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Aliases for SNX24 Gene

Aliases for SNX24 Gene

  • Sorting Nexin 24 2 3 5
  • Sorting Nexing 24 3
  • Sorting Nexin-24 3
  • PRO1284 3
  • SBBI31 3

External Ids for SNX24 Gene

Previous GeneCards Identifiers for SNX24 Gene

  • GC05P122508
  • GC05P122212
  • GC05P122257
  • GC05P122209
  • GC05P117368

Summaries for SNX24 Gene

GeneCards Summary for SNX24 Gene

SNX24 (Sorting Nexin 24) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include phosphatidylinositol binding. An important paralog of this gene is SNX22.

UniProtKB/Swiss-Prot for SNX24 Gene

  • May be involved in several stages of intracellular trafficking.

Additional gene information for SNX24 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SNX24 Gene

Genomics for SNX24 Gene

GeneHancer (GH) Regulatory Elements for SNX24 Gene

Promoters and enhancers for SNX24 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05I122843 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 563 +2.7 2662 4.8 PKNOX1 FOXA2 ARNT ARID4B SIN3A DMAP1 YY1 ZNF213 SP3 SP5 SNX24 GC05M122843 LOC105379154 SNX2 KRT8P33 PPIC CEP120 ENSG00000260686 PRDM6 RN7SL689P
GH05I122842 Enhancer 0.4 FANTOM5 550.8 -1.3 -1279 0.2 MAFK SNX24 LOC105379154 ENSG00000260686
GH05I122750 Enhancer 1.1 FANTOM5 Ensembl ENCODE 10.4 -91.2 -91166 2.8 STAT1 RFX1 CEBPB EBF1 EP300 RFX5 MAFF JUND ZNF366 POLR2A SNX2 SNX24 ENSG00000260686 PRDM6 PPIC LINC02201 RN7SL689P
GH05I122811 Enhancer 0.5 dbSUPER 19.6 -30.8 -30833 1.6 ZNF555 ZSCAN16 ZFP64 ZC3H11A ZNF781 ZNF518A ZNF697 ENSG00000260686 SNX2 CEP120 SNX24 RN7SL689P KRT8P33 ZNF474 LOC105379152 LOC105379154
GH05I122701 Enhancer 1.2 FANTOM5 ENCODE dbSUPER 5.9 -141.2 -141166 1.9 HDGF PKNOX1 EBF1 BATF IRF4 RELA POLR2A NFATC1 ATF7 ETV6 SNX2 PRDM6 RN7SL689P ENSG00000260686 SNX24 GC05M122721 LINC02201 ARGFXP1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SNX24 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SNX24 gene promoter:

Genomic Locations for SNX24 Gene

Genomic Locations for SNX24 Gene
185,916 bases
Plus strand

Genomic View for SNX24 Gene

Genes around SNX24 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SNX24 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SNX24 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SNX24 Gene

Proteins for SNX24 Gene

  • Protein details for SNX24 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Sorting nexin-24
    Protein Accession:
    Secondary Accessions:
    • Q6UY33

    Protein attributes for SNX24 Gene

    169 amino acids
    Molecular mass:
    19818 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for SNX24 Gene

    Alternative splice isoforms for SNX24 Gene


neXtProt entry for SNX24 Gene

Post-translational modifications for SNX24 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SNX24 Gene

Domains & Families for SNX24 Gene

Gene Families for SNX24 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for SNX24 Gene


Suggested Antigen Peptide Sequences for SNX24 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • The PX domain mediates specific binding to membranes enriched in phosphatidylinositol 3-phosphate (PtdIns(P3)).
  • Belongs to the sorting nexin family.
  • The PX domain mediates specific binding to membranes enriched in phosphatidylinositol 3-phosphate (PtdIns(P3)).
  • Belongs to the sorting nexin family.
genes like me logo Genes that share domains with SNX24: view

Function for SNX24 Gene

Molecular function for SNX24 Gene

UniProtKB/Swiss-Prot Function:
May be involved in several stages of intracellular trafficking.

