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Aliases for SNX11 Gene

Aliases for SNX11 Gene

  • Sorting Nexin 11 2 3 5

External Ids for SNX11 Gene

Previous GeneCards Identifiers for SNX11 Gene

  • GC17P045890
  • GC17P048665
  • GC17P046526
  • GC17P046659
  • GC17P043539
  • GC17P046184
  • GC17P041555

Summaries for SNX11 Gene

Entrez Gene Summary for SNX11 Gene

  • This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like some family members. This gene encodes a protein of unknown function. This gene results in two transcript variants differing in the 5' UTR, but encoding the same protein. [provided by RefSeq, Jul 2008]

GeneCards Summary for SNX11 Gene

SNX11 (Sorting Nexin 11) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include phosphatidylinositol binding and phosphatidylinositol phosphate binding. An important paralog of this gene is SNX10.

UniProtKB/Swiss-Prot for SNX11 Gene

  • Phosphoinositide-binding protein involved in protein sorting and membrane trafficking in endosomes.

Additional gene information for SNX11 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SNX11 Gene

Genomics for SNX11 Gene

GeneHancer (GH) Regulatory Elements for SNX11 Gene

Promoters and enhancers for SNX11 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17I048099 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE 579.6 -1.8 -1834 4.2 HDGF PKNOX1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B SLC30A9 SNX11 CBX1 CDK5RAP3 ENSG00000253347 ENSG00000230532
GH17I048106 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 578.7 +4.6 4595 2.6 HDGF PKNOX1 SMAD1 ARID4B SIN3A YBX1 ZBTB7B YY1 POLR2B E2F8 SNX11 COPZ2 ENSG00000266601 KPNB1 EFCAB13 NFE2L1 MIR152 ENSG00000263412 ENSG00000263766 SP2
GH17I048044 Promoter/Enhancer 2.5 VISTA EPDnew Ensembl ENCODE dbSUPER 39.3 -52.3 -52250 13 CLOCK DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 NFYC NFE2L1 SP2 SNX11 ENSG00000266601 KPNB1 MRPL45P2 CBX1 UBE2Z ENSG00000253347 EFCAB13
GH17I048238 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 22.6 +138.8 138805 7.2 HDGF PKNOX1 ARNT SIN3A FEZF1 IRF4 ZNF766 ZNF213 FOS KLF13 SNX11 CBX1 COPZ2 CDK5RAP3 ENSG00000230532 RNU6-1152P SKAP1 MIR1203 EGID-105371807 SP2-AS1
GH17I048023 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 18.7 -78.0 -78034 4.6 HDGF PKNOX1 CLOCK FOXA2 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 SP2 ENSG00000253347 CBX1 MRPL45P2 EFCAB13 ENSG00000266601 SNX11 CDK5RAP3 COPZ2 SKAP1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SNX11 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SNX11 gene promoter:

Genomic Locations for SNX11 Gene

Genomic Locations for SNX11 Gene
19,718 bases
Plus strand

Genomic View for SNX11 Gene

Genes around SNX11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SNX11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SNX11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SNX11 Gene

Proteins for SNX11 Gene

  • Protein details for SNX11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Sorting nexin-11
    Protein Accession:
    Secondary Accessions:
    • B3KRL6
    • B4DPY5
    • D3DTV0
    • Q53YC0
    • Q9H885

    Protein attributes for SNX11 Gene

    270 amino acids
    Molecular mass:
    30433 Da
    Quaternary structure:
    • Monomer.
    • Sequence=AAD27834.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SNX11 Gene

    Alternative splice isoforms for SNX11 Gene


neXtProt entry for SNX11 Gene

Post-translational modifications for SNX11 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SNX11 Gene

Domains & Families for SNX11 Gene

Gene Families for SNX11 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for SNX11 Gene


Graphical View of Domain Structure for InterPro Entry



  • The PX domain mediates interaction with membranes enriched in phosphatidylinositol 3-phosphate.
  • Belongs to the sorting nexin family.
  • The PX domain mediates interaction with membranes enriched in phosphatidylinositol 3-phosphate.
  • Belongs to the sorting nexin family.
genes like me logo Genes that share domains with SNX11: view

Function for SNX11 Gene

Molecular function for SNX11 Gene

UniProtKB/Swiss-Prot Function:
Phosphoinositide-binding protein involved in protein sorting and membrane trafficking in endosomes.

