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The protein encoded by this gene belongs to the acyltransferase family. It is located in the endoplasmic reticulum, and catalyzes the formation of fatty acid-cholesterol esters. This gene has been implicated in the formation of beta-amyloid and atherosclerotic plaques by controlling the equilibrium between free cholesterol and cytoplasmic cholesteryl esters. Alternatively splic... See more...
Aliases for SOAT1 Gene
Aliases for SOAT1 Gene
External Ids for SOAT1 Gene
- HGNC: 11177
- Entrez Gene: 6646
- Ensembl: ENSG00000057252
- OMIM: 102642
- UniProtKB: P35610
Previous HGNC Symbols for SOAT1 Gene
- SOAT
- STAT
Previous GeneCards Identifiers for SOAT1 Gene
- GC01P176787
- GC01P174691
- GC01P175783
- GC01P176502
- GC01P176453
- GC01P175994
- GC01P177529
- GC01P150491
Summaries for SOAT1 Gene
-
The protein encoded by this gene belongs to the acyltransferase family. It is located in the endoplasmic reticulum, and catalyzes the formation of fatty acid-cholesterol esters. This gene has been implicated in the formation of beta-amyloid and atherosclerotic plaques by controlling the equilibrium between free cholesterol and cytoplasmic cholesteryl esters. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2011]
GeneCards Summary for SOAT1 Gene
SOAT1 (Sterol O-Acyltransferase 1) is a Protein Coding gene. Diseases associated with SOAT1 include Chronic Leukemia and Sitosterolemia. Among its related pathways are Lipoprotein metabolism and cholesterol biosynthesis III (via desmosterol). Gene Ontology (GO) annotations related to this gene include cholesterol binding and sterol O-acyltransferase activity. An important paralog of this gene is SOAT2.
UniProtKB/Swiss-Prot Summary for SOAT1 Gene
-
Catalyzes the formation of fatty acid-cholesterol esters, which are less soluble in membranes than cholesterol. Plays a role in lipoprotein assembly and dietary cholesterol absorption (PubMed:9020103, PubMed:16154994). Utilizes oleoyl-CoA preferentially as susbstrate (PubMed:11294643). In addition to its acyltransferase activity, it may act as a ligase.
Additional gene information for SOAT1 Gene
- HGNC(11177)
- Entrez Gene(6646)
- Ensembl(ENSG00000057252)
- OMIM(102642)
- UniProtKB(P35610)
- Open Targets Platform(ENSG00000057252)
- Search for SOAT1 at DataMed
- Search for SOAT1 at HumanCyc
No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SOAT1 Gene
Genomics for SOAT1 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for SOAT1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around SOAT1 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SOAT1
- Top Transcription factor binding sites by QIAGEN in the SOAT1 gene promoter:
-
- c-Myc
- C/EBPbeta
- IRF-1
- p53
- STAT3
- TBP
- TFIID
Genomic Locations for SOAT1 Gene
Genomic Locations for SOAT1 Gene
- chr1:179,293,714-179,358,680
- (GRCh38/hg38)
- Size:
- 64,967 bases
- Orientation:
- Plus strand
- chr1:179,262,925-179,327,815
- (GRCh37/hg19)
- Size:
- 64,891 bases
- Orientation:
- Plus strand
Genomic View for SOAT1 Gene
Genes around SOAT1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1q25.2 by HGNC
- 1q25.2 by Entrez Gene
- 1q25.2 by Ensembl
SOAT1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for SOAT1 Gene
Proteins for SOAT1 Gene
-
Protein details for SOAT1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P35610-SOAT1_HUMAN
- Recommended name:
- Sterol O-acyltransferase 1
- Protein Accession:
- P35610
- A6NC40
- A8K3P4
- A9Z1V7
- B4DU95
- Q5T0X4
- Q8N1E4
Protein attributes for SOAT1 Gene
- Size:
- 550 amino acids
- Molecular mass:
- 64735 Da
- Quaternary structure:
-
- May form homo- or heterodimers. Interacts with UBIAD1.
