This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. Overexpression of this gene results in a decrease in the processing of insulin and hepatocyte growth factor receptors to their mature subunits. This decrease is caused by the misloca... See more...

Aliases for SNX15 Gene

Aliases for SNX15 Gene

  • Sorting Nexin 15 2 3 5
  • Sorting Nexin-15 3 4
  • Clone Iota Unknown Protein 3
  • HSAF001435 3
  • SNX15 5

External Ids for SNX15 Gene

Previous GeneCards Identifiers for SNX15 Gene

  • GC11P067310
  • GC11P066463
  • GC11P064557
  • GC11P064538
  • GC11P064552
  • GC11P064782
  • GC11P061121
  • GC11P064794

Summaries for SNX15 Gene

Entrez Gene Summary for SNX15 Gene

  • This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. Overexpression of this gene results in a decrease in the processing of insulin and hepatocyte growth factor receptors to their mature subunits. This decrease is caused by the mislocalization of furin, the endoprotease responsible for cleavage of insulin and hepatocyte growth factor receptors. This protein is involved in endosomal trafficking from the plasma membrane to recycling endosomes or the trans-Golgi network. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the upstream ADP-ribosylation factor-like 2 (ARL2) gene. [provided by RefSeq, Dec 2010]

GeneCards Summary for SNX15 Gene

SNX15 (Sorting Nexin 15) is a Protein Coding gene. Diseases associated with SNX15 include Hereditary Spastic Paraplegia. Among its related pathways are PDGFR-beta signaling pathway. Gene Ontology (GO) annotations related to this gene include protein serine/threonine kinase activity and phosphatidylinositol binding. An important paralog of this gene is RPS6KC1.

UniProtKB/Swiss-Prot Summary for SNX15 Gene

  • May be involved in several stages of intracellular trafficking. Overexpression of SNX15 disrupts the normal trafficking of proteins from the plasma membrane to recycling endosomes or the TGN.

Gene Wiki entry for SNX15 Gene

Additional gene information for SNX15 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SNX15 Gene

Genomics for SNX15 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for SNX15 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SNX15 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SNX15

Top Transcription factor binding sites by QIAGEN in the SNX15 gene promoter:
  • AREB6
  • Brachyury
  • E47
  • MAZR
  • p53
  • SREBP-1a
  • SREBP-1b
  • SREBP-1c
  • STAT1
  • Tal-1

Genomic Locations for SNX15 Gene

Genomic Locations for SNX15 Gene
chr11:65,027,439-65,040,572
(GRCh38/hg38)
Size:
13,134 bases
Orientation:
Plus strand
chr11:64,794,880-64,808,044
(GRCh37/hg19)
Size:
13,165 bases
Orientation:
Plus strand

Genomic View for SNX15 Gene

Genes around SNX15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SNX15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SNX15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SNX15 Gene

Proteins for SNX15 Gene

  • Protein details for SNX15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NRS6-SNX15_HUMAN
    Recommended name:
    Sorting nexin-15
    Protein Accession:
    Q9NRS6
    Secondary Accessions:
    • E5KQS6
    • Q9NRS5

    Protein attributes for SNX15 Gene

    Size:
    342 amino acids
    Molecular mass:
    38291 Da
    Quaternary structure:
    • Homodimer. Interacts with SNX1, SNX2 and SNX4.

    Three dimensional structures from OCA and Proteopedia for SNX15 Gene

    Alternative splice isoforms for SNX15 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SNX15 Gene

Post-translational modifications for SNX15 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SNX15 Gene

Antibody Products

  • Boster Bio Antibodies for SNX15
  • Santa Cruz Biotechnology (SCBT) Antibodies for SNX15

No data available for DME Specific Peptides for SNX15 Gene

Domains & Families for SNX15 Gene

Gene Families for SNX15 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for SNX15 Gene

InterPro:
Blocks:
  • Phox-like
  • MIT
ProtoNet:

Suggested Antigen Peptide Sequences for SNX15 Gene

GenScript: Design optimal peptide antigens:
  • Sorting nexin-15 (SNX15_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9NRS6

UniProtKB/Swiss-Prot:

SNX15_HUMAN :
  • The PX domain mediates interaction with membranes enriched in phosphatidylinositol 3-phosphate.
  • Belongs to the sorting nexin family.
Domain:
  • The PX domain mediates interaction with membranes enriched in phosphatidylinositol 3-phosphate.
Family:
  • Belongs to the sorting nexin family.
genes like me logo Genes that share domains with SNX15: view

Function for SNX15 Gene

Molecular function for SNX15 Gene

UniProtKB/Swiss-Prot Function:
May be involved in several stages of intracellular trafficking. Overexpression of SNX15 disrupts the normal trafficking of proteins from the plasma membrane to recycling endosomes or the TGN.

Phenotypes From GWAS Catalog for SNX15 Gene

Gene Ontology (GO) - Molecular Function for SNX15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
GO:0008289 lipid binding IEA --
GO:0035091 phosphatidylinositol binding IEA --
genes like me logo Genes that share ontologies with SNX15: view
genes like me logo Genes that share phenotypes with SNX15: view

Animal Models for SNX15 Gene

MGI Knock Outs for SNX15:
  • Snx15 Snx15<tm1.1(KOMP)Vlcg>

Animal Model Products

CRISPR Products

miRNA for SNX15 Gene

miRTarBase miRNAs that target SNX15

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SNX15

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SNX15 Gene

Localization for SNX15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SNX15 Gene

