The protein encoded by this gene belongs to the acyltransferase family. It is located in the endoplasmic reticulum, and catalyzes the formation of fatty acid-cholesterol esters. This gene has been implicated in the formation of beta-amyloid and atherosclerotic plaques by controlling the equilibrium between free cholesterol and cytoplasmic cholesteryl esters. Alternatively splic... See more...

Aliases for SOAT1 Gene

Aliases for SOAT1 Gene

  • Sterol O-Acyltransferase 1 2 3 4 5
  • ACAT 2 3 4
  • Sterol O-Acyltransferase (Acyl-Coenzyme A: Cholesterol Acyltransferase) 1 2 3
  • Acyl-Coenzyme A:Cholesterol Acyltransferase 1 3 4
  • EC 2.3.1.26 4 51
  • ACAT-1 3 4
  • ACACT 3 4
  • ACAT1 3 4
  • SOAT 3 4
  • STAT 3 4
  • Acyl-Coenzyme A: Cholesterol Acyltransferase 2
  • Cholesterol Acyltransferase 1 4
  • ACACT1 4
  • SOAT1 5

External Ids for SOAT1 Gene

Previous HGNC Symbols for SOAT1 Gene

  • SOAT
  • STAT

Previous GeneCards Identifiers for SOAT1 Gene

  • GC01P176787
  • GC01P174691
  • GC01P175783
  • GC01P176502
  • GC01P176453
  • GC01P175994
  • GC01P177529
  • GC01P150491

Summaries for SOAT1 Gene

Entrez Gene Summary for SOAT1 Gene

  • The protein encoded by this gene belongs to the acyltransferase family. It is located in the endoplasmic reticulum, and catalyzes the formation of fatty acid-cholesterol esters. This gene has been implicated in the formation of beta-amyloid and atherosclerotic plaques by controlling the equilibrium between free cholesterol and cytoplasmic cholesteryl esters. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2011]

GeneCards Summary for SOAT1 Gene

SOAT1 (Sterol O-Acyltransferase 1) is a Protein Coding gene. Diseases associated with SOAT1 include Chronic Leukemia and Sitosterolemia. Among its related pathways are Lipoprotein metabolism and cholesterol biosynthesis III (via desmosterol). Gene Ontology (GO) annotations related to this gene include cholesterol binding and sterol O-acyltransferase activity. An important paralog of this gene is SOAT2.

UniProtKB/Swiss-Prot Summary for SOAT1 Gene

  • Catalyzes the formation of fatty acid-cholesterol esters, which are less soluble in membranes than cholesterol. Plays a role in lipoprotein assembly and dietary cholesterol absorption (PubMed:9020103, PubMed:16154994). Utilizes oleoyl-CoA preferentially as susbstrate (PubMed:11294643). In addition to its acyltransferase activity, it may act as a ligase.

Tocris Summary for SOAT1 Gene

Gene Wiki entry for SOAT1 Gene

Additional gene information for SOAT1 Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SOAT1 Gene

Genomics for SOAT1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for SOAT1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J179293 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 610.2 +0.8 830 3.7 CEBPG SP1 HNRNPL CREB1 GATAD2A PRDM10 ZNF629 TFE3 ZNF512 RFX1 SOAT1 TOR3A AXDND1 LHX4 TDRD5 LOC100420262
GH01J179294 Enhancer 0.8 ENCODE 607.5 -1.2 -1153 0.2 GATAD2A ZNF512 CTCF FOXA1 ZNF24 REST RAD21 TRIM22 PKNOX1 CBX3 SOAT1 AXDND1 RPL39P11 ABL2
GH01J179309 Enhancer 1.1 FANTOM5 Ensembl ENCODE 13.2 +17.3 17287 4.8 IKZF1 DPF2 TCF12 CEBPB NFE2 ZNF316 FOS TRIM24 NCOR1 FOSL1 AXDND1 ABL2 TOR3A SOAT1 TDRD5 LOC100420262 lnc-AXDND1-1
GH01J179364 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 6.7 +72.2 72198 2.6 RNF2 CREB1 PRDM10 ZNF629 ZNF512 RFX1 LEF1 POLR2A BACH1 TARDBP AXDND1 HSALNG0008757 lnc-AXDND1-1 LHX4 TDRD5 RALGPS2 SOAT1 TOR3A piR-53562-032 NPHS2
GH01J179139 Promoter/Enhancer 1.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 6.7 -151.1 -151114 5.6 IKZF1 SP1 JUND EGR1 CEBPB EZH2 JUN TCF12 FOS FOSL1 ABL2 lnc-ANGPTL1-6 TOR3A AXDND1 SOAT1 piR-33303-009
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SOAT1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SOAT1

