are Signaling by GPCR and Immune response IFN alpha/beta signaling pathway. Gene Ontology (GO) annotations related to this gene include protein kinase binding and insulin-like growth factor receptor binding. An important paralog of this gene is SOCS2.
UniProtKB/Swiss-Prot Summary for SOCS1 Gene
-
SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS1 is involved in negative regulation of cytokines that signal through the JAK/STAT3 pathway. Through binding to JAKs, inhibits their kinase activity. In vitro, also suppresses Tec protein-tyrosine activity. Appears to be a major regulator of signaling by interleukin 6 (IL6) and leukemia inhibitory factor (LIF). Regulates interferon-gamma mediated sensory neuron survival (By similarity). Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize JAK2. SOCS1 appears to be a negative regulator in IGF1R signaling pathway.
Additional gene information for SOCS1 Gene
- HGNC(19383)
- Entrez Gene(8651)
- Ensembl(ENSG00000185338)
- OMIM(603597)
- UniProtKB(O15524)
- Open Targets Platform(ENSG00000185338)
- Monarch Initiative
- Search for SOCS1 at DataMed
- Search for SOCS1 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SOCS1 Gene
Genomics for SOCS1 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for SOCS1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around SOCS1 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SOCS1
- Top Transcription factor binding sites by QIAGEN in the SOCS1 gene promoter:
-
- AP-1
- ATF-2
- CREB
- deltaCREB
- STAT3
Genomic Locations for SOCS1 Gene
Genomic Locations for SOCS1 Gene
- chr16:11,254,408-11,256,204
- (GRCh38/hg38)
- Size:
- 1,797 bases
- Orientation:
- Minus strand
- chr16:11,348,262-11,350,039
- (GRCh37/hg19)
- Size:
- 1,778 bases
- Orientation:
- Minus strand
Genomic View for SOCS1 Gene
Genes around SOCS1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 16p13.13 by HGNC
- 16p13.13 by Entrez Gene
- 16p13.13 by Ensembl
SOCS1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for SOCS1 Gene
Proteins for SOCS1 Gene
-
Protein details for SOCS1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O15524-SOCS1_HUMAN
- Recommended name:
- Suppressor of cytokine signaling 1
- Protein Accession:
- O15524
- O15097
- Q9NSA7
Protein attributes for SOCS1 Gene
- Size:
- 211 amino acids
- Molecular mass:
- 23551 Da
- Quaternary structure:
-
- Interacts with multiple activated signaling proteins of the tyrosine kinase signaling pathway including JAK family kinases, TEC, KIT, GRB2 and VAV. Binding to JAKs is mediated through the KIR and SH2 domains to a phosphorylated tyrosine residue within the JAK JH1 domain. Binds the SH3 domain of GRB2 via diproline determinants in the N-terminus, and the N-terminal regulatory domain of VAV (By similarity). Interacts with the Elongin BC complex (ELOB and ELOC). Component of an ECS CBC(SOCS1) E3 ubiquitin-protein ligase complex which contains Elongin BC, CUL5, RBX1 and SOCS1 (By similarity). Interacts (via SH2 domain and SOCS box) with TRIM8 (By similarity). Interacts with AXL, CUL2 and FGFR3. Interacts with INSR (By similarity). Interacts with TRIM8 (PubMed:12163497).
