Aliases for SNX29 Gene

Aliases for SNX29 Gene

  • Sorting Nexin 29 2 3 5
  • RUN Domain-Containing Protein 2A 3 4
  • RUN Domain Containing 2A 2 3
  • Sorting Nexin-29 3 4
  • RUNDC2A 3 4
  • A-388D4.1 3
  • FLJ12363 2
  • SNX29 5

External Ids for SNX29 Gene

Previous HGNC Symbols for SNX29 Gene

  • RUNDC2A

Previous GeneCards Identifiers for SNX29 Gene

  • GC16P012053
  • GC16P012146
  • GC16P012071

Summaries for SNX29 Gene

GeneCards Summary for SNX29 Gene

SNX29 (Sorting Nexin 29) is a Protein Coding gene. Diseases associated with SNX29 include Monoclonal Paraproteinemia and Bare Lymphocyte Syndrome, Type Ii. Gene Ontology (GO) annotations related to this gene include microtubule motor activity and phosphatidylinositol binding. An important paralog of this gene is PLEKHM2.

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SNX29 Gene

Genomics for SNX29 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for SNX29 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SNX29 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SNX29

Top Transcription factor binding sites by QIAGEN in the SNX29 gene promoter:
  • AML1a
  • c-Myc
  • FOXO4
  • Ik-2
  • Lhx3a
  • LHX3b
  • Max1
  • PPAR-gamma1
  • PPAR-gamma2

Genomic Locations for SNX29 Gene

Genomic Locations for SNX29 Gene
chr16:11,976,734-12,574,287
(GRCh38/hg38)
Size:
597,554 bases
Orientation:
Plus strand
chr16:12,070,594-12,668,146
(GRCh37/hg19)
Size:
597,553 bases
Orientation:
Plus strand

Genomic View for SNX29 Gene

Genes around SNX29 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SNX29 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SNX29 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SNX29 Gene

Proteins for SNX29 Gene

  • Protein details for SNX29 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TEQ0-SNX29_HUMAN
    Recommended name:
    Sorting nexin-29
    Protein Accession:
    Q8TEQ0
    Secondary Accessions:
    • B5MDW2
    • Q8N2X2
    • Q9HA26

    Protein attributes for SNX29 Gene

    Size:
    813 amino acids
    Molecular mass:
    91254 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB14033.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305};

    Alternative splice isoforms for SNX29 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SNX29 Gene

Post-translational modifications for SNX29 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SNX29 Gene

Domains & Families for SNX29 Gene

Gene Families for SNX29 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for SNX29 Gene

InterPro:
Blocks:
  • Phox-like
ProtoNet:

Suggested Antigen Peptide Sequences for SNX29 Gene

GenScript: Design optimal peptide antigens:
  • RUN domain-containing protein 2A (RUN2A_HUMAN)
  • Sorting nexin-29 (SNX29_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8TEQ0

UniProtKB/Swiss-Prot:

SNX29_HUMAN :
  • Belongs to the sorting nexin family.
Family:
  • Belongs to the sorting nexin family.
genes like me logo Genes that share domains with SNX29: view

Function for SNX29 Gene

Phenotypes From GWAS Catalog for SNX29 Gene

Gene Ontology (GO) - Molecular Function for SNX29 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035091 phosphatidylinositol binding IEA --
genes like me logo Genes that share ontologies with SNX29: view
genes like me logo Genes that share phenotypes with SNX29: view

Animal Models for SNX29 Gene

MGI Knock Outs for SNX29:
  • Snx29 Snx29<tm1b(EUCOMM)Hmgu>

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SNX29

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SNX29 Gene

Localization for SNX29 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SNX29 gene
Compartment Confidence
cytosol 2
plasma membrane 1
mitochondrion 1
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for SNX29 Gene

Pathways & Interactions for SNX29 Gene

PathCards logo

SuperPathways for SNX29 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SNX29 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SNX29 Gene