Top Transcription factor binding sites by QIAGEN in the SOAT1 gene promoter:
  • c-Myc
  • C/EBPbeta
  • IRF-1
  • p53
  • STAT3
  • TBP
  • TFIID

Genomic Locations for SOAT1 Gene

Genomic Locations for SOAT1 Gene
chr1:179,293,714-179,358,680
(GRCh38/hg38)
Size:
64,967 bases
Orientation:
Plus strand
chr1:179,262,925-179,327,815
(GRCh37/hg19)
Size:
64,891 bases
Orientation:
Plus strand

Genomic View for SOAT1 Gene

Genes around SOAT1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SOAT1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SOAT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SOAT1 Gene

Proteins for SOAT1 Gene

  • Protein details for SOAT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P35610-SOAT1_HUMAN
    Recommended name:
    Sterol O-acyltransferase 1
    Protein Accession:
    P35610
    Secondary Accessions:
    • A6NC40
    • A8K3P4
    • A9Z1V7
    • B4DU95
    • Q5T0X4
    • Q8N1E4

    Protein attributes for SOAT1 Gene

    Size:
    550 amino acids
    Molecular mass:
    64735 Da
    Quaternary structure:
    • May form homo- or heterodimers. Interacts with UBIAD1.

    Alternative splice isoforms for SOAT1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SOAT1 Gene

Selected DME Specific Peptides for SOAT1 Gene

P35610:
  • DWWNSTS
  • PTYVVLAYTLPPASRFI
  • SAVVHEYALAVCLS
  • GYSKSSHPLI
  • CPLKNPTFLDYVRPR
  • VVDYIDEGRLVLEF
  • YAFGKFPTV
  • PTVNQYLYFLFAPTLIYRD
  • VRENVPRVL
  • NHRAKDLRAPPEQGKIFI
  • IVNDSRK
  • RRSLLDEL
  • FFAFLHCWLNAFAEMLRFGDRMFY
  • SNYYRTWNVVVHDWLY

Post-translational modifications for SOAT1 Gene

  • Ubiquitination at Lys45, Lys120, Lys62, and Lys531
  • Modification sites at PhosphoSitePlus

Other Protein References for SOAT1 Gene

Antibody Products

  • Abcam antibodies for SOAT1
  • Boster Bio Antibodies for SOAT1

Domains & Families for SOAT1 Gene

Gene Families for SOAT1 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • FDA approved drug targets
  • Predicted membrane proteins

Protein Domains for SOAT1 Gene

InterPro:
Blocks:
  • Membrane bound O-acyl transferase, MBOAT
ProtoNet:

Suggested Antigen Peptide Sequences for SOAT1 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ75659 (A8K3P4_HUMAN)
  • cDNA FLJ50124, highly similar to Sterol O-acyltransferase 1 (EC 2.3.1.26) (B4DFD8_HUMAN)
  • cDNA FLJ50223, highly similar to Sterol O-acyltransferase 1 (EC 2.3.1.26) (B4DU95_HUMAN)
  • Cholesterol acyltransferase 1 (SOAT1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P35610

UniProtKB/Swiss-Prot:

SOAT1_HUMAN :
  • Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.
Family:
  • Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.
genes like me logo Genes that share domains with SOAT1: view