Protein Expression for SOCS1 Gene
Post-translational modifications for SOCS1 Gene
Other Protein References for SOCS1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- LifeSpan BioSciences SOCS1 Antibody (LS-B2698) and SOCS1 Antibody (LS-B2697)
- G Biosciences Immunotag™ SOCS-1 Antibody
- NSJ Bioreagents SOCS1 Antibody
- Creative Diagnostics Anti-SOCS1 monoclonal antibody
- Creative Biolabs Recombinant Anti-Human SOCS1 Antibody
- GeneTex Anti-SOCS1 antibody
-
Custom Antibody ServicesOriGene Antibodies for SOCS1
- Novus Biologicals Antibodies for SOCS1
-
Abcam antibodies for SOCS1
- Invitrogen Antibodies for SOCS1 (AFLGC-Socs1)
- antibodies-online: Show 48 available SOCS1 Antibodies ranked by validation data
- Compare Top SOCS1 Antibodies
-
Recommended
- 140 WB Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 4 IHC Antibodies (anti-human)
- 4 IP Antibodies (anti-human)
- 2 IHC (p) Antibodies (anti-human)
- 1 IF Antibody (anti-human)
- 1 IF/ICC Antibody (anti-human)
- 75 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 4 IP Antibodies (anti-mouse)
- 1 IHC Antibody (anti-mouse)
- 60 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 4 IP Antibodies (anti-rat)
- 1 IHC Antibody (anti-rat)
-
Boster Bio Antibodies for SOCS1
-
Custom Antibody ServicesProSci Antibodies for SOCS1
-
Santa Cruz Biotechnology (SCBT) Antibodies for SOCS1
- Sino Biological Antibodies for SOCS1
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for SOCS1
- Origene Custom Protein Services for SOCS1
-
Abcam proteins for SOCS1
Assay Products
- Aviva Systems Biology SOCS1 ELISA Kit (Human) (OKCD09032)
- antibodies-online: Show 28 available SOCS1 Elisa Kits ranked by validation data
- Compare Top SOCS1 Elisa Kits
-
Quality Products:
- ABIN422769
- ABIN1572468
- ABIN5521575
- ABIN5519136
- ABIN5592613
- ABIN2539286
- ABIN4972882
- ABIN2951599
- ABIN6207607
- ABIN578750
- ABIN858373
- ABIN5521576
- ABIN5674725
- ABIN2951600
- ABIN5070932
- ABIN584387
- ABIN436798
- ABIN436802
- ABIN1572469
- ABIN5665064
- ABIN5521577
- ABIN5592614
- ABIN2539287
- ABIN6207608
- ABIN2951601
- ABIN5070730
No data available for DME Specific Peptides for SOCS1 Gene
Domains & Families for SOCS1 Gene
Gene Families for SOCS1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Predicted intracellular proteins
Protein Domains for SOCS1 Gene
- InterPro:
- Blocks:
-
- SOCS protein, C-terminal
- ProtoNet:
Suggested Antigen Peptide Sequences for SOCS1 Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA FLJ45719 fis, clone FELNG2001953, highly similar to Suppressor of cytokine signaling 1 (Q4JHT5_HUMAN)
- Suppressor of cytokine signalling protein (Q9NSA8_HUMAN)
- Tec-interacting protein 3 (SOCS1_HUMAN)
Graphical View of Domain Structure for InterPro Entry
O15524UniProtKB/Swiss-Prot:
SOCS1_HUMAN :- The ESS and SH2 domains are required for JAK phosphotyrosine binding. Further interaction with the KIR domain is necessary for signal and kinase inhibition.
- Belongs to the SOCS1 family.
- Domain:
-
- The ESS and SH2 domains are required for JAK phosphotyrosine binding. Further interaction with the KIR domain is necessary for signal and kinase inhibition.
- The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes. The Elongin BC complex binding domain is also known as BC-box with the consensus [APST]-L-x(3)-C-x(3)-[AILV] and is part of the SOCS box (By similarity).
- Family:
-
- Belongs to the SOCS1 family.
Function for SOCS1 Gene
Molecular function for SOCS1 Gene
- UniProtKB/Swiss-Prot Function:
- SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS1 is involved in negative regulation of cytokines that signal through the JAK/STAT3 pathway. Through binding to JAKs, inhibits their kinase activity. In vitro, also suppresses Tec protein-tyrosine activity. Appears to be a major regulator of signaling by interleukin 6 (IL6) and leukemia inhibitory factor (LIF). Regulates interferon-gamma mediated sensory neuron survival (By similarity). Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize JAK2. SOCS1 appears to be a negative regulator in IGF1R signaling pathway.
- UniProtKB/Swiss-Prot Induction:
- By a subset of cytokines including those belonging to the interferon, interleukin and colony-stimulating factor families.
