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Aliases for SNRPA1 Gene

Aliases for SNRPA1 Gene

  • Small Nuclear Ribonucleoprotein Polypeptide A' 2
  • Small Nuclear Ribonucleoprotein Polypeptide A 2 3 5
  • U2 SnRNP A 3 4
  • U2 Small Nuclear Ribonucleoprotein Polypeptide A 3
  • U2 Small Nuclear Ribonucleoprotein A 3
  • Lea1 3

External Ids for SNRPA1 Gene

Previous GeneCards Identifiers for SNRPA1 Gene

  • GC15M098673
  • GC15M095663
  • GC15M099414
  • GC15M099556
  • GC15M099553
  • GC15M099639
  • GC15M101821
  • GC15M077944

Summaries for SNRPA1 Gene

GeneCards Summary for SNRPA1 Gene

SNRPA1 (Small Nuclear Ribonucleoprotein Polypeptide A') is a Protein Coding gene. Among its related pathways are mRNA Splicing - Major Pathway and Gene Expression.

UniProtKB/Swiss-Prot for SNRPA1 Gene

  • This protein is associated with sn-RNP U2. It helps the A protein to bind stem loop IV of U2 snRNA.

Gene Wiki entry for SNRPA1 Gene

Additional gene information for SNRPA1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SNRPA1 Gene

Genomics for SNRPA1 Gene

GeneHancer (GH) Regulatory Elements for SNRPA1 Gene

Promoters and enhancers for SNRPA1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15I101293 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 553.8 -0.1 -72 4.7 PKNOX1 SMAD1 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B POLR2B SNRPA1 ENSG00000259172 LINS1 LOC100419174 CERS3-AS1 PRKXP1 RNU6-807P WASH3P LRRK1 ENSG00000270127
GH15I101745 Promoter/Enhancer 1.3 Ensembl dbSUPER 32.9 -450.9 -450919 2 HDGF RB1 NFRKB ZNF335 POLR2B POLR3A ZNF143 SMARCA5 ZNF202 ZNF362 LOC100128108 PIR33824 PIR52825 SNRPA1 WASH3P LRRK1 GC15P101730 GC15M101723
GH15I101197 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 18 +91.0 91039 14.3 HDGF PKNOX1 FOXA2 SMAD1 SIN3A FEZF1 IRF4 TCF12 GATA2 ZNF143 GC15M101194 CHSY1 SNRPA1 LOC100419174 LINS1 PRKXP1 TM2D3 WASH3P ASB7 LRRK1
GH15I100341 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 12.1 +953.3 953349 1.5 PKNOX1 CLOCK ARID4B SIN3A ZNF2 YY1 GLIS2 ZNF213 ZNF143 RUNX3 ADAMTS17 SNRPA1 SPATA41 CERS3-AS1 PIR51596
GH15I101445 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 13.5 -151.1 -151091 2.3 HDGF PKNOX1 FOXA2 MLX ARNT ARID4B DMAP1 YY1 SLC30A9 ZNF766 SNRPA1 PRKXP1 TM2D3 LINS1 LOC100419174 ASB7 ENSG00000270127 WASH3P PCSK6 CHSY1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SNRPA1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SNRPA1 gene promoter:

Genomic Locations for SNRPA1 Gene

Genomic Locations for SNRPA1 Gene
chr15:101,281,510-101,295,282
(GRCh38/hg38)
Size:
13,773 bases
Orientation:
Minus strand
chr15:101,821,715-101,835,487
(GRCh37/hg19)

Genomic View for SNRPA1 Gene

Genes around SNRPA1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SNRPA1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SNRPA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SNRPA1 Gene

Proteins for SNRPA1 Gene

  • Protein details for SNRPA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P09661-RU2A_HUMAN
    Recommended name:
    U2 small nuclear ribonucleoprotein A
    Protein Accession:
    P09661
    Secondary Accessions:
    • B2R5I6
    • Q8TBD2

    Protein attributes for SNRPA1 Gene

    Size:
    255 amino acids
    Molecular mass:
    28416 Da
    Quaternary structure:
    • Identified in the spliceosome C complex. Found in a pre-mRNA splicing complex with SFRS4, SFRS5, SNRNP70, SNRPA1, SRRM1 and SRRM2. Found in a pre-mRNA exonic splicing enhancer (ESE) complex with SNRNP70, SNRPA1, SRRM1 and TRA2B.

    Three dimensional structures from OCA and Proteopedia for SNRPA1 Gene

neXtProt entry for SNRPA1 Gene

Post-translational modifications for SNRPA1 Gene

  • Ubiquitination at posLast=149149, isoforms=205, and isoforms=221
  • Modification sites at PhosphoSitePlus

Other Protein References for SNRPA1 Gene

No data available for DME Specific Peptides for SNRPA1 Gene

Domains & Families for SNRPA1 Gene

Gene Families for SNRPA1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for SNRPA1 Gene

Graphical View of Domain Structure for InterPro Entry

P09661

UniProtKB/Swiss-Prot:

RU2A_HUMAN :
  • Belongs to the U2 small nuclear ribonucleoprotein A family.
Family:
  • Belongs to the U2 small nuclear ribonucleoprotein A family.
genes like me logo Genes that share domains with SNRPA1: view

Function for SNRPA1 Gene

Molecular function for SNRPA1 Gene

UniProtKB/Swiss-Prot Function:
This protein is associated with sn-RNP U2. It helps the A protein to bind stem loop IV of U2 snRNA.

Phenotypes From GWAS Catalog for SNRPA1 Gene

Gene Ontology (GO) - Molecular Function for SNRPA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA,IEA 22681889
GO:0005515 protein binding IPI 9716128
GO:0030620 U2 snRNA binding IBA --
genes like me logo Genes that share ontologies with SNRPA1: view
genes like me logo Genes that share phenotypes with SNRPA1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SNRPA1 Gene

Localization for SNRPA1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SNRPA1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SNRPA1 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear bodies (3)
  • Nuclear speckles (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SNRPA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0005681 spliceosomal complex IDA 9731529
GO:0005686 U2 snRNP TAS 2928112
GO:0016604 nuclear body IDA --
genes like me logo Genes that share ontologies with SNRPA1: view

Pathways & Interactions for SNRPA1 Gene

genes like me logo Genes that share pathways with SNRPA1: view

Pathways by source for SNRPA1 Gene

1 KEGG pathway for SNRPA1 Gene

Gene Ontology (GO) - Biological Process for SNRPA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0006397 mRNA processing IEA --
GO:0008380 RNA splicing TAS 2928112
GO:0035722 interleukin-12-mediated signaling pathway TAS --
genes like me logo Genes that share ontologies with SNRPA1: view

No data available for SIGNOR curated interactions for SNRPA1 Gene

Drugs & Compounds for SNRPA1 Gene

No Compound Related Data Available

Transcripts for SNRPA1 Gene

Unigene Clusters for SNRPA1 Gene

Small nuclear ribonucleoprotein polypeptide A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SNRPA1 Gene

No ASD Table

Relevant External Links for SNRPA1 Gene

GeneLoc Exon Structure for
SNRPA1
ECgene alternative splicing isoforms for
SNRPA1

Expression for SNRPA1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SNRPA1 Gene

Protein differential expression in normal tissues from HIPED for SNRPA1 Gene

This gene is overexpressed in Lymph node (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SNRPA1 Gene



Protein tissue co-expression partners for SNRPA1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SNRPA1 Gene:

SNRPA1

SOURCE GeneReport for Unigene cluster for SNRPA1 Gene:

Hs.528763

Evidence on tissue expression from TISSUES for SNRPA1 Gene

  • Liver(4.2)
  • Muscle(4.1)
  • Nervous system(3.1)
genes like me logo Genes that share expression patterns with SNRPA1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SNRPA1 Gene

Orthologs for SNRPA1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SNRPA1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SNRPA1 33 34
  • 99.74 (n)
oppossum
(Monodelphis domestica)
Mammalia SNRPA1 34
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SNRPA1 34
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SNRPA1 33 34
  • 94.51 (n)
cow
(Bos Taurus)
Mammalia SNRPA1 33 34
  • 93.33 (n)
rat
(Rattus norvegicus)
Mammalia Snrpa1 33
  • 92.42 (n)
mouse
(Mus musculus)
Mammalia Snrpa1 33 16 34
  • 91.5 (n)
chicken
(Gallus gallus)
Aves SNRPA1 33 34
  • 82.09 (n)
lizard
(Anolis carolinensis)
Reptilia SNRPA1 34
  • 88 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia snrpa1 33
  • 76.47 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.23786 33
zebrafish
(Danio rerio)
Actinopterygii snrpa1 33 34
  • 76.41 (n)
fruit fly
(Drosophila melanogaster)
Insecta U2A 35 33 34
  • 56.28 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007670 33
  • 56.13 (n)
worm
(Caenorhabditis elegans)
Secernentea mog-2 33 34
  • 55.51 (n)
H20J04.8 35
  • 47 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes LEA1 36
thale cress
(Arabidopsis thaliana)
eudicotyledons U2A 33
  • 54.26 (n)
rice
(Oryza sativa)
Liliopsida Os02g0234800 33
  • 59.42 (n)
wheat
(Triticum aestivum)
Liliopsida Ta.22751 33
corn
(Zea mays)
Liliopsida Zm.15425 33
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4424 34
  • 58 (a)
OneToOne
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes lea1 33
  • 49.64 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU06622 33
  • 48.39 (n)
Species where no ortholog for SNRPA1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for SNRPA1 Gene

ENSEMBL:
Gene Tree for SNRPA1 (if available)
TreeFam:
Gene Tree for SNRPA1 (if available)

Paralogs for SNRPA1 Gene

Pseudogenes.org Pseudogenes for SNRPA1 Gene

genes like me logo Genes that share paralogs with SNRPA1: view

No data available for Paralogs for SNRPA1 Gene

Variants for SNRPA1 Gene

Sequence variations from dbSNP and Humsavar for SNRPA1 Gene

SNP ID Clin Chr 15 pos Variation AA Info Type
rs1000008826 -- 101,295,209(-) A/G 5_prime_UTR_variant, non_coding_transcript_variant
rs1000410584 -- 101,287,815(-) CTCTCT/CTCT intron_variant
rs1000597095 -- 101,283,702(-) T/C intron_variant
rs1000672047 -- 101,282,514(-) T/G intron_variant
rs1000687369 -- 101,294,307(-) T/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SNRPA1 Gene

Variant ID Type Subtype PubMed ID
dgv2673n100 CNV gain 25217958
esv2760063 CNV gain+loss 17122850
esv34275 CNV gain 17911159
esv3637501 CNV gain 21293372
nsv1035599 CNV gain 25217958
nsv1049577 CNV gain 25217958
nsv428314 CNV loss 18775914
nsv570828 CNV gain 21841781
nsv570833 CNV loss 21841781
nsv833110 CNV gain+loss 17160897

Variation tolerance for SNRPA1 Gene

Residual Variation Intolerance Score: 57.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.92; 19.04% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SNRPA1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SNRPA1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SNRPA1 Gene

Disorders for SNRPA1 Gene

Additional Disease Information for SNRPA1

No disorders were found for SNRPA1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SNRPA1 Gene

Publications for SNRPA1 Gene

  1. Molecular cloning of the cDNA for the human U2 snRNA-specific A' protein. (PMID: 2928112) Sillekens PT … van Verooij WJ (Nucleic acids research 1989) 2 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. (PMID: 11991638) Jurica MS … Moore MJ (RNA (New York, N.Y.) 2002) 3 4 58
  5. The SRm160/300 splicing coactivator is required for exon-enhancer function. (PMID: 10339552) Eldridge AG … Blencowe BJ (Proceedings of the National Academy of Sciences of the United States of America 1999) 3 4 58

Products for SNRPA1 Gene

Sources for SNRPA1 Gene

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