Function for SOAT1 Gene

Molecular function for SOAT1 Gene

UniProtKB/Swiss-Prot Function:
Catalyzes the formation of fatty acid-cholesterol esters, which are less soluble in membranes than cholesterol. Plays a role in lipoprotein assembly and dietary cholesterol absorption (PubMed:9020103, PubMed:16154994). Utilizes oleoyl-CoA preferentially as susbstrate (PubMed:11294643). In addition to its acyltransferase activity, it may act as a ligase.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=an acyl-CoA + cholesterol = a cholesterol ester + CoA; Xref=Rhea:RHEA:17729, ChEBI:CHEBI:16113, ChEBI:CHEBI:17002, ChEBI:CHEBI:57287, ChEBI:CHEBI:58342; EC=2.3.1.26; Evidence={ECO:0000269|PubMed:18480028};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(9Z)-octadecenoyl-CoA + cholesterol = cholesteryl (9Z-octadecenoate) + CoA; Xref=Rhea:RHEA:41436, ChEBI:CHEBI:16113, ChEBI:CHEBI:46898, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387; Evidence={ECO:0000269|PubMed:11294643, ECO:0000269|PubMed:9020103};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=cholesterol + hexadecanoyl-CoA = cholesteryl hexadecanoate + CoA; Xref=Rhea:RHEA:42792, ChEBI:CHEBI:3663, ChEBI:CHEBI:16113, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379; Evidence={ECO:0000269|PubMed:9020103};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=cholesterol + octadecanoyl-CoA = cholesteryl octadecanoate + CoA; Xref=Rhea:RHEA:42812, ChEBI:CHEBI:16113, ChEBI:CHEBI:57287, ChEBI:CHEBI:57394, ChEBI:CHEBI:82750; Evidence={ECO:0000269|PubMed:9020103};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(9Z,12Z)-octadecadienoyl-CoA + cholesterol = cholesteryl (9Z,12Z)-octadecadienoate + CoA; Xref=Rhea:RHEA:42796, ChEBI:CHEBI:16113, ChEBI:CHEBI:41509, ChEBI:CHEBI:57287, ChEBI:CHEBI:57383; Evidence={ECO:0000269|PubMed:9020103};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + cholesterol = cholesteryl (5Z,8Z,11Z,14Z)-eicosatetraenoate + CoA; Xref=Rhea:RHEA:42816, ChEBI:CHEBI:16113, ChEBI:CHEBI:57287, ChEBI:CHEBI:57368, ChEBI:CHEBI:82751; Evidence={ECO:0000269|PubMed:9020103};.
UniProtKB/Swiss-Prot Induction:
Highly activated by the presence of cholesterol.

Enzyme Numbers (IUBMB) for SOAT1 Gene

Phenotypes From GWAS Catalog for SOAT1 Gene

Gene Ontology (GO) - Molecular Function for SOAT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000062 fatty-acyl-CoA binding IBA,IDA 16647063
GO:0004772 sterol O-acyltransferase activity IDA,IMP 8407899
GO:0005515 protein binding IPI 21044950
GO:0008374 O-acyltransferase activity IBA 21873635
GO:0015485 cholesterol binding IDA 16647063
genes like me logo Genes that share ontologies with SOAT1: view
genes like me logo Genes that share phenotypes with SOAT1: view

Animal Models for SOAT1 Gene

MGI Knock Outs for SOAT1:

Animal Model Products

CRISPR Products

miRNA for SOAT1 Gene

miRTarBase miRNAs that target SOAT1

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SOAT1

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SOAT1 Gene

Localization for SOAT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SOAT1 Gene

Endoplasmic reticulum membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SOAT1 gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 3
extracellular 2
mitochondrion 2
peroxisome 2
nucleus 2
cytosol 2
lysosome 2
cytoskeleton 1
endosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Endoplasmic reticulum (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SOAT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA,IDA 10623671
GO:0005789 endoplasmic reticulum membrane IDA,TAS --
GO:0016020 membrane IDA 9756919
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SOAT1: view

Pathways & Interactions for SOAT1 Gene

genes like me logo Genes that share pathways with SOAT1: view

Pathways by source for SOAT1 Gene

Gene Ontology (GO) - Biological Process for SOAT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA --
GO:0008202 steroid metabolic process IEA --
GO:0008203 cholesterol metabolic process IBA,IMP 8407899
GO:0010742 macrophage derived foam cell differentiation NAS 18971559
GO:0010878 cholesterol storage IMP 8407899
genes like me logo Genes that share ontologies with SOAT1: view

