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Aliases for SNX33 Gene

Aliases for SNX33 Gene

  • Sorting Nexin 33 2 3 5
  • SH3 And PX Domain-Containing Protein 3 3 4
  • SH3 And PX Domain Containing 3 2 3
  • SH3PXD3C 3 4
  • SH3PX3 3 4
  • SNX30 3 4
  • Sorting Nexin-33 3

External Ids for SNX33 Gene

Previous HGNC Symbols for SNX33 Gene

  • SH3PX3

Previous GeneCards Identifiers for SNX33 Gene

  • GC15P073730
  • GC15P075940
  • GC15P052697

Summaries for SNX33 Gene

Entrez Gene Summary for SNX33 Gene

  • The protein encoded by this gene is involved in cytoskeletal reorganization, vesicle trafficking, endocytosis, and mitosis. The encoded protein is essential for the creation of the cleavage furrow during mitosis and for completion of mitosis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015]

GeneCards Summary for SNX33 Gene

SNX33 (Sorting Nexin 33) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include identical protein binding and phosphatidylinositol binding. An important paralog of this gene is SNX18.

UniProtKB/Swiss-Prot for SNX33 Gene

  • Plays a role in the reorganization of the cytoskeleton, endocytosis and cellular vesicle trafficking via its interactions with membranes, WASL, DNM1 and DNM2. Acts both during interphase and at the end of mitotic cell divisions. Required for efficient progress through mitosis and cytokinesis. Required for normal formation of the cleavage furrow at the end of mitosis. Modulates endocytosis of cell-surface proteins, such as APP and PRNP; this then modulates the secretion of APP and PRNP peptides. Promotes membrane tubulation (in vitro). May promote the formation of macropinosomes.

Additional gene information for SNX33 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SNX33 Gene

Genomics for SNX33 Gene

GeneHancer (GH) Regulatory Elements for SNX33 Gene

Promoters and enhancers for SNX33 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15I075646 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 560.4 +1.7 1665 7.1 HDGF PKNOX1 FOXA2 MLX ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 SNX33 GC15P075650 IMP3 SIN3A MIR631 MAN2C1 ENSG00000260892
GH15I074888 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 27 -757.3 -757277 4 HDGF MLX ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B ZNF766 MPI RPP25 SIN3A ENSG00000203392 SNX33 ISLR PTPN9 MAN2C1 PML SCAMP5
GH15I074841 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 14.3 -804.0 -804047 5 HDGF PKNOX1 SMAD1 ZFP64 ARID4B NEUROD1 SIN3A DMAP1 ZNF2 ZBTB7B ULK3 SIN3A RPP25 EDC3 ENSG00000260274 ENSG00000203392 MPI SCAMP2 MAN2C1 SNX33
GH15I075022 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 14.3 -623.8 -623777 2.4 HDGF PKNOX1 CLOCK SMAD1 ZFP64 ARID4B NEUROD1 SIN3A DMAP1 ZNF2 ENSG00000260483 PPCDC SCAMP5 SIN3A CLK3 MAN2C1 ENSG00000260274 SNX33 ENSG00000203392 ISLR
GH15I075346 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE 14.3 -298.8 -298793 5 HDGF ARID4B SIN3A ZNF2 ZNF213 ZNF143 KLF13 ZNF263 SP3 SP5 NEIL1 ENSG00000275645 ENSG00000260274 DNM1P35 EDC3 SIN3A MAN2C1 SNUPN FBXO22 LOC441728
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SNX33 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SNX33 gene promoter:

Genomic Locations for SNX33 Gene

Genomic Locations for SNX33 Gene
chr15:75,647,906-75,662,301
(GRCh38/hg38)
Size:
14,396 bases
Orientation:
Plus strand
chr15:75,940,247-75,954,642
(GRCh37/hg19)

Genomic View for SNX33 Gene

Genes around SNX33 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SNX33 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SNX33 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SNX33 Gene

Proteins for SNX33 Gene

  • Protein details for SNX33 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WV41-SNX33_HUMAN
    Recommended name:
    Sorting nexin-33
    Protein Accession:
    Q8WV41
    Secondary Accessions:
    • B1NM17

    Protein attributes for SNX33 Gene

    Size:
    574 amino acids
    Molecular mass:
    65265 Da
    Quaternary structure:
    • Homodimer (via BAR domain). Interacts with ADAM15. Interacts with FASLG. Interacts (via SH3 domain) with DNM1 and DNM2. Interacts with WASL.

