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Aliases for SNX16 Gene

Aliases for SNX16 Gene

  • Sorting Nexin 16 2 3 5

External Ids for SNX16 Gene

Previous GeneCards Identifiers for SNX16 Gene

  • GC08M081590
  • GC08M082759
  • GC08M082435
  • GC08M082761
  • GC08M082874
  • GC08M078201
  • GC08M082711

Summaries for SNX16 Gene

Entrez Gene Summary for SNX16 Gene

  • This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. The protein encoded by this gene associates with late endosome membranes as is involved in tubule formation, cholesterol transport, and transport of tetraspanin CD81. The encoded protein also inhibits cell migration and tumorigenesis. [provided by RefSeq, Jan 2017]

GeneCards Summary for SNX16 Gene

SNX16 (Sorting Nexin 16) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include identical protein binding and phosphatidylinositol binding.

UniProtKB/Swiss-Prot for SNX16 Gene

  • May be involved in several stages of intracellular trafficking. Plays a role in protein transport from early to late endosomes. Plays a role in protein transport to the lysosome. Promotes degradation of EGFR after EGF signaling. Plays a role in intracellular transport of vesicular stomatitis virus nucleocapsids from the endosome to the cytoplasm.

Additional gene information for SNX16 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SNX16 Gene

Genomics for SNX16 Gene

GeneHancer (GH) Regulatory Elements for SNX16 Gene

Promoters and enhancers for SNX16 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08I081840 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 611.4 +0.8 757 2.5 HNRNPUL1 PKNOX1 ARNT ARID4B NEUROD1 SIN3A ZBTB7B IRF4 YY1 ZNF766 SNX16 LOC105375928 ZFAND1 HNRNPA1P36 LINC02235 CHMP4C
GH08I081781 Enhancer 0.7 ENCODE 19.9 +62.2 62195 0.2 CTCF RB1 MAX BATF RAD21 CC2D1A ZNF335 CTBP1 GATA3 ARID2 SNX16 CHMP4C ZFAND1 ENSG00000253334
GH08I081783 Enhancer 0.6 ENCODE 22.9 +59.0 58990 1.2 ZNF639 RFX1 MAFG BACH1 RFX5 ZNF316 GATA3 CREB1 NFE2 FOS SNX16 CHMP4C FABP5 ENSG00000253334 ZFAND1
GH08I081897 Enhancer 0.2 ENCODE 59.7 -54.7 -54673 2.7 SNX16 GC08P081893 PIR48087 LINC02235 GC08M081871
GH08I081896 Enhancer 0.2 ENCODE 59.2 -53.2 -53245 0.2 SNX16 GC08P081893 PIR48087 LINC02235 GC08M081871
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SNX16 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SNX16 gene promoter:

Genomic Locations for SNX16 Gene

Genomic Locations for SNX16 Gene
chr8:81,799,581-81,842,866
(GRCh38/hg38)
Size:
43,286 bases
Orientation:
Minus strand
chr8:82,711,816-82,755,101
(GRCh37/hg19)

Genomic View for SNX16 Gene

Genes around SNX16 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SNX16 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SNX16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SNX16 Gene

Proteins for SNX16 Gene

  • Protein details for SNX16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P57768-SNX16_HUMAN
    Recommended name:
    Sorting nexin-16
    Protein Accession:
    P57768
    Secondary Accessions:
    • A8K4D8
    • Q658L0
    • Q8N4U3

    Protein attributes for SNX16 Gene

    Size:
    344 amino acids
    Molecular mass:
    39167 Da
    Quaternary structure:
    • Homooligomer. Interacts with EGFR (By similarity).

    Three dimensional structures from OCA and Proteopedia for SNX16 Gene

    Alternative splice isoforms for SNX16 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SNX16 Gene

Post-translational modifications for SNX16 Gene

No Post-translational modifications

No data available for DME Specific Peptides for SNX16 Gene

Domains & Families for SNX16 Gene

Gene Families for SNX16 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for SNX16 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for SNX16 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P57768

UniProtKB/Swiss-Prot:

SNX16_HUMAN :
  • The PX domain mediates interaction with membranes enriched in phosphatidylinositol 3-phosphate.
  • Belongs to the sorting nexin family.
Domain:
  • The PX domain mediates interaction with membranes enriched in phosphatidylinositol 3-phosphate.
Family:
  • Belongs to the sorting nexin family.
genes like me logo Genes that share domains with SNX16: view

Function for SNX16 Gene

Molecular function for SNX16 Gene

UniProtKB/Swiss-Prot Function:
May be involved in several stages of intracellular trafficking. Plays a role in protein transport from early to late endosomes. Plays a role in protein transport to the lysosome. Promotes degradation of EGFR after EGF signaling. Plays a role in intracellular transport of vesicular stomatitis virus nucleocapsids from the endosome to the cytoplasm.

