Aliases for SNRPD1 Gene
External Ids for SNRPD1 Gene
Previous HGNC Symbols for SNRPD1 Gene
Previous GeneCards Identifiers for SNRPD1 Gene
This gene encodes a small nuclear ribonucleoprotein that belongs to the SNRNP core protein family. The protein may act as a charged protein scaffold to promote SNRNP assembly or strengthen SNRNP-SNRNP interactions through nonspecific electrostatic contacts with RNA. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2014]
GeneCards Summary for SNRPD1 Gene
SNRPD1 (Small Nuclear Ribonucleoprotein D1 Polypeptide) is a Protein Coding gene. Diseases associated with SNRPD1 include Lupus Erythematosus and Neurotic Disorder. Among its related pathways are Transport of the SLBP independent Mature mRNA and mRNA Splicing - Minor Pathway. Gene Ontology (GO) annotations related to this gene include RNA binding. An important paralog of this gene is LSM4.
UniProtKB/Swiss-Prot Summary for SNRPD1 Gene
Plays role in pre-mRNA splicing as core component of the SMN-Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome (PubMed:11991638, PubMed:18984161, PubMed:19325628, PubMed:23333303, PubMed:25555158, PubMed:26912367, PubMed:28502770, PubMed:28781166, PubMed:28076346). Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes (PubMed:11991638, PubMed:26912367, PubMed:28502770, PubMed:28781166, PubMed:28076346). Is also a component of the minor U12 spliceosome (PubMed:15146077). May act as a charged protein scaffold to promote snRNP assembly or strengthen snRNP-snRNP interactions through non-specific electrostatic contacts with RNA (Probable).