    Three dimensional structures from OCA and Proteopedia for SNX33 Gene

neXtProt entry for SNX33 Gene

Post-translational modifications for SNX33 Gene

Other Protein References for SNX33 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SNX33 Gene

Domains & Families for SNX33 Gene

Gene Families for SNX33 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for SNX33 Gene

Graphical View of Domain Structure for InterPro Entry

Q8WV41

UniProtKB/Swiss-Prot:

SNX33_HUMAN :
  • The PX and BAR domains mediate association with membranes and are required for membrane tubulation.
  • Belongs to the sorting nexin family.
Domain:
  • The PX and BAR domains mediate association with membranes and are required for membrane tubulation.
Family:
  • Belongs to the sorting nexin family.
genes like me logo Genes that share domains with SNX33: view

Function for SNX33 Gene

Molecular function for SNX33 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in the reorganization of the cytoskeleton, endocytosis and cellular vesicle trafficking via its interactions with membranes, WASL, DNM1 and DNM2. Acts both during interphase and at the end of mitotic cell divisions. Required for efficient progress through mitosis and cytokinesis. Required for normal formation of the cleavage furrow at the end of mitosis. Modulates endocytosis of cell-surface proteins, such as APP and PRNP; this then modulates the secretion of APP and PRNP peptides. Promotes membrane tubulation (in vitro). May promote the formation of macropinosomes.

Phenotypes From GWAS Catalog for SNX33 Gene

Gene Ontology (GO) - Molecular Function for SNX33 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16374509
GO:0035091 phosphatidylinositol binding IEA --
GO:0042802 identical protein binding IPI 19487689
genes like me logo Genes that share ontologies with SNX33: view
genes like me logo Genes that share phenotypes with SNX33: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SNX33 Gene

Localization for SNX33 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SNX33 Gene

Cytoplasm, cytosol. Membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Note=Primarily cytosolic, but a minor proportion is membrane-bound (PubMed:18353773). Not associated with membranes (PubMed:21048941). {ECO:0000269 PubMed:18353773, ECO:0000269 PubMed:21048941}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SNX33 gene
Compartment Confidence
cytosol 5
nucleus 4
plasma membrane 2
endosome 1

Gene Ontology (GO) - Cellular Components for SNX33 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IDA,IEA 18353773
GO:0016020 membrane IEA,IDA 18353773
GO:0019898 extrinsic component of membrane IDA 20964629
genes like me logo Genes that share ontologies with SNX33: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SNX33 Gene

Pathways & Interactions for SNX33 Gene

SuperPathways for SNX33 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SNX33 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000281 mitotic cytokinesis IEA,IMP 22718350
GO:0006810 transport IEA --
GO:0006886 intracellular protein transport IEA --
GO:0006897 endocytosis IEA,IMP 22718350
GO:0007032 endosome organization IMP 21048941
genes like me logo Genes that share ontologies with SNX33: view

No data available for Pathways by source and SIGNOR curated interactions for SNX33 Gene

Drugs & Compounds for SNX33 Gene

No Compound Related Data Available

Transcripts for SNX33 Gene

mRNA/cDNA for SNX33 Gene

Unigene Clusters for SNX33 Gene

Sorting nexin 33:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for SNX33 Gene

ExUns: 1a · 1b ^ 2 ^ 3
SP1:
SP2:

Relevant External Links for SNX33 Gene

GeneLoc Exon Structure for
SNX33
ECgene alternative splicing isoforms for
SNX33

Expression for SNX33 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SNX33 Gene

Protein differential expression in normal tissues from HIPED for SNX33 Gene

This gene is overexpressed in Lung (27.5), Gallbladder (12.9), and Pancreas (8.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SNX33 Gene



Protein tissue co-expression partners for SNX33 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SNX33 Gene:

SNX33

SOURCE GeneReport for Unigene cluster for SNX33 Gene:

Hs.8705

mRNA Expression by UniProt/SwissProt for SNX33 Gene:

Q8WV41-SNX33_HUMAN
Tissue specificity: Detected in heart and pancreas.

