Aliases for SNX9 Gene
External Ids for SNX9 Gene
Previous GeneCards Identifiers for SNX9 Gene
This gene encodes a member of the sorting nexin family. Members of this family contain a phosphoinositide binding domain, and are involved in intracellular trafficking. The encoded protein does not contain a coiled coil region, like some family members, but does contain a SRC homology domain near its N-terminus. The encoded protein is reported to have a variety of interaction partners, including of adaptor protein 2 , dynamin, tyrosine kinase non-receptor 2, Wiskott-Aldrich syndrome-like, and ARP3 actin-related protein 3. The encoded protein is implicated in several stages of intracellular trafficking, including endocytosis, macropinocytosis, and F-actin nucleation. [provided by RefSeq, Jul 2013]
GeneCards Summary for SNX9 Gene
SNX9 (Sorting Nexin 9) is a Protein Coding gene. Diseases associated with SNX9 include Wiskott-Aldrich Syndrome and Cataract 8, Multiple Types. Among its related pathways are Delta508-CFTR traffic / ER-to-Golgi in CF and Clathrin derived vesicle budding. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and phosphatidylinositol binding. An important paralog of this gene is SNX33.
UniProtKB/Swiss-Prot Summary for SNX9 Gene
Involved in endocytosis and intracellular vesicle trafficking, both during interphase and at the end of mitosis. Required for efficient progress through mitosis and cytokinesis. Required for normal formation of the cleavage furrow at the end of mitosis. Plays a role in endocytosis via clathrin-coated pits, but also clathrin-independent, actin-dependent fluid-phase endocytosis. Plays a role in macropinocytosis. Promotes internalization of TNFR. Promotes degradation of EGFR after EGF signaling. Stimulates the GTPase activity of DNM1. Promotes DNM1 oligomerization. Promotes activation of the Arp2/3 complex by WASL, and thereby plays a role in the reorganization of the F-actin cytoskeleton. Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate and promotes membrane tubulation. Has lower affinity for membranes enriched in phosphatidylinositol 3-phosphate.