The protein encoded by this gene is a component of the U1, U2, U4, and U5 small nuclear ribonucleoprotein complexes, precursors of the spliceosome. The encoded protein may also be a part of the U7 small nuclear ribonucleoprotein complex, which participates in the processing of the 3' end of histone transcripts. Several transcript variants encoding different isoforms have been f... See more...

Aliases for SNRPG Gene

Aliases for SNRPG Gene

  • Small Nuclear Ribonucleoprotein Polypeptide G 2 3 5
  • Sm-G 2 3 4
  • Small Nuclear Ribonucleoprotein G 3 4
  • Sm Protein G 3 4
  • SnRNP-G 3 4
  • SNRPG 5
  • PBSCG 4
  • SMG 3
  • SmG 4

External Ids for SNRPG Gene

Previous GeneCards Identifiers for SNRPG Gene

  • GC02M070518
  • GC02M070719
  • GC02M070483
  • GC02M070420
  • GC02M070362
  • GC02M070508
  • GC02M070245

Summaries for SNRPG Gene

Entrez Gene Summary for SNRPG Gene

  • The protein encoded by this gene is a component of the U1, U2, U4, and U5 small nuclear ribonucleoprotein complexes, precursors of the spliceosome. The encoded protein may also be a part of the U7 small nuclear ribonucleoprotein complex, which participates in the processing of the 3' end of histone transcripts. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]

GeneCards Summary for SNRPG Gene

SNRPG (Small Nuclear Ribonucleoprotein Polypeptide G) is a Protein Coding gene. Diseases associated with SNRPG include Lung Papillary Adenocarcinoma. Among its related pathways are Processing of Capped Intronless Pre-mRNA and mRNA Splicing - Major Pathway. An important paralog of this gene is LSM7.

UniProtKB/Swiss-Prot Summary for SNRPG Gene

  • Plays role in pre-mRNA splicing as core component of the SMN-Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome (PubMed:11991638, PubMed:18984161, PubMed:19325628, PubMed:23333303, PubMed:25555158, PubMed:26912367, PubMed:28502770, PubMed:28781166, PubMed:28076346). Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes (PubMed:11991638, PubMed:28502770, PubMed:28781166, PubMed:28076346). Is also a component of the minor U12 spliceosome (PubMed:15146077). As part of the U7 snRNP it is involved in histone 3'-end processing (PubMed:12975319).

Gene Wiki entry for SNRPG Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SNRPG Gene

Genomics for SNRPG Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for SNRPG Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SNRPG on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SNRPG

Top Transcription factor binding sites by QIAGEN in the SNRPG gene promoter:
  • AML1a
  • AREB6
  • CREB
  • deltaCREB
  • HOXA9
  • HOXA9B
  • Meis-1
  • Meis-1b
  • RSRFC4
  • YY1

Genomic Locations for SNRPG Gene

Latest Assembly
chr2:70,281,362-70,293,740
(GRCh38/hg38)
Size:
12,379 bases
Orientation:
Minus strand

Previous Assembly
chr2:70,508,494-70,520,872
(GRCh37/hg19 by Entrez Gene)
Size:
12,379 bases
Orientation:
Minus strand

chr2:70,508,494-70,520,903
(GRCh37/hg19 by Ensembl)
Size:
12,410 bases
Orientation:
Minus strand

Genomic View for SNRPG Gene

Genes around SNRPG on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SNRPG Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SNRPG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SNRPG Gene

Proteins for SNRPG Gene

  • Protein details for SNRPG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P62308-RUXG_HUMAN
    Recommended name:
    Small nuclear ribonucleoprotein G
    Protein Accession:
    P62308
    Secondary Accessions:
    • D6W5G6
    • Q15357
    • Q6IB86