Phenotypes From GWAS Catalog for SOCS1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004860 | protein kinase inhibitor activity | TAS | 9202125 |
| GO:0005159 | insulin-like growth factor receptor binding | IPI | 9727029 |
| GO:0005515 | protein binding | IPI | 16273093 |
| GO:0019210 | kinase inhibitor activity | IEA,ISS | -- |
| GO:0019901 | protein kinase binding | IPI | 9727029 |
Phenotypes for SOCS1 Gene
- MGI mutant phenotypes for SOCS1:
-
inferred from 9 alleles
- immune system phenotype
- respiratory system phenotype
- normal phenotype
- cardiovascular system phenotype
- cellular phenotype
- mortality/aging
- muscle phenotype
- homeostasis/metabolism phenotype
- growth/size/body region phenotype
- liver/biliary system phenotype
- renal/urinary system phenotype
- neoplasm
- digestive/alimentary phenotype
- endocrine/exocrine gland phenotype
- reproductive system phenotype
- vision/eye phenotype
- hematopoietic system phenotype
- integument phenotype
- GenomeRNAi human phenotypes for SOCS1:
-
- Mildly decreased CFP-tsO45G cell surface transport
- no effect
- Increased cell death HMECs cells
- Decreased viability
- Negative genetic interaction between BLM-/- and BLM+/+
- Decreased nuclei size in G2M
- Decreased telomerase activity
- Negative genetic interaction between PTEN-/- and PTEN+/+
- Decreased viability in colon lineage; decreased viability in glioblastoma multiforme (GBM) lineage
Animal Models for SOCS1 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for SOCS1 - Select products 50% OFF >
- * SOCS1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for SOCS1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SOCS1
-
Santa Cruz Biotechnology (SCBT) CRISPR for SOCS1
miRNA for SOCS1 Gene
- miRTarBase miRNAs that target SOCS1
-
- hsa-miR-155-5p (MIRT000456)
- mmu-miR-155-5p (MIRT003034)
- hsa-miR-19b-3p (MIRT004336)
- hsa-miR-19a-3p (MIRT004337)
- hsa-miR-30b-5p (MIRT006325)
- hsa-let-7i-5p (MIRT006373)
- hsa-miR-122-5p (MIRT007084)
- hsa-miR-30c-5p (MIRT007132)
- hsa-miR-30d-5p (MIRT053037)
- hsa-miR-221-3p (MIRT438547)
- hsa-miR-2113 (MIRT492190)
- hsa-miR-527 (MIRT492191)
- hsa-miR-518a-5p (MIRT492192)
- hsa-miR-4709-3p (MIRT492193)
- hsa-miR-4266 (MIRT492194)
- hsa-miR-5087 (MIRT492195)
- hsa-miR-503-3p (MIRT492196)
- hsa-miR-6851-5p (MIRT492197)
- hsa-miR-3689d (MIRT492198)
- hsa-miR-29b-1-5p (MIRT492199)
- hsa-miR-6861-5p (MIRT492200)
- hsa-miR-8060 (MIRT492201)
- hsa-miR-380-3p (MIRT492202)
- hsa-miR-411-3p (MIRT492203)
- hsa-miR-379-3p (MIRT492204)
- hsa-miR-4495 (MIRT492205)
- hsa-miR-4779 (MIRT492206)
- hsa-miR-4695-5p (MIRT492207)
- hsa-miR-331-3p (MIRT492208)
- hsa-miR-30a-5p (MIRT492209)
- hsa-miR-30e-5p (MIRT492210)
- hsa-let-7d-5p (MIRT492211)
- hsa-let-7g-5p (MIRT492212)
- hsa-let-7f-5p (MIRT492213)
- hsa-miR-4458 (MIRT492214)
- hsa-miR-98-5p (MIRT492215)
- hsa-let-7e-5p (MIRT492216)
- hsa-miR-4500 (MIRT492217)
- hsa-let-7c-5p (MIRT492218)
- hsa-let-7b-5p (MIRT492219)
- hsa-let-7a-5p (MIRT492220)
- hsa-miR-142-5p (MIRT731736)
- mmu-miR-155-3p (MIRT732850)
- mmu-miR-155-5p (MIRT734704)
- hsa-miR-21-5p (MIRT734892)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for SOCS1
- Browse OriGene Inhibitory RNA Products For SOCS1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SOCS1
Clone Products
- Applied Biological Materials (abm): Clones for SOCS1 - Select products 50% OFF >
- * SOCS1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for SOCS1
- Addgene plasmids for SOCS1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SOCS1
Cell Line Products
-
Horizon Cell Lines for SOCS1
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SOCS1 Gene
Localization for SOCS1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for SOCS1 Gene
- Nucleus. Cytoplasmic vesicle. Note=Detected in perinuclear cytoplasmic vesicles upon interaction with FGFR3.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
