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Aliases for SNTN Gene

Aliases for SNTN Gene

  • Sentan, Cilia Apical Structure Protein 2 3 5
  • S100A-Like Protein 2 3
  • S100A1L 3 4
  • S100 Calcium-Binding Protein A1-Like 4
  • Protein S100-A1-Like 4
  • S100AL 3
  • Sentan 3

External Ids for SNTN Gene

Summaries for SNTN Gene

GeneCards Summary for SNTN Gene

SNTN (Sentan, Cilia Apical Structure Protein) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include calcium ion binding.

UniProtKB/Swiss-Prot for SNTN Gene

  • May be a component of the linker structure that bridges the ciliary membrane and peripheral singlet microtubules.

Additional gene information for SNTN Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SNTN Gene

Genomics for SNTN Gene

GeneHancer (GH) Regulatory Elements for SNTN Gene

Promoters and enhancers for SNTN Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03I063652 Promoter 0.6 EPDnew 550.8 +0.0 41 0.1 RFX1 SNTN LOC105377119 GC03M063562
GH03I063653 Enhancer 0.2 ENCODE 550.8 +1.4 1392 0.2 SNTN LOC105377119 GC03M063562
GH03I063576 Enhancer 0.8 ENCODE 10.7 -75.3 -75262 2 NCOA3 GTF2F1 CLOCK SUZ12 NEUROD1 CEBPG BMI1 RFX5 ZNF507 MTA3 SYNPR-AS1 RNA5SP134 SNTN SYNPR GC03M063562
GH03I063687 Enhancer 0.6 VISTA 11 +35.5 35463 2 RFX1 EZH2 SNTN SYNPR-AS1 RNA5SP134 LOC105377119 GC03M063562
GH03I063624 Enhancer 0.5 ENCODE 11.2 -27.3 -27252 1.2 JUND POLR2A JUN ATF2 MYC ZNF18 SNTN RNA5SP134 SYNPR-AS1 GC03M063562
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SNTN on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SNTN gene promoter:

Genomic Locations for SNTN Gene

Genomic Locations for SNTN Gene
26,353 bases
Plus strand

Genomic View for SNTN Gene

Genes around SNTN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SNTN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SNTN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SNTN Gene

Proteins for SNTN Gene

  • Protein details for SNTN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • B7FF65

    Protein attributes for SNTN Gene

    147 amino acids
    Molecular mass:
    16468 Da
    Quaternary structure:
    No Data Available
    • Sentan means tip in Japanese.

neXtProt entry for SNTN Gene

Post-translational modifications for SNTN Gene

No Post-translational modifications

Other Protein References for SNTN Gene

No data available for DME Specific Peptides for SNTN Gene

Domains & Families for SNTN Gene

Gene Families for SNTN Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for SNTN Gene

Suggested Antigen Peptide Sequences for SNTN Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the S-100 family.
  • Belongs to the S-100 family.
genes like me logo Genes that share domains with SNTN: view

Function for SNTN Gene

Molecular function for SNTN Gene

UniProtKB/Swiss-Prot Function:
May be a component of the linker structure that bridges the ciliary membrane and peripheral singlet microtubules.

Phenotypes From GWAS Catalog for SNTN Gene

Gene Ontology (GO) - Molecular Function for SNTN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0046914 transition metal ion binding IEA --
genes like me logo Genes that share ontologies with SNTN: view

Phenotypes for SNTN Gene

genes like me logo Genes that share phenotypes with SNTN: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SNTN Gene

Localization for SNTN Gene

Subcellular locations from UniProtKB/Swiss-Prot for SNTN Gene

Cell projection, cilium. Note=Expressed exclusively at the cilium tip where it localizes between the cell membrane and peripheral A-subfibers. {ECO:0000250}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SNTN gene
Compartment Confidence
cytosol 3
plasma membrane 1
extracellular 1
nucleus 1

Gene Ontology (GO) - Cellular Components for SNTN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005929 cilium IEA --
GO:0042995 cell projection IEA --
genes like me logo Genes that share ontologies with SNTN: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SNTN Gene