    Protein attributes for SNRPG Gene

    Size:
    76 amino acids
    Molecular mass:
    8496 Da
    Quaternary structure:
    • Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome (PubMed:11991638, PubMed:19325628, PubMed:21516107, PubMed:25555158, PubMed:26912367, PubMed:28502770, PubMed:28781166, PubMed:28076346). Most spliceosomal snRNPs contain a common set of Sm proteins, SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (PubMed:19325628, PubMed:21516107, PubMed:25555158, PubMed:26912367, PubMed:28502770, PubMed:28781166, PubMed:28076346). Component of the U1 snRNP (PubMed:19325628, PubMed:25555158). The U1 snRNP is composed of the U1 snRNA and the 7 core Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG, and at least three U1 snRNP-specific proteins SNRNP70/U1-70K, SNRPA/U1-A and SNRPC/U1-C (PubMed:19325628, PubMed:25555158). Component of the U4/U6-U5 tri-snRNP complex composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, SNRNP40, SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, DDX23, CD2BP2, PPIH, SNU13, EFTUD2, SART1 and USP39, plus LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8 (PubMed:26912367). Component of the U7 snRNP complex, or U7 Sm protein core complex, that is composed of the U7 snRNA and at least LSM10, LSM11, SNRPB, SNRPD3, SNRPE, SNRPF and SNRPG; the complex does not contain SNRPD1 and SNRPD2 (PubMed:11574479, PubMed:12975319). Component of the U11/U12 snRNPs that are part of the U12-type spliceosome (PubMed:15146077). Part of the SMN-Sm complex that contains SMN1, GEMIN2/SIP1, DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6, GEMIN7, GEMIN8, STRAP/UNRIP and the Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG; catalyzes core snRNPs assembly (PubMed:18984161). Forms a 6S pICln-Sm complex composed of CLNS1A/pICln, SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG; ring-like structure where CLNS1A/pICln mimics additional Sm proteins and which is unable to assemble into the core snRNP (PubMed:18984161, PubMed:23333303).

    Three dimensional structures from OCA and Proteopedia for SNRPG Gene

neXtProt entry for SNRPG Gene

Post-translational modifications for SNRPG Gene

  • Ubiquitination at Lys10, Lys11, and Lys20
  • Modification sites at PhosphoSitePlus

Antibodies for research

  • Abcam antibodies for SNRPG
  • Boster Bio Antibodies for SNRPG

No data available for DME Specific Peptides for SNRPG Gene

Domains & Families for SNRPG Gene

Gene Families for SNRPG Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for SNRPG Gene

InterPro:
Blocks:
  • Like-Sm ribonucleoprotein-related, core

Suggested Antigen Peptide Sequences for SNRPG Gene

GenScript: Design optimal peptide antigens:
  • Sm protein G (RUXG_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P62308

UniProtKB/Swiss-Prot:

RUXG_HUMAN :
  • Belongs to the snRNP Sm proteins family.
Family:
  • Belongs to the snRNP Sm proteins family.
genes like me logo Genes that share domains with SNRPG: view

Function for SNRPG Gene

Molecular function for SNRPG Gene

UniProtKB/Swiss-Prot Function:
Plays role in pre-mRNA splicing as core component of the SMN-Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome (PubMed:11991638, PubMed:18984161, PubMed:19325628, PubMed:23333303, PubMed:25555158, PubMed:26912367, PubMed:28502770, PubMed:28781166, PubMed:28076346). Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes (PubMed:11991638, PubMed:28502770, PubMed:28781166, PubMed:28076346). Is also a component of the minor U12 spliceosome (PubMed:15146077). As part of the U7 snRNP it is involved in histone 3'-end processing (PubMed:12975319).

Phenotypes From GWAS Catalog for SNRPG Gene

Gene Ontology (GO) - Molecular Function for SNRPG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 contributes_to RNA binding IEA,IBA 21873635
GO:0005515 protein binding IPI 9417867
genes like me logo Genes that share ontologies with SNRPG: view
genes like me logo Genes that share phenotypes with SNRPG: view

miRNA for SNRPG Gene

miRTarBase miRNAs that target SNRPG

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SNRPG

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SNRPG Gene

Localization for SNRPG Gene

Subcellular locations from UniProtKB/Swiss-Prot for SNRPG Gene

Cytoplasm, cytosol. Nucleus. Note=SMN-mediated assembly into core snRNPs occurs in the cytosol before SMN-mediated transport to the nucleus to be included in spliceosomes. {ECO:0000305}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SNRPG gene
Compartment Confidence
nucleus 5
cytosol 5
extracellular 1
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for SNRPG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 28076346
GO:0005654 nucleoplasm IDA,TAS --
GO:0005681 spliceosomal complex IEA,TAS 7744013
GO:0005682 U5 snRNP IBA 21873635
GO:0005683 U7 snRNP IDA 11574479
genes like me logo Genes that share ontologies with SNRPG: view

Pathways & Interactions for SNRPG Gene

genes like me logo Genes that share pathways with SNRPG: view

Pathways by source for SNRPG Gene

Gene Ontology (GO) - Biological Process for SNRPG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000245 spliceosomal complex assembly NAS 7744013
GO:0000387 spliceosomal snRNP assembly IEA,TAS --
GO:0000398 mRNA splicing, via spliceosome IEA,TAS --
GO:0006369 termination of RNA polymerase II transcription TAS --
GO:0006397 mRNA processing IEA --
genes like me logo Genes that share ontologies with SNRPG: view