| plasma membrane | 3 |
| extracellular | 3 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| endoplasmic reticulum | 2 |
| endosome | 2 |
| lysosome | 2 |
| golgi apparatus | 2 |
| peroxisome | 1 |
- Nucleoplasm (3)
- Cytoplasmic bodies (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA | -- |
| GO:0005654 | nucleoplasm | IDA | -- |
| GO:0005737 | cytoplasm | TAS | 9202126 |
| GO:0005829 | cytosol | TAS | -- |
| GO:0005942 | phosphatidylinositol 3-kinase complex | IBA | 21873635 |
Pathways & Interactions for SOCS1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Activated TLR4 signalling | ||
| 2 | Prolactin Signaling Pathway |
Development Prolactin receptor signaling
.38
|
|
| 3 | IL-2 Pathway |
Prolactin Signaling
.54
Growth Hormone Signaling
.49
|
IL-4 Pathway
.34
|
| 4 | Class I MHC mediated antigen processing and presentation | ||
| 5 | Immune response IFN alpha/beta signaling pathway |
Immune response IFN alpha/beta signaling pathway
.74
|
|
Pathways by source for SOCS1 Gene
2 Sino Biological pathways for SOCS1 Gene
14 BioSystems pathways for SOCS1 Gene
24 Reactome pathways for SOCS1 Gene
7 GeneGo (Thomson Reuters) pathways for SOCS1 Gene
- Development EPO-induced Jak-STAT pathway
- Development Prolactin receptor signaling
- Development_Thrombopoetin signaling via JAK-STAT pathway
- Immune response IFN alpha/beta signaling pathway
- Immune response IFN gamma signaling pathway
8 Qiagen pathways for SOCS1 Gene
- Growth Hormone Signaling
- IL-4 Pathway
- IL-6 Pathway
- IL-9 Pathway
- JAK-STAT Pathway
1 Cell Signaling Technology pathway for SOCS1 Gene
1 GeneTex pathway for SOCS1 Gene
UniProtKB/Swiss-Prot O15524-SOCS1_HUMAN
- Pathway: Protein modification; protein ubiquitination.
Interacting Proteins for SOCS1 Gene
Selected Interacting proteins:
O15524-SOCS1_HUMAN
ENSP00000329418
for SOCS1 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for SOCS1
SIGNOR curated interactions for SOCS1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001932 | regulation of protein phosphorylation | IEA,ISS | -- |
| GO:0006469 | negative regulation of protein kinase activity | IEA | -- |
| GO:0007259 | JAK-STAT cascade | IEA | -- |
| GO:0009968 | negative regulation of signal transduction | IEA | -- |
| GO:0010533 | regulation of activation of Janus kinase activity | IEA | -- |
Transcripts for SOCS1 Gene
mRNA/cDNA for SOCS1 Gene
- 1 REFSEQ mRNAs :
- 6 NCBI additional mRNA sequence :
- 2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000332029 1247 nts (view in UCSC)
- ENST00000644787 1784 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for SOCS1 - Select products 50% OFF >
- * SOCS1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for SOCS1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SOCS1
-
Santa Cruz Biotechnology (SCBT) CRISPR for SOCS1
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for SOCS1
- Browse OriGene Inhibitory RNA Products For SOCS1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SOCS1
Clone Products
- Applied Biological Materials (abm): Clones for SOCS1 - Select products 50% OFF >
- * SOCS1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for SOCS1
- Addgene plasmids for SOCS1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SOCS1
Relevant External Links for SOCS1 Gene
- GeneLoc Exon Structure for
- SOCS1
Expression for SOCS1 Gene
This gene is overexpressed in Peripheral blood mononuclear cells (69.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SOCS1 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SOCS1
SOURCE GeneReport for Unigene cluster for SOCS1 Gene:
Hs.50640mRNA Expression by UniProt/SwissProt for SOCS1 Gene:
O15524-SOCS1_HUMAN
Tissue specificity:
Expressed in all tissues with high expression in spleen, small intestine and peripheral blood leukocytes.
