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Aliases for SNRPB2 Gene

Aliases for SNRPB2 Gene

  • Small Nuclear Ribonucleoprotein Polypeptide B2 2 3 5
  • U2 SnRNP B 3 4
  • Small Nuclear Ribonucleoprotein Polypeptide B 3
  • U2 Small Nuclear Ribonucleoprotein B 3
  • Msl1 3
  • U2B 3

External Ids for SNRPB2 Gene

Previous GeneCards Identifiers for SNRPB2 Gene

  • GC20P016698
  • GC20P016705

Summaries for SNRPB2 Gene

Entrez Gene Summary for SNRPB2 Gene

  • The protein encoded by this gene associates with stem loop IV of U2 small nuclear ribonucleoprotein (U2 snRNP) in the presence of snRNP-A'. The encoded protein may play a role in pre-mRNA splicing. Autoantibodies from patients with systemic lupus erythematosus frequently recognize epitopes on the encoded protein. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for SNRPB2 Gene

SNRPB2 (Small Nuclear Ribonucleoprotein Polypeptide B2) is a Protein Coding gene. Among its related pathways are mRNA Splicing - Major Pathway and Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and snRNA binding. An important paralog of this gene is SNRPA.

UniProtKB/Swiss-Prot for SNRPB2 Gene

  • Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11991638, PubMed:28502770, PubMed:28781166, PubMed:28076346). Associated with sn-RNP U2, where it contributes to the binding of stem loop IV of U2 snRNA (PubMed:9716128).

Gene Wiki entry for SNRPB2 Gene

Additional gene information for SNRPB2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SNRPB2 Gene

Genomics for SNRPB2 Gene

GeneHancer (GH) Regulatory Elements for SNRPB2 Gene

Promoters and enhancers for SNRPB2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH20J016729 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 650.7 +0.3 263 1.9 HDGF PKNOX1 SMAD1 ARNT ZFP64 ARID4B NEUROD1 SIN3A DMAP1 ZNF2 SNRPB2 ENSG00000228809 LOC100286962
GH20J016526 Enhancer 1.1 Ensembl ENCODE 9.7 -200.7 -200685 4.7 FOXA2 ARID4B SIN3A DMAP1 FOS NFKBIZ RXRA KAT8 SREBF1 NFIL3 KIF16B ENSG00000228809 SNRPB2 GC20P016478
GH20J016578 Enhancer 0.9 Ensembl ENCODE 10.1 -149.7 -149737 2.6 PKNOX1 FOXA2 NFIB INSM2 FEZF1 GATA3 POLR2A ZSCAN5C RCOR1 KLF8 ENSG00000275728 KIF16B SNRPB2 ENSG00000228809 ENSG00000273998
GH20J016541 Enhancer 0.6 ENCODE 10.4 -188.5 -188530 0.2 RXRA REST GABPA YY1 NR2F2 SP1 JUND HNF4A KIF16B ENSG00000228809 SNRPB2 GC20P016478
GH20J016532 Enhancer 0.4 ENCODE 9.7 -196.6 -196571 1.4 MITF HLF CREB1 KIF16B SNRPB2 ENSG00000228809 GC20P016478
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SNRPB2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SNRPB2 gene promoter:
  • MEF-2A
  • aMEF-2
  • AP-1
  • FOXL1
  • PPAR-gamma2
  • PPAR-gamma1
  • Pax-6
  • p53
  • MRF-2
  • FOXO3

Genomic Locations for SNRPB2 Gene

Genomic Locations for SNRPB2 Gene
12,603 bases
Plus strand
11,816 bases
Plus strand

Genomic View for SNRPB2 Gene

Genes around SNRPB2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SNRPB2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SNRPB2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SNRPB2 Gene

Proteins for SNRPB2 Gene

  • Protein details for SNRPB2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    U2 small nuclear ribonucleoprotein B
    Protein Accession:
    Secondary Accessions:
    • B2R7J3
    • D3DW21
    • Q9UJD4