Evidence on tissue expression from TISSUES for SNX33 Gene

  • Skin(4.2)
  • Stomach(4.2)
  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with SNX33: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for SNX33 Gene

Orthologs for SNX33 Gene

This gene was present in the common ancestor of animals.

Orthologs for SNX33 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SNX33 33 34
  • 99.42 (n)
cow
(Bos Taurus)
Mammalia SNX33 33 34
  • 91.24 (n)
dog
(Canis familiaris)
Mammalia SNX33 33 34
  • 90.58 (n)
rat
(Rattus norvegicus)
Mammalia Snx33 33
  • 88.97 (n)
mouse
(Mus musculus)
Mammalia Snx33 33 16 34
  • 88.68 (n)
oppossum
(Monodelphis domestica)
Mammalia SNX33 34
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SNX33 34
  • 84 (a)
OneToOne
chicken
(Gallus gallus)
Aves SNX33 33 34
  • 81.62 (n)
lizard
(Anolis carolinensis)
Reptilia SNX33 34
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia snx33 33
  • 70.63 (n)
Str.2090 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.29278 33
zebrafish
(Danio rerio)
Actinopterygii snx33 33 34
  • 71.15 (n)
fruit fly
(Drosophila melanogaster)
Insecta SH3PX1 34
  • 32 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea lst-4 33 34
  • 45.33 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 35 (a)
OneToMany
Species where no ortholog for SNX33 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SNX33 Gene

ENSEMBL:
Gene Tree for SNX33 (if available)
TreeFam:
Gene Tree for SNX33 (if available)

Paralogs for SNX33 Gene

Paralogs for SNX33 Gene

(3) SIMAP similar genes for SNX33 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SNX33: view

Variants for SNX33 Gene

Sequence variations from dbSNP and Humsavar for SNX33 Gene

SNP ID Clin Chr 15 pos Variation AA Info Type
rs1000117540 -- 75,648,478(+) C/ upstream_transcript_variant
rs1001179303 -- 75,654,209(+) C/A intron_variant
rs1001270659 -- 75,647,419(+) A/C upstream_transcript_variant
rs1001408101 -- 75,658,055(+) T/C 3_prime_UTR_variant
rs1001488948 -- 75,652,264(+) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SNX33 Gene

Variant ID Type Subtype PubMed ID
esv2749894 CNV deletion 23290073
esv2749895 CNV deletion 23290073
nsv1116463 OTHER inversion 24896259
nsv527186 CNV loss 19592680

Variation tolerance for SNX33 Gene

Residual Variation Intolerance Score: 11.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.59; 30.60% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SNX33 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SNX33

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SNX33 Gene

Disorders for SNX33 Gene

Additional Disease Information for SNX33

No disorders were found for SNX33 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SNX33 Gene

Publications for SNX33 Gene

  1. A novel sorting nexin modulates endocytic trafficking and alpha-secretase cleavage of the amyloid precursor protein. (PMID: 18353773) Schöbel S … Lichtenthaler SF (The Journal of biological chemistry 2008) 2 3 4 58
  2. Identification of preferred protein interactions by phage-display of the human Src homology-3 proteome. (PMID: 16374509) Kärkkäinen S … Saksela K (EMBO reports 2006) 2 3 4 58
  3. SNX9, SNX18 and SNX33 are required for progression through and completion of mitosis. (PMID: 22718350) Ma MP … Chircop M (Journal of cell science 2012) 3 4 58
  4. Specific amino acids in the BAR domain allow homodimerization and prevent heterodimerization of sorting nexin 33. (PMID: 20964629) Dislich B … Lichtenthaler SF (The Biochemical journal 2011) 3 4 58
  5. The SNX-PX-BAR family in macropinocytosis: the regulation of macropinosome formation by SNX-PX-BAR proteins. (PMID: 21048941) Wang JT … Teasdale RD (PloS one 2010) 3 4 58

Products for SNX33 Gene

Sources for SNX33 Gene

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