No data available for SIGNOR curated interactions for SOAT1 Gene

Drugs & Compounds for SOAT1 Gene

(47) Drugs for SOAT1 Gene - From: DrugBank, ApexBio, DGIdb, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Ezetimibe Approved Pharma Target, inhibitor Cholesterol transport inhibitor 333
cholesterol Approved, Investigational Pharma Agonist 0
Omega-3-acid ethyl esters Approved, Investigational Pharma Enzyme, inhibitor 0
Hesperetin Experimental Pharma Target, inhibitor 0
CE(18:2(9Z,12Z)) Experimental Pharma 0

(95) Additional Compounds for SOAT1 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(2E)-Decenoyl-CoA
  • (e)-S-2-Decenoate
  • (e)-S-2-Decenoate CoA
  • (e)-S-2-Decenoate coenzyme A
  • (e)-S-2-Decenoic acid
  • 2-trans-Decenoyl-CoA
10018-95-8
(2E)-Dodecenoyl-CoA
1066-12-2
(2E)-Hexadecenoyl-CoA
  • (e)-C16:1 N-14-CoA
  • (e)-Hexadec-2-enoyl-CoA tetraanion
  • (e)-Hexadec-2-enoyl-coenzyme A tetraanion
  • (e)-Hexadec-2-enoyl-coenzyme A(4-)
  • trans-2-Hexadecenoyl-CoA(4-)
4460-95-1
(2E)-Octenoyl-CoA
  • (e)-S-2-Octenoate
  • (e)-S-2-Octenoate CoA
  • (e)-S-2-Octenoate coenzyme A
  • (e)-S-2-Octenoic acid
  • 2,3-trans-Octenoyl coenzyme A
10018-94-7
(2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-coenzyme A
  • trans-Tetra-dec-2-enoyl-CoA
  • trans-Tetra-dec-2-enoyl-coa.
  • trans-Tetra-dec-2-enoyl-coenzyme A
  • trans-Tetra-dec-2-enoyl-coenzyme A.
38795-33-4

(3) Tocris Compounds for SOAT1 Gene

Compound Action Cas Number
CI 976 Selective ACAT inhibitor 114289-47-3
VULM 1457 ACAT inhibitor 228544-65-8
YM 750 ACAT inhibitor 138046-43-2

(4) ApexBio Compounds for SOAT1 Gene

Compound Action Cas Number
Avasimibe ACAT inhibitor,orally bioavailable 166518-60-1
CI 976 114289-47-3
VULM 1457 228544-65-8
YM 750 138046-43-2
genes like me logo Genes that share compounds with SOAT1: view

Drug Products

Transcripts for SOAT1 Gene

mRNA/cDNA for SOAT1 Gene

3 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SOAT1

Alternative Splicing Database (ASD) splice patterns (SP) for SOAT1 Gene

No ASD Table

Relevant External Links for SOAT1 Gene

GeneLoc Exon Structure for
SOAT1

Expression for SOAT1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SOAT1 Gene

mRNA differential expression in normal tissues according to GTEx for SOAT1 Gene

This gene is overexpressed in Adrenal Gland (x11.4).

Protein differential expression in normal tissues from HIPED for SOAT1 Gene

This gene is overexpressed in Monocytes (18.8), Breast (11.5), Adrenal (8.6), Islet of Langerhans (8.1), and Peripheral blood mononuclear cells (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SOAT1 Gene



Protein tissue co-expression partners for SOAT1 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SOAT1

SOURCE GeneReport for Unigene cluster for SOAT1 Gene:

Hs.445588

Evidence on tissue expression from TISSUES for SOAT1 Gene

  • Adrenal gland(3.5)
  • Nervous system(3.5)
  • Liver(3)
  • Intestine(2.6)
  • Kidney(2.6)
  • Heart(2.5)
  • Spleen(2.5)
  • Blood(2.5)
  • Lung(2.3)
  • Muscle(2.3)
  • Gall bladder(2.1)
  • Skin(2.1)
genes like me logo Genes that share expression patterns with SOAT1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SOAT1 Gene