Drugs & Compounds for SNX29 Gene

No Compound Related Data Available

Transcripts for SNX29 Gene

mRNA/cDNA for SNX29 Gene

4 REFSEQ mRNAs :
13 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SNX29

Alternative Splicing Database (ASD) splice patterns (SP) for SNX29 Gene

No ASD Table

Relevant External Links for SNX29 Gene

GeneLoc Exon Structure for
SNX29

Expression for SNX29 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SNX29 Gene

Protein differential expression in normal tissues from HIPED for SNX29 Gene

This gene is overexpressed in Fetal heart (31.4), Monocytes (13.9), and Peripheral blood mononuclear cells (10.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SNX29 Gene



Protein tissue co-expression partners for SNX29 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SNX29

SOURCE GeneReport for Unigene cluster for SNX29 Gene:

Hs.458401

Evidence on tissue expression from TISSUES for SNX29 Gene

  • Nervous system(4.7)
  • Spleen(4.2)
genes like me logo Genes that share expression patterns with SNX29: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SNX29 Gene

Orthologs for SNX29 Gene

This gene was present in the common ancestor of animals.

Orthologs for SNX29 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia SNX29 30 31
  • 97.29 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia SNX29 30 31
  • 89.59 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia SNX29 30 31
  • 89.3 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Snx29 30 17 31
  • 85.16 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Snx29 30
  • 84.83 (n)
Oppossum
(Monodelphis domestica)
Mammalia SNX29 31
  • 80 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia SNX29 31
  • 76 (a)
OneToOne
Chicken
(Gallus gallus)
Aves SNX29 30 31
  • 72.75 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia SNX29 31
  • 57 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia snx29 30
  • 67.7 (n)
Zebrafish
(Danio rerio)
Actinopterygii snx29 30 31
  • 65.1 (n)
OneToOne
Dr.9983 30
Fruit Fly
(Drosophila melanogaster)
Insecta CG5439 31
  • 13 (a)
OneToOne
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 29 (a)
OneToOne
Species where no ortholog for SNX29 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for SNX29 Gene

ENSEMBL:
Gene Tree for SNX29 (if available)
TreeFam:
Gene Tree for SNX29 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SNX29: view image

Paralogs for SNX29 Gene

(2) SIMAP similar genes for SNX29 Gene using alignment to 6 proteins:

  • SNX29_HUMAN
  • H3BPI1_HUMAN
  • H3BQF0_HUMAN
  • H3BT98_HUMAN
  • H7BXR5_HUMAN
  • J3KNF2_HUMAN

Pseudogenes.org Pseudogenes for SNX29 Gene

genes like me logo Genes that share paralogs with SNX29: view

Variants for SNX29 Gene

Additional dbSNP identifiers (rs#s) for SNX29 Gene

Structural Variations from Database of Genomic Variants (DGV) for SNX29 Gene

Variant ID Type Subtype PubMed ID
dgv1299n106 CNV deletion 24896259
dgv2730n100 CNV loss 25217958
dgv2731n100 CNV gain 25217958
dgv2732n100 CNV loss 25217958
dgv481e199 CNV deletion 23128226
esv1005656 CNV loss 20482838
esv1207869 CNV insertion 17803354
esv1672031 CNV insertion 17803354
esv1735749 CNV insertion 17803354
esv23890 CNV loss 19812545
esv2658919 CNV deletion 23128226
esv2664429 CNV deletion 23128226
esv2666642 CNV deletion 23128226
esv2669944 CNV deletion 23128226
esv2713986 CNV deletion 23290073
esv2713987 CNV deletion 23290073
esv2713988 CNV deletion 23290073
esv2713989 CNV deletion 23290073
esv2751546 CNV loss 17911159
esv2758630 CNV loss 17122850
esv2760409 CNV loss 21179565
esv29309 CNV loss 19812545
esv3308847 CNV mobile element insertion 20981092
esv3337175 CNV duplication 20981092
esv3553125 CNV deletion 23714750
esv3637952 CNV loss 21293372
esv3637953 CNV loss 21293372
esv3637954 CNV loss 21293372
esv3637956 CNV loss 21293372
esv3637958 CNV loss 21293372
esv3637959 CNV gain 21293372
esv3637960 CNV gain 21293372
esv3637963 CNV loss 21293372
esv3892793 CNV loss 25118596
nsv1036612 CNV gain 25217958
nsv1038535 CNV loss 25217958
nsv1039338 CNV gain+loss 25217958
nsv1039492 CNV loss 25217958
nsv1039590 CNV gain 25217958
nsv1040358 CNV loss 25217958
nsv1042146 CNV loss 25217958
nsv1043959 CNV gain 25217958
nsv1046002 CNV loss 25217958
nsv1049011 CNV loss 25217958
nsv1050004 CNV loss 25217958
nsv1052973 CNV loss 25217958
nsv1070748 CNV deletion 25765185
nsv1123010 CNV deletion 24896259
nsv1123011 CNV deletion 24896259
nsv1134500 CNV deletion 24896259
nsv1140074 CNV deletion 24896259
nsv1160342 CNV deletion 26073780
nsv1736 CNV deletion 18451855
nsv437802 CNV loss 16327808
nsv474208 CNV novel sequence insertion 20440878
nsv478553 CNV novel sequence insertion 20440878
nsv478679 CNV novel sequence insertion 20440878
nsv478886 CNV novel sequence insertion 20440878
nsv507803 OTHER sequence alteration 20534489
nsv516932 CNV gain 19592680
nsv517039 CNV loss 19592680
nsv520000 CNV loss 19592680
nsv524986 CNV loss 19592680
nsv527197 CNV loss 19592680
nsv528018 CNV loss 19592680
nsv528952 CNV loss 19592680
nsv571458 CNV gain 21841781
nsv571460 CNV gain 21841781
nsv571461 CNV loss 21841781
nsv571462 CNV loss 21841781
nsv571463 CNV loss 21841781
nsv571464 CNV loss 21841781
nsv571465 CNV loss 21841781
nsv571466 CNV loss 21841781
nsv827555 CNV loss 20364138
nsv833141 CNV gain 17160897
nsv9348 CNV loss 18304495
nsv9349 CNV loss 18304495
nsv952923 CNV deletion 24416366
nsv952924 CNV deletion 24416366
nsv977110 CNV duplication 23825009

Variation tolerance for SNX29 Gene

Residual Variation Intolerance Score: 22.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.12; 51.21% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SNX29 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SNX29

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SNX29 Gene

Disorders for SNX29 Gene

MalaCards: The human disease database

(2) MalaCards diseases for SNX29 Gene - From: DISEASES

Disorder Aliases PubMed IDs
monoclonal paraproteinemia
  • monoclonal paraproteinaemia
bare lymphocyte syndrome, type ii
  • bls, type ii
- elite association - COSMIC cancer census association via MalaCards
Search SNX29 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for SNX29

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with SNX29: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SNX29 Gene

Publications for SNX29 Gene

  1. The Phox (PX) domain proteins and membrane traffic. (PMID: 16782399) Seet LF … Hong W (Biochimica et biophysica acta 2006) 2 3
  2. The sequence and analysis of duplication-rich human chromosome 16. (PMID: 15616553) Martin J … Pennacchio LA (Nature 2004) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  4. VIRMA mediates preferential m6A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. (PMID: 29507755) Yue Y … Liu J (Cell discovery 2018) 3
  5. An AP-MS- and BioID-compatible MAC-tag enables comprehensive mapping of protein interactions and subcellular localizations. (PMID: 29568061) Liu X … Varjosalo M (Nature communications 2018) 3

Products for SNX29 Gene

Sources for SNX29 Gene