Aliases for SNX15 Gene
External Ids for SNX15 Gene
Previous GeneCards Identifiers for SNX15 Gene
This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. Overexpression of this gene results in a decrease in the processing of insulin and hepatocyte growth factor receptors to their mature subunits. This decrease is caused by the mislocalization of furin, the endoprotease responsible for cleavage of insulin and hepatocyte growth factor receptors. This protein is involved in endosomal trafficking from the plasma membrane to recycling endosomes or the trans-Golgi network. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the upstream ADP-ribosylation factor-like 2 (ARL2) gene. [provided by RefSeq, Dec 2010]
GeneCards Summary for SNX15 Gene
SNX15 (Sorting Nexin 15) is a Protein Coding gene. Diseases associated with SNX15 include Hereditary Spastic Paraplegia. Among its related pathways are PDGFR-beta signaling pathway. Gene Ontology (GO) annotations related to this gene include protein serine/threonine kinase activity and phosphatidylinositol binding. An important paralog of this gene is RPS6KC1.
UniProtKB/Swiss-Prot Summary for SNX15 Gene
May be involved in several stages of intracellular trafficking. Overexpression of SNX15 disrupts the normal trafficking of proteins from the plasma membrane to recycling endosomes or the TGN.