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Aliases for SNX7 Gene

Aliases for SNX7 Gene

  • Sorting Nexin 7 2 3 5

External Ids for SNX7 Gene

Previous GeneCards Identifiers for SNX7 Gene

  • GC01P099924
  • GC01P098252
  • GC01P098418
  • GC01P098839
  • GC01P099127
  • GC01P097250

Summaries for SNX7 Gene

Entrez Gene Summary for SNX7 Gene

  • This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region like some family members, and its exact function is unknown. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 11. [provided by RefSeq, Jun 2010]

GeneCards Summary for SNX7 Gene

SNX7 (Sorting Nexin 7) is a Protein Coding gene. Diseases associated with SNX7 include Spastic Paraplegia 29, Autosomal Dominant and Hereditary Spastic Paraplegia. Gene Ontology (GO) annotations related to this gene include phosphatidylinositol binding. An important paralog of this gene is SNX30.

UniProtKB/Swiss-Prot for SNX7 Gene

  • May be involved in several stages of intracellular trafficking.

Additional gene information for SNX7 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SNX7 Gene

Genomics for SNX7 Gene

GeneHancer (GH) Regulatory Elements for SNX7 Gene

Promoters and enhancers for SNX7 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I098660 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 565.8 +0.8 849 3.5 FOXA2 ARNT ARID4B SIN3A ZNF48 GLIS2 RUNX3 DEK GLIS1 MXD3 SNX7 PIR43426 ENSG00000280040 GC01P098562 GC01P098980
GH01I098704 Enhancer 0.5 ENCODE 23.7 +43.8 43778 1.6 NFIL3 MXI1 RFX1 HLF BMI1 SNX7 GC01P098980
GH01I098732 Enhancer 0.5 ENCODE 8.4 +71.7 71740 1.6 SP1 HLF IKZF1 DPF2 IKZF2 SNX7 GC01P098980
GH01I098903 Enhancer 0.5 ENCODE 7 +241.8 241829 0.9 JUND RFX1 POLR2A JUN CEBPB ZKSCAN1 PLPPR5 SNX7 GC01P098980
GH01I098991 Enhancer 0.7 Ensembl ENCODE 4.7 +330.1 330148 1.2 CTCF ZNF143 ZNF384 FOS RAD21 SNX7 LOC100129620 GC01P098980 PLPPR5
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SNX7 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SNX7 gene promoter:

Genomic Locations for SNX7 Gene

Genomic Locations for SNX7 Gene
chr1:98,661,662-98,760,500
(GRCh38/hg38)
Size:
98,839 bases
Orientation:
Plus strand
chr1:99,127,236-99,226,056
(GRCh37/hg19)

Genomic View for SNX7 Gene

Genes around SNX7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SNX7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SNX7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SNX7 Gene

Proteins for SNX7 Gene

  • Protein details for SNX7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UNH6-SNX7_HUMAN
    Recommended name:
    Sorting nexin-7
    Protein Accession:
    Q9UNH6
    Secondary Accessions:
    • A8KAF3
    • D3DT50
    • Q53FQ3
    • Q5VT09
    • Q5VT10
    • Q86U82
    • Q8WVD4
    • Q96FW9
    • Q9Y3Z7

    Protein attributes for SNX7 Gene

    Size:
    387 amino acids
    Molecular mass:
    45303 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAD27830.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAD96949.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SNX7 Gene

    Alternative splice isoforms for SNX7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SNX7 Gene

Post-translational modifications for SNX7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SNX7 Gene

Domains & Families for SNX7 Gene

Gene Families for SNX7 Gene

Protein Domains for SNX7 Gene

Suggested Antigen Peptide Sequences for SNX7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UNH6

UniProtKB/Swiss-Prot:

SNX7_HUMAN :
  • Belongs to the sorting nexin family.
Family:
  • Belongs to the sorting nexin family.
genes like me logo Genes that share domains with SNX7: view

Function for SNX7 Gene

Molecular function for SNX7 Gene

UniProtKB/Swiss-Prot Function:
May be involved in several stages of intracellular trafficking.

Phenotypes From GWAS Catalog for SNX7 Gene

Gene Ontology (GO) - Molecular Function for SNX7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
GO:0008289 lipid binding IEA --
GO:0035091 phosphatidylinositol binding IEA,IBA --
genes like me logo Genes that share ontologies with SNX7: view

Phenotypes for SNX7 Gene

genes like me logo Genes that share phenotypes with SNX7: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SNX7 Gene

Localization for SNX7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SNX7 Gene

Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SNX7 gene
Compartment Confidence
nucleus 4
endosome 4
cytosol 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoli fibrillar center (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SNX7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005768 endosome IBA --
GO:0016020 membrane IEA --
GO:0019898 extrinsic component of membrane IBA --
GO:0030659 cytoplasmic vesicle membrane IEA --
GO:0031410 cytoplasmic vesicle IEA --
genes like me logo Genes that share ontologies with SNX7: view

