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Aliases for SNUPN Gene

Aliases for SNUPN Gene

  • Snurportin 1 2 3 5
  • RNA U Transporter 1 3 4
  • RNUT1 3 4
  • RNA, U Transporter 1 2
  • Snurportin-1 3
  • Snurportin1 3
  • KPNBL 3
  • SPN1 4

External Ids for SNUPN Gene

Previous HGNC Symbols for SNUPN Gene

  • RNUT1

Previous GeneCards Identifiers for SNUPN Gene

  • GC15M073678
  • GC15M075890
  • GC15M052648

Summaries for SNUPN Gene

Entrez Gene Summary for SNUPN Gene

  • The nuclear import of the spliceosomal snRNPs U1, U2, U4 and U5, is dependent on the presence of a complex nuclear localization signal. The latter is composed of the 5'-2,2,7-terminal trimethylguanosine (m3G) cap structure of the U snRNA and the Sm core domain. The protein encoded by this gene interacts specifically with m3G-cap and functions as an snRNP-specific nuclear import receptor. Alternatively spliced transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for SNUPN Gene

SNUPN (Snurportin 1) is a Protein Coding gene. Among its related pathways are Gene Expression and RNA transport. Gene Ontology (GO) annotations related to this gene include protein transporter activity and RNA cap binding.

UniProtKB/Swiss-Prot for SNUPN Gene

  • Functions as an U snRNP-specific nuclear import adapter. Involved in the trimethylguanosine (m3G)-cap-dependent nuclear import of U snRNPs. Binds specifically to the terminal m3G-cap U snRNAs.

Gene Wiki entry for SNUPN Gene

Additional gene information for SNUPN Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SNUPN Gene

Genomics for SNUPN Gene

GeneHancer (GH) Regulatory Elements for SNUPN Gene

Promoters and enhancers for SNUPN Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15I075624 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE 576.8 +0.2 239 3.8 MLX DMAP1 YY1 SLC30A9 E2F8 ZNF143 SP3 NFYC SSRP1 ZNF610 SNUPN ENSG00000260235 ENSG00000260274 MAN2C1 SIN3A EDC3 COMMD4 DNM1P35 FBXO22
GH15I075449 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 35.9 +173.1 173113 8.1 CLOCK MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SIN3A ENSG00000276744 MAN2C1 ENSG00000260274 SNUPN EDC3 CLK3 DNM1P34 LOC101929333 FBXO22
GH15I075346 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE 32.6 +277.4 277356 5 HDGF ARID4B SIN3A ZNF2 ZNF213 ZNF143 KLF13 ZNF263 SP3 SP5 NEIL1 ENSG00000275645 ENSG00000260274 DNM1P35 EDC3 SIN3A MAN2C1 SNUPN FBXO22 LOC441728
GH15I075366 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 24.6 +257.7 257714 3.8 MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 ENSG00000260274 MAN2C1 DNM1P35 SIN3A LOC441728 FBXO22 EDC3 COMMD4 LOC101929333 CLK3
GH15I075637 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 21.9 -13.0 -13019 4.5 CLOCK ZFP64 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 ZNF263 ENSG00000275454 IMP3 MAN2C1 SNUPN ENSG00000203392 CSPG4 LOC441728 ENSG00000260274 COMMD4 SIN3A
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SNUPN on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SNUPN gene promoter:

Genomic Locations for SNUPN Gene

Genomic Locations for SNUPN Gene
28,387 bases
Minus strand

Genomic View for SNUPN Gene

Genes around SNUPN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SNUPN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SNUPN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SNUPN Gene

Proteins for SNUPN Gene

  • Protein details for SNUPN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • A6NE34
    • A8K0B0
    • D3DW76

    Protein attributes for SNUPN Gene

    360 amino acids
    Molecular mass:
    41143 Da
    Quaternary structure:
    • Component of an import snRNP complex composed of KPNB1, SNUPN, SMN1 and ZNF259. Component of a nuclear export receptor complex composed of KPNB1, Ran, SNUPN and XPO1. Found in a trimeric export complex with SNUPN, Ran and XPO1. Interacts (via IBB domain) with KPNB1; the interaction is direct. Interacts with DDX20, IPO7, SMN1, SNRPB and XPO1. Interacts directly with XPO1. Its interaction with XPO1 and binding to m3G-cap U snRNPs appears to be mutually exclusive.

