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The protein encoded by this gene belongs to the small nuclear ribonucleoprotein core protein family. It is required for pre-mRNA splicing and small nuclear ribonucleoprotein biogenesis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009] See more...
Aliases for SNRPD2 Gene
Aliases for SNRPD2 Gene
External Ids for SNRPD2 Gene
- HGNC: 11159
- Entrez Gene: 6633
- Ensembl: ENSG00000125743
- OMIM: 601061
- UniProtKB: P62316
Previous HGNC Symbols for SNRPD2 Gene
- SNRPD1
Previous GeneCards Identifiers for SNRPD2 Gene
- GC19M046834
- GC19M046581
- GC19M050866
- GC19M050882
- GC19M046190
- GC19M042619
Summaries for SNRPD2 Gene
-
The protein encoded by this gene belongs to the small nuclear ribonucleoprotein core protein family. It is required for pre-mRNA splicing and small nuclear ribonucleoprotein biogenesis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]
GeneCards Summary for SNRPD2 Gene
SNRPD2 (Small Nuclear Ribonucleoprotein D2 Polypeptide) is a Protein Coding gene. Diseases associated with SNRPD2 include Basal Ganglia Cerebrovascular Disease and Spinal Muscular Atrophy. Among its related pathways are Transport of the SLBP independent Mature mRNA and mRNA Splicing - Minor Pathway.
UniProtKB/Swiss-Prot Summary for SNRPD2 Gene
-
Plays role in pre-mRNA splicing as core component of the SMN-Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome (PubMed:11991638, PubMed:18984161, PubMed:19325628, PubMed:23333303, PubMed:25555158, PubMed:26912367, PubMed:28502770, PubMed:28781166, PubMed:28076346). Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes (PubMed:11991638, PubMed:28502770, PubMed:28781166, PubMed:28076346). Is also a component of the minor U12 spliceosome (PubMed:15146077).
Additional gene information for SNRPD2 Gene
- HGNC(11159)
- Entrez Gene(6633)
- Ensembl(ENSG00000125743)
- OMIM(601061)
- UniProtKB(P62316)
- Open Targets Platform(ENSG00000125743)
- Search for SNRPD2 at DataMed
- Search for SNRPD2 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SNRPD2 Gene
Genomics for SNRPD2 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for SNRPD2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around SNRPD2 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SNRPD2
- Top Transcription factor binding sites by QIAGEN in the SNRPD2 gene promoter:
-
- AML1a
- AP-2gamma
- AREB6
- CP2
- CUTL1
- GATA-1
- p300
- PPAR-gamma1
- PPAR-gamma2
- SREBP-1a
Genomic Locations for SNRPD2 Gene
Genomic Locations for SNRPD2 Gene
- chr19:45,687,454-45,692,569
- (GRCh38/hg38)
- Size:
- 5,116 bases
- Orientation:
- Minus strand
- chr19:46,190,712-46,195,827
- (GRCh37/hg19)
- Size:
- 5,116 bases
- Orientation:
- Minus strand
Genomic View for SNRPD2 Gene
Genes around SNRPD2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 19q13.2-q13.3 by HGNC
- 19q13.32 by Entrez Gene
- 19q13.32 by Ensembl
SNRPD2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for SNRPD2 Gene
Proteins for SNRPD2 Gene
-
Protein details for SNRPD2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P62316-SMD2_HUMAN
- Recommended name:
- Small nuclear ribonucleoprotein Sm D2
- Protein Accession:
- P62316
- A8K797
- J3KPM5
- P43330
Protein attributes for SNRPD2 Gene
- Size:
- 118 amino acids
- Molecular mass:
- 13527 Da
- Quaternary structure:
-
- Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome (PubMed:11991638, PubMed:19325628, PubMed:21516107, PubMed:25555158, PubMed:26912367, PubMed:28502770, PubMed:28781166, PubMed:28076346). Most spliceosomal snRNPs contain a common set of Sm proteins, SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (PubMed:10025403, PubMed:19325628, PubMed:21516107, PubMed:25555158, PubMed:26912367, PubMed:28502770, PubMed:28781166, PubMed:28076346). Component of the U1 snRNP (PubMed:19325628, PubMed:25555158). The U1 snRNP is composed of the U1 snRNA and the 7 core Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG, and at least three U1 snRNP-specific proteins SNRNP70/U1-70K, SNRPA/U1-A and SNRPC/U1-C (PubMed:19325628, PubMed:25555158). Component of the U4/U6-U5 tri-snRNP complex composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, SNRNP40, SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, DDX23, CD2BP2, PPIH, SNU13, EFTUD2, SART1 and USP39, plus LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8 (PubMed:26912367). Component of the U11/U12 snRNPs that are part of the U12-type spliceosome (PubMed:15146077). Part of the SMN-Sm complex that contains SMN1, GEMIN2/SIP1, DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6, GEMIN7, GEMIN8, STRAP/UNRIP and the Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG; catalyzes core snRNPs assembly. Forms a 6S pICln-Sm complex composed of CLNS1A/pICln, SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG; ring-like structure where CLNS1A/pICln mimics additional Sm proteins and which is unable to assemble into the core snRNP.