Protein Expression for SOAT1 Gene
Selected DME Specific Peptides for SOAT1 Gene
- P35610:
-
- DWWNSTS
- PTYVVLAYTLPPASRFI
- SAVVHEYALAVCLS
- GYSKSSHPLI
- CPLKNPTFLDYVRPR
- VVDYIDEGRLVLEF
- YAFGKFPTV
- PTVNQYLYFLFAPTLIYRD
- VRENVPRVL
- NHRAKDLRAPPEQGKIFI
- IVNDSRK
- RRSLLDEL
- FFAFLHCWLNAFAEMLRFGDRMFY
- SNYYRTWNVVVHDWLY
Post-translational modifications for SOAT1 Gene
Other Protein References for SOAT1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- LifeSpan BioSciences SOAT1 Antibody
- G Biosciences Immunotag™ SOAT1 Antibody
- Novus Biologicals Antibodies for SOAT1
-
Abcam antibodies for SOAT1
- Invitrogen Antibodies for SOAT1 (AFLGC-SOAT1)
-
Boster Bio Antibodies for SOAT1
-
Santa Cruz Biotechnology (SCBT) Antibodies for SOAT1
- Sino Biological Antibodies for SOAT1
Protein Products
-
OriGene Purified Proteins for SOAT1
- Search Origene for MassSpec and Protein Over-expression Lysates for SOAT1
- Origene Custom Protein Services for SOAT1
- antibodies-online: Show 7 available SOAT1 Proteins ranked by validation data
- Compare Top SOAT1 Proteins
-
Quality Products:
-
Abcam proteins for SOAT1
Assay Products
- antibodies-online: Show 1 available SOAT1 Elisa Kits ranked by validation data
- Compare Top SOAT1 Elisa Kits
-
Quality Products:
Domains & Families for SOAT1 Gene
Gene Families for SOAT1 Gene
- Human Protein Atlas (HPA):
-
- Enzymes
- FDA approved drug targets
- Predicted membrane proteins
Protein Domains for SOAT1 Gene
- InterPro:
- Blocks:
-
- Membrane bound O-acyl transferase, MBOAT
- ProtoNet:
Suggested Antigen Peptide Sequences for SOAT1 Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA FLJ75659 (A8K3P4_HUMAN)
- cDNA FLJ50124, highly similar to Sterol O-acyltransferase 1 (EC 2.3.1.26) (B4DFD8_HUMAN)
- cDNA FLJ50223, highly similar to Sterol O-acyltransferase 1 (EC 2.3.1.26) (B4DU95_HUMAN)
- Cholesterol acyltransferase 1 (SOAT1_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P35610UniProtKB/Swiss-Prot:
SOAT1_HUMAN :- Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.
- Family:
-
- Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.
Function for SOAT1 Gene
Molecular function for SOAT1 Gene
- UniProtKB/Swiss-Prot Function:
- Catalyzes the formation of fatty acid-cholesterol esters, which are less soluble in membranes than cholesterol. Plays a role in lipoprotein assembly and dietary cholesterol absorption (PubMed:9020103, PubMed:16154994). Utilizes oleoyl-CoA preferentially as susbstrate (PubMed:11294643). In addition to its acyltransferase activity, it may act as a ligase.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=an acyl-CoA + cholesterol = a cholesterol ester + CoA; Xref=Rhea:RHEA:17729, ChEBI:CHEBI:16113, ChEBI:CHEBI:17002, ChEBI:CHEBI:57287, ChEBI:CHEBI:58342; EC=2.3.1.26; Evidence={ECO:0000269|PubMed:18480028};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=(9Z)-octadecenoyl-CoA + cholesterol = cholesteryl (9Z-octadecenoate) + CoA; Xref=Rhea:RHEA:41436, ChEBI:CHEBI:16113, ChEBI:CHEBI:46898, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387; Evidence={ECO:0000269|PubMed:11294643, ECO:0000269|PubMed:9020103};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=cholesterol + hexadecanoyl-CoA = cholesteryl hexadecanoate + CoA; Xref=Rhea:RHEA:42792, ChEBI:CHEBI:3663, ChEBI:CHEBI:16113, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379; Evidence={ECO:0000269|PubMed:9020103};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=cholesterol + octadecanoyl-CoA = cholesteryl octadecanoate + CoA; Xref=Rhea:RHEA:42812, ChEBI:CHEBI:16113, ChEBI:CHEBI:57287, ChEBI:CHEBI:57394, ChEBI:CHEBI:82750; Evidence={ECO:0000269|PubMed:9020103};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=(9Z,12Z)-octadecadienoyl-CoA + cholesterol = cholesteryl (9Z,12Z)-octadecadienoate + CoA; Xref=Rhea:RHEA:42796, ChEBI:CHEBI:16113, ChEBI:CHEBI:41509, ChEBI:CHEBI:57287, ChEBI:CHEBI:57383; Evidence={ECO:0000269|PubMed:9020103};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + cholesterol = cholesteryl (5Z,8Z,11Z,14Z)-eicosatetraenoate + CoA; Xref=Rhea:RHEA:42816, ChEBI:CHEBI:16113, ChEBI:CHEBI:57287, ChEBI:CHEBI:57368, ChEBI:CHEBI:82751; Evidence={ECO:0000269|PubMed:9020103};.
