Aliases for SNRPD3 Gene
External Ids for SNRPD3 Gene
Previous GeneCards Identifiers for SNRPD3 Gene
This gene encodes a core component of the spliceosome, which is a nuclear ribonucleoprotein complex that functions in pre-mRNA splicing. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
GeneCards Summary for SNRPD3 Gene
SNRPD3 (Small Nuclear Ribonucleoprotein D3 Polypeptide) is a Protein Coding gene. Diseases associated with SNRPD3 include Lupus Erythematosus and Mixed Connective Tissue Disease. Among its related pathways are Processing of Capped Intronless Pre-mRNA and mRNA Splicing - Major Pathway. Gene Ontology (GO) annotations related to this gene include histone pre-mRNA DCP binding. An important paralog of this gene is ENSG00000286070.
UniProtKB/Swiss-Prot Summary for SNRPD3 Gene
Plays role in pre-mRNA splicing as core component of the SMN-Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome (PubMed:11991638, PubMed:18984161, PubMed:19325628, PubMed:25555158, PubMed:26912367, PubMed:28502770, PubMed:28781166, PubMed:28076346). Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes (PubMed:11991638, PubMed:28502770, PubMed:28781166, PubMed:28076346). Is also a component of the minor U12 spliceosome (PubMed:15146077). As part of the U7 snRNP it is involved in histone pre-mRNA 3'-end processing (By similarity).