Aliases for SNRPB Gene
External Ids for SNRPB Gene
Previous HGNC Symbols for SNRPB Gene
Previous GeneCards Identifiers for SNRPB Gene
The protein encoded by this gene is one of several nuclear proteins that are found in common among U1, U2, U4/U6, and U5 small ribonucleoprotein particles (snRNPs). These snRNPs are involved in pre-mRNA splicing, and the encoded protein may also play a role in pre-mRNA splicing or snRNP structure. Autoantibodies from patients with systemic lupus erythematosus frequently recognize epitopes on the encoded protein. Two transcript variants encoding different isoforms (B and B') have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for SNRPB Gene
SNRPB (Small Nuclear Ribonucleoprotein Polypeptides B And B1) is a Protein Coding gene. Diseases associated with SNRPB include Cerebrocostomandibular Syndrome and Isolated Pierre Robin Sequence. Among its related pathways are Processing of Capped Intronless Pre-mRNA and mRNA Splicing - Major Pathway. Gene Ontology (GO) annotations related to this gene include histone pre-mRNA DCP binding. An important paralog of this gene is SNRPN.
UniProtKB/Swiss-Prot Summary for SNRPB Gene
Plays role in pre-mRNA splicing as core component of the SMN-Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome (PubMed:11991638, PubMed:18984161, PubMed:19325628, PubMed:25555158, PubMed:26912367, PubMed:28502770, PubMed:28781166, PubMed:28076346). Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes (PubMed:11991638, PubMed:28502770, PubMed:28781166, PubMed:28076346). Is also a component of the minor U12 spliceosome (PubMed:15146077). As part of the U7 snRNP it is involved in histone pre-mRNA 3'-end processing (PubMed:12975319).