- UniProtKB/Swiss-Prot Induction:
- Highly activated by the presence of cholesterol.
Enzyme Numbers (IUBMB) for SOAT1 Gene
Phenotypes From GWAS Catalog for SOAT1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000062 | fatty-acyl-CoA binding | IBA,IDA | 16647063 |
| GO:0004772 | sterol O-acyltransferase activity | IDA,IMP | 8407899 |
| GO:0005515 | protein binding | IPI | 21044950 |
| GO:0008374 | O-acyltransferase activity | IBA | 21873635 |
| GO:0015485 | cholesterol binding | IDA | 16647063 |
Phenotypes for SOAT1 Gene
- MGI mutant phenotypes for SOAT1:
- inferred from 4 alleles
- GenomeRNAi human phenotypes for SOAT1:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for SOAT1 - Select products 50% OFF >
- * SOAT1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for SOAT1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SOAT1
-
Santa Cruz Biotechnology (SCBT) CRISPR for SOAT1
miRNA for SOAT1 Gene
- miRTarBase miRNAs that target SOAT1
-
- mmu-miR-7b-5p (MIRT009088)
- mmu-miR-340-5p (MIRT010212)
- mmu-miR-24-3p (MIRT013759)
- mmu-miR-149-5p (MIRT014501)
- mmu-miR-9-5p (MIRT015206)
- hsa-miR-193b-3p (MIRT016592)
- hsa-miR-215-5p (MIRT024321)
- hsa-miR-192-5p (MIRT026807)
- hsa-miR-98-5p (MIRT027734)
- hsa-miR-1303 (MIRT035871)
- hsa-miR-500a-3p (MIRT041152)
- hsa-miR-186-5p (MIRT045139)
- mmu-miR-804 (MIRT604647)
- mmu-miR-665-3p (MIRT604648)
- mmu-miR-1195 (MIRT604649)
- mmu-miR-3089-5p (MIRT604650)
- mmu-miR-706 (MIRT605467)
- mmu-miR-340-3p (MIRT605468)
- hsa-miR-4684-5p (MIRT699018)
- hsa-miR-3675-3p (MIRT699019)
- hsa-miR-2681-3p (MIRT699020)
- hsa-miR-6771-3p (MIRT699021)
- hsa-miR-548x-3p (MIRT699022)
- hsa-miR-548j-3p (MIRT699023)
- hsa-miR-548aq-3p (MIRT699024)
- hsa-miR-548am-3p (MIRT699025)
- hsa-miR-548aj-3p (MIRT699026)
- hsa-miR-548ah-3p (MIRT699027)
- hsa-miR-548ae-3p (MIRT699028)
- hsa-miR-548z (MIRT699029)
- hsa-miR-548h-3p (MIRT699030)
- hsa-miR-548d-3p (MIRT699031)
- hsa-miR-548bb-3p (MIRT699032)
- hsa-miR-548ac (MIRT699033)
- hsa-miR-7160-5p (MIRT699034)
- hsa-miR-4722-5p (MIRT699035)
- hsa-miR-6884-5p (MIRT699036)
- hsa-miR-485-5p (MIRT699037)
- hsa-miR-1827 (MIRT699038)
- hsa-miR-4649-3p (MIRT699039)
- hsa-miR-3664-3p (MIRT699040)
- hsa-miR-665 (MIRT699041)
- hsa-miR-4433a-3p (MIRT699042)
- hsa-miR-4459 (MIRT699043)
- hsa-miR-4768-3p (MIRT699044)
- hsa-miR-5690 (MIRT699045)
- hsa-miR-4478 (MIRT699046)
- hsa-miR-4419b (MIRT699047)
- hsa-miR-3929 (MIRT699048)
- hsa-miR-940 (MIRT699049)
- hsa-miR-6893-5p (MIRT699050)
- hsa-miR-6808-5p (MIRT699051)
- hsa-miR-4695-5p (MIRT699052)
- hsa-miR-4538 (MIRT699053)
- hsa-miR-4453 (MIRT699054)
- hsa-miR-510-5p (MIRT699055)
- hsa-miR-512-5p (MIRT699056)
- hsa-miR-122-3p (MIRT761282)
- hsa-miR-1321 (MIRT762519)
- hsa-miR-4270 (MIRT768253)
- hsa-miR-4441 (MIRT769156)
- hsa-miR-4682 (MIRT770944)
- hsa-miR-4739 (MIRT771845)
- hsa-miR-4756-5p (MIRT771984)
- hsa-miR-6753-5p (MIRT778371)
- hsa-miR-6754-5p (MIRT778385)
- hsa-miR-7113-5p (MIRT781476)
- hsa-miR-8077 (MIRT782394)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for SOAT1
- Browse OriGene Inhibitory RNA Products For SOAT1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SOAT1
Clone Products
- Applied Biological Materials (abm): Clones for SOAT1 - Select products 50% OFF >
- * SOAT1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for SOAT1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SOAT1