Orthologs for SOAT1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SOAT1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia SOAT1 30 31
  • 99.94 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia LOC490325 30
  • 90.77 (n)
SOAT1 31
  • 90 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia SOAT1 30 31
  • 87.92 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Soat1 30 17 31
  • 83.89 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Soat1 30
  • 83.85 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia SOAT1 31
  • 81 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 75 (a)
OneToMany
-- 31
  • 73 (a)
OneToMany
Chicken
(Gallus gallus)
Aves SOAT1 30 31
  • 69.61 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia SOAT1 31
  • 64 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia soat1 30
  • 66.11 (n)
Str.11436 30
Zebrafish
(Danio rerio)
Actinopterygii soat1 30 31
  • 62.54 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012216 30
  • 48.11 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta CG8112 30 31 32
  • 46.09 (n)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea mboa-1 30 31
  • 47.38 (n)
OneToMany
B0395.2 32
  • 35 (a)
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ARE1 31
  • 15 (a)
ManyToMany
ARE2 31
  • 15 (a)
ManyToMany
Species where no ortholog for SOAT1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for SOAT1 Gene

ENSEMBL:
Gene Tree for SOAT1 (if available)
TreeFam:
Gene Tree for SOAT1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SOAT1: view image

Paralogs for SOAT1 Gene

Paralogs for SOAT1 Gene

(1) SIMAP similar genes for SOAT1 Gene using alignment to 3 proteins:

  • SOAT1_HUMAN
  • B1APM4_HUMAN
  • B4DFD8_HUMAN
genes like me logo Genes that share paralogs with SOAT1: view

Variants for SOAT1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SOAT1 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
746440 Likely Benign: not provided 179,302,789(+) G/A SYNONYMOUS_VARIANT,FIVE_PRIME_UTR_VARIANT,INTRON_VARIANT
767731 Benign: not provided 179,341,109(+) G/A NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT
767732 Benign: not provided 179,341,178(+) G/A NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT
773819 Benign: not provided 179,342,188(+) A/G NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT
780280 Benign: not provided 179,341,140(+) C/G MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT

Additional dbSNP identifiers (rs#s) for SOAT1 Gene

Structural Variations from Database of Genomic Variants (DGV) for SOAT1 Gene

Variant ID Type Subtype PubMed ID
dgv121e212 CNV loss 25503493
dgv223n106 CNV deletion 24896259
dgv643n54 CNV loss 21841781
esv2666168 CNV deletion 23128226
esv2762031 CNV gain 21179565
esv3575338 CNV gain 25503493
esv3578289 CNV loss 25503493
esv3588049 CNV loss 21293372
esv990767 CNV deletion 20482838
nsv1005278 CNV gain 25217958
nsv518403 CNV gain 19592680
nsv523708 CNV loss 19592680
nsv548277 CNV loss 21841781
nsv548279 CNV gain 21841781

Variation tolerance for SOAT1 Gene

Residual Variation Intolerance Score: 25.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.59; 78.07% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SOAT1 Gene

Human Gene Mutation Database (HGMD)
SOAT1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SOAT1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SOAT1 Gene

Disorders for SOAT1 Gene

MalaCards: The human disease database

(8) MalaCards diseases for SOAT1 Gene - From: DISEASES, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search SOAT1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for SOAT1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with SOAT1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SOAT1 Gene

Publications for SOAT1 Gene

  1. Molecular cloning and functional expression of human acyl-coenzyme A:cholesterol acyltransferase cDNA in mutant Chinese hamster ovary cells. (PMID: 8407899) Chang CC … Chang TY (The Journal of biological chemistry 1993) 2 3 4 23
  2. Study on the association between SOAT1 polymorphisms, Alzheimer's disease risk and the level of CSF biomarkers. (PMID: 17622762) Lamsa R … Soininen H (Dementia and geriatric cognitive disorders 2007) 3 23 41
  3. The active site His-460 of human acyl-coenzyme A:cholesterol acyltransferase 1 resides in a hitherto undisclosed transmembrane domain. (PMID: 16154994) Guo ZY … Chang TY (The Journal of biological chemistry 2005) 3 4 23
  4. Association between acyl-coenzyme A: cholesterol acyltransferase gene and risk for Alzheimer's disease in Chinese. (PMID: 16043284) Zhao FG … Chan P (Neuroscience letters 2005) 3 23 41
  5. Human acyl-CoA:cholesterol acyltransferase-1 in the endoplasmic reticulum contains seven transmembrane domains. (PMID: 10438503) Lin S … Chang TY (The Journal of biological chemistry 1999) 3 4 23

Products for SOAT1 Gene

Sources for SOAT1 Gene