    Three dimensional structures from OCA and Proteopedia for SNUPN Gene

neXtProt entry for SNUPN Gene

Post-translational modifications for SNUPN Gene

  • Ubiquitination at isoforms=144 and posLast=228228

No data available for DME Specific Peptides for SNUPN Gene

Domains & Families for SNUPN Gene

Gene Families for SNUPN Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for SNUPN Gene

Suggested Antigen Peptide Sequences for SNUPN Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the snurportin family.
  • Belongs to the snurportin family.
genes like me logo Genes that share domains with SNUPN: view

Function for SNUPN Gene

Molecular function for SNUPN Gene

UniProtKB/Swiss-Prot Function:
Functions as an U snRNP-specific nuclear import adapter. Involved in the trimethylguanosine (m3G)-cap-dependent nuclear import of U snRNPs. Binds specifically to the terminal m3G-cap U snRNAs.

Phenotypes From GWAS Catalog for SNUPN Gene

Gene Ontology (GO) - Molecular Function for SNUPN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000339 RNA cap binding TAS 9670026
GO:0003723 RNA binding IEA --
GO:0005515 protein binding IPI 19339969
GO:0008565 protein transporter activity IEA --
genes like me logo Genes that share ontologies with SNUPN: view
genes like me logo Genes that share phenotypes with SNUPN: view

Animal Model Products

CRISPR Products

miRNA for SNUPN Gene

miRTarBase miRNAs that target SNUPN

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SNUPN Gene

Localization for SNUPN Gene

Subcellular locations from UniProtKB/Swiss-Prot for SNUPN Gene

Nucleus. Cytoplasm. Note=Nucleoplasmic shuttling protein. Its nuclear import involves the nucleocytoplasmic transport receptor importin beta (PubMed:10209022, PubMed:12095920). It is re-exported to the cytoplasm by the XPO1-dependent nuclear export receptor pathway (PubMed:10209022). {ECO:0000269 PubMed:10209022, ECO:0000269 PubMed:12095920}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SNUPN gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 5

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear membrane (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SNUPN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005643 nuclear pore TAS 9670026
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0070062 extracellular exosome IDA,HDA 23376485
genes like me logo Genes that share ontologies with SNUPN: view

Pathways & Interactions for SNUPN Gene

genes like me logo Genes that share pathways with SNUPN: view

Pathways by source for SNUPN Gene

3 Reactome pathways for SNUPN Gene
1 KEGG pathway for SNUPN Gene

Gene Ontology (GO) - Biological Process for SNUPN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000387 spliceosomal snRNP assembly TAS --
GO:0006606 protein import into nucleus IEA --
GO:0006810 transport IEA --
GO:0051170 nuclear import TAS --
GO:0061015 snRNA import into nucleus IEA --
genes like me logo Genes that share ontologies with SNUPN: view

No data available for SIGNOR curated interactions for SNUPN Gene

Drugs & Compounds for SNUPN Gene

No Compound Related Data Available

Transcripts for SNUPN Gene

Unigene Clusters for SNUPN Gene

Snurportin 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SNUPN Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b
SP1: - - - - - -
SP2: -
SP3: - - -
SP5: - - - - - - - - -
SP6: - - - - - - - -
SP7: - - -
SP8: -

Relevant External Links for SNUPN Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SNUPN Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SNUPN Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SNUPN Gene

This gene is overexpressed in Adrenal (36.9), Breast (18.2), and Peripheral blood mononuclear cells (8.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SNUPN Gene

NURSA nuclear receptor signaling pathways regulating expression of SNUPN Gene:


SOURCE GeneReport for Unigene cluster for SNUPN Gene:


Evidence on tissue expression from TISSUES for SNUPN Gene

  • Nervous system(4.7)
genes like me logo Genes that share expression patterns with SNUPN: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SNUPN Gene

Orthologs for SNUPN Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SNUPN Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SNUPN 33 34
  • 99.34 (n)
(Canis familiaris)
Mammalia SNUPN 33 34
  • 90.17 (n)
(Bos Taurus)
Mammalia SNUPN 33 34
  • 89.91 (n)
(Mus musculus)
Mammalia Snupn 33 16 34
  • 89.89 (n)
(Rattus norvegicus)
Mammalia Snupn 33
  • 89.55 (n)
(Monodelphis domestica)
Mammalia SNUPN 34
  • 84 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 81 (a)
-- 34
  • 80 (a)
-- 34
  • 77 (a)
-- 34
  • 72 (a)
(Gallus gallus)
Aves SNUPN 33 34
  • 70.57 (n)
(Anolis carolinensis)
Reptilia SNUPN 34
  • 72 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia snupn 33
  • 66.37 (n)
Str.7297 33
African clawed frog
(Xenopus laevis)
Amphibia MGC53674 33
(Danio rerio)
Actinopterygii snupn 33 34
  • 64.64 (n)
wufc41a03 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4465 33
fruit fly
(Drosophila melanogaster)
Insecta CG42303 34
  • 32 (a)
(Caenorhabditis elegans)
Secernentea F23F1.5 33 34
  • 48.63 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G24880 33
  • 50.09 (n)
(Oryza sativa)
Liliopsida Os01g0101300 33
  • 47.73 (n)
Species where no ortholog for SNUPN was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SNUPN Gene

Gene Tree for SNUPN (if available)
Gene Tree for SNUPN (if available)

Paralogs for SNUPN Gene

No data available for Paralogs for SNUPN Gene

Variants for SNUPN Gene

Sequence variations from dbSNP and Humsavar for SNUPN Gene

SNP ID Clin Chr 15 pos Variation AA Info Type
rs1000034559 -- 75,610,868(-) T/A intron_variant
rs1000062518 -- 75,603,647(-) C/A/T intron_variant
rs1000159412 -- 75,616,944(-) C/T intron_variant
rs1000233971 -- 75,617,298(-) T/C intron_variant
rs1000368626 -- 75,616,056(-) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SNUPN Gene

Variant ID Type Subtype PubMed ID
esv2749894 CNV deletion 23290073
esv2749895 CNV deletion 23290073
esv3636927 CNV loss 21293372
nsv1116463 OTHER inversion 24896259
nsv1127445 CNV deletion 24896259

Variation tolerance for SNUPN Gene

Residual Variation Intolerance Score: 60.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.62; 56.55% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SNUPN Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SNUPN Gene

Disorders for SNUPN Gene

Additional Disease Information for SNUPN

No disorders were found for SNUPN Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SNUPN Gene

Publications for SNUPN Gene

  1. CRM1-mediated recycling of snurportin 1 to the cytoplasm. (PMID: 10209022) Paraskeva E … Görlich D (The Journal of cell biology 1999) 3 4 22 58
  2. Snurportin1, an m3G-cap-specific nuclear import receptor with a novel domain structure. (PMID: 9670026) Huber J … Lührmann R (The EMBO journal 1998) 2 3 4 58
  3. Molecular determinants of snurportin 1 ligand affinity and structural response upon binding. (PMID: 19619473) Goette M … Grubmüller H (Biophysical journal 2009) 3 22 58
  4. Structural basis for leucine-rich nuclear export signal recognition by CRM1. (PMID: 19339969) Dong X … Chook YM (Nature 2009) 3 22 58
  5. Molecular basis for the recognition of snurportin 1 by importin beta. (PMID: 18187419) Mitrousis G … Cingolani G (The Journal of biological chemistry 2008) 4 22 58

Products for SNUPN Gene

Sources for SNUPN Gene

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