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SOAT1 Gene
Localization for SOAT1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for SOAT1 Gene
- Endoplasmic reticulum membrane. Multi-pass membrane protein.
| Compartment | Confidence |
|---|---|
| endoplasmic reticulum | 5 |
| plasma membrane | 3 |
| extracellular | 2 |
| mitochondrion | 2 |
| peroxisome | 2 |
| nucleus | 2 |
| cytosol | 2 |
| lysosome | 2 |
| cytoskeleton | 1 |
| endosome | 1 |
| golgi apparatus | 1 |
- Endoplasmic reticulum (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005783 | endoplasmic reticulum | IEA,IDA | 10623671 |
| GO:0005789 | endoplasmic reticulum membrane | IDA,TAS | -- |
| GO:0016020 | membrane | IDA | 9756919 |
| GO:0016021 | integral component of membrane | IEA | -- |
Pathways & Interactions for SOAT1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Statin Pathway |
.71
|
|
| 2 | Lipoprotein metabolism | ||
| 3 | Metabolism |
.40
|
|
| 4 | cholesterol biosynthesis III (via desmosterol) | ||
Pathways by source for SOAT1 Gene
1 BioSystems pathway for SOAT1 Gene
5 Reactome pathways for SOAT1 Gene
1 PharmGKB pathway for SOAT1 Gene
2 KEGG pathways for SOAT1 Gene
Interacting Proteins for SOAT1 Gene
Selected Interacting proteins:
P35610-SOAT1_HUMAN
ENSP00000356591
for SOAT1 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for SOAT1
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006629 | lipid metabolic process | IEA | -- |
| GO:0008202 | steroid metabolic process | IEA | -- |
| GO:0008203 | cholesterol metabolic process | IBA,IMP | 8407899 |
| GO:0010742 | macrophage derived foam cell differentiation | NAS | 18971559 |
| GO:0010878 | cholesterol storage | IMP | 8407899 |
No data available for SIGNOR curated interactions for SOAT1 Gene
Drugs & Compounds for SOAT1 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Ezetimibe | Approved | Pharma | Target, inhibitor | Cholesterol transport inhibitor | 333 | |
| cholesterol | Approved, Investigational | Pharma | Agonist | 0 | ||
| Omega-3-acid ethyl esters | Approved, Investigational | Pharma | Enzyme, inhibitor | 0 | ||
| Hesperetin | Experimental | Pharma | Target, inhibitor | 0 | ||
| CE(18:2(9Z,12Z)) | Experimental | Pharma | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| (2E)-Decenoyl-CoA |
|
10018-95-8 |
|
|||
| (2E)-Dodecenoyl-CoA |
|
1066-12-2 |
|
|||
| (2E)-Hexadecenoyl-CoA |
|
4460-95-1 |
|
|||
| (2E)-Octenoyl-CoA |
|
10018-94-7 |
|
|||
| (2E)-Tetradecenoyl-CoA |
|
38795-33-4 |
|
(3) Tocris Compounds for SOAT1 Gene
(4) ApexBio Compounds for SOAT1 Gene
Transcripts for SOAT1 Gene
mRNA/cDNA for SOAT1 Gene
- 3 REFSEQ mRNAs :
- 11 NCBI additional mRNA sequence :
- 4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000367619 6840 nts (view in UCSC)
- ENST00000426956 870 nts (view in UCSC)
- ENST00000539888 6794 nts (view in UCSC)
- ENST00000540564 6861 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for SOAT1 - Select products 50% OFF >
- * SOAT1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for SOAT1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SOAT1
-
Santa Cruz Biotechnology (SCBT) CRISPR for SOAT1
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for SOAT1
- Browse OriGene Inhibitory RNA Products For SOAT1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SOAT1
