SNX32 Gene (Protein Coding)

Sorting Nexin 32

GC11P065833
GIFtS:
38
See more...

Aliases for SNX32 Gene

Aliases for SNX32 Gene

  • Sorting Nexin 32 2 3 5
  • Sorting Nexin-32 3 4
  • Sorting Nexin-6B 3 4
  • SNX6B 3 4
  • Sorting Nexin 6B 2
  • FLJ30934 2
  • SNX32 5

External Ids for SNX32 Gene

Previous HGNC Symbols for SNX32 Gene

  • SNX6B

Previous GeneCards Identifiers for SNX32 Gene

  • GC11P065357
  • GC11P065601
  • GC11P061927

Summaries for SNX32 Gene

GeneCards Summary for SNX32 Gene

SNX32 (Sorting Nexin 32) is a Protein Coding gene. Diseases associated with SNX32 include Eastern Equine Encephalitis. Among its related pathways are Endocytosis. Gene Ontology (GO) annotations related to this gene include phosphatidylinositol binding. An important paralog of this gene is SNX6.

UniProtKB/Swiss-Prot Summary for SNX32 Gene

Additional gene information for SNX32 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SNX32 Gene

Genomics for SNX32 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for SNX32 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SNX32 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SNX32

Top Transcription factor binding sites by QIAGEN in the SNX32 gene promoter:
  • ATF6
  • GATA-6
  • Gfi-1
  • N-Myc
  • NF-E2
  • NF-E2 p45
  • Pax-4a
  • POU2F1
  • POU2F1a
  • RORalpha1

Genomic Locations for SNX32 Gene

Latest Assembly
chr11:65,833,640-65,856,896
(GRCh38/hg38)
Size:
23,257 bases
Orientation:
Plus strand

Previous Assembly
chr11:65,601,434-65,621,172
(GRCh37/hg19 by Entrez Gene)
Size:
19,739 bases
Orientation:
Plus strand

chr11:65,601,112-65,624,367
(GRCh37/hg19 by Ensembl)
Size:
23,256 bases
Orientation:
Plus strand

Genomic View for SNX32 Gene

Genes around SNX32 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SNX32 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SNX32 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for SNX32 Gene

Proteins for SNX32 Gene

Products:

  1. Antibodies for research
  2. Protein products for research
  3. Assay products for research

  • Protein details for SNX32 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86XE0-SNX32_HUMAN
    Recommended name:
    Sorting nexin-32
    Protein Accession:
    Q86XE0
    Secondary Accessions:
    • Q8IW53
    • Q96NG4

    Protein attributes for SNX32 Gene

    Size:
    403 amino acids
    Molecular mass:
    46399 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for SNX32 Gene

    Alternative splice isoforms for SNX32 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SNX32 Gene

Protein Expression for SNX32 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for SNX32 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SNX32 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibodies for research

  • Boster Bio Antibodies for SNX32

No data available for DME Specific Peptides for SNX32 Gene

Domains & Families for SNX32 Gene

Gene Families for SNX32 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for SNX32 Gene

InterPro:
Blocks:
  • Phox-like
ProtoNet:

Suggested Antigen Peptide Sequences for SNX32 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ51060, weakly similar to Sorting nexin-6 (B4DS03_HUMAN)
  • Sorting nexin-6B (SNX32_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q86XE0

UniProtKB/Swiss-Prot:

SNX32_HUMAN :
  • Belongs to the sorting nexin family.
Family:
  • Belongs to the sorting nexin family.
genes like me logo Genes that share domains with SNX32: view

Function for SNX32 Gene

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  1. Animal Models for research
  2. CRISPR products for research
  3. miRNA products for research
  4. Inhibitory RNAs for research
  5. Clone products for research
  6. Cell Lines for research

Molecular function for SNX32 Gene

UniProtKB/Swiss-Prot Function:
May be involved in several stages of intracellular trafficking.

Phenotypes From GWAS Catalog for SNX32 Gene

Gene Ontology (GO) - Molecular Function for SNX32 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21516116
GO:0035091 phosphatidylinositol binding IEA --
genes like me logo Genes that share ontologies with SNX32: view
genes like me logo Genes that share phenotypes with SNX32: view

Animal Models for research

miRNA for SNX32 Gene

miRTarBase miRNAs that target SNX32

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SNX32

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SNX32 Gene

Localization for SNX32 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SNX32 gene
Compartment Confidence
endosome 4
cytosol 4
nucleus 3
plasma membrane 1
cytoskeleton 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cell Junctions (1)
  • Focal adhesion sites (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SNX32 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005768 endosome IBA 21873635
GO:0005829 cytosol IEA --
genes like me logo Genes that share ontologies with SNX32: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for SNX32 Gene

Pathways & Interactions for SNX32 Gene

PathCards logo

SuperPathways for SNX32 Gene

SuperPathway Contained pathways
1 Endocytosis
Endocytosis
-
genes like me logo Genes that share pathways with SNX32: view

Pathways by source for SNX32 Gene

1 KEGG pathway for SNX32 Gene

Gene Ontology (GO) - Biological Process for SNX32 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015031 protein transport IEA --
GO:0016241 regulation of macroautophagy NAS 26172538
GO:0042147 retrograde transport, endosome to Golgi IBA 21873635
genes like me logo Genes that share ontologies with SNX32: view

No data available for SIGNOR curated interactions for SNX32 Gene

Drugs & Compounds for SNX32 Gene

Products:

  1. Drug products for research
No Compound Related Data Available

Transcripts for SNX32 Gene

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  1. CRISPR products for research
  2. miRNA products for research
  3. Inhibitory RNAs for research
  4. Clone products for research

mRNA/cDNA for SNX32 Gene

1 REFSEQ mRNAs :
12 NCBI additional mRNA sequence :
9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SNX32

Alternative Splicing Database (ASD) splice patterns (SP) for SNX32 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b · 3c · 3d ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14
SP1: - - - -
SP2: - - - -
SP3: - - -
SP4: - - - -
SP5: - - - -
SP6:
SP7: -

Relevant External Links for SNX32 Gene

GeneLoc Exon Structure for
SNX32

Expression for SNX32 Gene

Products:

  1. Primer products for research
  2. Gene Expression Assays for research

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SNX32 Gene

mRNA expression in normal human tissues for SNX32 Gene
mRNA expression by GTEx for SNX32 GenemRNA expression by BioGPS for SNX32 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SNX32 Gene

This gene is overexpressed in Brain - Cortex (x6.9), Brain - Nucleus accumbens (basal ganglia) (x6.0), Brain - Caudate (basal ganglia) (x5.3), Brain - Frontal Cortex (BA9) (x5.2), Brain - Putamen (basal ganglia) (x5.1), and Brain - Anterior cingulate cortex (BA24) (x4.6).

Protein differential expression in normal tissues from HIPED for SNX32 Gene

This gene is overexpressed in Heart (32.6), Frontal cortex (27.9), and Adipocyte (8.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SNX32 Gene



Protein tissue co-expression partners for SNX32 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SNX32

SOURCE GeneReport for Unigene cluster for SNX32 Gene:

Hs.591950

Evidence on tissue expression from TISSUES for SNX32 Gene

  • Nervous system(4.7)
  • Eye(2.3)
  • Blood(2.2)
  • Kidney(2.1)
  • Intestine(2.1)
  • Bone marrow(2)
genes like me logo Genes that share expression patterns with SNX32: view

Primer products for research

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SNX32 Gene

Orthologs for SNX32 Gene

This gene was present in the common ancestor of animals.

Orthologs for SNX32 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia SNX32 30 31
  • 99.17 (n)
 OneToOne
Dog
(Canis familiaris)
 Mammalia SNX32 30 31
  • 89.45 (n)
 OneToOne
Oppossum
(Monodelphis domestica)
 Mammalia SNX32 31
  • 88 (a)
 OneToOne
Mouse
(Mus musculus)
 Mammalia Snx32 30 17 31
  • 87.06 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Snx32 30
  • 84.25 (n)
Cow
(Bos Taurus)
 Mammalia SNX32 31
  • 56 (a)
 OneToOne
Platypus
(Ornithorhynchus anatinus)
 Mammalia SNX32 31
  • 55 (a)
 OneToOne
Zebrafish
(Danio rerio)
 Actinopterygii si:dkey-28n18.9 31
  • 22 (a)
 ManyToMany
Fruit Fly
(Drosophila melanogaster)
 Insecta Snx6 31
  • 47 (a)
 OneToMany
Worm
(Caenorhabditis elegans)
 Secernentea snx-6 31
  • 40 (a)
 OneToMany
Sea Squirt
(Ciona savignyi)
 Ascidiacea CSA.5377 31
  • 46 (a)
 OneToMany
Species where no ortholog for SNX32 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)

Evolution for SNX32 Gene

ENSEMBL:
Gene Tree for SNX32 (if available)
TreeFam:
Gene Tree for SNX32 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SNX32: view image

Paralogs for SNX32 Gene

Paralogs for SNX32 Gene

(2) SIMAP similar genes for SNX32 Gene using alignment to 1 proteins:

  • SNX32_HUMAN
genes like me logo Genes that share paralogs with SNX32: view

Variants for SNX32 Gene

Products:

  1. SNP Genotyping and Copy Number Assays for research

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SNX32 Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
rs17854065 - p.His155Asn
rs17855647 - p.Ala282Val
rs17857243 - p.Ser354Tyr

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for SNX32 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for SNX32 Gene

Variant ID Type Subtype PubMed ID
dgv659e59 CNV duplication 20981092
esv2662850 CNV deletion 23128226
esv2744633 CNV deletion 23290073
esv2744634 CNV deletion 23290073
esv2759834 CNV gain 17122850
esv3626682 CNV gain 21293372
nsv1159905 CNV duplication 26073780
nsv555215 CNV loss 21841781

Variation tolerance for SNX32 Gene

Residual Variation Intolerance Score: 35.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.82; 34.26% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SNX32 Gene

Human Gene Mutation Database (HGMD)
SNX32
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SNX32

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SNX32 Gene

Disorders for SNX32 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SNX32 Gene - From: COP

Disorder Aliases PubMed IDs
eastern equine encephalitis
  • eee
- elite association - COSMIC cancer census association via MalaCards
Search SNX32 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for SNX32

Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with SNX32: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SNX32 Gene

Publications for SNX32 Gene

  1. The Phox (PX) domain proteins and membrane traffic. (PMID: 16782399) Seet LF … Hong W (Biochimica et biophysica acta 2006) 2 3
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  3. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  4. rec-YnH enables simultaneous many-by-many detection of direct protein-protein and protein-RNA interactions. (PMID: 30217970) Yang JS … Maurer SP (Nature communications 2018) 3
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3

ExternalLinks

View latest publications for SNX32 gene in Mastermind

Products for SNX32 Gene

  • Addgene plasmids for SNX32

Sources for SNX32 Gene