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The protein encoded by this gene belongs to the small nuclear ribonucleoprotein core protein family. It is required for pre-mRNA splicing and small nuclear ribonucleoprotein biogenesis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]
SNRPD2 (Small Nuclear Ribonucleoprotein D2 Polypeptide) is a Protein Coding gene. Diseases associated with SNRPD2 include Basal Ganglia Cerebrovascular Disease and Spinal Muscular Atrophy. Among its related pathways are Transport of the SLBP independent Mature mRNA and mRNA Splicing - Minor Pathway.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003723 | RNA binding | HDA | 22658674 |
GO:0005515 | protein binding | IPI | 9417867 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IEA,IDA | 28076346 |
GO:0005654 | nucleoplasm | TAS | -- |
GO:0005681 | spliceosomal complex | TAS | 1701240 |
GO:0005682 | U5 snRNP | IBA | 21873635 |
GO:0005685 | U1 snRNP | IBA,IDA | 21113136 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | mRNA Splicing - Major Pathway |
.79
|
.47
.41
|
2 | Transport of the SLBP independent Mature mRNA |
.55
|
|
3 | Gene Expression |
.48
|
|
4 | mRNA Splicing - Minor Pathway |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000245 | spliceosomal complex assembly | TAS | 7527560 |
GO:0000387 | spliceosomal snRNP assembly | IBA,TAS | -- |
GO:0000398 | mRNA splicing, via spliceosome | TAS | -- |
GO:0006397 | mRNA processing | IEA | -- |
GO:0008380 | RNA splicing | IEA,TAS | 1701240 |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Dihydroartemisinin | Experimental, Investigational | Pharma | Target, ligand | 115 |
ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7a | · | 7b | · | 7c | · | 7d | · | 7e |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | |||||||||||||||||||||
SP2: | - | - | - | ||||||||||||||||||||||
SP3: | - | - | - | ||||||||||||||||||||||
SP4: | - | - | - | ||||||||||||||||||||||
SP5: | - | - | - | - | - | ||||||||||||||||||||
SP6: | - | - |
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | SNRPD2 30 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | SNRPD2 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | SNRPD2 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Gm5449 31 |
|
OneToOne | |
Snrpd2 30 17 |
|
||||
Dog (Canis familiaris) |
Mammalia | SNRPD2 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | SNRPD2 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Snrpd2 30 |
|
||
Lizard (Anolis carolinensis) |
Reptilia | SNRPD2 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | snrpd2 30 |
|
||
Str.10758 30 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.4271 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | snrpd2 30 31 |
|
OneToOne | |
Dr.12513 30 |
|
||||
Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.778 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | CG1249 32 |
|
|
|
SmD2 30 31 |
|
OneToOne | |||
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP003936 30 |
|
||
Worm (Caenorhabditis elegans) |
Secernentea | snr-4 30 31 |
|
OneToOne | |
K. Lactis Yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0D09284g 30 |
|
||
A. gosspyii yeast (Eremothecium gossypii) |
Saccharomycetes | AGOS_AGR277W 30 |
|
||
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | SMD2 30 31 33 |
|
OneToOne | |
Thale Cress (Arabidopsis thaliana) |
eudicotyledons | AT3G62840 30 |
|
||
Alicante grape (Vitis vinifera) |
eudicotyledons | Vvi.3324 30 |
|
||
Rice (Oryza sativa) |
Liliopsida | Os05g0314100 30 |
|
||
Os.24812 30 |
|
||||
Barley (Hordeum vulgare) |
Liliopsida | Hv.2981 30 |
|
||
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToOne | |
Bread mold (Neurospora crassa) |
Ascomycetes | NCU03778 30 |
|
||
Fission Yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | smd2 30 |
|
||
Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.4211 30 |
|
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv3644509 | CNV | gain | 21293372 |
nsv960855 | CNV | duplication | 23825009 |
Disorder | Aliases | PubMed IDs |
---|---|---|
basal ganglia cerebrovascular disease |
|
|
spinal muscular atrophy |
|
|