Phenotypes From GWAS Catalog for SNX11 Gene

Gene Ontology (GO) - Molecular Function for SNX11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0008289 lipid binding IEA --
GO:0035091 phosphatidylinositol binding IEA --
GO:1901981 phosphatidylinositol phosphate binding IDA 23615901
genes like me logo Genes that share ontologies with SNX11: view
genes like me logo Genes that share phenotypes with SNX11: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SNX11 Gene

Localization for SNX11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SNX11 Gene

Membrane; Peripheral membrane protein; Cytoplasmic side. Endosome.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SNX11 gene
Compartment Confidence
endosome 5
cytosol 4
nucleus 2
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for SNX11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005768 endosome IDA,IEA 23615901
GO:0016020 membrane IEA --
GO:0019898 extrinsic component of membrane IBA --
genes like me logo Genes that share ontologies with SNX11: view

Pathways & Interactions for SNX11 Gene

SuperPathways for SNX11 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SNX11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006886 intracellular protein transport IEA --
GO:0006897 endocytosis IBA --
GO:0015031 protein transport IEA --
GO:0016050 vesicle organization IMP 23615901
genes like me logo Genes that share ontologies with SNX11: view

No data available for Pathways by source and SIGNOR curated interactions for SNX11 Gene

Drugs & Compounds for SNX11 Gene

No Compound Related Data Available

Transcripts for SNX11 Gene

Unigene Clusters for SNX11 Gene

Sorting nexin 11:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SNX11 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c · 10d · 10e · 10f
SP1: - - - - -
SP2: - - - - -
SP3: - - - - - - - - -
SP4: - - - - - -
SP5: - - - - -
SP6: - - - - - - - - - -
SP7: - - - - -
SP8: - - - - - -
SP9: -
SP10: -
SP11: -

Relevant External Links for SNX11 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SNX11 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SNX11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SNX11 Gene

This gene is overexpressed in Whole Blood (x4.9).

Protein differential expression in normal tissues from HIPED for SNX11 Gene

This gene is overexpressed in Pancreatic juice (26.9) and Breast (26.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SNX11 Gene

Protein tissue co-expression partners for SNX11 Gene

NURSA nuclear receptor signaling pathways regulating expression of SNX11 Gene:


SOURCE GeneReport for Unigene cluster for SNX11 Gene:


Evidence on tissue expression from TISSUES for SNX11 Gene

  • Kidney(4.2)
  • Lung(4.2)
  • Thyroid gland(4.2)
  • Skin(4.1)
  • Nervous system(3.8)
genes like me logo Genes that share expression patterns with SNX11: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SNX11 Gene

Orthologs for SNX11 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SNX11 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SNX11 33 34
  • 99.63 (n)
(Bos Taurus)
Mammalia SNX11 33 34
  • 88.64 (n)
(Canis familiaris)
Mammalia SNX11 33 34
  • 88.4 (n)
(Rattus norvegicus)
Mammalia Snx11 33
  • 85.06 (n)
(Mus musculus)
Mammalia Snx11 33 16 34
  • 82.96 (n)
(Monodelphis domestica)
Mammalia SNX11 34
  • 73 (a)
(Ornithorhynchus anatinus)
Mammalia SNX11 34
  • 68 (a)
(Gallus gallus)
Aves -- 34
  • 89 (a)
-- 34
  • 81 (a)
SNX11 33
  • 76.68 (n)
(Anolis carolinensis)
Reptilia SNX11 34
  • 88 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia snx11 33
  • 70.21 (n)
Str.15224 33
(Danio rerio)
Actinopterygii snx11 34
  • 26 (a)
Dr.16273 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1432 33
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SNX3 34
  • 26 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 22 (a)
Species where no ortholog for SNX11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SNX11 Gene

Gene Tree for SNX11 (if available)
Gene Tree for SNX11 (if available)

Paralogs for SNX11 Gene

Paralogs for SNX11 Gene

(3) SIMAP similar genes for SNX11 Gene using alignment to 9 proteins:

genes like me logo Genes that share paralogs with SNX11: view

Variants for SNX11 Gene

Sequence variations from dbSNP and Humsavar for SNX11 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000191654 -- 48,106,707(+) C/T upstream_transcript_variant
rs1000226766 -- 48,108,244(+) TTACTTAC/TTAC intron_variant
rs1000324571 -- 48,115,918(+) /G intron_variant
rs1000404740 -- 48,112,478(+) A/G intron_variant
rs1000531645 -- 48,107,284(+) C/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for SNX11 Gene

Variant ID Type Subtype PubMed ID
esv1007058 CNV deletion 20482838
esv3582798 CNV loss 25503493
nsv112217 CNV deletion 16902084
nsv469808 CNV loss 16826518

Variation tolerance for SNX11 Gene

Residual Variation Intolerance Score: 32.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.72; 15.26% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SNX11 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SNX11 Gene

Disorders for SNX11 Gene

Additional Disease Information for SNX11

No disorders were found for SNX11 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SNX11 Gene

Publications for SNX11 Gene

  1. Structure of sorting nexin 11 (SNX11) reveals a novel extended phox homology (PX) domain critical for inhibition of SNX10-induced vacuolation. (PMID: 23615901) Xu J … Liu J (The Journal of biological chemistry 2013) 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. A large family of endosome-localized proteins related to sorting nexin 1. (PMID: 11485546) Teasdale RD … Gleeson PA (The Biochemical journal 2001) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for SNX11 Gene

Sources for SNX11 Gene

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