Pathways & Interactions for SNTN Gene

No Data Available

Interacting Proteins for SNTN Gene

Gene Ontology (GO) - Biological Process for SNTN Gene


No data available for Pathways by source and SIGNOR curated interactions for SNTN Gene

Drugs & Compounds for SNTN Gene

No Compound Related Data Available

Transcripts for SNTN Gene

mRNA/cDNA for SNTN Gene

Unigene Clusters for SNTN Gene

Sentan, cilia apical structure protein:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SNTN Gene

No ASD Table

Relevant External Links for SNTN Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SNTN Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SNTN Gene

mRNA differential expression in normal tissues according to GTEx for SNTN Gene

This gene is overexpressed in Fallopian Tube (x21.2), Cervix - Endocervix (x16.0), and Lung (x11.6).

NURSA nuclear receptor signaling pathways regulating expression of SNTN Gene:


SOURCE GeneReport for Unigene cluster for SNTN Gene:


Evidence on tissue expression from TISSUES for SNTN Gene

  • Lung(3.1)
genes like me logo Genes that share expression patterns with SNTN: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SNTN Gene

Orthologs for SNTN Gene

This gene was present in the common ancestor of chordates.

Orthologs for SNTN Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SNTN 33 34
  • 99.32 (n)
(Canis familiaris)
Mammalia SNTN 33 34
  • 86.85 (n)
(Bos Taurus)
Mammalia SNTN 33 34
  • 85.71 (n)
(Mus musculus)
Mammalia Sntn 33 16 34
  • 82.99 (n)
(Rattus norvegicus)
Mammalia Sntn 33
  • 82.05 (n)
(Monodelphis domestica)
Mammalia SNTN 34
  • 67 (a)
(Gallus gallus)
Aves SNTN 33 34
  • 62.73 (n)
(Anolis carolinensis)
Reptilia SNTN 34
  • 55 (a)
Species where no ortholog for SNTN was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SNTN Gene

Gene Tree for SNTN (if available)
Gene Tree for SNTN (if available)

Paralogs for SNTN Gene

(1) SIMAP similar genes for SNTN Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SNTN: view

No data available for Paralogs for SNTN Gene

Variants for SNTN Gene

Sequence variations from dbSNP and Humsavar for SNTN Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000565770 -- 63,664,357(+) A/T 3_prime_UTR_variant
rs1000938275 -- 63,653,105(+) A/T intron_variant
rs1001105066 -- 63,655,531(+) C/A intron_variant
rs1001111468 -- 63,662,390(+) C/T intron_variant
rs1001516341 -- 63,657,404(+) A/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SNTN Gene

Variant ID Type Subtype PubMed ID
nsv834716 CNV loss 17160897
nsv590459 CNV loss 21841781
nsv460581 CNV loss 19166990
nsv3849 CNV insertion 18451855
nsv1008751 CNV gain 25217958
esv2422509 CNV deletion 17116639

Variation tolerance for SNTN Gene

Residual Variation Intolerance Score: 57.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.15; 39.07% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SNTN Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SNTN Gene

Disorders for SNTN Gene

Additional Disease Information for SNTN

No disorders were found for SNTN Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SNTN Gene

Publications for SNTN Gene

  1. Sentan: a novel specific component of the apical structure of vertebrate motile cilia. (PMID: 18829862) Kubo A … Amagai M (Molecular biology of the cell 2008) 2 3 4 58
  2. The DNA sequence, annotation and analysis of human chromosome 3. (PMID: 16641997) Muzny DM … Gibbs RA (Nature 2006) 3 4 58
  3. Genome-wide association of echocardiographic dimensions, brachial artery endothelial function and treadmill exercise responses in the Framingham Heart Study. (PMID: 17903301) Vasan RS … Benjamin EJ (BMC medical genetics 2007) 44 58
  4. Transcriptional gene expression profile of human nasopharynx. (PMID: 15289893) Liu XQ … Zeng YX (International journal of molecular medicine 2004) 4 58

Products for SNTN Gene

Sources for SNTN Gene

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