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Aliases for SNX31 Gene

Aliases for SNX31 Gene

  • Sorting Nexin 31 2 3 5

External Ids for SNX31 Gene

Previous GeneCards Identifiers for SNX31 Gene

  • GC08M101656
  • GC08M101585
  • GC08M096784

Summaries for SNX31 Gene

GeneCards Summary for SNX31 Gene

SNX31 (Sorting Nexin 31) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include phosphatidylinositol binding. An important paralog of this gene is SNX17.

UniProtKB/Swiss-Prot for SNX31 Gene

  • May be involved in protein trafficking.

Additional gene information for SNX31 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SNX31 Gene

Genomics for SNX31 Gene

GeneHancer (GH) Regulatory Elements for SNX31 Gene

Promoters and enhancers for SNX31 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08I100648 Promoter/Enhancer 1 EPDnew Ensembl 557.3 +14.1 14091 1.2 CTCF ZNF335 ZBTB20 EZH2 SNX31 LOC105375671 ANKRD46 GC08P100637 GC08P100632
GH08I100663 Enhancer 0.8 ENCODE 578.7 -0.4 -384 0.8 ELF3 FOXA2 ARID4B RAD21 RARA YY1 RXRA PPARG TGIF2 ZNF217 SNX31 LOC105375672 RNU6-1092P GC08P100637 GC08P100632
GH08I100666 Enhancer 1.1 Ensembl ENCODE 39.2 -4.1 -4071 2.7 PKNOX1 SIN3A ZNF2 ETS1 ATF7 FOS NFIL3 ATF4 GLIS1 ETV4 SNX31 LOC105375672 RNU6-1092P GC08P100632 GC08P100637
GH08I100718 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 7.2 -57.7 -57703 4.8 HDGF PKNOX1 CLOCK FOXA2 SMAD1 MLX ARNT ARID4B SIN3A DMAP1 PABPC1 LOC105375673 ENSG00000271882 SNX31 MIR7705 GC08P100637 GC08P100632
GH08I100564 Enhancer 1.1 Ensembl ENCODE 10.5 +99.2 99214 0.4 ELF3 PKNOX1 RB1 ARID4B SIN3A ZNF2 KLF5 IRF4 RAD21 SCRT2 LOC105375671 SNX31 RNU4-83P PABPC1 ANKRD46
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SNX31 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SNX31 gene promoter:

Genomic Locations for SNX31 Gene

Genomic Locations for SNX31 Gene
90,534 bases
Minus strand

Genomic View for SNX31 Gene

Genes around SNX31 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SNX31 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SNX31 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SNX31 Gene

Proteins for SNX31 Gene

  • Protein details for SNX31 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Sorting nexin-31
    Protein Accession:
    Secondary Accessions:
    • C9J6L9
    • Q8N0U9

    Protein attributes for SNX31 Gene

    440 amino acids
    Molecular mass:
    50802 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SNX31 Gene


neXtProt entry for SNX31 Gene

Post-translational modifications for SNX31 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SNX31 Gene

Domains & Families for SNX31 Gene

Gene Families for SNX31 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transporters

Protein Domains for SNX31 Gene


Suggested Antigen Peptide Sequences for SNX31 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the sorting nexin family.
  • Belongs to the sorting nexin family.
genes like me logo Genes that share domains with SNX31: view

Function for SNX31 Gene

Molecular function for SNX31 Gene

UniProtKB/Swiss-Prot Function:
May be involved in protein trafficking.

Phenotypes From GWAS Catalog for SNX31 Gene

Gene Ontology (GO) - Molecular Function for SNX31 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0035091 phosphatidylinositol binding IBA,IEA --
genes like me logo Genes that share ontologies with SNX31: view
genes like me logo Genes that share phenotypes with SNX31: view

Animal Models for SNX31 Gene

MGI Knock Outs for SNX31:

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for SNX31 Gene

Localization for SNX31 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SNX31 gene
Compartment Confidence
endosome 4
cytosol 3
nucleus 2
mitochondrion 1
endoplasmic reticulum 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Golgi apparatus (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SNX31 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005769 early endosome IBA --
GO:0005856 cytoskeleton IEA --
GO:0043234 protein complex IEA --
genes like me logo Genes that share ontologies with SNX31: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for SNX31 Gene