Clone Products
- Applied Biological Materials (abm): Clones for SOAT1 - Select products 50% OFF >
- * SOAT1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for SOAT1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SOAT1
Relevant External Links for SOAT1 Gene
- GeneLoc Exon Structure for
- SOAT1
Expression for SOAT1 Gene
mRNA differential expression in normal tissues according to GTEx for SOAT1 Gene
This gene is overexpressed in Adrenal Gland (x11.4).
This gene is overexpressed in Monocytes (18.8), Breast (11.5), Adrenal (8.6), Islet of Langerhans (8.1), and Peripheral blood mononuclear cells (6.4).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SOAT1 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SOAT1
SOURCE GeneReport for Unigene cluster for SOAT1 Gene:
Hs.445588Evidence on tissue expression from TISSUES for SOAT1 Gene
- Adrenal gland(3.5)
- Nervous system(3.5)
- Liver(3)
- Intestine(2.6)
- Kidney(2.6)
- Heart(2.5)
- Spleen(2.5)
- Blood(2.5)
- Lung(2.3)
- Muscle(2.3)
- Gall bladder(2.1)
- Skin(2.1)
Primer Products
-
OriGene qPCR primer pairs for SOAT1
-
OriGene qPCR primer pairs and template standards for SOAT1
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SOAT1 Gene
Orthologs for SOAT1 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | SOAT1 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | LOC490325 30 |
|
||
| SOAT1 31 |
|
OneToOne | |||
| Cow (Bos Taurus) |
Mammalia | SOAT1 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Soat1 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Soat1 30 |
|
||
| Platypus (Ornithorhynchus anatinus) |
Mammalia | SOAT1 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
OneToMany | |
| -- 31 |
|
OneToMany | |||
| Chicken (Gallus gallus) |
Aves | SOAT1 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | SOAT1 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | soat1 30 |
|
||
| Str.11436 30 |
|
||||
| Zebrafish (Danio rerio) |
Actinopterygii | soat1 30 31 |
|
OneToOne | |
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP012216 30 |
|
||
| Fruit Fly (Drosophila melanogaster) |
Insecta | CG8112 30 31 32 |
|
OneToMany | |
| Worm (Caenorhabditis elegans) |
Secernentea | mboa-1 30 31 |
|
OneToMany | |
| B0395.2 32 |
|
|
|||
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | ARE1 31 |
|
ManyToMany | |
| ARE2 31 |
|
ManyToMany |
- Species where no ortholog for SOAT1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for SOAT1 Gene
- ENSEMBL:
- Gene Tree for SOAT1 (if available)
- TreeFam:
- Gene Tree for SOAT1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for SOAT1: view image
Paralogs for SOAT1 Gene
Variants for SOAT1 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SOAT1 Gene
| SNP ID | Clinical significance and condition | Chr 01 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 746440 | Likely Benign: not provided | 179,302,789(+) | G/A | SYNONYMOUS_VARIANT,FIVE_PRIME_UTR_VARIANT,INTRON_VARIANT | |
| 767731 | Benign: not provided | 179,341,109(+) | G/A | NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT | |
| 767732 | Benign: not provided | 179,341,178(+) | G/A | NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT | |
| 773819 | Benign: not provided | 179,342,188(+) | A/G | NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT | |
| 780280 | Benign: not provided | 179,341,140(+) | C/G | MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv121e212 | CNV | loss | 25503493 |
| dgv223n106 | CNV | deletion | 24896259 |
| dgv643n54 | CNV | loss | 21841781 |
| esv2666168 | CNV | deletion | 23128226 |
| esv2762031 | CNV | gain | 21179565 |
| esv3575338 | CNV | gain | 25503493 |
| esv3578289 | CNV | loss | 25503493 |
| esv3588049 | CNV | loss | 21293372 |
| esv990767 | CNV | deletion | 20482838 |
| nsv1005278 | CNV | gain | 25217958 |
| nsv518403 | CNV | gain | 19592680 |
| nsv523708 | CNV | loss | 19592680 |
| nsv548277 | CNV | loss | 21841781 |
| nsv548279 | CNV | gain | 21841781 |
Residual Variation Intolerance Score:
25.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
6.59;
78.07% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for SOAT1 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SOAT1 Gene
Disorders for SOAT1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| chronic leukemia |
|
|
| sitosterolemia |
|
|
| familial hypercholesterolemia |
|
|
| alzheimer disease 4 |
|
|
| atherosclerosis susceptibility |
|
Search SOAT1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for SOAT1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for SOAT1 Gene
Publications for SOAT1 Gene
- Molecular cloning and functional expression of human acyl-coenzyme A:cholesterol acyltransferase cDNA in mutant Chinese hamster ovary cells. (PMID: 8407899) Chang CC … Chang TY (The Journal of biological chemistry 1993) 2 3 4 23
- Study on the association between SOAT1 polymorphisms, Alzheimer's disease risk and the level of CSF biomarkers. (PMID: 17622762) Lamsa R … Soininen H (Dementia and geriatric cognitive disorders 2007) 3 23 41
- The active site His-460 of human acyl-coenzyme A:cholesterol acyltransferase 1 resides in a hitherto undisclosed transmembrane domain. (PMID: 16154994) Guo ZY … Chang TY (The Journal of biological chemistry 2005) 3 4 23
- Association between acyl-coenzyme A: cholesterol acyltransferase gene and risk for Alzheimer's disease in Chinese. (PMID: 16043284) Zhao FG … Chan P (Neuroscience letters 2005) 3 23 41
- Human acyl-CoA:cholesterol acyltransferase-1 in the endoplasmic reticulum contains seven transmembrane domains. (PMID: 10438503) Lin S … Chang TY (The Journal of biological chemistry 1999) 3 4 23
ExternalLinks
Products for SOAT1 Gene
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- VectorBuilder Stable cell line generation for SOAT1
- antibodies-online: Show 9 available SOAT1 Antibodies ranked by validation data
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- antibodies-online: Show 7 available SOAT1 Proteins ranked by validation data
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- Santa Cruz Biotechnology (SCBT) Antibodies for SOAT1
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- Santa Cruz Biotechnology (SCBT) CRISPR for SOAT1
- Horizon Cell Lines for SOAT1
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SOAT1
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- Boster Bio Antibodies for SOAT1
- Browse Boster Bio ELISA Kits
Sources for SOAT1 Gene
- (1) GeneCards
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- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
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