Cytoplasm. Membrane. Peripheral membrane protein. Cytoplasmic side. Cytoplasmic vesicle membrane. Peripheral membrane protein. Cytoplasmic side.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SNX15 gene
Compartment Confidence
nucleus 5
cytosol 5
plasma membrane 4
endosome 2
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Plasma membrane (3)
  • Vesicles (3)
  • Nucleoli (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SNX15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IEA --
GO:0005769 early endosome IBA 21873635
GO:0005829 cytosol NAS 11085978
GO:0005886 plasma membrane IDA --
genes like me logo Genes that share ontologies with SNX15: view

Pathways & Interactions for SNX15 Gene

PathCards logo

SuperPathways for SNX15 Gene

SuperPathway Contained pathways
1 PDGFR-beta signaling pathway
genes like me logo Genes that share pathways with SNX15: view

Pathways by source for SNX15 Gene

1 BioSystems pathway for SNX15 Gene

Gene Ontology (GO) - Biological Process for SNX15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006886 intracellular protein transport NAS 11085978
GO:0015031 protein transport IEA --
genes like me logo Genes that share ontologies with SNX15: view

No data available for SIGNOR curated interactions for SNX15 Gene

Drugs & Compounds for SNX15 Gene

No Compound Related Data Available

Transcripts for SNX15 Gene

mRNA/cDNA for SNX15 Gene

2 REFSEQ mRNAs :
14 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SNX15

Alternative Splicing Database (ASD) splice patterns (SP) for SNX15 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13
SP1:
SP2: -
SP3: - - -
SP4:
SP5:

Relevant External Links for SNX15 Gene

GeneLoc Exon Structure for
SNX15

Expression for SNX15 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SNX15 Gene

Protein differential expression in normal tissues from HIPED for SNX15 Gene

This gene is overexpressed in Fetal Brain (15.8) and Peripheral blood mononuclear cells (13.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SNX15 Gene



Protein tissue co-expression partners for SNX15 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SNX15

SOURCE GeneReport for Unigene cluster for SNX15 Gene:

Hs.80132

mRNA Expression by UniProt/SwissProt for SNX15 Gene:

Q9NRS6-SNX15_HUMAN
Tissue specificity: Widely expressed.

Evidence on tissue expression from TISSUES for SNX15 Gene

  • Nervous system(4.7)
  • Liver(4.2)
  • Thyroid gland(4.2)
  • Muscle(2.4)
  • Kidney(2.3)
genes like me logo Genes that share expression patterns with SNX15: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for SNX15 Gene

Orthologs for SNX15 Gene

This gene was present in the common ancestor of animals.

Orthologs for SNX15 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia SNX15 30 31
  • 99.51 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia SNX15 30 31
  • 88.17 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia SNX15 30 31
  • 87.67 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Snx15 30 17 31
  • 84.72 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Snx15 30
  • 83.63 (n)
Oppossum
(Monodelphis domestica)
Mammalia SNX15 31
  • 68 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia SNX15 31
  • 55 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia snx15 30
  • 55.27 (n)
Zebrafish
(Danio rerio)
Actinopterygii snx15 30 31
  • 58.37 (n)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta CG7156 31
  • 10 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea rskd-1 31
  • 7 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 10 (a)
OneToMany
Species where no ortholog for SNX15 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for SNX15 Gene

ENSEMBL:
Gene Tree for SNX15 (if available)
TreeFam:
Gene Tree for SNX15 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SNX15: view image

Paralogs for SNX15 Gene

Paralogs for SNX15 Gene

(1) SIMAP similar genes for SNX15 Gene using alignment to 7 proteins:

  • SNX15_HUMAN
  • E5KQS6_HUMAN
  • E9PK26_HUMAN
  • E9PMW6_HUMAN
  • E9PNI5_HUMAN
  • E9PR81_HUMAN
  • V9GYD0_HUMAN
genes like me logo Genes that share paralogs with SNX15: view

Variants for SNX15 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SNX15 Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
rs495820 - p.Arg334Cys

Additional dbSNP identifiers (rs#s) for SNX15 Gene

Structural Variations from Database of Genomic Variants (DGV) for SNX15 Gene

Variant ID Type Subtype PubMed ID
esv3626669 CNV gain 21293372
nsv1113400 CNV deletion 24896259
nsv1113401 CNV deletion 24896259
nsv1122633 CNV deletion 24896259
nsv526181 CNV gain 19592680
nsv983034 CNV duplication 23825009

Variation tolerance for SNX15 Gene

Residual Variation Intolerance Score: 89.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.79; 73.62% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SNX15 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SNX15

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SNX15 Gene

Disorders for SNX15 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SNX15 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
hereditary spastic paraplegia
  • spastic paraplegia 3, autosomal dominant
- elite association - COSMIC cancer census association via MalaCards
Search SNX15 in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with SNX15: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SNX15 Gene

Publications for SNX15 Gene

  1. Identification of rare DNA variants in mitochondrial disorders with improved array-based sequencing. (PMID: 20843780) Wang W … Scharfe C (Nucleic acids research 2011) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  3. A clinical, genetic and candidate gene study of Silver syndrome, a complicated form of hereditary spastic paraplegia. (PMID: 15372247) Warner TT … Crosby AH (Journal of neurology 2004) 3 23
  4. Identification and characterization of SNX15, a novel sorting nexin involved in protein trafficking. (PMID: 11085978) Phillips SA … Haft CR (The Journal of biological chemistry 2001) 3 4
  5. Overexpression of a novel sorting nexin, SNX15, affects endosome morphology and protein trafficking. (PMID: 11208079) Barr VA … Haft CR (Traffic (Copenhagen, Denmark) 2000) 2 3

Products for SNX15 Gene

  • Signalway Proteins for SNX15

Sources for SNX15 Gene