Pathways & Interactions for SNX31 Gene

SuperPathways for SNX31 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SNX31 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006886 intracellular protein transport IBA --
GO:0015031 protein transport IEA --
GO:1990126 retrograde transport, endosome to plasma membrane IBA --
genes like me logo Genes that share ontologies with SNX31: view

No data available for Pathways by source and SIGNOR curated interactions for SNX31 Gene

Drugs & Compounds for SNX31 Gene

No Compound Related Data Available

Transcripts for SNX31 Gene

Unigene Clusters for SNX31 Gene

Sorting nexin 31:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SNX31 Gene

No ASD Table

Relevant External Links for SNX31 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SNX31 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SNX31 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SNX31 Gene

This gene is overexpressed in Bladder (x24.4) and Esophagus - Mucosa (x5.6).

Protein differential expression in normal tissues from HIPED for SNX31 Gene

This gene is overexpressed in Colon (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SNX31 Gene

Protein tissue co-expression partners for SNX31 Gene

NURSA nuclear receptor signaling pathways regulating expression of SNX31 Gene:


SOURCE GeneReport for Unigene cluster for SNX31 Gene:

genes like me logo Genes that share expression patterns with SNX31: view

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SNX31 Gene

Orthologs for SNX31 Gene

This gene was present in the common ancestor of animals.

Orthologs for SNX31 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SNX31 33 34
  • 99.47 (n)
(Bos Taurus)
Mammalia SNX31 33 34
  • 88.13 (n)
(Canis familiaris)
Mammalia SNX31 33 34
  • 87.95 (n)
(Mus musculus)
Mammalia Snx31 33 16 34
  • 80.37 (n)
(Rattus norvegicus)
Mammalia Snx31 33
  • 80.33 (n)
(Ornithorhynchus anatinus)
Mammalia SNX31 34
  • 74 (a)
(Monodelphis domestica)
Mammalia SNX31 34
  • 65 (a)
(Anolis carolinensis)
Reptilia SNX31 34
  • 60 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia snx31 33
  • 57.01 (n)
Str.20203 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.3842 33
(Danio rerio)
Actinopterygii snx27b 34
  • 16 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG5734 34
  • 26 (a)
(Caenorhabditis elegans)
Secernentea snx-17 34
  • 18 (a)
Species where no ortholog for SNX31 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SNX31 Gene

Gene Tree for SNX31 (if available)
Gene Tree for SNX31 (if available)

Paralogs for SNX31 Gene

Variants for SNX31 Gene

Sequence variations from dbSNP and Humsavar for SNX31 Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs1000008949 -- 100,581,937(-) C/T genic_downstream_transcript_variant, intron_variant
rs1000098090 -- 100,651,877(-) G/A genic_upstream_transcript_variant, intron_variant
rs1000116299 -- 100,616,424(-) T/C intron_variant
rs1000234429 -- 100,616,182(-) G/A intron_variant
rs1000285701 -- 100,574,798(-) G/A genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SNX31 Gene

Variant ID Type Subtype PubMed ID
esv2659653 CNV deletion 23128226
esv2678325 CNV deletion 23128226
esv2761452 CNV gain 21179565
esv3618193 CNV loss 21293372
nsv1015501 CNV loss 25217958
nsv438073 CNV loss 16468122
nsv527071 CNV loss 19592680

Variation tolerance for SNX31 Gene

Residual Variation Intolerance Score: 79.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 14.22; 96.21% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SNX31 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SNX31 Gene

Disorders for SNX31 Gene

Additional Disease Information for SNX31

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for SNX31 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SNX31 Gene

Publications for SNX31 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  2. The Phox (PX) domain proteins and membrane traffic. (PMID: 16782399) Seet LF … Hong W (Biochimica et biophysica acta 2006) 2 3 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58
  5. Genome-wide shRNA screening identifies host factors involved in early endocytic events for HIV-1-induced CD4 down-regulation. (PMID: 25496667) Landi A … Verhasselt B (Retrovirology 2014) 3 58

Products for SNX31 Gene

Sources for SNX31 Gene

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