Pathways & Interactions for SNX7 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SNX7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006897 endocytosis IBA --
GO:0015031 protein transport IEA --
GO:0016050 vesicle organization IBA --
genes like me logo Genes that share ontologies with SNX7: view

No data available for Pathways by source and SIGNOR curated interactions for SNX7 Gene

Drugs & Compounds for SNX7 Gene

No Compound Related Data Available

Transcripts for SNX7 Gene

Unigene Clusters for SNX7 Gene

Sorting nexin 7:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for SNX7 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10
SP1: -
SP2: -

Relevant External Links for SNX7 Gene

GeneLoc Exon Structure for
SNX7
ECgene alternative splicing isoforms for
SNX7

Expression for SNX7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SNX7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SNX7 Gene

This gene is overexpressed in Adrenal (18.9), Testis (12.8), Plasma (11.8), and Colon (9.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SNX7 Gene



Protein tissue co-expression partners for SNX7 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SNX7 Gene:

SNX7

SOURCE GeneReport for Unigene cluster for SNX7 Gene:

Hs.197015

Evidence on tissue expression from TISSUES for SNX7 Gene

  • Nervous system(4.3)
  • Intestine(4.2)
  • Stomach(4.2)
genes like me logo Genes that share expression patterns with SNX7: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SNX7 Gene

Orthologs for SNX7 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SNX7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SNX7 33 34
  • 99.33 (n)
dog
(Canis familiaris)
Mammalia SNX7 33 34
  • 93.01 (n)
cow
(Bos Taurus)
Mammalia SNX7 33 34
  • 91.33 (n)
rat
(Rattus norvegicus)
Mammalia Snx7 33
  • 86.27 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia SNX7 34
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Snx7 33 16 34
  • 84.76 (n)
oppossum
(Monodelphis domestica)
Mammalia SNX7 34
  • 82 (a)
OneToOne
chicken
(Gallus gallus)
Aves SNX7 33 34
  • 76.98 (n)
lizard
(Anolis carolinensis)
Reptilia SNX7 34
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia snx7 33
  • 70.72 (n)
Str.3486 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.6955 33
zebrafish
(Danio rerio)
Actinopterygii snx7 33 34
  • 64.57 (n)
Dr.13759 33
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SNX4 34
  • 21 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9288 34
  • 36 (a)
OneToMany
Species where no ortholog for SNX7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SNX7 Gene

ENSEMBL:
Gene Tree for SNX7 (if available)
TreeFam:
Gene Tree for SNX7 (if available)

Paralogs for SNX7 Gene

Paralogs for SNX7 Gene

(2) SIMAP similar genes for SNX7 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for SNX7 Gene

genes like me logo Genes that share paralogs with SNX7: view

Variants for SNX7 Gene

Sequence variations from dbSNP and Humsavar for SNX7 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000120062 -- 98,690,859(+) C/A intron_variant
rs1000256156 -- 98,746,432(+) G/T intron_variant
rs1000258249 -- 98,750,671(+) T/C intron_variant
rs1000284300 -- 98,683,968(+) C/G intron_variant
rs1000323265 -- 98,694,301(+) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SNX7 Gene

Variant ID Type Subtype PubMed ID
esv2662446 CNV deletion 23128226
esv2670043 CNV deletion 23128226
esv2715240 CNV deletion 23290073
esv2715252 CNV deletion 23290073
esv3566348 CNV deletion 23714750
esv3586905 CNV gain 21293372
esv3586908 CNV loss 21293372
nsv1010934 CNV loss 25217958
nsv2065 CNV deletion 18451855
nsv830747 CNV loss 17160897
nsv830760 CNV gain 17160897

Variation tolerance for SNX7 Gene

Residual Variation Intolerance Score: 37.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.80; 66.88% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SNX7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SNX7

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SNX7 Gene

Disorders for SNX7 Gene

MalaCards: The human disease database

(2) MalaCards diseases for SNX7 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
spastic paraplegia 29, autosomal dominant
  • spg29
hereditary spastic paraplegia
  • spastic paraplegia 3, autosomal dominant
- elite association - COSMIC cancer census association via MalaCards
Search SNX7 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for SNX7

genes like me logo Genes that share disorders with SNX7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SNX7 Gene

Publications for SNX7 Gene

  1. Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes. (PMID: 21873549) Strawbridge RJ … Florez JC (Diabetes 2011) 3 44 58
  2. New locus for hereditary spastic paraplegia maps to chromosome 1p31.1-1p21.1. (PMID: 16130112) Orlacchio A … Bernardi G (Annals of neurology 2005) 3 22 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. A large family of endosome-localized proteins related to sorting nexin 1. (PMID: 11485546) Teasdale RD … Gleeson PA (The Biochemical journal 2001) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for SNX7 Gene

Sources for SNX7 Gene

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