Evidence on tissue expression from TISSUES for SOCS1 Gene
- Lung(3.6)
- Blood(3.2)
- Skin(3.1)
- Lymph node(3)
- Spleen(2.9)
- Intestine(2.9)
- Liver(2.9)
- Nervous system(2.8)
- Kidney(2.7)
- Bone marrow(2.7)
- Heart(2.7)
- Muscle(2.6)
- Pancreas(2.4)
- Stomach(2.4)
- Thyroid gland(2.4)
- Bone(2.1)
Primer Products
-
OriGene qPCR primer pairs for SOCS1
-
OriGene qPCR primer pairs and template standards for SOCS1
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for SOCS1 Gene
Orthologs for SOCS1 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | SOCS1 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | SOCS1 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | SOCS1 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Socs1 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Socs1 30 17 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | SOCS1 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | SOCS1 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | SOCS1 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | SOCS1 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | socs1 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | socs1a 30 31 |
|
OneToMany | |
| socs1b 31 |
|
OneToMany |
- Species where no ortholog for SOCS1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for SOCS1 Gene
- ENSEMBL:
- Gene Tree for SOCS1 (if available)
- TreeFam:
- Gene Tree for SOCS1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for SOCS1: view image
Paralogs for SOCS1 Gene
Variants for SOCS1 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SOCS1 Gene
| SNP ID | Clinical significance and condition | Chr 16 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 721574 | Benign: not provided | 11,254,915(-) | G/A | SYNONYMOUS_VARIANT | |
| rs11549428 | Likely Benign: not specified; not provided. - | 11,254,849(-) | C/Gp.Gln210His | MISSENSE_VARIANT | |
| rs1555512165 | Uncertain Significance: not provided | 11,255,370(-) | CG/C | FRAMESHIFT_VARIANT | |
| rs587778690 | Not Provided: not specified | 11,255,339(-) | G/GCCGGGA | INFRAME_INSERTION | |
| rs587778691 | Not Provided: not specified | 11,255,329(-) | GGGGGCC/G | INFRAME_DELETION |
Gene Damage Index Score:
0.50;
10.88% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for SOCS1 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SOCS1 Gene
Disorders for SOCS1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| coronary heart disease 1 |
|
|
| diabetes mellitus, noninsulin-dependent |
|
|
| myeloproliferative neoplasm |
|
|
| barrett's adenocarcinoma |
|
|
| n syndrome |
|
|
Search SOCS1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for SOCS1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for SOCS1 Gene
Publications for SOCS1 Gene
- Suppressor of cytokine signaling 1 gene expression and polymorphisms in systemic lupus erythematosus. (PMID: 20064913) Chan HC … Yen JH (Lupus 2010) 3 23 41
- Functional SOCS1 polymorphisms are associated with variation in obesity in whites. (PMID: 19215277) Gylvin T … Pociot F (Diabetes, obesity & metabolism 2009) 3 23 41
- Functional polymorphism in the suppressor of cytokine signaling 1 gene associated with adult asthma. (PMID: 17099141) Harada M … Tamari M (American journal of respiratory cell and molecular biology 2007) 3 23 41
- Suppressors of cytokine signaling (SOCS) 1 and SOCS3 interact with and modulate fibroblast growth factor receptor signaling. (PMID: 16410555) Ben-Zvi T … Monsonego-Ornan E (Journal of cell science 2006) 3 4 23
- TRIM8/GERP RING finger protein interacts with SOCS-1. (PMID: 12163497) Toniato E … Rothman P (The Journal of biological chemistry 2002) 3 4 23
ExternalLinks
Products for SOCS1 Gene
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- antibodies-online: Show 48 available SOCS1 Antibodies ranked by validation data
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- 140 WB Antibodies (anti-human)
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- 2 IHC (p) Antibodies (anti-human)
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- 75 WB Antibodies (anti-mouse)
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- 4 IP Antibodies (anti-mouse)
- 1 IHC Antibody (anti-mouse)
- 60 WB Antibodies (anti-rat)
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- antibodies-online: Show 28 available SOCS1 Elisa Kits ranked by validation data
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- antibodies-online: Show 6 available SOCS1 Proteins ranked by validation data
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Sources for SOCS1 Gene
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