Phenotypes From GWAS Catalog for SNX16 Gene

Gene Ontology (GO) - Molecular Function for SNX16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008289 lipid binding IEA --
GO:0035091 phosphatidylinositol binding IDA,IEA 12813048
GO:0042802 identical protein binding IPI 12813048
genes like me logo Genes that share ontologies with SNX16: view

Phenotypes for SNX16 Gene

GenomeRNAi human phenotypes for SNX16:
genes like me logo Genes that share phenotypes with SNX16: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for SNX16

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SNX16 Gene

Localization for SNX16 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SNX16 Gene

Early endosome membrane; Peripheral membrane protein; Cytoplasmic side. Late endosome membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Lysosome.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SNX16 gene
Compartment Confidence
endosome 5
cytosol 4
mitochondrion 3
lysosome 3
nucleus 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for SNX16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005764 lysosome IEA --
GO:0005768 endosome IEA --
GO:0005769 early endosome IDA 12813048
GO:0005770 late endosome IDA 12813048
GO:0005829 cytosol IEA --
genes like me logo Genes that share ontologies with SNX16: view

Pathways & Interactions for SNX16 Gene

SuperPathways for SNX16 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SNX16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006622 protein targeting to lysosome IMP 12813048
GO:0006810 transport IEA --
GO:0008333 endosome to lysosome transport IMP 12813048
GO:0015031 protein transport IEA --
GO:0045022 early endosome to late endosome transport IMP 12813048
genes like me logo Genes that share ontologies with SNX16: view

No data available for Pathways by source and SIGNOR curated interactions for SNX16 Gene

Drugs & Compounds for SNX16 Gene

No Compound Related Data Available

Transcripts for SNX16 Gene

Unigene Clusters for SNX16 Gene

Sorting nexin 16:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for SNX16

Alternative Splicing Database (ASD) splice patterns (SP) for SNX16 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9
SP1:
SP2: -
SP3: - - -

Relevant External Links for SNX16 Gene

GeneLoc Exon Structure for
SNX16
ECgene alternative splicing isoforms for
SNX16

Expression for SNX16 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SNX16 Gene

Protein differential expression in normal tissues from HIPED for SNX16 Gene

This gene is overexpressed in Testis (35.3), Breast (10.1), and Lung (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SNX16 Gene



NURSA nuclear receptor signaling pathways regulating expression of SNX16 Gene:

SNX16

SOURCE GeneReport for Unigene cluster for SNX16 Gene:

Hs.492121

mRNA Expression by UniProt/SwissProt for SNX16 Gene:

P57768-SNX16_HUMAN
Tissue specificity: Detected in placenta, lung, liver,heart and pancreas.

Evidence on tissue expression from TISSUES for SNX16 Gene

  • Liver(4.2)
  • Pancreas(4.2)
  • Stomach(4.2)
genes like me logo Genes that share expression patterns with SNX16: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for SNX16 Gene

Orthologs for SNX16 Gene

This gene was present in the common ancestor of animals.

Orthologs for SNX16 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SNX16 33 34
  • 99.61 (n)
dog
(Canis familiaris)
Mammalia SNX16 33 34
  • 90.99 (n)
cow
(Bos Taurus)
Mammalia SNX16 33 34
  • 90.86 (n)
rat
(Rattus norvegicus)
Mammalia Snx16 33
  • 86.63 (n)
mouse
(Mus musculus)
Mammalia Snx16 33 16 34
  • 85.56 (n)
oppossum
(Monodelphis domestica)
Mammalia SNX16 34
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SNX16 34
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves SNX16 33 34
  • 74.14 (n)
lizard
(Anolis carolinensis)
Reptilia SNX16 34
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia snx16 33
  • 65.55 (n)
zebrafish
(Danio rerio)
Actinopterygii snx16 33 34
  • 60.87 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG6410 35
  • 43 (a)
Snx16 34
  • 23 (a)
OneToOne
Species where no ortholog for SNX16 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SNX16 Gene

ENSEMBL:
Gene Tree for SNX16 (if available)
TreeFam:
Gene Tree for SNX16 (if available)

Paralogs for SNX16 Gene

(2) SIMAP similar genes for SNX16 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with SNX16: view

No data available for Paralogs for SNX16 Gene

Variants for SNX16 Gene

Sequence variations from dbSNP and Humsavar for SNX16 Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs1000002069 -- 81,823,677(-) T/C intron_variant
rs1000028372 -- 81,804,775(-) A/T intron_variant
rs1000162910 -- 81,804,058(-) T/C intron_variant
rs1000256582 -- 81,816,598(-) G/A intron_variant
rs1000332455 -- 81,820,727(-) C/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SNX16 Gene

Variant ID Type Subtype PubMed ID
nsv967610 CNV duplication 23825009
nsv831369 CNV gain+loss 17160897
nsv6277 CNV deletion 18451855
nsv611609 CNV gain 21841781
nsv465722 CNV gain 19166990
esv3328109 CNV insertion 20981092
esv2761440 CNV loss 21179565

Variation tolerance for SNX16 Gene

Residual Variation Intolerance Score: 42.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.33; 41.49% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SNX16 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SNX16

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SNX16 Gene

Disorders for SNX16 Gene

Additional Disease Information for SNX16

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for SNX16 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SNX16 Gene

Publications for SNX16 Gene

  1. Evidence for a role of SNX16 in regulating traffic between the early and later endosomal compartments. (PMID: 12813048) Hanson BJ … Hong W (The Journal of biological chemistry 2003) 2 3 4 22 58
  2. Evaluation of nine candidate genes in patients with normal tension glaucoma: a case control study. (PMID: 19754948) Wolf C … Weisschuh N (BMC medical genetics 2009) 3 22 44 58
  3. A genome-wide search for loci interacting with known prostate cancer risk-associated genetic variants. (PMID: 22219177) Tao S … Sun J (Carcinogenesis 2012) 3 44 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Sorting out the cellular functions of sorting nexins. (PMID: 12461558) Worby CA … Dixon JE (Nature reviews. Molecular cell biology 2002) 2 3 58

Products for SNX16 Gene

Sources for SNX16 Gene

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