    Protein attributes for SNRPB2 Gene

    225 amino acids
    Molecular mass:
    25486 Da
    Quaternary structure:
    • Identified in the spliceosome B complex (PubMed:28781166). Identified in the spliceosome C complex (PubMed:11991638, PubMed:28502770, PubMed:28076346). Present in a spliceosome complex assembled in vitro, and composed of SNRPB2, HPRP8BP and CRNKL1 (PubMed:12084575). Contributes to the binding of stem loop IV of U2 snRNA with SNRPP1 (PubMed:9716128).
    • Patients with systemic lupus erythematosus produce antibodies which interact with snRNP proteins.

    Three dimensional structures from OCA and Proteopedia for SNRPB2 Gene

neXtProt entry for SNRPB2 Gene

Post-translational modifications for SNRPB2 Gene

  • Ubiquitination at posLast=219219, isoforms=93, isoforms=85, isoforms=77, and isoforms=57
  • Modification sites at PhosphoSitePlus

Other Protein References for SNRPB2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SNRPB2 Gene

Domains & Families for SNRPB2 Gene

Gene Families for SNRPB2 Gene

Suggested Antigen Peptide Sequences for SNRPB2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the RRM U1 A/B family.
  • Belongs to the RRM U1 A/B family.
genes like me logo Genes that share domains with SNRPB2: view

Function for SNRPB2 Gene

Molecular function for SNRPB2 Gene

UniProtKB/Swiss-Prot Function:
Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11991638, PubMed:28502770, PubMed:28781166, PubMed:28076346). Associated with sn-RNP U2, where it contributes to the binding of stem loop IV of U2 snRNA (PubMed:9716128).

Gene Ontology (GO) - Molecular Function for SNRPB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IEA --
GO:0005515 protein binding IPI 9716128
GO:0030619 U1 snRNA binding IBA --
GO:0035614 snRNA stem-loop binding IBA --
genes like me logo Genes that share ontologies with SNRPB2: view
genes like me logo Genes that share phenotypes with SNRPB2: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SNRPB2 Gene

Localization for SNRPB2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SNRPB2 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SNRPB2 gene
Compartment Confidence
nucleus 5

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear speckles (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SNRPB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001650 fibrillar center IDA --
GO:0005634 nucleus IDA,IEA 28076346
GO:0005654 nucleoplasm TAS --
GO:0005681 spliceosomal complex IDA 9731529
GO:0005685 U1 snRNP IBA --
genes like me logo Genes that share ontologies with SNRPB2: view

Pathways & Interactions for SNRPB2 Gene

genes like me logo Genes that share pathways with SNRPB2: view

Pathways by source for SNRPB2 Gene

1 KEGG pathway for SNRPB2 Gene

Gene Ontology (GO) - Biological Process for SNRPB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0006397 mRNA processing IEA --
GO:0008380 RNA splicing IEA --
genes like me logo Genes that share ontologies with SNRPB2: view

No data available for SIGNOR curated interactions for SNRPB2 Gene

Drugs & Compounds for SNRPB2 Gene

No Compound Related Data Available

Transcripts for SNRPB2 Gene

mRNA/cDNA for SNRPB2 Gene

Unigene Clusters for SNRPB2 Gene

Small nuclear ribonucleoprotein polypeptide B:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SNRPB2 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7
SP2: - - -
SP3: - -
SP4: -

Relevant External Links for SNRPB2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SNRPB2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SNRPB2 Gene

Protein differential expression in normal tissues from HIPED for SNRPB2 Gene

This gene is overexpressed in CD8 Tcells (7.7) and Peripheral blood mononuclear cells (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SNRPB2 Gene

Protein tissue co-expression partners for SNRPB2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SNRPB2 Gene:


SOURCE GeneReport for Unigene cluster for SNRPB2 Gene:


Evidence on tissue expression from TISSUES for SNRPB2 Gene

  • Nervous system(4.8)
  • Lung(2.2)
genes like me logo Genes that share expression patterns with SNRPB2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SNRPB2 Gene

Orthologs for SNRPB2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SNRPB2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SNRPB2 34 33
  • 99.11 (n)
(Ornithorhynchus anatinus)
Mammalia SNRPB2 34
  • 94 (a)
(Canis familiaris)
Mammalia SNRPB2 34 33
  • 93.63 (n)
-- 34
  • 89 (a)
(Bos Taurus)
Mammalia SNRPB2 34 33
  • 93.58 (n)
(Rattus norvegicus)
Mammalia Snrpb2 33
  • 90.67 (n)
(Mus musculus)
Mammalia Snrpb2 16 34 33
  • 89.63 (n)
(Monodelphis domestica)
Mammalia SNRPB2 34
  • 72 (a)
(Gallus gallus)
Aves SNRPB2 34 33
  • 79.41 (n)
(Anolis carolinensis)
Reptilia SNRPB2 34
  • 87 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia snrpb2 33
  • 74.14 (n)
(Danio rerio)
Actinopterygii snrpb2 34 33
  • 71.67 (n)
Dr.14007 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8470 33
fruit fly
(Drosophila melanogaster)
Insecta snf 34 35
  • 68 (a)
(Caenorhabditis elegans)
Secernentea rnp-3 34 33
  • 54.72 (n)
rnp-2 34
  • 48 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MSL1 34
  • 23 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G06960 33
  • 59.39 (n)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.1622 33
(Oryza sativa)
Liliopsida Os03g0298800 33
  • 60.61 (n)
(Triticum aestivum)
Liliopsida Ta.9408 33
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10455 34
  • 52 (a)
Species where no ortholog for SNRPB2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for SNRPB2 Gene

Gene Tree for SNRPB2 (if available)
Gene Tree for SNRPB2 (if available)
Evolutionary constrained regions (ECRs) for SNRPB2: view image

Paralogs for SNRPB2 Gene

Paralogs for SNRPB2 Gene

(1) SIMAP similar genes for SNRPB2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SNRPB2: view

Variants for SNRPB2 Gene

Sequence variations from dbSNP and Humsavar for SNRPB2 Gene

SNP ID Clin Chr 20 pos Variation AA Info Type
VAR_035487 A colorectal cancer sample p.Lys19Gln
rs1000797936 -- 16,730,205(+) A/G intron_variant
rs1001030440 -- 16,734,640(+) T/C intron_variant
rs1001073869 -- 16,741,380(+) A/G 3_prime_UTR_variant
rs1001092297 -- 16,733,854(+) G/A intron_variant

Variation tolerance for SNRPB2 Gene

Residual Variation Intolerance Score: 35.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.09; 1.97% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SNRPB2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SNRPB2 Gene

Disorders for SNRPB2 Gene

Additional Disease Information for SNRPB2

No disorders were found for SNRPB2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SNRPB2 Gene

Publications for SNRPB2 Gene

  1. Analysis of a cDNA clone expressing a human autoimmune antigen: full-length sequence of the U2 small nuclear RNA-associated B" antigen. (PMID: 2951739) Habets WJ … van Venrooij WJ (Proceedings of the National Academy of Sciences of the United States of America 1987) 2 3 4 58
  2. Cryo-EM structure of a human spliceosome activated for step 2 of splicing. (PMID: 28076346) Bertram K … Lührmann R (Nature 2017) 3 4 58
  3. Cryo-EM Structure of a Pre-catalytic Human Spliceosome Primed for Activation. (PMID: 28781166) Bertram K … Stark H (Cell 2017) 3 4 58
  4. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PMID: 15592455) Rush J … Comb MJ (Nature biotechnology 2005) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for SNRPB2 Gene

Sources for SNRPB2 Gene

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