- Miscellaneous:
-
- In the autoimmune disease systemic lupus erythematosus, antinuclear antibodies are developed with Sm specificity.
Three dimensional structures from OCA and Proteopedia for SNRPD2 Gene
Protein Expression for SNRPD2 Gene
Post-translational modifications for SNRPD2 Gene
Other Protein References for SNRPD2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- LifeSpan BioSciences SNRPD2 Antibody
-
Custom Antibody ServicesOriGene Antibodies for SNRPD2
- Novus Biologicals Antibodies for SNRPD2
- Invitrogen Antibodies for SNRPD2 (AFLGC-SNRPD2)
-
Boster Bio Antibodies for SNRPD2
- Sino Biological Antibodies for SNRPD2
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for SNRPD2
- Origene Custom Protein Services for SNRPD2
- ProSpec Recombinant Proteins for SNRPD2
-
Signalway Proteins for SNRPD2
-
Abcam proteins for SNRPD2
No data available for DME Specific Peptides for SNRPD2 Gene
Domains & Families for SNRPD2 Gene
Gene Families for SNRPD2 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for SNRPD2 Gene
- InterPro:
- Blocks:
-
- Like-Sm ribonucleoprotein-related, core
- ProtoNet:
Suggested Antigen Peptide Sequences for SNRPD2 Gene
- GenScript: Design optimal peptide antigens:
-
- snRNP core protein D2 (SMD2_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P62316- Family:
-
- Belongs to the snRNP core protein family.
Function for SNRPD2 Gene
Molecular function for SNRPD2 Gene
- UniProtKB/Swiss-Prot Function:
- Plays role in pre-mRNA splicing as core component of the SMN-Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome (PubMed:11991638, PubMed:18984161, PubMed:19325628, PubMed:23333303, PubMed:25555158, PubMed:26912367, PubMed:28502770, PubMed:28781166, PubMed:28076346). Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes (PubMed:11991638, PubMed:28502770, PubMed:28781166, PubMed:28076346). Is also a component of the minor U12 spliceosome (PubMed:15146077).
Phenotypes From GWAS Catalog for SNRPD2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003723 | RNA binding | HDA | 22658674 |
| GO:0005515 | protein binding | IPI | 9417867 |
Phenotypes for SNRPD2 Gene
- GenomeRNAi human phenotypes for SNRPD2:
-
- no effect
- Decreased centriole number
- Decreased viability
- Decreased vaccinia virus (VACV) infection
- Decreased viability of wild-type and TP53 knockout cells
- Decreased shRNA abundance (Z-score < -2)
- Increased gamma-H2AX phosphorylation
- Negative genetic interaction between KRASG13D/+ and KRAS+/-
- Reduced mammosphere formation
- Decreased shRNA abundance
- Decreased influenza A virus infection
- FOXO1 nuclear localization
- Inconclusive
- Decreased homologous recombination repair frequency
- Increased shRNA abundance (Z-score > 2)
- Decreased interferon-beta reporter expression
- Increased G2M DNA content
- S arrest
- Multipolar spindles
- Metaphase cells
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for SNRPD2 - Select products 50% OFF >
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-
OriGene CRISPR knockouts for SNRPD2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SNRPD2
-
Santa Cruz Biotechnology (SCBT) CRISPR for SNRPD2
miRNA for SNRPD2 Gene
- miRTarBase miRNAs that target SNRPD2
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for SNRPD2
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Clone Products
- Applied Biological Materials (abm): Clones for SNRPD2 - Select products 50% OFF >
- * SNRPD2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for SNRPD2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SNRPD2
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SNRPD2 Gene
Localization for SNRPD2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for SNRPD2 Gene
- Cytoplasm, cytosol. Nucleus. Note=SMN-mediated assembly into core snRNPs occurs in the cytosol before SMN-mediated transport to the nucleus to be included in spliceosomes. {ECO:0000305}.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
| extracellular | 4 |
| plasma membrane | 1 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| peroxisome | 1 |
| endoplasmic reticulum | 1 |
| golgi apparatus | 1 |
- Cytosol (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA,IDA | 28076346 |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005681 | spliceosomal complex | TAS | 1701240 |
| GO:0005682 | U5 snRNP | IBA | 21873635 |
| GO:0005685 | U1 snRNP | IBA,IDA | 21113136 |
Pathways & Interactions for SNRPD2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | mRNA Splicing - Major Pathway |