No data available for SIGNOR curated interactions for SNRPG Gene

Drugs & Compounds for SNRPG Gene

No Compound Related Data Available

Transcripts for SNRPG Gene

mRNA/cDNA for SNRPG Gene

7 REFSEQ mRNAs :
17 NCBI additional mRNA sequence :
9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SNRPG

Alternative Splicing Database (ASD) splice patterns (SP) for SNRPG Gene

No ASD Table

Relevant External Links for SNRPG Gene

GeneLoc Exon Structure for
SNRPG

Expression for SNRPG Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SNRPG Gene

Protein differential expression in normal tissues from HIPED for SNRPG Gene

This gene is overexpressed in Pancreas (35.0), Lung (13.5), Breast (11.8), and Bone (8.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SNRPG Gene



Protein tissue co-expression partners for SNRPG Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SNRPG

SOURCE GeneReport for Unigene cluster for SNRPG Gene:

Hs.465167

Evidence on tissue expression from TISSUES for SNRPG Gene

  • Nervous system(4.6)
  • Pancreas(4.2)
  • Bone(4)
  • Liver(3.5)
genes like me logo Genes that share expression patterns with SNRPG: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SNRPG Gene

Orthologs for SNRPG Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SNRPG Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia SNRPG 30
  • 100 (a)
OneToOne
LOC100614811 29
  • 97.75 (n)
Mouse
(Mus musculus)
Mammalia Snrpg 30
  • 100 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia SNRPG 29 30
  • 97.81 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia SNRPG 30
  • 97 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia SNRPG 29 30
  • 93.86 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Snrpgl2 29
  • 85.53 (n)
Chicken
(Gallus gallus)
Aves SNRPG 30
  • 97 (a)
OneToOne
FAM136A 29
  • 81.14 (n)
Lizard
(Anolis carolinensis)
Reptilia SNRPG 30
  • 84 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia snrpg 29
  • 78.95 (n)
Zebrafish
(Danio rerio)
Actinopterygii SNRPG 30
  • 89 (a)
OneToOne
zgc:103688 29
  • 77.19 (n)
Dr.14228 29
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.812 29
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002706 29
  • 67.98 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta SmG 29 30
  • 62.72 (n)
OneToOne
Worm
(Caenorhabditis elegans)
Secernentea snr-7 29 30
  • 59.21 (n)
OneToOne
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SMX2 30 32
  • 49 (a)
OneToOne
Species where no ortholog for SNRPG was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for SNRPG Gene

ENSEMBL:
Gene Tree for SNRPG (if available)
TreeFam:
Gene Tree for SNRPG (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SNRPG: view image
Alliance of Genome Resources:
Additional Orthologs for SNRPG

Paralogs for SNRPG Gene

Variants for SNRPG Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for SNRPG Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for SNRPG Gene

Variant ID Type Subtype PubMed ID
esv2523050 CNV deletion 19546169
esv2760537 CNV gain 21179565
nsv518294 CNV loss 19592680
nsv963614 CNV duplication 23825009
nsv979017 CNV duplication 23825009

Variation tolerance for SNRPG Gene

Residual Variation Intolerance Score: 54.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.38; 8.43% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SNRPG Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SNRPG
Leiden Open Variation Database (LOVD)
SNRPG

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SNRPG Gene

Disorders for SNRPG Gene

MalaCards: The human disease database

(1) MalaCards diseases for SNRPG Gene - From: COP

Disorder Aliases PubMed IDs
lung papillary adenocarcinoma
  • papillary adenocarcinoma of the lung
- elite association - COSMIC cancer census association via MalaCards
Search SNRPG in MalaCards View complete list of genes associated with diseases

Additional Disease Information for SNRPG

genes like me logo Genes that share disorders with SNRPG: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SNRPG Gene

Publications for SNRPG Gene

  1. Carcinogenesis and translational controls: TACC1 is down-regulated in human cancers and associates with mRNA regulators. (PMID: 12165861) Conte N … Birnbaum D (Oncogene 2002) 3 4 22
  2. snRNP Sm proteins share two evolutionarily conserved sequence motifs which are involved in Sm protein-protein interactions. (PMID: 7744013) Hermann H … Lührmann R (The EMBO journal 1995) 2 3 4
  3. Cryo-EM Structure of a Pre-catalytic Human Spliceosome Primed for Activation. (PMID: 28781166) Bertram K … Stark H (Cell 2017) 3 4
  4. Cryo-EM structure of a human spliceosome activated for step 2 of splicing. (PMID: 28076346) Bertram K … Lührmann R (Nature 2017) 3 4
  5. Molecular architecture of the human U4/U6.U5 tri-snRNP. (PMID: 26912367) Agafonov DE … Stark H (Science (New York, N.Y.) 2016) 3 4

Products for SNRPG Gene

Sources for SNRPG Gene