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Aliases for SNX32 Gene

Aliases for SNX32 Gene

  • Sorting Nexin 32 2 3 5
  • Sorting Nexin-6B 3 4
  • SNX6B 3 4
  • Sorting Nexin 6B 2
  • Sorting Nexin-32 3

External Ids for SNX32 Gene

Previous HGNC Symbols for SNX32 Gene

  • SNX6B

Previous GeneCards Identifiers for SNX32 Gene

  • GC11P065357
  • GC11P065601
  • GC11P061927

Summaries for SNX32 Gene

GeneCards Summary for SNX32 Gene

SNX32 (Sorting Nexin 32) is a Protein Coding gene. Among its related pathways are Endocytosis. Gene Ontology (GO) annotations related to this gene include phosphatidylinositol binding. An important paralog of this gene is SNX6.

UniProtKB/Swiss-Prot for SNX32 Gene

  • May be involved in several stages of intracellular trafficking.

Additional gene information for SNX32 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SNX32 Gene

Genomics for SNX32 Gene

GeneHancer (GH) Regulatory Elements for SNX32 Gene

Promoters and enhancers for SNX32 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11I065833 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE 624 +0.2 226 1.6 HDGF PKNOX1 ATF1 SMAD1 NFIB ZSCAN4 PLRG1 KLF5 EGR1 ZNF207 SNX32 MRPL11 ZFPL1 LOC105369352 EIF1AD RBM4B BBS1 NAALADL1 POLA2 MUS81
GH11I065886 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 68.6 +61.8 61817 18.4 CLOCK ZFP64 FEZF1 DMAP1 YY1 SLC30A9 E2F8 ZNF143 ZNF263 SP3 FOSL1 FIBP CCDC85B SNX32 ENSG00000258297 EIF1AD RBM14 MUS81 SART1 POLA2
GH11I065851 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 59.4 +23.8 23843 12.2 CLOCK MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 MUS81 CFL1 EIF1AD POLA2 PCNX3 SART1 ENSG00000258297 ZFPL1 RBM14 RBM4
GH11I065813 Enhancer 1.2 FANTOM5 Ensembl ENCODE dbSUPER 48.3 -18.6 -18625 2.5 MEIS2 CBFA2T3 EBF1 ATF2 MITF GATA3 IKZF1 TARDBP CREB1 FOXP2 SNX32 CTSW EFEMP2 AP5B1 CDC42EP2 RELA EHBP1L1 KAT5 MAP3K11 GC11M065816
GH11I065878 Promoter/Enhancer 1.2 EPDnew Ensembl ENCODE 42 +46.3 46289 3.7 SREBF1 ZNF3 POLR2A GABPB1 MAX ZFP36 CTSW SNX32 FIBP
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SNX32 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SNX32 gene promoter:

Genomic Locations for SNX32 Gene

Genomic Locations for SNX32 Gene
23,256 bases
Plus strand

Genomic View for SNX32 Gene

Genes around SNX32 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SNX32 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SNX32 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SNX32 Gene

Proteins for SNX32 Gene

  • Protein details for SNX32 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Sorting nexin-32
    Protein Accession:
    Secondary Accessions:
    • Q8IW53
    • Q96NG4

    Protein attributes for SNX32 Gene

    403 amino acids
    Molecular mass:
    46399 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SNX32 Gene


neXtProt entry for SNX32 Gene

Post-translational modifications for SNX32 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SNX32 Gene

No data available for DME Specific Peptides for SNX32 Gene

Domains & Families for SNX32 Gene

Gene Families for SNX32 Gene

Protein Domains for SNX32 Gene

Suggested Antigen Peptide Sequences for SNX32 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the sorting nexin family.
  • Belongs to the sorting nexin family.
genes like me logo Genes that share domains with SNX32: view

Function for SNX32 Gene

Molecular function for SNX32 Gene

UniProtKB/Swiss-Prot Function:
May be involved in several stages of intracellular trafficking.

Phenotypes From GWAS Catalog for SNX32 Gene

Gene Ontology (GO) - Molecular Function for SNX32 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21516116
GO:0035091 phosphatidylinositol binding IBA --
genes like me logo Genes that share ontologies with SNX32: view

Phenotypes for SNX32 Gene

genes like me logo Genes that share phenotypes with SNX32: view

Animal Model Products

CRISPR Products

miRNA for SNX32 Gene

miRTarBase miRNAs that target SNX32

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SNX32 Gene

Localization for SNX32 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SNX32 gene
Compartment Confidence
endosome 4
nucleus 3
cytosol 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cell Junctions (1)
  • Focal adhesion sites (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SNX32 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005768 endosome IBA --
GO:0019898 extrinsic component of membrane IBA --
genes like me logo Genes that share ontologies with SNX32: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for SNX32 Gene

Pathways & Interactions for SNX32 Gene

SuperPathways for SNX32 Gene

SuperPathway Contained pathways
1 Endocytosis
genes like me logo Genes that share pathways with SNX32: view