.79
|
.47
.41
|
| 2 | Transport of the SLBP independent Mature mRNA |
.55
|
|
| 3 | Gene Expression |
.48
|
|
| 4 | mRNA Splicing - Minor Pathway | ||
Pathways by source for SNRPD2 Gene
1 BioSystems pathway for SNRPD2 Gene
7 Reactome pathways for SNRPD2 Gene
1 KEGG pathway for SNRPD2 Gene
Interacting Proteins for SNRPD2 Gene
Selected Interacting proteins:
P62316-SMD2_HUMAN
ENSP00000342374
for SNRPD2 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for SNRPD2
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000245 | spliceosomal complex assembly | TAS | 7527560 |
| GO:0000387 | spliceosomal snRNP assembly | IBA,TAS | -- |
| GO:0000398 | mRNA splicing, via spliceosome | TAS | -- |
| GO:0006397 | mRNA processing | IEA | -- |
| GO:0008380 | RNA splicing | IEA,TAS | 1701240 |
No data available for SIGNOR curated interactions for SNRPD2 Gene
Drugs & Compounds for SNRPD2 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Dihydroartemisinin | Experimental, Investigational | Pharma | Target, ligand | 115 |
Transcripts for SNRPD2 Gene
mRNA/cDNA for SNRPD2 Gene
- 4 REFSEQ mRNAs :
- 12 NCBI additional mRNA sequence :
- 8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000342669 901 nts (view in UCSC)
- ENST00000391932 615 nts (view in UCSC)
- ENST00000585392 379 nts (view in UCSC)
- ENST00000587367 596 nts (view in UCSC)
- ENST00000587579 290 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for SNRPD2 - Select products 50% OFF >
- * SNRPD2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for SNRPD2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SNRPD2
-
Santa Cruz Biotechnology (SCBT) CRISPR for SNRPD2
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for SNRPD2
- Browse OriGene Inhibitory RNA Products For SNRPD2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SNRPD2
Clone Products
- Applied Biological Materials (abm): Clones for SNRPD2 - Select products 50% OFF >
- * SNRPD2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for SNRPD2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SNRPD2
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7a | · | 7b | · | 7c | · | 7d | · | 7e |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | |||||||||||||||||||||
| SP2: | - | - | - | ||||||||||||||||||||||
| SP3: | - | - | - | ||||||||||||||||||||||
| SP4: | - | - | - | ||||||||||||||||||||||
| SP5: | - | - | - | - | - | ||||||||||||||||||||
| SP6: | - | - |
Relevant External Links for SNRPD2 Gene
- GeneLoc Exon Structure for
- SNRPD2
Expression for SNRPD2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Ovary (Reproductive System)
- Primary Oocyte Primary Follicle
-
Gonad
- Primary Oocyte Primary Follicle
- Endoderm (Gastrulation Derivatives)
This gene is overexpressed in Peripheral blood mononuclear cells (9.2) and Tlymphocyte (7.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SNRPD2 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SNRPD2
SOURCE GeneReport for Unigene cluster for SNRPD2 Gene:
Hs.515472Evidence on tissue expression from TISSUES for SNRPD2 Gene
- Lung(4.8)
- Blood(4.6)
- Nervous system(4.2)
- Skin(4)
- Liver(3.1)
- Muscle(3)
- Heart(2.7)
- Kidney(2.7)
- Intestine(2.6)
- Bone marrow(2.5)
- Lymph node(2.5)
- Spleen(2.5)
- Thyroid gland(2.4)
- Stomach(2.4)
- Eye(2.2)
Primer Products
-
OriGene qPCR primer pairs for SNRPD2
-
OriGene qPCR primer pairs and template standards for SNRPD2
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SNRPD2 Gene
Orthologs for SNRPD2 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | SNRPD2 30 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | SNRPD2 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | SNRPD2 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Gm5449 31 |
|
OneToOne | |
| Snrpd2 30 17 |
|
||||
| Dog (Canis familiaris) |
Mammalia | SNRPD2 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | SNRPD2 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Snrpd2 30 |
|
||
| Lizard (Anolis carolinensis) |
Reptilia | SNRPD2 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | snrpd2 30 |
|
||
| Str.10758 30 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.4271 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | snrpd2 30 31 |
|
OneToOne | |
| Dr.12513 30 |
|
||||
| Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.778 30 |
|
||
| Fruit Fly (Drosophila melanogaster) |
Insecta | CG1249 32 |
|
|
|
| SmD2 30 31 |
|
OneToOne | |||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP003936 30 |