Phenotypes From GWAS Catalog for SNX24 Gene

Gene Ontology (GO) - Molecular Function for SNX24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008289 lipid binding IEA --
GO:0010314 phosphatidylinositol-5-phosphate binding IEA --
GO:0032266 phosphatidylinositol-3-phosphate binding IEA --
GO:0035091 phosphatidylinositol binding IEA --
GO:0070273 phosphatidylinositol-4-phosphate binding IEA --
genes like me logo Genes that share ontologies with SNX24: view
genes like me logo Genes that share phenotypes with SNX24: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SNX24 Gene

Localization for SNX24 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SNX24 Gene

Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SNX24 gene
Compartment Confidence
cytosol 3
nucleus 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for SNX24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0030659 cytoplasmic vesicle membrane IEA --
GO:0031410 cytoplasmic vesicle IEA --
genes like me logo Genes that share ontologies with SNX24: view

Pathways & Interactions for SNX24 Gene

SuperPathways for SNX24 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SNX24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015031 protein transport IEA --
genes like me logo Genes that share ontologies with SNX24: view

No data available for Pathways by source and SIGNOR curated interactions for SNX24 Gene

Drugs & Compounds for SNX24 Gene

No Compound Related Data Available

Transcripts for SNX24 Gene

Unigene Clusters for SNX24 Gene

Sorting nexin 24:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SNX24 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9
SP1: - -
SP2: -
SP3: - - -

Relevant External Links for SNX24 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SNX24 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SNX24 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SNX24 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x4.5).

Protein differential expression in normal tissues from HIPED for SNX24 Gene

This gene is overexpressed in Placenta (12.9), Fetal ovary (10.6), Adrenal (6.4), Fetal testis (6.0), and Breast (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SNX24 Gene

NURSA nuclear receptor signaling pathways regulating expression of SNX24 Gene:


SOURCE GeneReport for Unigene cluster for SNX24 Gene:


Evidence on tissue expression from TISSUES for SNX24 Gene

  • Kidney(4.2)
  • Lung(4.2)
genes like me logo Genes that share expression patterns with SNX24: view

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SNX24 Gene

Orthologs for SNX24 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SNX24 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SNX24 33 34
  • 99.61 (n)
(Canis familiaris)
Mammalia SNX24 33 34
  • 94.7 (n)
(Bos Taurus)
Mammalia SNX24 33 34
  • 94.08 (n)
(Monodelphis domestica)
Mammalia SNX24 34
  • 94 (a)
(Mus musculus)
Mammalia Snx24 33 16 34
  • 89.74 (n)
(Rattus norvegicus)
Mammalia Snx24 33
  • 88.36 (n)
(Ornithorhynchus anatinus)
Mammalia SNX24 34
  • 86 (a)
(Gallus gallus)
Aves SNX24 33 34
  • 84.81 (n)
(Anolis carolinensis)
Reptilia SNX24 34
  • 75 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia snx24 33
  • 80.04 (n)
(Danio rerio)
Actinopterygii snx24 33 34
  • 73.02 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6285 33
Species where no ortholog for SNX24 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SNX24 Gene

Gene Tree for SNX24 (if available)
Gene Tree for SNX24 (if available)

Paralogs for SNX24 Gene

Paralogs for SNX24 Gene

(3) SIMAP similar genes for SNX24 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with SNX24: view

Variants for SNX24 Gene

Sequence variations from dbSNP and Humsavar for SNX24 Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1000000360 -- 122,858,334(+) G/T genic_upstream_transcript_variant, intron_variant
rs1000017676 -- 122,916,522(+) C/T genic_upstream_transcript_variant, intron_variant
rs1000025420 -- 122,851,480(+) T/A genic_upstream_transcript_variant, intron_variant
rs1000036843 -- 122,851,282(+) A/C genic_upstream_transcript_variant, intron_variant
rs1000039200 -- 122,973,788(+) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SNX24 Gene

Variant ID Type Subtype PubMed ID
dgv213n6 CNV deletion 16902084
dgv3169n106 CNV deletion 24896259
esv1008444 CNV deletion 20482838
esv1686062 CNV deletion 17803354
esv2095337 CNV deletion 18987734
esv2569438 CNV deletion 19546169
esv2730708 CNV deletion 23290073
esv2730709 CNV deletion 23290073
esv3566579 CNV deletion 23714750
esv3606594 CNV loss 21293372
esv4604 CNV loss 18987735
esv5852 CNV loss 19470904
nsv1017500 CNV loss 25217958
nsv1032251 CNV gain 25217958
nsv1073493 CNV deletion 25765185
nsv1074869 CNV deletion 25765185
nsv1149609 CNV deletion 26484159
nsv830471 CNV gain 17160897
nsv950127 CNV duplication 24416366

Variation tolerance for SNX24 Gene

Residual Variation Intolerance Score: 27.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.12; 2.64% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SNX24 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SNX24 Gene

Disorders for SNX24 Gene

Additional Disease Information for SNX24

No disorders were found for SNX24 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SNX24 Gene

Publications for SNX24 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 58
  3. Sorting out the cellular functions of sorting nexins. (PMID: 12461558) Worby CA … Dixon JE (Nature reviews. Molecular cell biology 2002) 2 3 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58

Products for SNX24 Gene

Sources for SNX24 Gene

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