Pathways by source for SNX32 Gene

1 KEGG pathway for SNX32 Gene

Gene Ontology (GO) - Biological Process for SNX32 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006897 endocytosis IBA --
GO:0015031 protein transport IEA --
GO:0016050 vesicle organization IBA --
GO:0016241 regulation of macroautophagy NAS 26172538
genes like me logo Genes that share ontologies with SNX32: view

No data available for SIGNOR curated interactions for SNX32 Gene

Drugs & Compounds for SNX32 Gene

No Compound Related Data Available

Transcripts for SNX32 Gene

Unigene Clusters for SNX32 Gene

Sorting nexin 32:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SNX32 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b · 3c · 3d ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14
SP1: - - - -
SP2: - - - -
SP3: - - -
SP4: - - - -
SP5: - - - -
SP7: -

Relevant External Links for SNX32 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SNX32 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SNX32 Gene

mRNA differential expression in normal tissues according to GTEx for SNX32 Gene

This gene is overexpressed in Brain - Cortex (x6.9), Brain - Nucleus accumbens (basal ganglia) (x6.0), Brain - Caudate (basal ganglia) (x5.3), Brain - Frontal Cortex (BA9) (x5.2), Brain - Putamen (basal ganglia) (x5.1), and Brain - Anterior cingulate cortex (BA24) (x4.6).

Protein differential expression in normal tissues from HIPED for SNX32 Gene

This gene is overexpressed in Heart (32.6), Frontal cortex (27.9), and Adipocyte (8.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SNX32 Gene

Protein tissue co-expression partners for SNX32 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SNX32 Gene:


SOURCE GeneReport for Unigene cluster for SNX32 Gene:


Evidence on tissue expression from TISSUES for SNX32 Gene

  • Nervous system(4.7)
  • Blood(2.2)
  • Intestine(2.1)
  • Bone marrow(2)
  • Spleen(2)
  • Stomach(2)
genes like me logo Genes that share expression patterns with SNX32: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SNX32 Gene

Orthologs for SNX32 Gene

This gene was present in the common ancestor of animals.

Orthologs for SNX32 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SNX32 33 34
  • 99.17 (n)
(Canis familiaris)
Mammalia SNX32 33 34
  • 89.45 (n)
(Monodelphis domestica)
Mammalia SNX32 34
  • 88 (a)
(Mus musculus)
Mammalia Snx32 33 16 34
  • 87.06 (n)
(Rattus norvegicus)
Mammalia Snx32 33
  • 84.25 (n)
(Bos Taurus)
Mammalia SNX32 34
  • 56 (a)
(Ornithorhynchus anatinus)
Mammalia SNX32 34
  • 55 (a)
(Danio rerio)
Actinopterygii si:dkey-28n18.9 34
  • 22 (a)
fruit fly
(Drosophila melanogaster)
Insecta Snx6 34
  • 47 (a)
(Caenorhabditis elegans)
Secernentea snx-6 34
  • 40 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5377 34
  • 46 (a)
Species where no ortholog for SNX32 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for SNX32 Gene

Gene Tree for SNX32 (if available)
Gene Tree for SNX32 (if available)

Paralogs for SNX32 Gene

Paralogs for SNX32 Gene

(2) SIMAP similar genes for SNX32 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SNX32: view

Variants for SNX32 Gene

Sequence variations from dbSNP and Humsavar for SNX32 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000042091 -- 65,850,810(+) G/A/C coding_sequence_variant, non_coding_transcript_variant, synonymous_variant
rs1000181791 -- 65,834,582(+) T/G intron_variant
rs1000239290 -- 65,839,629(+) C/G intron_variant
rs1000311415 -- 65,839,329(+) A/C intron_variant
rs1000519348 -- 65,833,146(+) G/A/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for SNX32 Gene

Variant ID Type Subtype PubMed ID
dgv659e59 CNV duplication 20981092
esv2662850 CNV deletion 23128226
esv2744633 CNV deletion 23290073
esv2744634 CNV deletion 23290073
esv2759834 CNV gain 17122850
esv3626682 CNV gain 21293372
nsv1159905 CNV duplication 26073780
nsv555215 CNV loss 21841781

Variation tolerance for SNX32 Gene

Residual Variation Intolerance Score: 35.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.82; 34.26% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SNX32 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SNX32 Gene

Disorders for SNX32 Gene

Additional Disease Information for SNX32

No disorders were found for SNX32 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SNX32 Gene

Publications for SNX32 Gene

  1. The Phox (PX) domain proteins and membrane traffic. (PMID: 16782399) Seet LF … Hong W (Biochimica et biophysica acta 2006) 2 3 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. Retromer Ensures the Degradation of Autophagic Cargo by Maintaining Lysosome Function in Drosophila. (PMID: 26172538) Maruzs T … Sass M (Traffic (Copenhagen, Denmark) 2015) 3 58
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58

Products for SNX32 Gene

Sources for SNX32 Gene

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