|
||
| Worm (Caenorhabditis elegans) |
Secernentea | snr-4 30 31 |
|
OneToOne | |
| K. Lactis Yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0D09284g 30 |
|
||
| A. gosspyii yeast (Eremothecium gossypii) |
Saccharomycetes | AGOS_AGR277W 30 |
|
||
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | SMD2 30 31 33 |
|
OneToOne | |
| Thale Cress (Arabidopsis thaliana) |
eudicotyledons | AT3G62840 30 |
|
||
| Alicante grape (Vitis vinifera) |
eudicotyledons | Vvi.3324 30 |
|
||
| Rice (Oryza sativa) |
Liliopsida | Os05g0314100 30 |
|
||
| Os.24812 30 |
|
||||
| Barley (Hordeum vulgare) |
Liliopsida | Hv.2981 30 |
|
||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToOne | |
| Bread mold (Neurospora crassa) |
Ascomycetes | NCU03778 30 |
|
||
| Fission Yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | smd2 30 |
|
||
| Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.4211 30 |
|
- Species where no ortholog for SNRPD2 was found in the sources mined by GeneCards:
-
- Actinobacteria (Mycobacterium tuberculosis)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Beta proteobacteria (Neisseria meningitidis)
- Chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for SNRPD2 Gene
- ENSEMBL:
- Gene Tree for SNRPD2 (if available)
- TreeFam:
- Gene Tree for SNRPD2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for SNRPD2: view image
Paralogs for SNRPD2 Gene
(2) SIMAP similar genes for SNRPD2 Gene using alignment to 3 proteins:
- SMD2_HUMAN
- K7EJB5_HUMAN
- K7ERG4_HUMAN
Pseudogenes.org Pseudogenes for SNRPD2 Gene
No data available for Paralogs for SNRPD2 Gene
Variants for SNRPD2 Gene
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv3644509 | CNV | gain | 21293372 |
| nsv960855 | CNV | duplication | 23825009 |
Residual Variation Intolerance Score:
43.1% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for SNRPD2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- SNRPD2
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SNRPD2 Gene
Disorders for SNRPD2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| basal ganglia cerebrovascular disease |
|
|
| spinal muscular atrophy |
|
|
Search SNRPD2 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for SNRPD2
No data available for UniProtKB/Swiss-Prot and Genatlas for SNRPD2 Gene
Publications for SNRPD2 Gene
- cDNA cloning of the Sm proteins D2 and D3 from human small nuclear ribonucleoproteins: evidence for a direct D1-D2 interaction. (PMID: 7527560) Lehmeier T … Lührmann R (Proceedings of the National Academy of Sciences of the United States of America 1994) 2 3 4
- Cryo-EM Structure of a Pre-catalytic Human Spliceosome Primed for Activation. (PMID: 28781166) Bertram K … Stark H (Cell 2017) 3 4
- Cryo-EM structure of a human spliceosome activated for step 2 of splicing. (PMID: 28076346) Bertram K … Lührmann R (Nature 2017) 3 4
- Molecular architecture of the human U4/U6.U5 tri-snRNP. (PMID: 26912367) Agafonov DE … Stark H (Science (New York, N.Y.) 2016) 3 4
- Crystal structure of human U1 snRNP, a small nuclear ribonucleoprotein particle, reveals the mechanism of 5' splice site recognition. (PMID: 25555158) Kondo Y … Nagai K (eLife 2015) 3 4
ExternalLinks
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- OriGene qPCR primer pairs for SNRPD2
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- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- VectorBuilder Custom and pre-made DNA vectors for SNRPD2 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for SNRPD2 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for SNRPD2 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for SNRPD2 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for SNRPD2
- antibodies-online: Show 34 available SNRPD2 Antibodies ranked by validation data
- Compare Top SNRPD2 Antibodies
- antibodies-online: Search results for available SNRPD2 related products ranked by validation data
- antibodies-online: Show 12 available SNRPD2 Proteins ranked by validation data
- Compare Top SNRPD2 Proteins
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SNRPD2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SNRPD2
- Search GeneCopoeia for miRNA 3'UTR Target clone products for SNRPD2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SNRPD2
- Boster Bio Antibodies for SNRPD2
- Browse Boster Bio ELISA Kits
- Signalway Proteins for SNRPD2
Sources for SNRPD2 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB